Growth hormone replacement throughout life: insights into age-related responses to treatment.

[1]  J. Svensson,et al.  Baseline characteristics and effects of growth hormone therapy over two years in younger and elderly adults with adult onset GH deficiency. , 2006, The Journal of clinical endocrinology and metabolism.

[2]  K. Takano,et al.  Metabolic disorders in adult growth hormone deficiency: A study of 110 patients at a single institute in Japan. , 2006, Endocrine journal.

[3]  P. Kind,et al.  Does long-term GH replacement therapy in hypopituitary adults with GH deficiency normalise quality of life? , 2006, European journal of endocrinology.

[4]  M. Kołtowska-Häggström,et al.  Determinants of cardiovascular risk in 2589 hypopituitary GH-deficient adults - a KIMS database analysis. , 2006, European journal of endocrinology.

[5]  S. Ezzat,et al.  The influence of growth hormone status on physical impairments, functional limitations, and health-related quality of life in adults. , 2006, Endocrine reviews.

[6]  M. Vance,et al.  CLINICAL PRACTICE GUIDELINE Evaluation and Treatment of Adult Growth Hormone Deficiency: An Endocrine Society Clinical Practice Guideline , 2006 .

[7]  M. Kołtowska-Häggström,et al.  Isolated growth hormone (GH) deficiency in adult patients: baseline clinical characteristics and responses to GH replacement in comparison with hypopituitary patients. A sub-analysis of the KIMS database. , 2005, Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society.

[8]  M. C. Savanelli,et al.  Does a gender-related effect of growth hormone (GH) replacement exist on cardiovascular risk factors, cardiac morphology, and performance and atherosclerosis? Results of a two-year open, prospective study in young adult men and women with severe GH deficiency. , 2005, The Journal of clinical endocrinology and metabolism.

[9]  W. Blum,et al.  Quality of life in childhood onset growth hormone-deficient patients in the transition phase from childhood to adulthood. , 2005, The Journal of clinical endocrinology and metabolism.

[10]  N. Mauras,et al.  Limited efficacy of growth hormone (GH) during transition of GH-deficient patients from adolescence to adulthood: a phase III multicenter, double-blind, randomized two-year trial. , 2005, The Journal of clinical endocrinology and metabolism.

[11]  A. Colao,et al.  Common carotid intima-media thickness in growth hormone (GH)-deficient adolescents: a prospective study after GH withdrawal and restarting GH replacement. , 2005, The Journal of clinical endocrinology and metabolism.

[12]  M. Maghnie,et al.  Diagnosis of GH deficiency in the transition period: accuracy of insulin tolerance test and insulin-like growth factor-I measurement. , 2005, European journal of endocrinology.

[13]  P. Clayton,et al.  Consensus statement on the management of the GH-treated adolescent in the transition to adult care. , 2005, European journal of endocrinology.

[14]  C. Garel,et al.  Do all patients with childhood-onset growth hormone deficiency (GHD) and ectopic neurohypophysis have persistent GHD in adulthood? , 2005, The Journal of clinical endocrinology and metabolism.

[15]  S. Shalet,et al.  The Insulin-Like Growth Factor I Generation Test in Adults , 2005, Hormone Research in Paediatrics.

[16]  W. Blum,et al.  Continued growth hormone (GH) treatment after final height is necessary to complete somatic development in childhood-onset GH-deficient patients. , 2004, The Journal of clinical endocrinology and metabolism.

[17]  D. Dunger,et al.  Comparison of continuation or cessation of growth hormone (GH) therapy on body composition and metabolic status in adolescents with severe GH deficiency at completion of linear growth. , 2004, The Journal of clinical endocrinology and metabolism.

[18]  P. Wilton,et al.  Aspects of growth hormone deficiency and replacement in elderly hypopituitary adults. , 2004, Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society.

[19]  J. Stepan,et al.  The effects of GH replacement in adult GH‐deficient patients: changes in body composition without concomitant changes in the adipokines and insulin resistance , 2004, Clinical endocrinology.

[20]  R. Clayton,et al.  Growth hormone and pituitary radiotherapy, but not serum insulin-like growth factor-I concentrations, predict excess mortality in patients with acromegaly. , 2004, The Journal of clinical endocrinology and metabolism.

