Microfabrication technologies for oral drug delivery.

[1]  S. Takayama,et al.  Organs-on-a-Chip: A Focus on Compartmentalized Microdevices , 2012, Annals of Biomedical Engineering.

[2]  Mandy B. Esch,et al.  The role of body-on-a-chip devices in drug and toxicity studies. , 2011, Annual review of biomedical engineering.

[3]  Stephen J. Haswell,et al.  Microsystems for personalized biomolecular diagnostics , 2011 .

[4]  Kyung-Jin Jang,et al.  Fluid-shear-stress-induced translocation of aquaporin-2 and reorganization of actin cytoskeleton in renal tubular epithelial cells. , 2011, Integrative biology : quantitative biosciences from nano to macro.

[5]  Jiajie Yu,et al.  Microscale 3-D hydrogel scaffold for biomimetic gastrointestinal (GI) tract model. , 2011, Lab on a chip.

[6]  Asher Mullard,et al.  2010 FDA drug approvals , 2011, Nature Reviews Drug Discovery.

[7]  A. Khademhosseini,et al.  BIOMIMETIC GRADIENT HYDROGELS FOR TISSUE ENGINEERING. , 2010, The Canadian journal of chemical engineering.

[8]  Shuvo Roy,et al.  A microfluidic bioreactor with integrated transepithelial electrical resistance (TEER) measurement electrodes for evaluation of renal epithelial cells , 2010, Biotechnology and bioengineering.

[9]  S. Murthy,et al.  Synergic effects of crypt-like topography and ECM proteins on intestinal cell behavior in collagen based membranes. , 2010, Biomaterials.

[10]  Ali Khademhosseini,et al.  Directed 3D cell alignment and elongation in microengineered hydrogels. , 2010, Biomaterials.

[11]  M. Staples Microchips and controlled-release drug reservoirs. , 2010, Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology.

[12]  A. Khademhosseini,et al.  Cell-laden microengineered gelatin methacrylate hydrogels. , 2010, Biomaterials.

[13]  D. Ingber,et al.  Reconstituting Organ-Level Lung Functions on a Chip , 2010, Science.

[14]  William B. Liechty,et al.  Polymers for drug delivery systems. , 2010, Annual review of chemical and biomolecular engineering.

[15]  R. Donnelly,et al.  Microneedle-based drug delivery systems: Microfabrication, drug delivery, and safety , 2010, Drug delivery.

[16]  G. Whitesides,et al.  Soft lithography for micro- and nanoscale patterning , 2010, Nature Protocols.

[17]  Matthew D. McDermott,et al.  The hydrogel template method for fabrication of homogeneous nano/microparticles. , 2010, Journal of controlled release : official journal of the Controlled Release Society.

[18]  Yuandong Gu,et al.  Hard and soft micro- and nanofabrication: An integrated approach to hydrogel-based biosensing and drug delivery. , 2010, Journal of controlled release : official journal of the Controlled Release Society.

[19]  K. Suh,et al.  A multi-layer microfluidic device for efficient culture and analysis of renal tubular cells. , 2010, Lab on a chip.

[20]  Matthew H. M. Lim,et al.  Perfused multiwell plate for 3D liver tissue engineering. , 2010, Lab on a chip.

[21]  Kristy M Ainslie,et al.  Microfabricated devices for enhanced bioadhesive drug delivery: attachment to and small-molecule release through a cell monolayer under flow. , 2009, Small.

[22]  Nicholas A Peppas,et al.  Micro- and nanotechnologies for intelligent and responsive biomaterial-based medical systems. , 2009, Advanced drug delivery reviews.

[23]  Shashi K Murthy,et al.  Influence of micro-well biomimetic topography on intestinal epithelial Caco-2 cell phenotype. , 2009, Biomaterials.

[24]  Yuki Imura,et al.  A Microfluidic System to Evaluate Intestinal Absorption , 2009, Analytical sciences : the international journal of the Japan Society for Analytical Chemistry.

