Transmembrane Domains 4 and 7 of the M1Muscarinic Acetylcholine Receptor Are Critical for Ligand Binding and the Receptor Activation Switch*
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J W Saldanha | E C Hulme | J. Saldanha | E. Hulme | Z L Lu | Zhi-Liang Lu
[1] J. Wess,et al. Functional role of proline and tryptophan residues highly conserved among G protein‐coupled receptors studied by mutational analysis of the m3 muscarinic receptor. , 1993, The EMBO journal.
[2] K D Ridge,et al. Light-induced exposure of the cytoplasmic end of transmembrane helix seven in rhodopsin. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[3] E. Hulme,et al. A Network of Conserved Intramolecular Contacts Defines the Off-state of the Transmembrane Switch Mechanism in a Seven-transmembrane Receptor* , 2000, The Journal of Biological Chemistry.
[4] S. Trumpp-Kallmeyer,et al. This is not a G protein-coupled receptor. , 1993, Trends in pharmacological sciences.
[5] E. Hulme,et al. The function of a highly-conserved arginine residue in activation of the muscarinic M1 receptor. , 1995, European journal of pharmacology.
[6] E C Hulme,et al. The Functional Topography of Transmembrane Domain 3 of the M1 Muscarinic Acetylcholine Receptor, Revealed by Scanning Mutagenesis* , 1999, The Journal of Biological Chemistry.
[7] M. Sabio,et al. Recognition of cholinergic agonists by the muscarinic receptor. 1. Acetylcholine and other agonists with the NCCOCC backbone. , 1983, Journal of medicinal chemistry.
[8] J L Sussman,et al. Protein Data Bank (PDB): database of three-dimensional structural information of biological macromolecules. , 1998, Acta crystallographica. Section D, Biological crystallography.
[9] M. Brann,et al. Identification of a Ligand-dependent Switch within a Muscarinic Receptor* , 1998, The Journal of Biological Chemistry.
[10] K. Palczewski,et al. Crystal Structure of Rhodopsin: A G‐Protein‐Coupled Receptor , 2002, Chembiochem : a European journal of chemical biology.
[11] Elaine C. Meng,et al. An Activation Switch in the Ligand Binding Pocket of the C5a Receptor* , 2001, The Journal of Biological Chemistry.
[12] M. Zuscik,et al. Novel Aromatic Residues in Transmembrane Domains IV and V Involved in Agonist Binding at α1a-Adrenergic Receptors* , 2000, The Journal of Biological Chemistry.
[13] D. Oprian,et al. Constitutively active mutants of rhodopsin , 1992, Neuron.
[14] T. Schwartz,et al. Conversion of agonist site to metal-ion chelator site in the beta(2)-adrenergic receptor. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[15] S. Sealfon,et al. Conserved helix 7 tyrosine functions as an activation relay in the serotonin 5HT(2C) receptor. , 2000, Brain research. Molecular brain research.
[16] C. Guenet,et al. Site-directed mutagenesis of the putative human muscarinic M2 receptor binding site. , 1999, European journal of pharmacology.
[17] K. Page,et al. Scanning mutagenesis identifies amino acid side chains in transmembrane domain 5 of the M(1) muscarinic receptor that participate in binding the acetyl methyl group of acetylcholine. , 2000, Molecular pharmacology.
[18] K. Konvička,et al. A proposed structure for transmembrane segment 7 of G protein-coupled receptors incorporating an asn-Pro/Asp-Pro motif. , 1998, Biophysical journal.
[19] E. Hulme,et al. The role of the aspartate-arginine-tyrosine triad in the m1 muscarinic receptor: mutations of aspartate 122 and tyrosine 124 decrease receptor expression but do not abolish signaling. , 1997, Molecular pharmacology.
[20] R. Barlow. Introduction to Chemical Pharmacology , 1964 .
[21] M. Karplus,et al. CHARMM: A program for macromolecular energy, minimization, and dynamics calculations , 1983 .
[22] C. Fraser,et al. Site-directed mutagenesis of the rat m1 muscarinic acetylcholine receptor. Role of conserved cysteines in receptor function. , 1992, The Journal of biological chemistry.
[23] S. Lazareno,et al. Probing of the location of the allosteric site on m1 muscarinic receptors by site-directed mutagenesis. , 1995, Molecular pharmacology.
[24] J. Wess,et al. Role of conserved threonine and tyrosine residues in acetylcholine binding and muscarinic receptor activation. A study with m3 muscarinic receptor point mutants. , 1992, The Journal of biological chemistry.
[25] J. Anderson,et al. A mutation in the hamster alpha1B-adrenergic receptor that differentiates two steps in the pathway of receptor internalization. , 1997, Molecular pharmacology.
[26] T. Blundell,et al. Comparative protein modelling by satisfaction of spatial restraints. , 1993, Journal of molecular biology.
[27] Marvin C. Gershengorn,et al. Interactions between Conserved Residues in Transmembrane Helices 1, 2, and 7 of the Thyrotropin-releasing Hormone Receptor* , 1997, The Journal of Biological Chemistry.
[28] J. Jakubík,et al. Evidence for a Tandem Two-site Model of Ligand Binding to Muscarinic Acetylcholine Receptors* , 2000, The Journal of Biological Chemistry.
[29] Gebhard F. X. Schertler,et al. Arrangement of rhodopsin transmembrane α-helices , 1997, Nature.
[30] E. Hulme,et al. Alanine-scanning mutagenesis of transmembrane domain 6 of the M(1) muscarinic acetylcholine receptor suggests that Tyr381 plays key roles in receptor function. , 1999, Molecular pharmacology.
[31] T. Schwartz,et al. Partial agonism through a zinc-Ion switch constructed between transmembrane domains III and VII in the tachykinin NK(1) receptor. , 2000, Molecular pharmacology.
[32] K Konvicka,et al. A reciprocal mutation supports helix 2 and helix 7 proximity in the gonadotropin-releasing hormone receptor. , 1994, Molecular pharmacology.
[33] H. Khorana,et al. Requirement of Rigid-Body Motion of Transmembrane Helices for Light Activation of Rhodopsin , 1996, Science.
[34] L. Audoly,et al. Substitution of charged amino acid residues in transmembrane regions 6 and 7 affect ligand binding and signal transduction of the prostaglandin EP3 receptor. , 1997, Molecular pharmacology.
[35] K. Nakanishi,et al. Movement of retinal along the visual transduction path. , 2000, Science.
[36] E. Hulme,et al. The conformational switch in 7-transmembrane receptors: the muscarinic receptor paradigm. , 1999, European journal of pharmacology.
[37] E. Hulme,et al. Scanning mutagenesis of transmembrane domain 3 of the m1 muscarinic acetylcholine receptor , 1998, Journal of Physiology-Paris.
[38] S. Karnik,et al. Role of Transmembrane Helix IV in G-protein Specificity of the Angiotensin II Type 1 Receptor* , 1999, The Journal of Biological Chemistry.