Know your neighbors: microbial recognition at the intestinal barrier and its implications for gut homeostasis and inflammatory bowel disease
暂无分享,去创建一个
[1] Minhu Chen,et al. Blocking Dectin-1 prevents colorectal tumorigenesis by suppressing prostaglandin E2 production in myeloid-derived suppressor cells and enhancing IL-22 binding protein expression , 2023, Nature Communications.
[2] Yi Li,et al. The orphan receptor Nur77 binds cytoplasmic LPS to activate the non-canonical NLRP3 inflammasome. , 2023, Immunity.
[3] B. Stecher,et al. Label or Concept - What Is a Pathobiont? , 2020, Trends in microbiology.
[4] A. Moran,et al. Toll-like receptor 9 expressed in proximal intestinal enteroendocrine cells detects bacteria resulting in secretion of cholecystokinin. , 2020, Biochemical and biophysical research communications.
[5] Marie E. Latulippe,et al. Establishing What Constitutes a Healthy Human Gut Microbiome: State of the Science, Regulatory Considerations, and Future Directions , 2019, The Journal of nutrition.
[6] T. Meyer,et al. ADP heptose, a novel pathogen-associated molecular pattern identified in Helicobacter pylori , 2019, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[7] W. Hardt,et al. Mucus Architecture and Near-Surface Swimming Affect Distinct Salmonella Typhimurium Infection Patterns along the Murine Intestinal Tract , 2019, Cell reports.
[8] T. Ayabe,et al. Paneth cell granule dynamics on secretory responses to bacterial stimuli in enteroids , 2019, Scientific Reports.
[9] Si Ming Man,et al. ALPK1: innate attraction to the sweetness of bacteria , 2018, Cell Research.
[10] J. Satsangi,et al. Mitochondrial DNA Is a Pro-Inflammatory Damage-Associated Molecular Pattern Released During Active IBD. , 2018, Inflammatory bowel diseases.
[11] G. Barton,et al. A Map of Toll‐like Receptor Expression in the Intestinal Epithelium Reveals Distinct Spatial, Cell Type‐Specific, and Temporal Patterns , 2018, Immunity.
[12] Xiaojun Ding,et al. Alpha-kinase 1 is a cytosolic innate immune receptor for bacterial ADP-heptose , 2018, Nature.
[13] B. Stockinger,et al. The Environmental Sensor AHR Protects from Inflammatory Damage by Maintaining Intestinal Stem Cell Homeostasis and Barrier Integrity , 2018, Immunity.
[14] P. Turnbaugh,et al. A Metabolite-Triggered Tuft Cell-ILC2 Circuit Drives Small Intestinal Remodeling , 2018, Cell.
[15] Juan Camilo Castrillón-Betancur,et al. The Interaction of Human Pathogenic Fungi With C-Type Lectin Receptors , 2018, Front. Immunol..
[16] R. Margolskee,et al. Activation of intestinal tuft cell-expressed Sucnr1 triggers type 2 immunity in the mouse small intestine , 2018, Proceedings of the National Academy of Sciences.
[17] Mark S. Anderson,et al. Detection of succinate by intestinal tuft cells triggers a type 2 innate immune circuit , 2018, bioRxiv.
[18] E. Burstein,et al. Loss of Paneth Cell Autophagy Causes Acute Susceptibility to Toxoplasma gondii-Mediated Inflammation. , 2018, Cell host & microbe.
[19] Qiang Tian,et al. Human Gut Microbiota and Gastrointestinal Cancer , 2018, Genom. Proteom. Bioinform..
[20] C. Dejong,et al. Enteroendocrine L Cells Sense LPS after Gut Barrier Injury to Enhance GLP-1 Secretion. , 2017, Cell reports.
[21] T. Vilsbøll,et al. Current Therapies That Modify Glucagon Secretion: What Is the Therapeutic Effect of Such Modifications? , 2017, Current Diabetes Reports.
[22] S. Colgan,et al. Microbial-Derived Butyrate Promotes Epithelial Barrier Function through IL-10 Receptor–Dependent Repression of Claudin-2 , 2017, The Journal of Immunology.
[23] T. Meyer,et al. ALPK1 and TIFA dependent innate immune response triggered by the Helicobacter pylori type IV secretion system , 2017, bioRxiv.
