Regulation of Cadherin Adhesive Activity

Adhesive interactions between cells are dynamic and regulated during tissue development and homeostasis. Cadherins are major cell–cell adhesion molecules involved in the development and maintenance of all solid tissues ([Takeichi 1991][1]; [Gumbiner 1996][2]). Therefore, regulation of cadherin-

[1]  F. Breviario,et al.  Catenin-dependent and -independent Functions of Vascular Endothelial Cadherin (*) , 1995, The Journal of Biological Chemistry.

[2]  E. Knust,et al.  The Drosophila genes crumbs and stardust are involved in the biogenesis of adherens junctions. , 1996, Development.

[3]  K. Green,et al.  Posttranslational regulation of plakoglobin expression. Influence of the desmosomal cadherins on plakoglobin metabolic stability. , 1994, The Journal of biological chemistry.

[4]  R. Kemler /-Catenin Mediates the Interaction of the Cadherin-Catenin Complex with Epidermal Growth Factor Receptor , 2002 .

[5]  R. Kemler,et al.  The Membrane-proximal Region of the E-Cadherin Cytoplasmic Domain Prevents Dimerization and Negatively Regulates Adhesion Activity , 1998, The Journal of cell biology.

[6]  R. Kemler From cadherins to catenins: cytoplasmic protein interactions and regulation of cell adhesion. , 1993, Trends in genetics : TIG.

[7]  A. Nomoto,et al.  Nectin/PRR: An Immunoglobulin-like Cell Adhesion Molecule Recruited to Cadherin-based Adherens Junctions through Interaction with Afadin, a PDZ Domain–containing Protein , 1999, The Journal of cell biology.

[8]  N. Nomura,et al.  Role of IQGAP1, a target of the small GTPases Cdc42 and Rac1, in regulation of E-cadherin- mediated cell-cell adhesion. , 1998, Science.

[9]  Xiaoping Du,et al.  Inside-out integrin signalling , 1992, Current Biology.

[10]  P. Bryant,et al.  Dlg protein is required for junction structure, cell polarity, and proliferation control in Drosophila epithelia , 1996, The Journal of cell biology.

[11]  L. Orci,et al.  Induction of epithelial tubular morphogenesis in vitro by fibroblast-derived soluble factors , 1991, Cell.

[12]  M. Takeichi,et al.  Cadherin cell adhesion receptors as a morphogenetic regulator. , 1991, Science.

[13]  Carien M. Niessen,et al.  The Juxtamembrane Region of the Cadherin Cytoplasmic Tail Supports Lateral Clustering, Adhesive Strengthening, and Interaction with p120ctn , 1998, The Journal of cell biology.

[14]  J Vandekerckhove,et al.  Scatter factor: molecular characteristics and effect on the invasiveness of epithelial cells , 1990, The Journal of cell biology.

[15]  A. Hall,et al.  The Small GTPases Rho and Rac Are Required for the Establishment of Cadherin-dependent Cell–Cell Contacts , 1997, The Journal of cell biology.

[16]  B. Gumbiner,et al.  Lateral dimerization is required for the homophilic binding activity of C-cadherin , 1996, The Journal of cell biology.

[17]  M. Ozawa,et al.  p120ctn Binds to the Membrane-proximal Region of the E-cadherin Cytoplasmic Domain and Is Involved in Modulation of Adhesion Activity* , 1999, The Journal of Biological Chemistry.

[18]  M. Itoh,et al.  Functional domains of alpha-catenin required for the strong state of cadherin-based cell adhesion. , 1999 .

[19]  K. Miyazawa,et al.  Tyrosine Phosphorylation of β-Catenin and Plakoglobin Enhanced by Hepatocyte Growth Factor and Epidermal Growth Factor in Human Carcinoma Cells , 1994 .

[20]  S. Kuroda,et al.  Cdc42 and Rac1 Regulate the Interaction of IQGAP1 with β-Catenin* , 1999, The Journal of Biological Chemistry.

[21]  W. Birchmeier,et al.  V-src kinase shifts the cadherin-based cell adhesion from the strong to the weak state and beta catenin is not required for the shift , 1995, The Journal of cell biology.

[22]  M. Takeichi,et al.  Cadherin-mediated cell-cell adhesion is perturbed by v-src tyrosine phosphorylation in metastatic fibroblasts , 1992, The Journal of cell biology.

[23]  A. Brown,et al.  Expression of Wnt-1 in PC12 cells results in modulation of plakoglobin and E-cadherin and increased cellular adhesion , 1993, The Journal of cell biology.

[24]  J. Gerhart,et al.  Region-specific cell activities in amphibian gastrulation. , 1986, Annual review of cell biology.

[25]  J. Daniel,et al.  Identification of a new catenin: the tyrosine kinase substrate p120cas associates with E-cadherin complexes , 1994, Molecular and cellular biology.

[26]  T. Uemura,et al.  α-Catenin-Vinculin Interaction Functions to Organize the Apical Junctional Complex in Epithelial Cells , 1998, The Journal of cell biology.

[27]  B. Gumbiner,et al.  beta-Catenin has Wnt-like activity and mimics the Nieuwkoop signaling center in Xenopus dorsal-ventral patterning. , 1995, Developmental biology.

[28]  S. J. Smith,et al.  Quantitative analysis of cadherin-catenin-actin reorganization during development of cell-cell adhesion , 1996, The Journal of cell biology.

[29]  D. Rimm,et al.  Receptor protein tyrosine phosphatase PTPmu associates with cadherins and catenins in vivo , 1995, The Journal of cell biology.