[21]  S. Shalet,et al.  Seeking the optimal target range for insulin-like growth factor I during the treatment of adult growth hormone disorders. , 2003, The Journal of clinical endocrinology and metabolism.

[22]  P. Chanson,et al.  Cardiac Effects of Growth Hormone in Adults With Growth Hormone Deficiency: A Meta-Analysis , 2003, Circulation.

[23]  M. Tauber,et al.  Adolescents with partial growth hormone (GH) deficiency develop alterations of body composition after GH discontinuation and require follow-up. , 2003, The Journal of clinical endocrinology and metabolism.

[24]  K. Attie,et al.  Growth hormone (GH) dose-response in young adults with childhood-onset GH deficiency: a two-year, multicenter, multiple-dose, placebo-controlled study. , 2003, The Journal of clinical endocrinology and metabolism.

[25]  C. Quigley,et al.  Effect of growth hormone (GH) treatment on bone in postpubertal GH-deficient patients: a 2-year randomized, controlled, dose-ranging study. , 2003, The Journal of clinical endocrinology and metabolism.

[26]  F. Casanueva,et al.  The effectiveness of arginine + GHRH test compared with GHRH + GHRP‐6 test in diagnosing growth hormone deficiency in adults , 2003, Clinical endocrinology.

[27]  D. Dunger,et al.  The effect of cessation of growth hormone (GH) therapy on bone mineral accretion in GH-deficient adolescents at the completion of linear growth. , 2003, The Journal of clinical endocrinology and metabolism.

[28]  R. Abs.  Update on the diagnosis of GH deficiency in adults. , 2003, European journal of endocrinology.

[29]  E P Krenning,et al.  Reference data for bone density and body composition measured with dual energy x ray absorptiometry in white children and young adults , 2002, Archives of disease in childhood.

[30]  F. Orio,et al.  The cardiovascular risk of GH-deficient adolescents. , 2002, The Journal of clinical endocrinology and metabolism.

[31]  W. Blum,et al.  Body composition, IGF-I and IGFBP-3 concentrations as outcome measures in severely GH-deficient (GHD) patients after childhood GH treatment: a comparison with adult onset GHD patients. , 2002, The Journal of clinical endocrinology and metabolism.

[32]  P. Clayton,et al.  Lipid profiles in untreated severe congenital isolated growth hormone deficiency through the lifespan , 2002, Clinical endocrinology.

[33]  R. Murray,et al.  Low‐dose GH replacement improves the adverse lipid profile associated with the adult GH deficiency syndrome , 2002, Clinical endocrinology.

[34]  D. Bonaduce,et al.  The cardiovascular risk of adult GH deficiency (GHD) improved after GH replacement and worsened in untreated GHD: a 12-month prospective study. , 2002, The Journal of clinical endocrinology and metabolism.

[35]  I. Bosaeus,et al.  Currently used growth‐promoting treatment of children results in normal bone mass and density. A prospective trial of discontinuing growth hormone treatment in adolescents ‡ , 2001, Clinical endocrinology.

[36]  M. Alpsten,et al.  A prospective study of 5 years of GH replacement therapy in GH-deficient adults: sustained effects on body composition, bone mass, and metabolic indices. , 2001, The Journal of clinical endocrinology and metabolism.

[37]  G. Grimby,et al.  GH is needed for the maturation of muscle mass and strength in adolescents. , 2001, The Journal of clinical endocrinology and metabolism.

[38]  S. Chew,et al.  Sustained reduction in circulating cholesterol in adult hypopituitary patients given low dose titrated growth hormone replacement therapy: a two year study , 2000, Clinical endocrinology.

[39]  F. Casanueva,et al.  GH-releasing hormone and GH-releasing peptide-6 for diagnostic testing in GH-deficient adults , 2000, The Lancet.

[40]  M. Thorén,et al.  Growth hormone deficiency and replacement in elderly hypopituitary adults , 2000, Clinical endocrinology.

[41]  N. Skakkebaek,et al.  Continuation of growth hormone (GH) replacement in GH-deficient patients during transition from childhood to adulthood: a two-year placebo-controlled study. , 2000, The Journal of clinical endocrinology and metabolism.

[42]  N. Skakkebaek,et al.  Continuation of growth hormone (GH) therapy in GH-deficient patients during transition from childhood to adulthood: impact on insulin sensitivity and substrate metabolism. , 2000, The Journal of clinical endocrinology and metabolism.

