Microfluidic paper-based chip platform for formaldehyde concentration detection

Abstract An integrated platform consisting of a microfluidic paper-based chip and a mini-box detection system is proposed for the concentration detection of formaldehyde. In the proposed approach, the reaction region of the paper-based chip is implanted with Acetoacetanilide reagent, and the formaldehyde concentration is deduced from the UV light-induced fluorescence intensity of the formaldehyde-Acetoacetanilide complex (dihydropyridine) produced in a Hantzsch reaction process at room temperature for 2 min. The experimental results obtained using control samples with formaldehyde concentrations ranging from 0 to 8 ppm show that the formaldehyde concentration (Y) and fluorescence intensity (X) are related as Y = 0.0039 e0.058X. Moreover, the correlation coefficient (R2) is equal to 0.9987. The real-world applicability of the proposed paper-based platform is demonstrated by measuring the formaldehyde concentration in eleven commercial food samples. It is found that the measurement results deviate from those obtained using a standard bench top method by no more than 4.7%. Overall, the results presented in this study show that the proposed system provides a rapid and reliable technique for formaldehyde concentration detection.

[1]  Min Su,et al.  Aptamer-based fluorescent and visual biosensor for multiplexed monitoring of cancer cells in microfluidic paper-based analytical devices , 2016 .

[2]  Yuhuan Zhang,et al.  A portable system for on-site quantification of formaldehyde in air based on G-quadruplex halves coupled with A smartphone reader. , 2016, Biosensors & bioelectronics.

[3]  Dong-Weon Lee,et al.  Hydrochloric acid-impregnated paper for gallium-based liquid metal microfluidics , 2015 .

[4]  T. Gessei,et al.  Highly sensitive and rapid gas biosensor for formaldehyde based on an enzymatic cycling system , 2015 .

[5]  Zhi-Qi Zhang,et al.  Microwave-assisted on-line derivatization for sensitive flow injection fluorometric determination of formaldehyde in some foods. , 2009, Talanta.

[6]  Chunsun Zhang,et al.  A novel paper-based microfluidic enhanced chemiluminescence biosensor for facile, reliable and highly-sensitive gene detection of Listeria monocytogenes , 2015 .

[7]  Takashi Kaneta,et al.  Chelate titrations of Ca(2+) and Mg(2+) using microfluidic paper-based analytical devices. , 2016, Analytica chimica acta.

[8]  Lung-Ming Fu,et al.  Micro-magnetofluidics in microfluidic systems: A review , 2016 .

[9]  Lung-Ming Fu,et al.  Rapid integrated microfluidic paper-based system for sulfur dioxide detection , 2017 .

[10]  J. Haines,et al.  International programme on chemical safety , 1996, The Lancet.

[11]  Hyun C. Yoon,et al.  An animal cell culture monitoring system using a smartphone-mountable paper-based analytical device , 2016 .

[12]  Lung-Ming Fu,et al.  A comprehensive review of micro-distillation methods , 2017 .

[13]  Lung-Ming Fu,et al.  Micro-distillation system for formaldehyde concentration detection , 2016 .

[14]  Charles S Henry,et al.  Paper-based analytical devices for environmental analysis. , 2016, The Analyst.

[15]  Mei Yang,et al.  Colorimetric measurement of Fe3+ using a functional paper-based sensor based on catalytic oxidation of gold nanoparticles , 2017 .

[16]  Li-juan Han,et al.  Determination of formaldehyde in aquatic products by a sensitive catalytic fluorescence method , 2014 .

[17]  Rong Wang,et al.  Simple method of deposition of CuO nanoparticles on a cellulose paper and its antibacterial activity , 2015 .

[18]  A. Afkhami,et al.  Preconcentration of trace amounts of formaldehyde from water, biological and food samples using an efficient nanosized solid phase, and its determination by a novel kinetic method , 2011, Microchimica Acta.

[19]  Masaki Tsuchiya,et al.  Microfluidic devices fabricated using stereolithography for preparation of monodisperse double emulsions , 2016 .

[20]  F. Suliman,et al.  A novel microfluidic device for estimating the total phenolic/antioxidant level in honey samples using a formaldehyde/potassium permanganate chemiluminescence system , 2014 .

[21]  Mj Mark Prins,et al.  Biomass pyrolysis in a heated-grid reactor: visualization of carbon monoxide and formaldehyde using laser-induced fluorescence , 2011 .

[22]  Jaclyn A. Adkins,et al.  Recent developments in paper-based microfluidic devices. , 2015, Analytical chemistry.

[23]  Danila Moscone,et al.  A paper-based nanomodified electrochemical biosensor for ethanol detection in beers. , 2017, Analytica chimica acta.

[24]  Waheed-uz-Zaman,et al.  A simple spot test quantification method to determine formaldehyde in aqueous samples , 2016 .

[25]  Li Wang,et al.  A novel label-free microfluidic paper-based immunosensor for highly sensitive electrochemical detection of carcinoembryonic antigen. , 2016, Biosensors & bioelectronics.

[26]  S. Burgess,et al.  A novel multi-pad paper plate (MP3) based assays for rapid animal disease diagnostics , 2016 .

