Metal Nanoparticles for Electrochemical Sensing: Progress and Challenges in the Clinical Transition of Point-of-Care Testing

With the rise in public health awareness, research on point-of-care testing (POCT) has significantly advanced. Electrochemical biosensors (ECBs) are one of the most promising candidates for the future of POCT due to their quick and accurate response, ease of operation, and cost effectiveness. This review focuses on the use of metal nanoparticles (MNPs) for fabricating ECBs that has a potential to be used for POCT. The field has expanded remarkably from its initial enzymatic and immunosensor-based setups. This review provides a concise categorization of the ECBs to allow for a better understanding of the development process. The influence of structural aspects of MNPs in biocompatibility and effective sensor design has been explored. The advances in MNP-based ECBs for the detection of some of the most prominent cancer biomarkers (carcinoembryonic antigen (CEA), cancer antigen 125 (CA125), Herceptin-2 (HER2), etc.) and small biomolecules (glucose, dopamine, hydrogen peroxide, etc.) have been discussed in detail. Additionally, the novel coronavirus (2019-nCoV) ECBs have been briefly discussed. Beyond that, the limitations and challenges that ECBs face in clinical applications are examined and possible pathways for overcoming these limitations are discussed.

[1]  C. Liu,et al.  Exploring the Trans-Cleavage Activity of CRISPR Cas12a (cpf1) for the Development of a Universal Electrochemical Biosensor. , 2019, Angewandte Chemie.

[2]  V. Petrenko,et al.  Specific phages-based electrochemical impedimetric immunosensors for label-free and ultrasensitive detection of dual prostate-specific antigens , 2019, Sensors and Actuators B: Chemical.

[3]  M. Shamsipur,et al.  A sandwich-type electrochemical immunosensor based on in situ silver deposition for determination of serum level of HER2 in breast cancer patients. , 2018, Biosensors & bioelectronics.

[4]  M. Hasanzadeh,et al.  Ultrasensitive immunoassay of glycoprotein 125 (CA 125) in untreated human plasma samples using poly (CTAB‑chitosan) doped with silver nanoparticles. , 2018, International journal of biological macromolecules.

[5]  Wenzhao Jia,et al.  Biocompatible Enzymatic Roller Pens for Direct Writing of Biocatalytic Materials: “Do‐it‐Yourself” Electrochemical Biosensors , 2015, Advanced healthcare materials.

[6]  Zhitao Zhang,et al.  Superaligned Carbon Nanotubes Guide Oriented Cell Growth and Promote Electrophysiological Homogeneity for Synthetic Cardiac Tissues , 2017, Advanced materials.

[7]  Hui-fang Huang,et al.  Electrochemical Biosensor for DNA Methylation Detection through Hybridization Chain-Amplified Reaction Coupled with a Tetrahedral DNA Nanostructure. , 2019, ACS applied materials & interfaces.

[8]  Yanli Hu,et al.  Microstructure evolution of sandwich graphite oxide/interlayer-embedded Au nanoparticles induced from γ-rays for carcinoembryonic antigen biosensor , 2019, Nanotechnology.

[9]  Xiaobo Zhang,et al.  The label-free immunosensor based on rhodium@palladium nanodendrites/sulfo group functionalized multi-walled carbon nanotubes for the sensitive analysis of carcino embryonic antigen. , 2017, Analytica chimica acta.

[10]  Klaus Kern,et al.  Electronic properties and atomic structure of graphene oxide membranes , 2011 .

[11]  M. Karim,et al.  Hollow Reticular Shaped Highly Ordered Rice Husk Carbon for the Simultaneous Determination of Dopamine and Uric Acid , 2020 .

[12]  C. Brocker,et al.  Evolutionary divergence and functions of the human acyl-CoA thioesterase gene (ACOT) family , 2010, Human Genomics.

[13]  A. Mokhtarzadeh,et al.  Ultrasensitive immunoassay of carcinoma antigen 125 in untreated human plasma samples using gold nanoparticles with flower like morphology: A new platform in early stage diagnosis of ovarian cancer and efficient management. , 2018, International journal of biological macromolecules.

