论文信息 - Immunological reconstitution in long-term survivors of thalassemia major patients after hematopoietic stem cell transplantation.

Immunological reconstitution in long-term survivors of thalassemia major patients after hematopoietic stem cell transplantation.

We studied the immune function of 33 long-term survivors of thalassemia after hematopoietic stem cell transplantation. Lymphocyte subsets, lymphoproliferative response and immunoglobulin were normal but the level of natural killer cells was low. Five and seven patients had suboptimal antibody response at 4 week after pneumococcal and hepatitis B vaccine, respectively, but this response returned to normal by 6 months.

[1] K. Chik,et al. Haematopoietic stem cell transplantation for thalassaemia major in Hong Kong: prognostic factors and outcome , 2002, Bone Marrow Transplantation.

[2] Y. Ishigatsubo,et al. Immune reconstitution assessed during five years after allogeneic bone marrow transplantation , 2001, Bone Marrow Transplantation.

[3] Chi-kong Li,et al. Transfusion‐Related Immunomodulation in Chinese Children with Thalassaemia , 1997, Vox sanguinis.

[4] F. Chew,et al. Age- and sex-related changes in lymphocyte subpopulations of healthy Asian subjects: from birth to adulthood. , 1996, Cytometry.

[5] M. Romeo,et al. Immune status and immune response to diphtheria-tetanus and polio vaccines in allogeneic bone marrow-transplanted thalassemic patients. , 1994, Bone marrow transplantation.

[6] K. Sullivan,et al. Recovery of antibody production in human allogeneic marrow graft recipients: influence of time posttransplantation, the presence or absence of chronic graft-versus-host disease, and antithymocyte globulin treatment , 1981 .