[25]  N. Peppas,et al.  Impact of Absorption and Transport on Intelligent Therapeutics and Nano-scale Delivery of Protein Therapeutic Agents. , 2009, Chemical engineering science.

[26]  Sharon G. Kujawa,et al.  Development of a Microfluidics-Based Intracochlear Drug Delivery Device , 2009, Audiology and Neurotology.

[27]  Mandy B. Esch,et al.  Characterization of a gastrointestinal tract microscale cell culture analog used to predict drug toxicity , 2009, Biotechnology and bioengineering.

[28]  Gretchen J. Mahler,et al.  Characterization of Caco-2 and HT29-MTX cocultures in an in vitro digestion/cell culture model used to predict iron bioavailability. , 2009, The Journal of nutritional biochemistry.

[29]  Joseph M DeSimone,et al.  Top-down particle fabrication: control of size and shape for diagnostic imaging and drug delivery. , 2009, Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology.

[30]  M. Lutolf Biomaterials: Spotlight on hydrogels. , 2009, Nature materials.

[31]  Michael L Shuler,et al.  A novel system for evaluation of drug mixtures for potential efficacy in treating multidrug resistant cancers , 2009, Biotechnology and bioengineering.

[32]  Yu Zhou,et al.  Current micropump technologies and their biomedical applications , 2009 .

[33]  Nicholas A Peppas,et al.  Complexation hydrogels for intestinal delivery of interferon beta and calcitonin. , 2009, Journal of controlled release : official journal of the Controlled Release Society.

[34]  Nicholas A Peppas,et al.  Engineering design and molecular dynamics of mucoadhesive drug delivery systems as targeting agents. , 2009, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[35]  J. Hanes,et al.  Mucus-penetrating nanoparticles for drug and gene delivery to mucosal tissues. , 2009, Advanced drug delivery reviews.

[36]  Ju Hun Yeon,et al.  Drug permeability assay using microhole-trapped cells in a microfluidic device. , 2009, Analytical chemistry.

[37]  Tejal A Desai,et al.  Biomimetic nanowire coatings for next generation adhesive drug delivery systems. , 2009, Nano letters.

[38]  Kristy M Ainslie,et al.  Microfabricated implants for applications in therapeutic delivery, tissue engineering, and biosensing. , 2008, Lab on a chip.

[39]  Michael L Shuler,et al.  Incorporation of 3T3‐L1 Cells To Mimic Bioaccumulation in a Microscale Cell Culture Analog Device for Toxicity Studies , 2008, Biotechnology progress.

[40]  Yordan Kostov,et al.  The Design and Fabrication of Three‐Chamber Microscale Cell Culture Analog Devices with Integrated Dissolved Oxygen Sensors , 2008, Biotechnology progress.

[41]  Aaron Sin,et al.  Development of a Microscale Cell Culture Analog To Probe Naphthalene Toxicity , 2008, Biotechnology progress.

[42]  Stephanie E. A. Gratton,et al.  The effect of particle design on cellular internalization pathways , 2008, Proceedings of the National Academy of Sciences.

[43]  A. Gaharwar,et al.  Dual-stimuli responsive PNiPAM microgel achieved via layer-by-layer assembly: magnetic and thermoresponsive. , 2008, Journal of colloid and interface science.

[44]  Kristy M Ainslie,et al.  Microfabrication of an asymmetric, multi-layered microdevice for controlled release of orally delivered therapeutics. , 2008, Lab on a chip.

[45]  Michael L Shuler,et al.  Development of a gastrointestinal tract microscale cell culture analog to predict drug transport. , 2008, Molecular & cellular biomechanics : MCB.

[46]  Jung-Hwan Park,et al.  Dissolving microneedles for transdermal drug delivery. , 2008, Biomaterials.

[47]  H. Kimura,et al.  An integrated microfluidic system for long-term perfusion culture and on-line monitoring of intestinal tissue models. , 2008, Lab on a chip.

[48]  Nicholas A Peppas,et al.  Wheat germ agglutinin functionalized complexation hydrogels for oral insulin delivery. , 2008, Biomacromolecules.

