Beam parameters optimization and characterization for a TUrning LInac for Protontherapy.

TULIP (TUrning LInac for Protontherapy) is a novel compact accelerator system for protontherapy mounted on a rotating gantry (Amaldi et al., 2013, 2010, 2009). Its high-energy Linac has the unique property of being able to modulate the beam energy from one pulse to the next, in only a couple of milliseconds. The main purpose of this study is to optimize the properties of the beam exiting the Linac to make them compatible to medical therapy and to characterize their medical physics properties for later implementation in a Treatment Planning System. For this purpose, multi-particle tracking and Monte Carlo (MC) simulations are used to follow the particles through their path up to the treatment isocenter, following the so-called phase-space method. The data compiled includes particle fluences in air and depth-dose curves and provides the basis for a specific model of the TULIP beam.

[1]  S Giordanengo,et al.  The CNAO dose delivery system for modulated scanning ion beam radiotherapy. , 2014, Medical physics.

[2]  Sandro Rossi,et al.  The National Centre for Oncological Hadrontherapy (CNAO): Status and perspectives. , 2015, Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics.

[3]  S. Russenschuck.  Field Computation for Accelerator Magnets: Analytical and Numerical Methods for Electromagnetic Design and Optimization , 2010 .

[4]  A. Ferrari,et al.  FLUKA: A Multi-Particle Transport Code , 2005 .

[5]  Saverio Braccini,et al.  High Frequency Linacs for Hadrontherapy , 2009 .

[6]  V. Vlachoudis,et al.  The FLUKA Code: Developments and Challenges for High Energy and Medical Applications , 2014 .

[7]  K. Parodi,et al.  A Monte Carlo-based treatment-planning tool for ion beam therapy , 2013, Journal of radiation research.

[8]  Paolo Nenzi,et al.  First acceleration of a proton beam in a side coupled drift tube linac , 2015 .

[9]  A Mairani,et al.  Dosimetric commissioning and quality assurance of scanned ion beams at the Italian National Center for Oncological Hadrontherapy. , 2015, Medical physics.

[10]  Julia Bauer,et al.  The FLUKA Code: An Accurate Simulation Tool for Particle Therapy , 2016, Front. Oncol..

[11]  A. Latina,et al.  JACoW : Design of a 750 MHz IH structure for medical applications , 2017 .

[12]  S Giordanengo,et al.  Review of technologies and procedures of clinical dosimetry for scanned ion beam radiotherapy. , 2017, Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics.

[13]  Manjit Dosanjh,et al.  Monte Carlo Calculations Supporting Patient Plan Verification in Proton Therapy , 2016, Front. Oncol..

[14]  S Lorentini,et al.  Characterization and validation of a Monte Carlo code for independent dose calculation in proton therapy treatments with pencil beam scanning , 2015, Physics in medicine and biology.

[15]  E. Griesmayer,et al.  Beam-transport study of an isocentric rotating ion gantry with minimum number of quadrupoles , 2005 .

[16]  Maurizio Vretenar,et al.  A Compact High-Frequency RFQ for Medical Applications , 2014 .

[17]  A. Latina,et al.  High gradient linac for proton therapy , 2017 .

[18]  Ugo Amaldi,et al.  History of hadron therapy accelerators. , 2015, Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics.

[19]  A. Grudiev,et al.  BEAM DYNAMICS IN A HIGH FREQUENCY RFQ , 2015 .

[20]  Antony John Lomax,et al.  In the context of radiosurgery - pros and cons of rescanning as a solution for treating moving targets with scanned particle beams. , 2014, Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics.

[21]  K Parodi,et al.  Dosimetric accuracy assessment of a treatment plan verification system for scanned proton beam radiotherapy: one-year experimental results and Monte Carlo analysis of the involved uncertainties , 2013, Physics in medicine and biology.

[22]  K Parodi,et al.  A Monte Carlo-based treatment planning tool for proton therapy , 2013, Physics in medicine and biology.

[23]  Silvia Verdú-Andrés,et al.  CABOTO, a high-gradient linac for hadrontherapy , 2013, Journal of radiation research.

[24]  A. Degiovanni.  High gradient proton linacs for medical applications , 2014 .

[25]  Prescribing, recording, and reporting proton-beam therapy: contents. , 2007, Journal of the ICRU.

[26]  Damien Charles Weber,et al.  An evaluation of rescanning technique for liver tumour treatments using a commercial PBS proton therapy system. , 2016, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.