[24] C. Arrieumerlou,et al. Innate Recognition of Intracellular Bacterial Growth Is Driven by the TIFA-Dependent Cytosolic Surveillance Pathway. , 2017, Cell reports.
[25] T. Sparwasser,et al. MyD88 signaling in dendritic cells and the intestinal epithelium controls immunity against intestinal infection with C. rodentium , 2017, PLoS pathogens.
[26] J. Doré,et al. TLR ligands and butyrate increase Pyy expression through two distinct but inter‐regulated pathways , 2017, Cellular microbiology.
[27] C. Arrieumerlou,et al. ALPK1 controls TIFA/TRAF6-dependent innate immunity against heptose-1,7-bisphosphate of gram-negative bacteria , 2017, PLoS pathogens.
[28] N. Terry,et al. Serotonergic Mechanisms Regulating the GI Tract: Experimental Evidence and Therapeutic Relevance. , 2016, Handbook of experimental pharmacology.
[29] W. D. de Vos,et al. A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice , 2016, Nature Medicine.
[30] S. Gray-Owen,et al. Heptose Sounds the Alarm: Innate Sensing of a Bacterial Sugar Stimulates Immunity , 2016, PLoS pathogens.
[31] S. Gringhuis,et al. C-type lectin receptors in the control of T helper cell differentiation , 2016, Nature Reviews Immunology.
[32] Changying Jiang,et al. Dectin-3 Deficiency Promotes Colitis Development due to Impaired Antifungal Innate Immune Responses in the Gut , 2016, PLoS pathogens.
[33] T. Matozaki,et al. Promotion of Intestinal Epithelial Cell Turnover by Commensal Bacteria: Role of Short-Chain Fatty Acids , 2016, PloS one.
[34] L. Joosten,et al. The Role of Dectin-2 for Host Defense Against Disseminated Candidiasis , 2016, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.
[35] R. Locksley,et al. Tuft-cell-derived IL-25 regulates an intestinal ILC2–epithelial response circuit , 2015, Nature.
[36] Robert A. Carter,et al. Critical Role for the DNA Sensor AIM2 in Stem Cell Proliferation and Cancer , 2015, Cell.
[37] B. Schwikowski,et al. Bacterial Internalization, Localization, and Effectors Shape the Epithelial Immune Response during Shigella flexneri Infection , 2015, Infection and Immunity.
[38] Jianjun Li,et al. Cytosolic detection of the bacterial metabolite HBP activates TIFA-dependent innate immunity , 2015, Science.
[39] T. Weir,et al. Crosstalk between Microbiota-Derived Short-Chain Fatty Acids and Intestinal Epithelial HIF Augments Tissue Barrier Function. , 2015, Cell host & microbe.
[40] Rustem F. Ismagilov,et al. Indigenous Bacteria from the Gut Microbiota Regulate Host Serotonin Biosynthesis , 2015, Cell.
[41] R. Flavell,et al. Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome , 2015, Nature Communications.
[42] P. Schneider,et al. Epithelial NAIPs protect against colonic tumorigenesis , 2015, The Journal of experimental medicine.
[43] H. Herzog,et al. Regulation of energy homeostasis by the NPY system , 2015, Trends in Endocrinology & Metabolism.
[44] Maxim N. Artyomov,et al. Interferon-λ cures persistent murine norovirus infection in the absence of adaptive immunity , 2015, Science.
[45] M. Diamond,et al. Commensal microbes and interferon-λ determine persistence of enteric murine norovirus infection , 2015, Science.
[46] R. Ley,et al. Intestinal epithelial cell toll-like receptor 5 regulates the intestinal microbiota to prevent low-grade inflammation and metabolic syndrome in mice. , 2014, Gastroenterology.
[47] T. Denning,et al. Prevention and cure of rotavirus infection via TLR5/NLRC4–mediated production of IL-22 and IL-18 , 2014, Science.
[48] P. Loke,et al. Bacterial sensor Nod2 prevents inflammation of the small intestine by restricting the expansion of the commensal Bacteroides vulgatus. , 2014, Immunity.
[49] Sandhya Kortagere,et al. Symbiotic Bacterial Metabolites Regulate Gastrointestinal Barrier Function via the Xenobiotic Sensor PXR and Toll‐like Receptor 4 , 2014, Immunity.