[49]  Mauro Ferrari,et al.  Mesoporous silicon particles as a multistage delivery system for imaging and therapeutic applications. , 2008, Nature nanotechnology.

[50]  Robert Langer,et al.  A biodegradable and biocompatible gecko-inspired tissue adhesive , 2008, Proceedings of the National Academy of Sciences.

[51]  Göran Stemme,et al.  Painless Drug Delivery Through Microneedle-Based Transdermal Patches Featuring Active Infusion , 2008, IEEE Transactions on Biomedical Engineering.

[52]  Li Shi,et al.  Nanoimprint lithography based fabrication of shape-specific, enzymatically-triggered smart nanoparticles. , 2008, Journal of controlled release : official journal of the Controlled Release Society.

[53]  Ali Khademhosseini,et al.  Micro- and nanoscale technologies for tissue engineering and drug discovery applications , 2007, Expert opinion on drug discovery.

[54]  D. Hauss Oral lipid-based formulations. , 2007, Advanced drug delivery reviews.

[55]  S. Mitragotri,et al.  Making polymeric micro- and nanoparticles of complex shapes , 2007, Proceedings of the National Academy of Sciences.

[56]  Hongyan He,et al.  Fabrication of particulate reservoir-containing, capsulelike, and self-folding polymer microstructures for drug delivery. , 2007, Small.

[57]  T. Desai,et al.  Off-wafer fabrication and surface modification of asymmetric 3D SU-8 microparticles , 2006, Nature Protocols.

[58]  Wijaya Martanto,et al.  Microinfusion Using Hollow Microneedles , 2006, Pharmaceutical Research.

[59]  N. Peppas,et al.  Lectin functionalized complexation hydrogels for oral protein delivery. , 2006, Journal of controlled release : official journal of the Controlled Release Society.

[60]  N. Peppas,et al.  Is the oral route possible for peptide and protein drug delivery? , 2006, Drug discovery today.

[61]  Nicholas Ferrell,et al.  Fabrication of polymeric microparticles for drug delivery by soft lithography. , 2006, Biomaterials.

[62]  A. Khademhosseini,et al.  Hydrogels in Biology and Medicine: From Molecular Principles to Bionanotechnology , 2006 .

[63]  Wijaya Martanto,et al.  Mechanism of fluid infusion during microneedle insertion and retraction. , 2006, Journal of controlled release : official journal of the Controlled Release Society.

[64]  Robert Langer,et al.  Application of Micro- and Nano-Electromechanical Devices to Drug Delivery , 2006, Pharmaceutical Research.

[65]  Mark G. Allen,et al.  Polymer Microneedles for Controlled-Release Drug Delivery , 2006, Pharmaceutical Research.

[66]  Dhananjay Dendukuri,et al.  Continuous-flow lithography for high-throughput microparticle synthesis , 2006, Nature materials.

[67]  Nicholas A Peppas,et al.  Novel oral insulin delivery systems based on complexation polymer hydrogels: single and multiple administration studies in type 1 and 2 diabetic rats. , 2006, Journal of controlled release : official journal of the Controlled Release Society.

[68]  Nicholas A Peppas,et al.  Microfabricated drug delivery devices. , 2005, International journal of pharmaceutics.

[69]  Tejal A Desai,et al.  Micromachined devices: the impact of controlled geometry from cell-targeting to bioavailability. , 2005, Journal of controlled release : official journal of the Controlled Release Society.

[70]  L. J. Lee,et al.  Self-folding of three-dimensional hydrogel microstructures. , 2005, The journal of physical chemistry. B.

[71]  Tejal A. Desai,et al.  Microfabrication of Multilayer, Asymmetric, Polymeric Devices for Drug Delivery , 2005 .

[72]  Tejal A Desai,et al.  Gastrointestinal patch systems for oral drug delivery. , 2005, Drug discovery today.

[73]  Roxanne Khamsi,et al.  Labs on a chip: Meet the stripped down rat , 2005, Nature.