[43]  H. C. Hoeck,et al.  Diagnosis of growth hormone (GH) deficiency in adults with hypothalamic-pituitary disorders: comparison of test results using pyridostigmine plus GH-releasing hormone (GHRH), clonidine plus GHRH, and insulin-induced hypoglycemia as GH secretagogues. , 2000, The Journal of clinical endocrinology and metabolism.

[44]  S. Jackson,et al.  The effect of GH replacement therapy on endothelial function and oxidative stress in adult growth hormone deficiency. , 2000, European journal of endocrinology.

[45]  S. Asa,et al.  Measures of submaximal aerobic performance evaluate and predict functional response to growth hormone (GH) treatment in GH-deficient adults. , 1999, The Journal of clinical endocrinology and metabolism.

[46]  B. Bengtsson,et al.  Discontinuation of Growth Hormone (GH) Treatment: Metabolic Effects in GH-Deficient and GH-Sufficient Adolescent Patients Compared with Control Subjects* , 1999 .

[47]  F. Alford,et al.  The effect of 24 months recombinant human growth hormone (rh-GH) on LDL cholesterol, triglyceride-rich lipoproteins and apo [a] in hypopituitary adults previously treated with conventional replacement therapy. , 1999, Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society.

[48]  B. Bengtsson,et al.  GH replacement in 1034 growth hormone deficient hypopituitary adults: demographic and clinical characteristics, dosing and safety , 1999, Clinical endocrinology.

[49]  W. Drake,et al.  Optimizing growth hormone replacement therapy by dose titration in hypopituitary adults. , 1998, The Journal of clinical endocrinology and metabolism.

[50]  F. Casanueva,et al.  Preserved growth hormone (GH) secretion in aged and very old subjects after testing with the combined stimulus GH-releasing hormone plus GH-releasing hexapeptide-6. , 1998, The Journal of clinical endocrinology and metabolism.

[51]  P. Douglas,et al.  Insulin-like growth factor-1 but not growth hormone augments mammalian myocardial contractility by sensitizing the myofilament to Ca2+ through a wortmannin-sensitive pathway: studies in rat and ferret isolated muscles. , 1998, Circulation research.

[52]  P. O'neill,et al.  The diagnosis of severe growth hormone deficiency in elderly patients with hypothalamic–pituitary disease , 1998, Clinical endocrinology.

[53]  E. Arvat,et al.  Diagnosis of GH deficiency in adults. , 1998, Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society.

[54]  E. Ghigo,et al.  Consensus guidelines for the diagnosis and treatment of adults with growth hormone deficiency: summary statement of the Growth Hormone Research Society Workshop on Adult Growth Hormone Deficiency. , 1998, The Journal of clinical endocrinology and metabolism.

[55]  M. Hüfner,et al.  The effect of recombinant human GH replacement therapy on lipoprotein(a) and other lipid parameters in adults with acquired GH deficiency: results of a double-blind and placebo-controlled trial. , 1997, European journal of endocrinology.

[56]  H. C. Hoeck,et al.  Reproducibility of Growth Hormone and Cortisol Responses to the Insulin Tolerance Test and the Short ACTH Test in Normal Adults , 1997, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

[57]  L. Hagmar,et al.  Increased cerebrovascular mortality in patients with hypopituitarism , 1997, Clinical endocrinology.

[58]  A. Sovijärvi,et al.  Effect of physical training on exercise capacity and gas exchange in patients with chronic heart failure. , 1996, Chest.

[59]  S. Shalet,et al.  Body composition in growth hormone deficient adults over the age of 60 years , 1996, Clinical endocrinology.

[60]  M. Salvatore,et al.  Improved left ventricular function after growth hormone replacement in patients with hypopituitarism: Assessment with radionuclide angiography , 1996, European Journal of Nuclear Medicine.

[61]  R. Clayton,et al.  The effect of hypopituitarism on life expectancy. , 1996, The Journal of clinical endocrinology and metabolism.

[62]  S. Shalet,et al.  Beyond the somatopause: growth hormone deficiency in adults over the age of 60 years. , 1996, The Journal of clinical endocrinology and metabolism.

[63]  B. Bengtsson,et al.  Growth hormone-deficient adults are insulin-resistant. , 1995, Metabolism: clinical and experimental.