[50] W. Hardt,et al. Epithelium-intrinsic NAIP/NLRC4 inflammasome drives infected enterocyte expulsion to restrict Salmonella replication in the intestinal mucosa. , 2014, Cell host & microbe.
[51] P. Dube,et al. Integrin-Mediated First Signal for Inflammasome Activation in Intestinal Epithelial Cells , 2014, The Journal of Immunology.
[52] H. Clevers,et al. Paneth cell extrusion and release of antimicrobial products is directly controlled by immune cell–derived IFN-γ , 2014, The Journal of experimental medicine.
[53] P. Sansonetti,et al. The cytosolic bacterial peptidoglycan sensor Nod2 affords stem cell protection and links microbes to gut epithelial regeneration. , 2014, Cell host & microbe.
[54] S. Grivennikov,et al. Microbiome, Inflammation, and Cancer , 2014, Cancer journal.
[55] Y. Belkaid,et al. Role of the Microbiota in Immunity and Inflammation , 2014, Cell.
[56] E. Elinav,et al. NLRP6 Inflammasome Orchestrates the Colonic Host-Microbial Interface by Regulating Goblet Cell Mucus Secretion , 2014, Cell.
[57] S. Rampelli,et al. Inflammation and colorectal cancer, when microbiota-host mutualism breaks. , 2014, World journal of gastroenterology.
[58] Huidong Shi,et al. Activation of Gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesis. , 2014, Immunity.
[59] S. Nordlander,et al. NLRC4 expression in intestinal epithelial cells mediates protection against an enteric pathogen , 2013, Mucosal Immunology.
[60] K. Maloy,et al. Nlrp3 Activation in the Intestinal Epithelium Protects against a Mucosal Pathogen , 2013, Mucosal Immunology.
[61] B. Verrier,et al. Dectin-1 Is Essential for Reverse Transcytosis of Glycosylated SIgA-Antigen Complexes by Intestinal M Cells , 2013, PLoS biology.
[62] F. Sutterwala,et al. Mitochondrial cardiolipin is required for Nlrp3 inflammasome activation. , 2013, Immunity.
[63] A. De Luca,et al. Tryptophan catabolites from microbiota engage aryl hydrocarbon receptor and balance mucosal reactivity via interleukin-22. , 2013, Immunity.
[64] R. Sumpter,et al. Intestinal epithelial autophagy is essential for host defense against invasive bacteria. , 2013, Cell host & microbe.
[65] N A Mabbott,et al. Microfold (M) cells: important immunosurveillance posts in the intestinal epithelium , 2013, Mucosal Immunology.
[66] E. Elinav,et al. Microbiota-induced activation of epithelial IL-6 signaling links inflammasome-driven inflammation with transmissible cancer , 2013, Proceedings of the National Academy of Sciences.
[67] Sang-Uk Seo,et al. Role of the gut microbiota in immunity and inflammatory disease , 2013, Nature Reviews Immunology.
[68] R. Vance,et al. Recognition of bacteria by inflammasomes. , 2013, Annual review of immunology.
[69] Philip Rosenstiel,et al. NOD2-mediated dysbiosis predisposes mice to transmissible colitis and colorectal cancer. , 2013, The Journal of clinical investigation.
[70] T. Billiar,et al. Intestinal epithelial Toll-like receptor 4 regulates goblet cell development and is required for necrotizing enterocolitis in mice. , 2012, Gastroenterology.
[71] William A. Walters,et al. Transient inability to manage proteobacteria promotes chronic gut inflammation in TLR5-deficient mice. , 2012, Cell host & microbe.
[72] E. Wherry,et al. Commensal bacteria calibrate the activation threshold of innate antiviral immunity. , 2012, Immunity.
[73] F. Bushman,et al. Innate Lymphoid Cells Promote Anatomical Containment of Lymphoid-Resident Commensal Bacteria , 2012, Science.
[74] A. McKenzie,et al. Epithelial cell-specific Act1 adaptor mediates interleukin-25-dependent helminth expulsion through expansion of Lin(-)c-Kit(+) innate cell population. , 2012, Immunity.
[75] Moshe Arditi,et al. Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis. , 2012, Immunity.
[76] C. Sasakawa,et al. The Shigella flexneri effector OspI deamidates UBC13 to dampen the inflammatory response , 2012, Nature.