[74]  Deborah E Leckband,et al.  Regiospecific control of protein expression in cells cultured on two-component counter gradients of extracellular matrix proteins. , 2005, Langmuir : the ACS journal of surfaces and colloids.

[75]  Tongtong Liu,et al.  Evaluation of a novel in vitro Caco-2 hepatocyte hybrid system for predicting in vivo oral bioavailability. , 2004, Drug metabolism and disposition: the biological fate of chemicals.

[76]  N A Peppas,et al.  Devices based on intelligent biopolymers for oral protein delivery. , 2004, International journal of pharmaceutics.

[77]  Masaki Nishikawa,et al.  Feasibility of a simple double-layered coculture system incorporating metabolic processes of the intestine and liver tissue: application to the analysis of benzo[a]pyrene toxicity. , 2004, Toxicology in vitro : an international journal published in association with BIBRA.

[78]  Nicholas A Peppas,et al.  Hydrogels for oral delivery of therapeutic proteins , 2004, Expert opinion on biological therapy.

[79]  Nicholas A Peppas,et al.  Mucosal insulin delivery systems based on complexation polymer hydrogels: effect of particle size on insulin enteral absorption. , 2004, Journal of controlled release : official journal of the Controlled Release Society.

[80]  Yasuyuki Sakai,et al.  Enhanced cytochrome P450 capacities of Caco-2 and Hep G2 cells in new coculture system under the static and perfused conditions : evidence for possible organ-to-organ interactions against exogenous stimuli , 2004 .

[81]  Robert Langer,et al.  Differential degradation rates in vivo and in vitro of biocompatible poly(lactic acid) and poly(glycolic acid) homo- and co-polymers for a polymeric drug-delivery microchip , 2004, Journal of biomaterials science. Polymer edition.

[82]  Tejal A Desai,et al.  Synthesis of cytoadhesive poly(methylmethacrylate) for applications in targeted drug delivery. , 2003, Journal of biomedical materials research. Part A.

[83]  Robert Langer,et al.  Multi-pulse drug delivery from a resorbable polymeric microchip device , 2003, Nature materials.

[84]  N. Peppas,et al.  Novel complexation hydrogels for oral peptide delivery: in vitro evaluation of their cytocompatibility and insulin-transport enhancing effects using Caco-2 cell monolayers. , 2003, Journal of biomedical materials research. Part A.

[85]  Robert Langer,et al.  Small-scale systems for in vivo drug delivery , 2003, Nature Biotechnology.

[86]  S. Gorb,et al.  From micro to nano contacts in biological attachment devices , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[87]  I. Gómez-Orellana,et al.  Challenges for the oral delivery of macromolecules , 2003, Nature Reviews Drug Discovery.

[88]  T. Desai,et al.  Bioadhesive poly(methyl methacrylate) microdevices for controlled drug delivery. , 2003, Journal of controlled release : official journal of the Controlled Release Society.

[89]  T. Desai,et al.  Microfabricated drug delivery systems: from particles to pores. , 2003, Advanced drug delivery reviews.

[90]  T. Desai,et al.  Bioadhesive microdevices with multiple reservoirs: a new platform for oral drug delivery. , 2002, Journal of controlled release : official journal of the Controlled Release Society.

[91]  Gordon L Amidon,et al.  A Mechanistic Approach to Understanding the Factors Affecting Drug Absorption: A Review of Fundamentals , 2002, Journal of clinical pharmacology.

[92]  M. Wirth,et al.  Lectin-mediated Drug Delivery: Discrimination Between Cytoadhesion and Cytoinvasion and Evidence for Lysosomal Accumulation of Wheat Germ Agglutinin in the Caco-2 Model , 2002, Journal of drug targeting.

[93]  David J Brayden,et al.  In Vitro Models of the Intestinal Barrier , 2001, Alternatives to laboratory animals : ATLA.

[94]  M. Allen,et al.  Lack of Pain Associated with Microfabricated Microneedles , 2001, Anesthesia and analgesia.

