SoNar, a Highly Responsive NAD+/NADH Sensor, Allows High-Throughput Metabolic Screening of Anti-tumor Agents.

[1]  Yuzheng Zhao,et al.  Profiling metabolic states with genetically encoded fluorescent biosensors for NADH. , 2015, Current opinion in biotechnology.

[2]  T. Mak,et al.  Modulation of oxidative stress as an anticancer strategy , 2013, Nature Reviews Drug Discovery.

[3]  David A. Scott,et al.  Genome engineering using the CRISPR-Cas9 system , 2013, Nature Protocols.

[4]  K. Coombes,et al.  KEAP1-dependent synthetic lethality induced by AKT and TXNRD1 inhibitors in lung cancer. , 2013, Cancer research.

[5]  Le Cong,et al.  Multiplex Genome Engineering Using CRISPR/Cas Systems , 2013, Science.

[6]  M. Sporn,et al.  NRF2 and cancer: the good, the bad and the importance of context , 2012, Nature Reviews Cancer.

[7]  Joseph S. Bair.  The development of deoxynyboquinone as a personalized anticancer compound , 2012 .

[8]  Elizabeth I. Parkinson,et al.  An NQO1 substrate with potent antitumor activity that selectively kills by PARP1-induced programmed necrosis. , 2012, Cancer research.

[9]  D. Ross,et al.  NAD(P)H:quinone oxidoreductase 1 (NQO1) in the sensitivity and resistance to antitumor quinones. , 2012, Biochemical pharmacology.

[10]  Y. Wang,et al.  Shikonin and its analogs inhibit cancer cell glycolysis by targeting tumor pyruvate kinase-M2 , 2011, Oncogene.

[11]  J. Albeck,et al.  Imaging cytosolic NADH-NAD(+) redox state with a genetically encoded fluorescent biosensor. , 2011, Cell metabolism.

[12]  J. Loscalzo,et al.  Genetically encoded fluorescent sensors for intracellular NADH detection. , 2011, Cell metabolism.

[13]  T. Mak,et al.  Regulation of cancer cell metabolism , 2011, Nature Reviews Cancer.

[14]  M. V. Vander Heiden.  Targeting cancer metabolism: a therapeutic window opens. , 2011, Nature reviews. Drug discovery.

[15]  V. Seewaldt,et al.  Tumor and Stem Cell Biology Cancer Research Optical Redox Ratio Differentiates Breast Cancer Cell Lines Based on Estrogen Receptor Status , 2010 .

[16]  Jinming Gao,et al.  Beta-lapachone micellar nanotherapeutics for non-small cell lung cancer therapy. , 2010, Cancer research.

[17]  G. Semenza,et al.  Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression , 2010, Proceedings of the National Academy of Sciences.

[18]  L. Cantley,et al.  Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation , 2009, Science.

[19]  A. Heikal,et al.  Two-photon autofluorescence dynamics imaging reveals sensitivity of intracellular NADH concentration and conformation to cell physiology at the single-cell level. , 2009, Journal of photochemistry and photobiology. B, Biology.

[20]  Ru Wei,et al.  The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth , 2008, Nature.

[21]  N. Ramanujam,et al.  In vivo multiphoton microscopy of NADH and FAD redox states, fluorescence lifetimes, and cellular morphology in precancerous epithelia , 2007, Proceedings of the National Academy of Sciences.

[22]  Dudley Lamming,et al.  Nutrient-Sensitive Mitochondrial NAD+ Levels Dictate Cell Survival , 2007, Cell.

[23]  J. Minna,et al.  An NQO1- and PARP-1-mediated cell death pathway induced in non-small-cell lung cancer cells by β-lapachone , 2007, Proceedings of the National Academy of Sciences.

[24]  J. Herman,et al.  Dysfunctional KEAP1–NRF2 Interaction in Non-Small-Cell Lung Cancer , 2006, PLoS medicine.

[25]  H. Osago,et al.  The simultaneous measurement of nicotinamide adenine dinucleotide and related compounds by liquid chromatography/electrospray ionization tandem mass spectrometry. , 2006, Analytical biochemistry.

[26]  G. Mills,et al.  Simultaneous inhibition of PDK1/AKT and Fms-like tyrosine kinase 3 signaling by a small-molecule KP372-1 induces mitochondrial dysfunction and apoptosis in acute myelogenous leukemia. , 2006, Cancer research.

[27]  G. Mills,et al.  The Akt inhibitor KP372-1 inhibits proliferation and induces apoptosis and anoikis in squamous cell carcinoma of the head and neck. , 2006, Oral oncology.

[28]  S. Lukyanov,et al.  Genetically encoded fluorescent indicator for intracellular hydrogen peroxide , 2006, Nature Methods.

[29]  G. Mills,et al.  Inhibition of Akt survival pathway by a small-molecule inhibitor in human glioblastoma , 2006, Molecular Cancer Therapeutics.

[30]  G. Mills,et al.  The Akt inhibitor KP372-1 suppresses Akt activity and cell proliferation and induces apoptosis in thyroid cancer cells , 2005, British Journal of Cancer.

[31]  Jinming Gao,et al.  Development of β-Lapachone Prodrugs for Therapy Against Human Cancer Cells with Elevated NAD(P)H:Quinone Oxidoreductase 1 Levels , 2005, Clinical Cancer Research.

[32]  R. Tsien,et al.  Imaging Dynamic Redox Changes in Mammalian Cells with Green Fluorescent Protein Indicators* , 2004, Journal of Biological Chemistry.

[33]  L. Oberley,et al.  Dicumarol inhibition of NADPH:quinone oxidoreductase induces growth inhibition of pancreatic cancer via a superoxide-mediated mechanism. , 2003, Cancer research.

[34]  S. Biswal,et al.  Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray. , 2002, Cancer research.

[35]  D. Siegel,et al.  NAD(P)H:Quinone Oxidoreductase Activity Is the Principal Determinant of β-Lapachone Cytotoxicity* , 2000, The Journal of Biological Chemistry.

[36]  L. Gaboury,et al.  Steady state and time-resolved fluorescence properties of metastatic and non-metastatic malignant cells from different species. , 1995, Journal of photochemistry and photobiology. B, Biology.

[37]  H. Krebs,et al.  The redox state of free nicotinamide-adenine dinucleotide in the cytoplasm and mitochondria of rat liver. , 1967, The Biochemical journal.

[38]  O. Warburg.  On the origin of cancer cells. , 1956, Science.