[77] L. De Cecco,et al. Induction of Paneth cell degranulation by orally administered Toll‐like receptor ligands , 2012, Journal of cellular physiology.
[78] R. Ley,et al. The Antibacterial Lectin RegIIIγ Promotes the Spatial Segregation of Microbiota and Host in the Intestine , 2011, Science.
[79] Kyoko Takahashi,et al. Epigenetic Control of the Host Gene by Commensal Bacteria in Large Intestinal Epithelial Cells* , 2011, The Journal of Biological Chemistry.
[80] N. Harpaz,et al. Constitutive activation of epithelial TLR4 augments inflammatory responses to mucosal injury and drives colitis‐associated tumorigenesis , 2011, Inflammatory Bowel Diseases.
[81] J. Bertin,et al. A Functional Role for Nlrp6 in Intestinal Inflammation and Tumorigenesis , 2011, The Journal of Immunology.
[82] E. Kurt-Jones,et al. Pattern Recognition Receptors and the Innate Immune Response to Viral Infection , 2011, Viruses.
[83] M. Chamaillard,et al. Nod-like receptor pyrin domain-containing protein 6 (NLRP6) controls epithelial self-renewal and colorectal carcinogenesis upon injury , 2011, Proceedings of the National Academy of Sciences.
[84] M. Neurath,et al. Tumor development in murine ulcerative colitis depends on MyD88 signaling of colonic F4/80+CD11b(high)Gr1(low) macrophages. , 2011, The Journal of clinical investigation.
[85] H. Erdjument-Bromage,et al. TLR signaling augments macrophage bactericidal activity through mitochondrial ROS , 2011, Nature.
[86] M. Lamkanfi,et al. The Nlrp3 inflammasome: contributions to intestinal homeostasis. , 2011, Trends in immunology.
[87] A. Iwasaki,et al. Microbiota regulates immune defense against respiratory tract influenza A virus infection , 2011, Proceedings of the National Academy of Sciences.
[88] Hans Clevers,et al. Distinct ATOH1 and Neurog3 requirements define tuft cells as a new secretory cell type in the intestinal epithelium , 2011, The Journal of cell biology.
[89] D. Charnock-Jones,et al. Developmental control of the Nlrp6 inflammasome and a substrate, IL-18, in mammalian intestine. , 2011, American journal of physiology. Gastrointestinal and liver physiology.
[90] E. Elinav,et al. Inflammation-induced tumorigenesis in the colon is regulated by caspase-1 and NLRC4 , 2010, Proceedings of the National Academy of Sciences.
[91] C. Arrieumerlou,et al. Cell-cell propagation of NF-κB transcription factor and MAP kinase activation amplifies innate immunity against bacterial infection. , 2010, Immunity.
[92] E. Cario. Heads up! How the intestinal epithelium safeguards mucosal barrier immunity through the inflammasome and beyond , 2010, Current opinion in gastroenterology.
[93] C. Blobel,et al. MyD88 signaling in nonhematopoietic cells protects mice against induced colitis by regulating specific EGF receptor ligands , 2010, Proceedings of the National Academy of Sciences.
[94] M. Lamkanfi,et al. IL-18 Production Downstream of the Nlrp3 Inflammasome Confers Protection against Colorectal Tumor Formation , 2010, The Journal of Immunology.
[95] Shuang Chen,et al. Toll-Like Receptor 2 Signaling Protects Mice from Tumor Development in a Mouse Model of Colitis-Induced Cancer , 2010, PloS one.
[96] C. Pothoulakis,et al. TRIF Mediates Toll-like Receptor 5-induced Signaling in Intestinal Epithelial Cells* , 2010, The Journal of Biological Chemistry.
[97] R. Xu,et al. Toll-like receptor 4 differentially regulates epidermal growth factor-related growth factors in response to intestinal mucosal injury , 2010, Laboratory Investigation.
[98] F. Marincola,et al. MyD88-mediated signaling prevents development of adenocarcinomas of the colon: role of interleukin 18 , 2010, The Journal of experimental medicine.
[99] F. Powrie,et al. Pathogenic and protective roles of MyD88 in leukocytes and epithelial cells in mouse models of inflammatory bowel disease. , 2010, Gastroenterology.