[95]  N. Peppas,et al.  Physicochemical foundations and structural design of hydrogels in medicine and biology. , 2000, Annual review of biomedical engineering.

[96]  S. Quake,et al.  From micro- to nanofabrication with soft materials. , 2000, Science.

[97]  C. Lehr,et al.  Lectin-mediated drug delivery: the second generation of bioadhesives. , 2000, Journal of controlled release : official journal of the Controlled Release Society.

[98]  Y. Huang,et al.  Molecular aspects of muco- and bioadhesion: tethered structures and site-specific surfaces. , 2000, Journal of controlled release : official journal of the Controlled Release Society.

[99]  Michael J Cima,et al.  Microchip technology in drug delivery , 2000, Annals of medicine.

[100]  G. Whitesides,et al.  Unconventional Methods for Fabricating and Patterning Nanostructures. , 1999, Chemical reviews.

[101]  M. Einarson Controlled-release microchip , 1999, Nature Biotechnology.

[102]  M. Yazdanian,et al.  Correlating Partitioning and Caco-2 Cell Permeability of Structurally Diverse Small Molecular Weight Compounds , 1998, Pharmaceutical Research.

[103]  M. Allen,et al.  Microfabricated microneedles: a novel approach to transdermal drug delivery. , 1998, Journal of pharmaceutical sciences.

[104]  M. Delp,et al.  Physiological Parameter Values for Physiologically Based Pharmacokinetic Models , 1997, Toxicology and industrial health.

[105]  D. Thakker,et al.  Applications of the Caco-2 model in the design and development of orally active drugs: elucidation of biochemical and physical barriers posed by the intestinal epithelium , 1997 .

[106]  J. Woodley,et al.  Binding of tomato lectin to the intestinal mucosa and its potential for oral drug delivery. , 1990, Biochemical Society transactions.

[107]  P. Artursson,et al.  Epithelial transport of drugs in cell culture. I: A model for studying the passive diffusion of drugs over intestinal absorptive (Caco-2) cells. , 1990, Journal of pharmaceutical sciences.

[108]  Matthew D. McDermott,et al.  Hydrogel templates for the fabrication of homogeneous polymer microparticles. , 2011, Methods in molecular biology.

[109]  M. Shuler,et al.  In vitro microscale systems for systematic drug toxicity study , 2010, Bioprocess and biosystems engineering.

[110]  N. Peppas,et al.  The effect of complexation hydrogels on insulin transport in intestinal epithelial cell models. , 2010, Acta biomaterialia.

[111]  Ali Khademhosseini,et al.  Microfluidics for drug discovery and development: from target selection to product lifecycle management. , 2008, Drug discovery today.

[112]  Samir Mitragotri,et al.  Shape Induced Inhibition of Phagocytosis of Polymer Particles , 2008, Pharmaceutical Research.

[113]  N. Peppas,et al.  Oral insulin delivery systems based on complexation polymer hydrogels , 2006 .

[114]  T. Desai,et al.  Microdevices for Oral Drug Delivery , 2006 .

[115]  Ralph Spolenak,et al.  Adhesion design maps for bio-inspired attachment systems. , 2005, Acta biomaterialia.

[116]  M Ferrari,et al.  Acute Toxicity of Intravenously Administered Microfabricated Silicon Dioxide Drug Delivery Particles in Mice , 2005, Drugs in R&D.

[117]  Peter W. Swaan,et al.  Microfabricated Porous Silicon Particles Enhance Paracellular Delivery of Insulin Across Intestinal Caco-2 Cell Monolayers , 2004, Pharmaceutical Research.

[118]  Jung-Hwan Park,et al.  Biodegradable polymer microneedles: fabrication, mechanics and transdermal drug delivery , 2004, The 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

[119]  T. Park,et al.  Integration of Cell Culture and Microfabrication Technology , 2003, Biotechnology progress.

[120]  M. Allen,et al.  Microfabricated microneedles for gene and drug delivery. , 2000, Annual review of biomedical engineering.