Role of clusterin gene 3'-UTR polymorphisms and promoter hypomethylation in the pathogenesis of pseudoexfoliation syndrome and pseudoexfoliation glaucoma.

[1]  R. Mills,et al.  RNA Sequencing of Lens Capsular Epithelium Implicates Novel Pathways in Pseudoexfoliation Syndrome , 2022, Investigative ophthalmology & visual science.

[2]  M. Feehan,et al.  A global genetic epidemiological review of pseudoexfoliation syndrome , 2021, Exploration of Medicine.

[3]  L. Vijaya,et al.  Increased Desmosine in the lens capsules is associated with augmented elastin turnover in Pseudoexfoliation syndrome. , 2021, Experimental eye research.

[4]  L. Germain,et al.  Contribution of the Transcription Factors Sp1/Sp3 and AP-1 to Clusterin Gene Expression during Corneal Wound Healing of Tissue-Engineered Human Corneas , 2021, International Journal of Molecular Sciences.

[5]  C. O'brien,et al.  Differential Lysyl oxidase like 1 expression in pseudoexfoliation glaucoma is orchestrated via DNA methylation. , 2020, Experimental eye research.

[6]  Pranjya Paramita Mohanty,et al.  Epigenetic silencing of heat shock protein 70 through DNA hypermethylation in pseudoexfoliation syndrome and glaucoma , 2020, Journal of Human Genetics.

[7]  C. O'brien,et al.  Lysyl Oxidase Like 1: Biological roles and regulation. , 2020, Experimental eye research.

[8]  Birsen Can Demirdöğen,et al.  Evaluation of Tear Fluid and Aqueous Humor Concentration of Clusterin as Biomarkers for Early Diagnosis of Pseudoexfoliation Syndrome and Pseudoexfoliative Glaucoma , 2019, Current eye research.

[9]  Pranjya Paramita Mohanty,et al.  De novo variants in an extracellular matrix protein coding gene, fibulin-5 (FBLN5) are associated with pseudoexfoliation , 2019, European Journal of Human Genetics.

[10]  Pranjya Paramita Mohanty,et al.  Altered unfolded protein response and proteasome impairment in pseudoexfoliation pathogenesis , 2019, Experimental eye research.

[11]  E. Hennig,et al.  GWAS links variants in neuronal development and actin remodeling related loci with pseudoexfoliation syndrome without glaucoma , 2017, Experimental eye research.

[12]  Biswajit Padhy,et al.  Pseudoexfoliation and Alzheimer’s associated CLU risk variant, rs2279590, lies within an enhancer element and regulates CLU, EPHX2 and PTK2B gene expression , 2017, Human molecular genetics.

[13]  Sarah C. Nelson,et al.  Genetic association study of exfoliation syndrome identifies a protective rare variant at LOXL1 and five new susceptibility loci , 2017, Nature Genetics.

[14]  C. Gieger,et al.  Pseudoexfoliation syndrome-associated genetic variants affect transcription factor binding and alternative splicing of LOXL1 , 2017, Nature Communications.

[15]  S. Love,et al.  Clusterin levels are increased in Alzheimer's disease and influence the regional distribution of Aβ , 2017, Brain pathology.

[16]  Keith A. Johnson,et al.  Effect of CR1 Genetic Variants on Cerebrospinal Fluid and Neuroimaging Biomarkers in Healthy, Mild Cognitive Impairment and Alzheimer's Disease Cohorts , 2016, Molecular Neurobiology.

[17]  T. Luider,et al.  Elevated Expression of the Cerebrospinal Fluid Disease Markers Chromogranin A and Clusterin in Astrocytes of Multiple Sclerosis White Matter Lesions , 2016, Journal of neuropathology and experimental neurology.

[18]  A. Plateroti,et al.  Pseudoexfoliation Syndrome and Pseudoexfoliation Glaucoma: A Review of the Literature with Updates on Surgical Management , 2015, Journal of ophthalmology.

[19]  J. Hejtmancik,et al.  Evaluation of Genetic Polymorphisms in Clusterin and Tumor Necrosis Factor-Alpha Genes in South Indian Individuals with Pseudoexfoliation Syndrome , 2015, Current eye research.

[20]  M. Nöthen,et al.  A common variant mapping to CACNA1A is associated with susceptibility to exfoliation syndrome , 2015, Nature Genetics.

