The antifungal effect induced by itraconazole in Candida parapsilosis largely depends on the oxidative stress generated at the mitochondria

[1]  J. Argüelles,et al.  Lack of Functional Trehalase Activity in Candida parapsilosis Increases Susceptibility to Itraconazole , 2022, Journal of fungi.

[2]  P. van Dijck,et al.  Interesting antifungal drug targets in the central metabolism of Candida albicans. , 2021, Trends in pharmacological sciences.

[3]  C. Vágvölgyi,et al.  A Candida parapsilosis Overexpression Collection Reveals Genes Required for Pathogenesis , 2021, Journal of fungi.

[4]  K. Kuchler,et al.  Sugar Phosphorylation Controls Carbon Source Utilization and Virulence of Candida albicans , 2020, Frontiers in Microbiology.

[5]  F. Madeo,et al.  Fungal infections in humans: the silent crisis , 2020, Microbial cell.

[6]  Duncan W. Wilson,et al.  Cooperative Role of MAPK Pathways in the Interaction of Candida albicans with the Host Epithelium , 2019, Microorganisms.

[7]  J. Argüelles,et al.  The MAPK Hog1 mediates the response to amphotericin B in Candida albicans. , 2019, Fungal genetics and biology : FG & B.

[8]  Joshua D. Nosanchuk,et al.  Candida parapsilosis: from Genes to the Bedside , 2019, Clinical Microbiology Reviews.

[9]  J. Adrio,et al.  Antifungals , 2018, Reactions Weekly.

[10]  J. Argüelles,et al.  Micafungin Enhances the Human Macrophage Response to Candida albicans through β-Glucan Exposure , 2018, Antimicrobial Agents and Chemotherapy.

[11]  O. Kniemeyer,et al.  Induction of Mitochondrial Reactive Oxygen Species Production by Itraconazole, Terbinafine, and Amphotericin B as a Mode of Action against Aspergillus fumigatus , 2017, Antimicrobial Agents and Chemotherapy.

[12]  J. Perfect,et al.  Central Role of the Trehalose Biosynthesis Pathway in the Pathogenesis of Human Fungal Infections: Opportunities and Challenges for Therapeutic Development , 2017, Microbiology and Molecular Biology Reviews.

[13]  John R Perfect,et al.  Trehalose pathway as an antifungal target , 2017, Virulence.

[14]  J. Argüelles.  Trehalose as antifungal target: The picture is still incomplete , 2017, Virulence.

[15]  J. Argüelles,et al.  Homozygous deletion of ATC1 and NTC1 genes in Candida parapsilosis abolishes trehalase activity and affects cell growth, sugar metabolism, stress resistance, infectivity and biofilm formation. , 2015, Fungal genetics and biology : FG & B.

[16]  F. Kong,et al.  Development of fluconazole resistance in a series of Candida parapsilosis isolates from a persistent candidemia patient with prolonged antifungal therapy , 2015, BMC Infectious Diseases.

[17]  David W. Denning,et al.  How to bolster the antifungal pipeline , 2015, Science.

[18]  Desmond G. Higgins,et al.  Comparative Phenotypic Analysis of the Major Fungal Pathogens Candida parapsilosis and Candida albicans , 2014, PLoS pathogens.

[19]  J. Argüelles,et al.  The Production of Reactive Oxygen Species Is a Universal Action Mechanism of Amphotericin B against Pathogenic Yeasts and Contributes to the Fungicidal Effect of This Drug , 2014, Antimicrobial Agents and Chemotherapy.

[20]  D. Horn,et al.  Epidemiology and Outcomes of Invasive Candidiasis Due to Non-albicans Species of Candida in 2,496 Patients: Data from the Prospective Antifungal Therapy (PATH) Registry 2004–2008 , 2014, PloS one.

[21]  J. Pla,et al.  The HOG Pathway Is Critical for the Colonization of the Mouse Gastrointestinal Tract by Candida albicans , 2014, PloS one.

[22]  P. van Dijck,et al.  Relevance of Trehalose in Pathogenicity: Some General Rules, Yet Many Exceptions , 2013, PLoS pathogens.

[23]  Diogo M. Camacho,et al.  Fungicidal drugs induce a common oxidative-damage cellular death pathway. , 2013, Cell reports.

[24]  David W. Denning,et al.  Hidden Killers: Human Fungal Infections , 2012, Science Translational Medicine.

[25]  J. Pemán,et al.  Prospective Multicenter Study of the Epidemiology, Molecular Identification, and Antifungal Susceptibility of Candida parapsilosis, Candida orthopsilosis, and Candida metapsilosis Isolated from Patients with Candidemia , 2011, Antimicrobial Agents and Chemotherapy.

[26]  J. Argüelles,et al.  Amphotericin B induces trehalose synthesis and simultaneously activates an antioxidant enzymatic response in Candida albicans. , 2011, Biochimica et biophysica acta.

[27]  E. Herrero,et al.  Amphotericin B mediates killing in Cryptococcus neoformans through the induction of a strong oxidative burst. , 2011, Microbes and infection.

[28]  M. Pfaller,et al.  Epidemiology of Invasive Mycoses in North America , 2010, Critical reviews in microbiology.

[29]  E. Matallana,et al.  The three trehalases Nth1p, Nth2p and Ath1p participate in the mobilization of intracellular trehalose required for recovery from saline stress in Saccharomyces cerevisiae. , 2009, Microbiology.

[30]  I. Stansfield,et al.  Phylogenetic diversity of stress signalling pathways in fungi , 2009, BMC Evolutionary Biology.

[31]  A. Gácser,et al.  Candida parapsilosis, an Emerging Fungal Pathogen , 2008, Clinical Microbiology Reviews.

[32]  F. Saliba,et al.  Renal impairment and amphotericin B formulations in patients with invasive fungal infections. , 2008, Medical mycology.

[33]  Alistair J. P. Brown,et al.  Effects of Depleting the Essential Central Metabolic Enzyme Fructose-1,6-Bisphosphate Aldolase on the Growth and Viability of Candida albicans: Implications for Antifungal Drug Target Discovery , 2006, Eukaryotic Cell.

[34]  J. Argüelles,et al.  Response to oxidative stress caused by H2O2 in Saccharomyces cerevisiae mutants deficient in trehalase genes , 2002, Archives of Microbiology.

[35]  J. Thevelein,et al.  Disruption of the Candida albicans TPS2 Gene Encoding Trehalose-6-Phosphate Phosphatase Decreases Infectivity without Affecting Hypha Formation , 2002, Infection and Immunity.

[36]  D. Kontoyiannis.  Modulation of fluconazole sensitivity by the interaction of mitochondria and erg3p in Saccharomyces cerevisiae. , 2000, The Journal of antimicrobial chemotherapy.

[37]  W. Powderly,et al.  Amphotericin B: current understanding of mechanisms of action , 1990, Antimicrobial Agents and Chemotherapy.

[38]  Oliver H. Lowry,et al.  Protein measurement with the Folin phenol reagent. , 1951, The Journal of biological chemistry.

[39]  F. Dromer,et al.  Antifungal drug resistance in pathogenic fungi. , 1998, Medical mycology.