[64]  I. Robinson,et al.  Central effects of growth hormone-releasing hexapeptide (GHRP-6) on growth hormone release are inhibited by central somatostatin action. , 1995, The Journal of endocrinology.

[65]  V. Klauss,et al.  Effect of growth hormone (hGH) replacement therapy on physical work capacity and cardiac and pulmonary function in patients with hGH deficiency acquired in adulthood. , 1995, The Journal of clinical endocrinology and metabolism.

[66]  A. O’Sullivan,et al.  Diagnosis of growth-hormone deficiency in adults , 1994, The Lancet.

[67]  B. Bengtsson,et al.  High fibrinogen and plasminogen activator inhibitor activity in growth hormone-deficient adults. , 1994, Arteriosclerosis and thrombosis : a journal of vascular biology.

[68]  H. de Boer,et al.  Serum lipid levels in growth hormone-deficient men. , 1994, Metabolism: clinical and experimental.

[69]  R. Heaney,et al.  Timing of peak bone mass in Caucasian females and its implication for the prevention of osteoporosis. Inference from a cross-sectional model. , 1994, The Journal of clinical investigation.

[70]  G. Watts,et al.  Growth hormone treatment improves serum lipids and lipoproteins in adults with growth hormone deficiency. , 1993, Metabolism: clinical and experimental.

[71]  C. Carella,et al.  Body composition, bone metabolism, and heart structure and function in growth hormone (GH)-deficient adults before and after GH replacement therapy at low doses. , 1993, The Journal of clinical endocrinology and metabolism.

[72]  L. Wilhelmsen,et al.  Cardiovascular risk factors in adult patients with growth hormone deficiency. , 1993, Acta endocrinologica.

[73]  P. Sönksen,et al.  The growth hormone deficiency syndrome in adults , 1992, Clinical endocrinology.

[74]  H. de Boer,et al.  Body composition in adult growth hormone-deficient men, assessed by anthropometry and bioimpedance analysis. , 1992, The Journal of clinical endocrinology and metabolism.

[75]  C. Boreham,et al.  Growth hormone treatment of adults withgrowth hormone deficiency: results of a 13‐month placebo controlled cross‐over study , 1992, Clinical endocrinology.

[76]  R. Rizzoli,et al.  Critical years and stages of puberty for spinal and femoral bone mass accumulation during adolescence. , 1991, The Journal of clinical endocrinology and metabolism.

[77]  C. Wiles,et al.  Growth hormone treatment in growth hormone-deficient adults. II. Effects on exercise performance. , 1991, Journal of applied physiology.

[78]  B. Bengtsson,et al.  Premature mortality due to cardiovascular disease in hypopituitarism , 1990, The Lancet.

[79]  E. Ghigo,et al.  ARGININE POTENTIATES THE GHRH‐ BUT NOT THE PYRIDOSTIGMINE‐INDUCED GH SECRETION IN NORMAL SHORT CHILDREN. FURTHER EVIDENCE FOR A SOMATOSTATIN SUPPRESSING EFFECT OF ARGININE , 1990, Clinical endocrinology.

[80]  P. Sönksen,et al.  The effects of treatment with recombinant human growth hormone on body composition and metabolism in adults with growth hormone deficiency. , 1989, The New England journal of medicine.

[81]  N. Skakkebaek,et al.  BENEFICIAL EFFECTS OF GROWTH HORMONE TREATMENT IN GH-DEFICIENT ADULTS , 1989, The Lancet.

[82]  R. McCARTER,et al.  The influence of age on the 24-hour integrated concentration of growth hormone in normal individuals. , 1985, The Journal of clinical endocrinology and metabolism.

[83]  E. Ghigo,et al.  Is GH therapy useful to preserve bone mass in transition-phase patients with GH deficiency? , 2005, Journal of endocrinological investigation.

[84]  A. Toogood.  The Somatopause , 2004, Treatments in endocrinology.

[85]  J. Cunningham,et al.  The effect of low dose recombinant human growth hormone replacement on regional fat distribution, insulin sensitivity, and cardiovascular risk factors in hypopituitary adults. , 1995, The Journal of clinical endocrinology and metabolism.

[86]  S. Atkinson,et al.  The contributions of growth and puberty to peak bone mass. , 1991, Growth, development, and aging : GDA.