Heme Alkylation by Artesunic Acid and Trioxaquine DU1301, Two Antimalarial Trioxanes

The sesquiterpene Artemisinin, an antimalarial drug that is effective against multidrug‐resistant Plasmodium falciparum strains, contains a 1,2,4‐trioxane, and the endoperoxide function plays a key role in its biological activity. However, its poor solubility means that hemisynthetic derivatives, such as artesunic acid, are preferred for drugs.

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