[100] Jie-shou Li,et al. Epithelial-specific blockade of MyD88-dependent pathway causes spontaneous small intestinal inflammation. , 2010, Clinical immunology.
[101] G. Eberl,et al. Bacteria and MAMP-induced morphogenesis of the immune system. , 2010, Current opinion in immunology.
[102] R. Xu,et al. The role of prostaglandin E2 (PGE 2) in toll-like receptor 4 (TLR4)-mediated colitis-associated neoplasia , 2010, BMC gastroenterology.
[103] H. Herfarth,et al. The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer , 2010, The Journal of experimental medicine.
[104] Jongdae Lee,et al. ERK activation drives intestinal tumorigenesis in Apcmin/+ mice , 2010, Nature Medicine.
[105] Linheng Li,et al. Interferon-gamma regulates intestinal epithelial homeostasis through converging beta-catenin signaling pathways. , 2010, Immunity.
[106] M. Kastan,et al. The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis. , 2010, Immunity.
[107] Maria T. Abreu,et al. Toll-like receptor signalling in the intestinal epithelium: how bacterial recognition shapes intestinal function , 2010, Nature Reviews Immunology.
[108] Zhen-hua Hu,et al. Differential effects of NOD2 polymorphisms on colorectal cancer risk: a meta-analysis , 2010, International Journal of Colorectal Disease.
[109] J. Rehwinkel,et al. RIGorous Detection: Exposing Virus Through RNA Sensing , 2010, Science.
[110] R. Mensink,et al. The absence of functional dectin-1 on enterocytes may serve to prevent intestinal damage , 2010, European journal of gastroenterology & hepatology.
[111] Shunsuke Kimura,et al. Uptake through glycoprotein 2 of FimH+ bacteria by M cells initiates mucosal immune response , 2009, Nature.
[112] Michael Krawczak,et al. Investigation of innate immunity genes CARD4, CARD8 and CARD15 as germline susceptibility factors for colorectal cancer , 2009, BMC gastroenterology.
[113] J. Hugot,et al. Nod2 regulates the host response towards microflora by modulating T cell function and epithelial permeability in mouse Peyer's patches , 2009, Gut.
[114] Tomas Hrncir,et al. Nod2 is required for the regulation of commensal microbiota in the intestine , 2009, Proceedings of the National Academy of Sciences.
[115] Hong Guo,et al. Induction of microRNA-155 during Helicobacter pylori infection and its negative regulatory role in the inflammatory response. , 2009, The Journal of infectious diseases.
[116] P. Sansonetti,et al. Shigella phagocytic vacuolar membrane remnants participate in the cellular response to pathogen invasion and are regulated by autophagy. , 2009, Cell host & microbe.
[117] M. Cooper,et al. New Approach for M-Cell-Specific Molecules Screening by Comprehensive Transcriptome Analysis , 2009, DNA research : an international journal for rapid publication of reports on genes and genomes.
[118] V. Hornung,et al. RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III–transcribed RNA intermediate , 2009, Nature Immunology.
[119] G. Gerken,et al. Colitis-associated variant of TLR2 causes impaired mucosal repair because of TFF3 deficiency. , 2009, Gastroenterology.
[120] B. Müller-Myhsok,et al. Epistasis Between Toll-Like Receptor-9 Polymorphisms and Variants in NOD2 and IL23R Modulates Susceptibility to Crohn's Disease , 2009, The American Journal of Gastroenterology.
[121] R. Xu,et al. Innate immune signaling by Toll‐like receptor‐4 (TLR4) shapes the inflammatory microenvironment in colitis‐associated tumors , 2009, Inflammatory bowel diseases.
[122] H. Herfarth,et al. Modulation of the Intestinal Microbiota Alters Colitis-Associated Colorectal Cancer Susceptibility , 2009, PloS one.
[123] Guido Gerken,et al. TLR2 Mediates Gap Junctional Intercellular Communication through Connexin-43 in Intestinal Epithelial Barrier Injury* , 2009, The Journal of Biological Chemistry.
[124] L. Eckmann,et al. Paneth cells directly sense gut commensals and maintain homeostasis at the intestinal host-microbial interface , 2008, Proceedings of the National Academy of Sciences.
[125] Gabriel Núñez,et al. The innate immune receptor Nod1 protects the intestine from inflammation-induced tumorigenesis. , 2008, Cancer research.