[30]  D. Vestweber,et al.  Expression and distribution of cell adhesion molecule uvomorulin in mouse preimplantation embryos. , 1987, Developmental biology.

[31]  T. Fleming,et al.  From egg to epithelium. , 1988, Annual review of cell biology.

[32]  Frans,et al.  Loss of epithelial differentiation and gain of invasiveness correlates with tyrosine phosphorylation of the E-cadherin/beta-catenin complex in cells transformed with a temperature-sensitive v-SRC gene , 1993, The Journal of cell biology.

[33]  J. Papkoff,et al.  Wnt-1 modulates cell-cell adhesion in mammalian cells by stabilizing beta-catenin binding to the cell adhesion protein cadherin , 1994, The Journal of cell biology.

[34]  Philippe Soriano,et al.  Shroom, a PDZ Domain–Containing Actin-Binding Protein, Is Required for Neural Tube Morphogenesis in Mice , 1999, Cell.

[35]  Wayne A. Hendrickson,et al.  Structure-Function Analysis of Cell Adhesion by Neural (N-) Cadherin , 1998, Neuron.

[36]  R. Kemler,et al.  Altered Cell Adhesion Activity by Pervanadate Due to the Dissociation of α-Catenin from the E-Cadherin·Catenin Complex* , 1998, The Journal of Biological Chemistry.

[37]  Akinao Nose,et al.  Expressed recombinant cadherins mediate cell sorting in model systems , 1988, Cell.

[38]  D L Rimm,et al.  Alpha 1(E)-catenin is an actin-binding and -bundling protein mediating the attachment of F-actin to the membrane adhesion complex. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[39]  John G. Collard,et al.  Inhibition of invasion of epithelial cells by Tiam1-Rac signaling. , 1997, Science.

[40]  J. Stow,et al.  Recycling of E-cadherin: a potential mechanism for regulating cadherin dynamics. , 1999 .

[41]  A. Hall,et al.  Rho GTPases and the actin cytoskeleton. , 1998, Science.

[42]  J. Daniel,et al.  Tyrosine phosphorylation and cadherin/catenin function , 1997, BioEssays : news and reviews in molecular, cellular and developmental biology.

[43]  K. Kosik,et al.  δ-catenin, an Adhesive Junction–associated Protein Which Promotes Cell Scattering , 1999, The Journal of cell biology.

[44]  B. Gumbiner,et al.  Cell Adhesion: The Molecular Basis of Tissue Architecture and Morphogenesis , 1996, Cell.

[45]  D. Walker Functional Domains , 1996 .

[46]  E. Knust,et al.  Bazooka provides an apical cue for Inscuteable localization in Drosophila neuroblasts , 1999, Nature.

[47]  M. Takeichi,et al.  Experimental specification of cell sorting, tissue spreading, and specific spatial patterning by quantitative differences in cadherin expression. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[48]  B. Gumbiner,et al.  Analysis of C-cadherin Regulation during Tissue Morphogenesis with an Activating Antibody , 1999, The Journal of cell biology.

[49]  S. Kuroda,et al.  Regulation of cadherin-mediated cell-cell adhesion by the Rho family GTPases. , 1999, Current opinion in cell biology.

[50]  Albert B. Reynolds,et al.  Selective Uncoupling of P120ctn from E-Cadherin Disrupts Strong Adhesion , 2000, The Journal of cell biology.

[51]  P. McCrea,et al.  Purification of a 92-kDa cytoplasmic protein tightly associated with the cell-cell adhesion molecule E-cadherin (uvomorulin). Characterization and extractability of the protein complex from the cell cytostructure. , 1991, The Journal of biological chemistry.

[52]  H. Kotani,et al.  Regulation of Cell–Cell Adhesion by Rac and Rho Small G Proteins in MDCK Cells , 1997, The Journal of cell biology.

[53]  M. Takeichi,et al.  The 102 kd cadherin-associated protein: Similarity to vinculin and posttranscriptional regulation of expression , 1991, Cell.

[54]  E. Wieschaus,et al.  armadillo, bazooka, and stardust are critical for early stages in formation of the zonula adherens and maintenance of the polarized blastoderm epithelium in Drosophila , 1996, The Journal of cell biology.

[55]  W. Nelson,et al.  Biosynthesis of the cell adhesion molecule uvomorulin (E-cadherin) in Madin-Darby canine kidney epithelial cells. , 1991, The Journal of biological chemistry.

[56]  M. Takeichi,et al.  p120ctn Acts as an Inhibitory Regulator of Cadherin Function in Colon Carcinoma Cells , 1999, The Journal of cell biology.

[57]  M. Itoh,et al.  Functional Domains of α-Catenin Required for the Strong State of Cadherin-based Cell Adhesion , 1999, The Journal of cell biology.

[58]  H. Aberle,et al.  Beta-catenin mediates the interaction of the cadherin-catenin complex with epidermal growth factor receptor , 1994, The Journal of cell biology.

[59]  B. Gumbiner,et al.  Regulation of C-cadherin function during activin induced morphogenesis of Xenopus animal caps , 1994, The Journal of cell biology.

[60]  P. Auvinen,et al.  CDC42 and Rac1 control different actin-dependent processes in the Drosophila wing disc epithelium , 1995, The Journal of cell biology.

[61]  A. P. Soler,et al.  Interaction of alpha-actinin with the cadherin/catenin cell-cell adhesion complex via alpha-catenin , 1995, The Journal of cell biology.