Yellow Nail Syndrome Patients with Diffuse Panbronchiolitis-like Pulmonary Manifestation

Yellow nail syndrome (YNS) is a rare clinical syndrome characterized by a triad of yellow thick nail, lymphedema and respiratory diseases. We experienced 2 cases of YNS with diffuse panbronchiolitis (DPB)-like pulmonary manifestation. Since YNS might be hidden to those who have been diagnosed with DPB, physicians should be alert to recognize nail signs of YNS in case of DPB refractory to macrolide therapy. We hereby review previous case reports of YNS and discuss its pulmonary manifestations.

[1]  S. Vignes,et al.  Yellow nail syndrome: a review , 2017, Orphanet Journal of Rare Diseases.

[2]  D. Hansell,et al.  Bronchiectasis in yellow nail syndrome , 2017, Respirology.

[3]  A. Mishra,et al.  Yellow nail syndrome in rheumatoid arthritis: an aetiology beyond thiol drugs , 2016, Oxford medical case reports.

[4]  S. Agrawal,et al.  T and B Cell Deficiency Associated with Yellow Nail Syndrome , 2012, Scandinavian journal of immunology.

[5]  D. Díaz‐Valle,et al.  Conjunctival changes associated with yellow nail syndrome , 2011 .

[6]  F. Maldonado,et al.  Yellow nail syndrome: analysis of 41 consecutive patients. , 2008, Chest.

[7]  N. Adams,et al.  Diffuse panbronchiolitis , 2008, European Respiratory Journal.

[8]  H. Baden,et al.  Yellow nail syndrome. , 1990, Journal of the American Academy of Dermatology.

[9]  Yellow nails. , 1973, The Lancet.

[10]  J. Ellis,et al.  Yellow nails. A report of six cases. , 1970, Archives of dermatology.