[126] C. Shi,et al. MyD88 and Trif Target Beclin 1 to Trigger Autophagy in Macrophages* , 2008, Journal of Biological Chemistry.
[127] Gérard Eberl,et al. Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis , 2008, Nature.
[128] Shizuo Akira,et al. Toll‐like Receptor and RIG‐1‐like Receptor Signaling , 2008, Annals of the New York Academy of Sciences.
[129] Ronald P. DeMatteo,et al. Vancomycin-resistant enterococci exploit antibiotic-induced innate immune deficits , 2008, Nature.
[130] M. Netea,et al. Dectin‐1 synergizes with TLR2 and TLR4 for cytokine production in human primary monocytes and macrophages , 2008, Cellular microbiology.
[131] A. Velcich,et al. The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria , 2008, Proceedings of the National Academy of Sciences.
[132] A. Fürholz,et al. Murine intestinal cells expressing Trpm5 are mostly brush cells and express markers of neuronal and inflammatory cells , 2008, The Journal of comparative neurology.
[133] S. Lira,et al. Toll-like receptor signaling in small intestinal epithelium promotes B-cell recruitment and IgA production in lamina propria. , 2008, Gastroenterology.
[134] M. Ono. Molecular links between tumor angiogenesis and inflammation: inflammatory stimuli of macrophages and cancer cells as targets for therapeutic strategy , 2008, Cancer science.
[135] F. Marincola,et al. Induction of pro-inflammatory programs in enteroendocrine cells by the Toll-like receptor agonists flagellin and bacterial LPS. , 2008, International immunology.
[136] L. O’Neill. When signaling pathways collide: positive and negative regulation of toll-like receptor signal transduction. , 2008, Immunity.
[137] J. K. Kundu,et al. Inflammation: gearing the journey to cancer. , 2008, Mutation research.
[138] D. Philpott,et al. The ubiquitin-editing enzyme A20 restricts nucleotide-binding oligomerization domain containing 2-triggered signals. , 2008, Immunity.
[139] S. Sa,et al. Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens , 2008, Nature Medicine.
[140] S. Akira,et al. TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-β , 2008, Nature Immunology.
[141] R. Xu,et al. Toll-like receptor-4 promotes the development of colitis-associated colorectal tumors. , 2007, Gastroenterology.
[142] E. Kremmer,et al. The pattern‐recognition molecule Nod1 is localized at the plasma membrane at sites of bacterial interaction , 2007, Cellular microbiology.
[143] F. Martinon,et al. Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration , 2007, Cell Death and Differentiation.
[144] G. Plitas,et al. MyD88-mediated signals induce the bactericidal lectin RegIIIγ and protect mice against intestinal Listeria monocytogenes infection , 2007, The Journal of experimental medicine.
[145] R. Medzhitov,et al. Regulation of Spontaneous Intestinal Tumorigenesis Through the Adaptor Protein MyD88 , 2007, Science.
[146] A. Plebani,et al. Intestinal bacteria trigger T cell-independent immunoglobulin A(2) class switching by inducing epithelial-cell secretion of the cytokine APRIL. , 2007, Immunity.
[147] D. Podolsky,et al. TLRs in the Gut. IV. Negative regulation of Toll-like receptors and intestinal homeostasis: addition by subtraction. , 2007, American journal of physiology. Gastrointestinal and liver physiology.
[148] N. Harpaz,et al. Enteroendocrine cells express functional Toll-like receptors. , 2007, American journal of physiology. Gastrointestinal and liver physiology.
[149] J. Hugot,et al. The NOD2-RICK Complex Signals from the Plasma Membrane* , 2007, Journal of Biological Chemistry.
[150] F. Martinon,et al. Inflammasome Components NALP 1 and 3 Show Distinct but Separate Expression Profiles in Human Tissues Suggesting a Site-specific Role in the Inflammatory Response , 2007, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.
[151] Judy H Cho,et al. Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis , 2007, Nature Genetics.
[152] K. McCoy,et al. Use of axenic animals in studying the adaptation of mammals to their commensal intestinal microbiota. , 2007, Seminars in immunology.
[153] G Gerken,et al. Toll-like receptor 2 controls mucosal inflammation by regulating epithelial barrier function. , 2007, Gastroenterology.
