An evaluation of the effects of high‐dose fexofenadine on the central nervous system: a double‐blind, placebo‐controlled study in healthy volunteers

Background As regards central nervous system (CNS) effects there are three types of antihistamines. Those that cross the blood‐brain barrier and cause widespread impairment of cognitive and psychomotor function; those that cross into the brain and, although without much impairment at low clinical doses, have a dose‐related relationship to impairment; and those that do not cross into the brain and therefore possess no intrinsic potential for impairing CNS function.

[1]  I. Hindmarch,et al.  Comparison of five anxiolytic benzodiazepines on measures of psychomotor performance and sleep. , 1990, Neuropsychobiology.

[2]  B. Jarvis,et al.  Fexofenadine , 2000, Drugs.

[3]  F. Gengo,et al.  Antihistamines, drowsiness, and psychomotor impairment: central nervous system effect of cetirizine. , 1987, Annals of allergy.

[4]  I. Hindmarch.  A 1,4-benzodiazepine, temazepam (K 3917), its effect on some psychological parameters of sleep and behaviour. , 1975, Arzneimittel-Forschung.

[5]  A. Nicholson,et al.  Studies on the central effects of the H1-antagonist, loratadine , 2004, European Journal of Clinical Pharmacology.

[6]  E. Juniper,et al.  Comparison of the efficacy, safety and quality of life provided by fexofenadine hydrochloride 120 mg, loratadine 10 mg and placebo administered once daily for the treatment of seasonal allergic rhinitis , 2000, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[7]  Herbert M. Simpson,et al.  DRUGS DETECTED IN FATALLY INJURED DRIVERS IN THE PROVINCE OF ONTARIO , 1981 .

[8]  K. Simons,et al.  Peripheral H1-blockade effect of fexofenadine. , 1997, Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.

[9]  F. Simons.  Non‐cardiac adverse effects of antihistamines (H1‐receptor antagonists) , 1999, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[10]  E. Volkerts,et al.  Does cetirizine belong to the new generation of antihistamines? An investigation into its acute and subchronic effects on highway driving, psychometric test performance and daytime sleepiness , 1992 .

[11]  I Hindmarch,et al.  The effects of clobazam and lorazepam on aspects of psychomotor performance and car handling ability. , 1980, British journal of clinical pharmacology.

[12]  I. Hindmarch,et al.  Antihistamines: models to assess sedative properties, assessment of sedation, safety and other side‐effects , 1999, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[13]  I. Hindmarch,et al.  The psychomotor and cognitive effects of a new antihistamine, mizolastine, compared to terfenadine, triprolidine and placebo in healthy volunteers , 2004, European Journal of Clinical Pharmacology.

[14]  I. Hindmarch,et al.  The Effects of Practice on Choice Reaction Time and Critical Flicker Fusion Threshold , 1997 .

[15]  I Hindmarch.  Psychomotor function and psychoactive drugs. , 1980, British journal of clinical pharmacology.

[16]  H. Roberts,et al.  How many people think they have hay fever, and what they do about it. , 1992, The British journal of general practice : the journal of the Royal College of General Practitioners.

[17]  J. F. O'Hanlon,et al.  Effects of loratadine and cetirizine on actual driving and psychometric test performance, and EEG during driving , 2004, European Journal of Clinical Pharmacology.

[18]  F E Simons,et al.  Comparison of the central nervous system effects produce by six H1‐receptor antagonists , 1996, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[19]  J. Bousquet,et al.  The clinical safety of H1‐receptor antagonists: An EAACI position paper * , 1996, Allergy.

[20]  J. Ortonne,et al.  Fexofenadine hydrochloride in the treatment of chronic idiopathic urticaria: A placebo-controlled, parallel-group, dose-ranging study , 1998 .

[21]  F. Simons,et al.  Central nervous system effects of H1-receptor antagonists in the elderly. , 1999, Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.

[22]  D. B. Tower.  Cerebral circulation revisited: An historical essay , 1991, Neurochemical Research.

[23]  John R Bloomfield,et al.  Effects of Fexofenadine, Diphenhydramine, and Alcohol on Driving Performance , 2000, Annals of Internal Medicine.

[24]  I. Hindmarch,et al.  A comparison of five commonly prescribed antidepressants with particular reference to their behavioural toxicity , 1993 .

[25]  A N Nicholson,et al.  Antihistamines and aircrew: usefulness of fexofenadine. , 2000, Aviation, space, and environmental medicine.

[26]  A. Parrott,et al.  Critical Flicker Fusion Thresholds and Their Relationship to Other Measures of Alertness , 1982 .

[27]  P. Howarth,et al.  Double-blind, placebo-controlled study comparing the efficacy and safety of fexofenadine hydrochloride (120 and 180 mg once daily) and cetirizine in seasonal allergic rhinitis. , 1999, The Journal of allergy and clinical immunology.

[28]  A. Gaillard,et al.  The influence of antihistamines on human performance , 2004, European Journal of Clinical Pharmacology.

[29]  G S Watson,et al.  Effects of fexofenadine, diphenhydramine, and alcohol on driving performance. A randomized, placebo-controlled trial in the Iowa driving simulator. , 2000, Annals of internal medicine.

[30]  I. Hindmarch,et al.  A double-blind, placebo-controlled investigation of the effects of fexofenadine, loratadine and promethazine on cognitive and psychomotor function. , 1999, British journal of clinical pharmacology.

[31]  J. O'hanlon,et al.  Fexofenadine's effects, alone and with alcohol, on actual driving and psychomotor performance. , 1998, The Journal of allergy and clinical immunology.

[32]  A. Harris,et al.  Loratadine: a non‐sedating antihistamine. Review of its effects on cognition, psychomotor performance, mood and sedation , 1999, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[33]  G. Starmer.  Antihistamines and highway safety. , 1985, Accident; analysis and prevention.