Role of Nanobiotechnology in Developing Personalized Medicine for Cancer

Personalized medicine simply means the prescription of specific therapeutics best suited for an individual. Personalization of cancer therapies is based on a better understanding of the disease at the molecular level. Nanotechnology will play an important role in this area. Nanobiotechnology is being used to refine discovery of biomarkers, molecular diagnostics, drug discovery and drug delivery, which are important basic components of personalized medicine and are applicable to management of cancer as well. Examples are given of the application of quantum dots, gold nanoparticles, and molecular imaging in diagnostics and combination with therapeutics - another important feature of personalized medicine. Personalized medicine is beginning to be recognized and is expected to become a part of medical practice within the next decade. Personalized management of cancer, facilitated by nanobiotechnology, is expected to enable early detection of cancer, more effective and less toxic treatment increasing the chances of cure.

[1]  King Li,et al.  Combined vascular targeted imaging and therapy: A paradigm for personalized treatment , 2002, Journal of cellular biochemistry. Supplement.

[2]  M. Bednarski,et al.  Tumor Regression by Targeted Gene Delivery to the Neovasculature , 2002, Science.

[3]  C. Mirkin,et al.  Nanoparticle-Based Bio-Bar Codes for the Ultrasensitive Detection of Proteins , 2003, Science.

[4]  M. Bruchez,et al.  Immunofluorescent labeling of cancer marker Her2 and other cellular targets with semiconductor quantum dots , 2003, Nature Biotechnology.

[5]  T. Mihaljevic,et al.  Near-infrared fluorescent type II quantum dots for sentinel lymph node mapping , 2004, Nature Biotechnology.

[6]  A. Rait,et al.  A sterically stabilized immunolipoplex for systemic administration of a therapeutic gene , 2004, Gene Therapy.

[7]  Hedi Mattoussi,et al.  Tracking metastatic tumor cell extravasation with quantum dot nanocrystals and fluorescence emission-scanning microscopy , 2004, Nature Medicine.

[8]  Ick Chan Kwon,et al.  Self-assembled nanoparticles based on glycol chitosan bearing 5beta-cholanic acid for RGD peptide delivery. , 2004, Journal of controlled release : official journal of the Controlled Release Society.

[9]  Richard D. Smith,et al.  Proteomic analyses using an accurate mass and time tag strategy. , 2004, BioTechniques.

[10]  Conroy Sun,et al.  Self-Assembled Coatings on Individual Monodisperse Magnetite Nanoparticles for Efficient Intracellular Uptake , 2004, Biomedical microdevices.

[11]  K. Jain Role of oncoproteomics in the personalized management of cancer , 2004, Expert review of proteomics.

[12]  Optical nanosensors for detecting proteins and biomarkers in individual living cells. , 2005, Methods in molecular biology.

[13]  K. Jain The role of nanobiotechnology in drug discovery. , 2005, Drug discovery today.

[14]  Gil U. Lee,et al.  Mesoporous membrane device for asymmetric biosensing. , 2005, Langmuir : the ACS journal of surfaces and colloids.

[15]  K. Jain,et al.  Nanotechnology in clinical laboratory diagnostics. , 2005, Clinica chimica acta; international journal of clinical chemistry.

[16]  Grace Hu,et al.  Molecular MR imaging of melanoma angiogenesis with ανβ3‐targeted paramagnetic nanoparticles , 2005, Magnetic resonance in medicine.

[17]  K. Jain,et al.  Nanotechnology-based Drug Delivery for Cancer , 2005, Technology in cancer research & treatment.

[18]  Xiaohua Huang,et al.  Surface plasmon resonance scattering and absorption of anti-EGFR antibody conjugated gold nanoparticles in cancer diagnostics: applications in oral cancer. , 2005, Nano letters.

[19]  Youngseon Choi,et al.  Targeting Cancer Cells with DNA-Assembled Dendrimers: A Mix-and-Match Strategy for Cancer , 2005, Cell cycle.

[20]  K K Jain,et al.  Personalised medicine for cancer: from drug development into clinical practice , 2005, Expert opinion on pharmacotherapy.

[21]  Serge Muyldermans,et al.  Nanobodies as novel agents for cancer therapy , 2005, Expert opinion on biological therapy.

[22]  Rebekah Drezek,et al.  Protease-activated quantum dot probes. , 2005, Biochemical and biophysical research communications.

[23]  Richard D. Smith,et al.  Advanced nanoscale separations and mass spectrometry for sensitive high-throughput proteomics , 2005, Expert review of proteomics.