[154] M. Neurath,et al. Epithelial NEMO links innate immunity to chronic intestinal inflammation , 2007, Nature.
[155] G. Núñez,et al. RICK/RIP2 Mediates Innate Immune Responses Induced through Nod1 and Nod2 but Not TLRs1 , 2007, The Journal of Immunology.
[156] X. Qin,et al. The adaptor protein CARD9 is required for innate immune responses to intracellular pathogens , 2007, Nature Immunology.
[157] Thomas Lengauer,et al. A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1 , 2007, Nature Genetics.
[158] Sarah L. Brown,et al. Myd88-dependent positioning of Ptgs2-expressing stromal cells maintains colonic epithelial proliferation during injury. , 2007, The Journal of clinical investigation.
[159] Yu-Tseung Liu,et al. Maintenance of colonic homeostasis by distinctive apical TLR9 signalling in intestinal epithelial cells , 2006, Nature Cell Biology.
[160] R. Xu,et al. Cox-2 is regulated by Toll-like receptor-4 (TLR4) signaling: Role in proliferation and apoptosis in the intestine. , 2006, Gastroenterology.
[161] L. Hooper,et al. Symbiotic Bacteria Direct Expression of an Intestinal Bactericidal Lectin , 2006, Science.
[162] J. Meijerink,et al. Muc2-deficient mice spontaneously develop colitis, indicating that MUC2 is critical for colonic protection. , 2006, Gastroenterology.
[163] J. Coppee,et al. Anti-Inflammatory Effect of Lactobacillus casei on Shigella-Infected Human Intestinal Epithelial Cells1 , 2006, The Journal of Immunology.
[164] P. Rutgeerts,et al. Toll‐like receptor‐1, ‐2, and ‐6 polymorphisms influence disease extension in inflammatory bowel diseases , 2006, Inflammatory bowel diseases.
[165] B. Batten,et al. Cutting Edge: Bacterial Modulation of Epithelial Signaling via Changes in Neddylation of Cullin-11 , 2005, The Journal of Immunology.
[166] C. Hofmann,et al. CpG motifs of bacterial DNA essentially contribute to the perpetuation of chronic intestinal inflammation. , 2005, Gastroenterology.
[167] F. Martinon,et al. NLRs join TLRs as innate sensors of pathogens. , 2005, Trends in immunology.
[168] R. Xavier,et al. Membrane recruitment of NOD2 in intestinal epithelial cells is essential for nuclear factor–κB activation in muramyl dipeptide recognition , 2005, The Journal of cell biology.
[169] H. Schjerven,et al. Regulation of the Polymeric Ig Receptor by Signaling through TLRs 3 and 4: Linking Innate and Adaptive Immune Responses1 , 2005, The Journal of Immunology.
[170] R. Xu,et al. Toll-like receptor-4 is required for intestinal response to epithelial injury and limiting bacterial translocation in a murine model of acute colitis. , 2005, American journal of physiology. Gastrointestinal and liver physiology.
[171] S. Sugie,et al. Dose-dependent promoting effect of dextran sodium sulfate on mouse colon carcinogenesis initiated with azoxymethane. , 2005, Histology and histopathology.
[172] Richard A. Flavell,et al. Nod2-Dependent Regulation of Innate and Adaptive Immunity in the Intestinal Tract , 2005, Science.
[173] Jason M Doherty,et al. Activated macrophages are an adaptive element of the colonic epithelial progenitor niche necessary for regenerative responses to injury. , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[174] Michael Karin,et al. IKKβ Links Inflammation and Tumorigenesis in a Mouse Model of Colitis-Associated Cancer , 2004, Cell.
[175] G. Gerken,et al. Toll-like receptor 2 enhances ZO-1-associated intestinal epithelial barrier integrity via protein kinase C. , 2004, Gastroenterology.
[176] A. Macpherson,et al. Induction of Protective IgA by Intestinal Dendritic Cells Carrying Commensal Bacteria , 2004, Science.
[177] C. Neut,et al. Self inflicted rectal ulcer: hearing is believing , 2003, Gut.
[178] D. Philpott,et al. Peptidoglycan Molecular Requirements Allowing Detection by Nod1 and Nod2* , 2003, Journal of Biological Chemistry.