[27]  Yang Yufang,et al.  Preparation and application of melamine-formaldehyde photochromic microcapsules , 2013 .

[28]  W. Cao,et al.  Oxygen sensing properties of gadolinium labeled hematoporphyrin monomethyl ether based on filter paper , 2015 .

[29]  Jie Xu,et al.  Detection of heavy metal by paper-based microfluidics. , 2016, Biosensors & bioelectronics.

[30]  Shou-Nian Ding,et al.  Graphite paper-based bipolar electrode electrochemiluminescence sensing platform. , 2017, Biosensors & bioelectronics.

[31]  C. Serra,et al.  Transportable, fast and high sensitive near real-time analyzers: Formaldehyde detection , 2013 .

[32]  Z. Su,et al.  Facile preparation of fluorescent Au nanoclusters-based test papers for recyclable detection of Hg2+ and Pb2+ , 2017 .

[33]  Jie Hu,et al.  Recent Developments of Three-Dimensional Paper-Based Electrochemical Devices for Cancer Cell Detection and Anticancer Drug Screening. , 2016, Current pharmaceutical biotechnology.

[34]  Min Liu,et al.  Open bipolar electrode-electrochemiluminescence imaging sensing using paper-based microfluidics , 2015 .

[35]  Wei Liu,et al.  Paper-based laser induced fluorescence immunodevice combining with CdTe embedded silica nanoparticles signal enhancement strategy , 2017 .

[36]  Mengyuan He,et al.  A paper-supported aptasensor for total IgE based on luminescence resonance energy transfer from upconversion nanoparticles to carbon nanoparticles , 2017 .

[37]  L. Fu,et al.  An integrated microfluidic chip for formaldehyde analysis in Chinese herbs , 2014 .

[38]  Ligang Chen,et al.  Determination of formaldehyde in fruit juice based on magnetic strong cation-exchange resin modified with 2,4-dinitrophenylhydrazine , 2012 .

[39]  Marcos A. S. Brasil,et al.  Exploitation of pulsed flows for on-line dispersive liquid-liquid microextraction: Spectrophotometric determination of formaldehyde in milk. , 2015, Talanta.

[40]  Da Xing,et al.  Paper-based bipolar electrode-electrochemiluminescence (BPE-ECL) device with battery energy supply and smartphone read-out: A handheld ECL system for biochemical analysis at the point-of-care level , 2016 .

[41]  J. Burrows,et al.  Slant column MAX-DOAS measurements of nitrogen dioxide, formaldehyde, glyoxal and oxygen dimer in the urban environment of Athens , 2016 .

[42]  Xuan Weng,et al.  Rapid detection of formaldehyde concentration in food on a polydimethylsiloxane (PDMS) microfluidic chip , 2009 .

[43]  M. Shao,et al.  Variations and sources of ambient formaldehyde for the 2008 Beijing Olympic games , 2010 .

[44]  Hong Liu,et al.  Preparation of cellulose fiber–TiO2 nanobelt–silver nanoparticle hierarchically structured hybrid paper and its photocatalytic and antibacterial properties , 2013 .

[45]  Fei Li,et al.  Advances in paper-based point-of-care diagnostics. , 2014, Biosensors & bioelectronics.

[46]  Tian Jian Lu,et al.  Direct writing electrodes using a ball pen for paper-based point-of-care testing. , 2015, The Analyst.

[47]  Ligang Chen,et al.  Determination of formaldehyde in beer based on cloud point extraction using 2,4-dinitrophenylhydrazine as derivative reagent , 2012 .

[48]  Jung-Min Oh,et al.  Recent developments in electrochemical paper-based analytical devices , 2015 .

[49]  Yong He,et al.  Fabrication of paper-based microfluidic analysis devices: a review , 2015 .

[50]  Meng Shi,et al.  Paper-based cell culture platform and its emerging biomedical applications , 2017 .

[51]  T. Kitaoka,et al.  Solvent-free alcohol oxidation using paper-structured catalysts: Flow dynamics and reaction kinetics , 2016 .

[52]  Lung-Ming Fu,et al.  Passive mixers in microfluidic systems: A review , 2016 .

[53]  Jinghua Yu,et al.  A novel microfluidic paper-based colorimetric sensor based on molecularly imprinted polymer membranes for highly selective and sensitive detection of bisphenol A , 2017 .

[54]  C. Serra,et al.  Development of microfluidic analytical method for on-line gaseous Formaldehyde detection , 2017 .

[55]  Seokheun Choi,et al.  Cellular flow in paper-based microfluidics , 2016 .

[56]  Bin Ding,et al.  A facile and highly sensitive colorimetric sensor for the detection of formaldehyde based on electro-spinning/netting nano-fiber/nets , 2012 .

[57]  L. Fu,et al.  Rapid prototyping of glass-based microfluidic chips utilizing two-pass defocused CO2 laser beam method , 2013 .

[58]  Shoji Motomizu,et al.  Development of Novel Reagent for Hantzsch Reaction for the Determination of Formaldehyde by Spectrophotometry and Fluorometry , 2007, Analytical sciences : the international journal of the Japan Society for Analytical Chemistry.