Bridging the gap: a family of novel DNA polymerases that replicate faulty DNA.

DNA replication can be likened to a car travelling down a long highway. Normally the road is paved smooth, but, as often occurs during travel, the road sometimes contains bumps and roadblocks. Such is the case for the replication machinery as it travels down DNA. While DNA damaged by natural and manmade agents normally is repaired by a multitude of repair pathways, some lesions inevitably escape repair and, as a result, are encountered by the DNA replication machinery. Many of the lesions cannot be bypassed by the replicative DNA polymerases and will lead to cell death if not overcome. Just how cells handle these road blocks has been a longstanding problem.

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