[179] M. Hornef,et al. Intracellular Recognition of Lipopolysaccharide by Toll-like Receptor 4 in Intestinal Epithelial Cells , 2003, The Journal of experimental medicine.
[180] S. Davies,et al. Crohn's disease and the NOD2 gene: a role for paneth cells. , 2003, Gastroenterology.
[181] J. Bertin,et al. Nod1 Detects a Unique Muropeptide from Gram-Negative Bacterial Peptidoglycan , 2003, Science.
[182] Johan Auwerx,et al. Impaired expression of peroxisome proliferator-activated receptor γ in ulcerative colitis , 2003 .
[183] P. Rosenstiel,et al. TNF-α and IFN-γ regulate the expression of the NOD2 (CARD15) gene in human intestinal epithelial cells ☆ ☆☆ ★ ★★ ♢ , 2003 .
[184] M. Chamaillard,et al. Nod2 Is a General Sensor of Peptidoglycan through Muramyl Dipeptide (MDP) Detection* , 2003, The Journal of Biological Chemistry.
[185] Å. Danielsson,et al. Increased expression of antimicrobial peptides and lysozyme in colonic epithelial cells of patients with ulcerative colitis , 2003, Clinical and experimental immunology.
[186] M. Hornef,et al. Toll-like Receptor 4 Resides in the Golgi Apparatus and Colocalizes with Internalized Lipopolysaccharide in Intestinal Epithelial Cells , 2002, The Journal of experimental medicine.
[187] Kan Yang,et al. Colorectal Cancer in Mice Genetically Deficient in the Mucin Muc2 , 2002, Science.
[188] S. Clare,et al. Impaired Resistance and Enhanced Pathology During Infection with a Noninvasive, Attaching-Effacing Enteric Bacterial Pathogen, Citrobacter rodentium, in Mice Lacking IL-12 or IFN-γ , 2002, The Journal of Immunology.
[189] M. Abreu,et al. Decreased Expression of Toll-Like Receptor-4 and MD-2 Correlates with Intestinal Epithelial Cell Protection Against Dysregulated Proinflammatory Gene Expression in Response to Bacterial Lipopolysaccharide1 , 2001, The Journal of Immunology.
[190] I. Moro,et al. CD14 Is Expressed and Released as Soluble CD14 by Human Intestinal Epithelial Cells In Vitro: Lipopolysaccharide Activation of Epithelial Cells Revisited , 2001, Infection and Immunity.
[191] Mourad Sahbatou,et al. Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease , 2001, Nature.
[192] Judy H. Cho,et al. A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease , 2001, Nature.
[193] A. Young,et al. Prokaryotic Regulation of Epithelial Responses by Inhibition of IκB-α Ubiquitination , 2000 .
[194] D. Podolsky,et al. Lipopolysaccharide Activates Distinct Signaling Pathways in Intestinal Epithelial Cell Lines Expressing Toll-Like Receptors1 , 2000, The Journal of Immunology.
[195] M. Kagnoff,et al. Expression and regulation of the human beta-defensins hBD-1 and hBD-2 in intestinal epithelium. , 1999, Journal of immunology.
[196] G. Fantuzzi,et al. Interleukin-18 Regulation of Interferon γ Production and Cell Proliferation as Shown in Interleukin-1β–Converting Enzyme (Caspase-1)-Deficient Mice , 1998 .
[197] B. Hogan,et al. Intestinal tumorigenesis is suppressed in mice lacking the metalloproteinase matrilysin. , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[198] M. Pasparakis,et al. NF-κB in the regulation of epithelial homeostasis and inflammation , 2011, Cell Research.
[199] D. Hackam,et al. Toll-like receptor-4 inhibits enterocyte proliferation via impaired beta-catenin signaling in necrotizing enterocolitis. , 2010, Gastroenterology.
[200] D. Philpott,et al. Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry , 2010, Nature Immunology.
[201] S. Gordon,et al. Dectin-1 is required for β-glucan recognition and control of fungal infection , 2007, Nature Immunology.
[202] J. Birchall,et al. LPS up-regulates mucin and cytokine mRNA expression and stimulates mucin and cytokine secretion in goblet cells. , 2003, Cellular immunology.
[203] S. Kaufmann,et al. Heat shock proteins and the immune response. , 1990, Immunology today.