[21]  Debananda Padhi,et al.  Role of an extracellular chaperone, Clusterin in the pathogenesis of Pseudoexfoliation Syndrome and Pseudoexfoliation Glaucoma. , 2014, Experimental eye research.

[22]  A. D. den Hollander,et al.  Association of a Polymorphism in the BIRC6 Gene with Pseudoexfoliative Glaucoma , 2014, PloS one.

[23]  M. Kageyama,et al.  Novel common variants and susceptible haplotype for exfoliation glaucoma specific to Asian population , 2014, Scientific Reports.

[24]  R. Ritch,et al.  Clusterin and complement activation in exfoliation glaucoma. , 2014, Investigative ophthalmology & visual science.

[25]  L. Tan,et al.  Genetic variation in Clusterin gene and Alzheimer's disease risk in Han Chinese , 2013, Neurobiology of Aging.

[26]  Yen-Ching Chen,et al.  Genetic polymorphisms of clusterin gene are associated with a decreased risk of Alzheimer’s disease , 2012, European Journal of Epidemiology.

[27]  S. Bassett,et al.  Alzheimer's risk variants in the clusterin gene are associated with alternative splicing , 2011, Translational Psychiatry.

[28]  Christian Y Mardin,et al.  Genome-wide association study with DNA pooling identifies variants at CNTNAP2 associated with pseudoexfoliation syndrome , 2011, European Journal of Human Genetics.

[29]  N. Voelcker,et al.  Detecting protein aggregates on untreated human tissue samples by atomic force microscopy recognition imaging. , 2010, Biophysical journal.

[30]  U. Schlötzer-Schrehardt,et al.  Exploring functional candidate genes for genetic association in german patients with pseudoexfoliation syndrome and pseudoexfoliation glaucoma. , 2009, Investigative ophthalmology & visual science.

[31]  Jack A. Taylor,et al.  SNPinfo: integrating GWAS and candidate gene information into functional SNP selection for genetic association studies , 2009, Nucleic Acids Res..

[32]  T. Tammela,et al.  Clusterin is epigenetically regulated in prostate cancer , 2008, International journal of cancer.

[33]  P. Mitchell,et al.  Genetic analysis of the clusterin gene in pseudoexfoliation syndrome , 2008, Molecular vision.

[34]  U. Schlötzer-Schrehardt,et al.  Association of LOXL1 common sequence variants in German and Italian patients with pseudoexfoliation syndrome and pseudoexfoliation glaucoma. , 2008, Investigative ophthalmology & visual science.

[35]  M. Hauser,et al.  Analysis of LOXL1 polymorphisms in a United States population with pseudoexfoliation glaucoma , 2008, Molecular vision.

[36]  G. Naumann,et al.  Impaired cytoprotective mechanisms in eyes with pseudoexfoliation syndrome/glaucoma. , 2007, Investigative ophthalmology & visual science.

[37]  Kari Stefansson,et al.  Common Sequence Variants in the LOXL1 Gene Confer Susceptibility to Exfoliation Glaucoma , 2007, Science.

[38]  T. Suuronen,et al.  Epigenetic regulation of clusterin/apolipoprotein J expression in retinal pigment epithelial cells. , 2007, Biochemical and biophysical research communications.

[39]  Stefani N. Thomas,et al.  Proteomic analysis of exfoliation deposits. , 2007, Investigative ophthalmology & visual science.

[40]  G. Naumann,et al.  Ocular and systemic pseudoexfoliation syndrome. , 2006, American journal of ophthalmology.

[41]  G. Naumann,et al.  Clusterin deficiency in eyes with pseudoexfoliation syndrome may be implicated in the aggregation and deposition of pseudoexfoliative material. , 2006, Investigative ophthalmology & visual science.

[42]  P. Howe,et al.  Regulation of Clusterin Gene Expression by Transforming Growth Factor β* , 1997, The Journal of Biological Chemistry.

[43]  Tapati Basak,et al.  An Introduction to Basic Statistical Models in Genetics , 2021, Open Journal of Statistics.

[44]  W. Deng,et al.  Validating GWAS-Identified Risk Loci for Alzheimer’s Disease in Han Chinese Populations , 2014, Molecular Neurobiology.