[14]  Xingpeng Guo,et al.  Porous graphene based electrochemical immunosensor using Cu3(BTC)2 metal-organic framework as nonenzymatic label. , 2020, Talanta.

[15]  Zhanfang Ma,et al.  Multiple functional strategies for amplifying sensitivity of amperometric immunoassay for tumor markers: A review. , 2017, Biosensors & bioelectronics.

[16]  Busshitsu Zairyō Kenkyū Kikō.  Science and technology of advanced materials , 2000 .

[17]  R. Forster,et al.  Properties of Anti-CA125 antibody layers on screen-printed carbon electrodes modified by gold and platinum nanostructures , 2019, Electrochimica Acta.

[18]  R. Dahiya,et al.  Textile-Based Potentiometric Electrochemical pH Sensor for Wearable Applications , 2019, Biosensors.

[19]  Xuefang Gu,et al.  Electrochemical detection of carcinoembryonic antigen. , 2018, Biosensors & bioelectronics.

[20]  H. J. N. P. D. Mello,et al.  Enzymatically functionalized polyaniline thin films produced with one-step electrochemical immobilization and its application in glucose and urea potentiometric biosensors , 2020, Biomedical Microdevices.

[21]  Qiang Zhang,et al.  A sensitive Salmonella biosensor using platinum nanoparticle loaded manganese dioxide nanoflowers and thin-film pressure detector , 2020 .

[22]  Ki-Hyun Kim,et al.  Recent advances in nanomaterial-based electrochemical detection of antibiotics: Challenges and future perspectives. , 2020, Biosensors & bioelectronics.

[23]  Xiaobo Zhang,et al.  Sandwich-type electrochemical immunosensor based on Au@Pt DNRs/NH2-MoSe2 NSs nanocomposite as signal amplifiers for the sensitive detection of alpha-fetoprotein. , 2019, Bioelectrochemistry.

[24]  S. K. Vashist,et al.  Achievement and assessment of direct electron transfer of glucose oxidase in electrochemical biosensing using carbon nanotubes, graphene, and their nanocomposites , 2017, Microchimica Acta.

[25]  Ping Wang,et al.  An ultrasensitive sandwich-type electrochemical immunosensor based on the signal amplification strategy of echinoidea-shaped Au@Ag-Cu2O nanoparticles for prostate specific antigen detection. , 2018, Biosensors & bioelectronics.

[26]  Khalid Mujasam Batoo,et al.  Fabrication and characterizations of Al nanoparticles doped ZnO nanostructures-based integrated electrochemical biosensor , 2020 .

[27]  M. Hasanzadeh,et al.  A novel biosensor for the monitoring of ovarian cancer tumor protein CA 125 in untreated human plasma samples using a novel nano-ink: a new platform for efficient diagnosis of cancer using paper based microfluidic technology , 2020 .

[28]  A. Gopalan,et al.  Highly sensitive voltammetric immunosensor for the detection of prostate specific antigen based on silver nanoprobe assisted graphene oxide modified screen printed carbon electrode. , 2020, Talanta.

[29]  B. Piro,et al.  Silver nanoparticles on graphene quantum dots as nanozyme for efficient H2O2 reduction in a glucose biosensor , 2019, Materials Research Express.

[30]  Anil Gattani,et al.  Recent progress in electrochemical biosensors as point of care diagnostics in livestock health. , 2019, Analytical biochemistry.

[31]  Zuanguang Chen,et al.  Electrochemical biosensor based on gold nanoflowers-encapsulated magnetic metal-organic framework nanozymes for drug evaluation with in-situ monitoring of H2O2 released from H9C2 cardiac cells , 2020 .

[32]  B. Jebasingh,et al.  A comprehensive review on latent heat and thermal conductivity of nanoparticle dispersed phase change material for low-temperature applications , 2020 .

[33]  Xiaomei Pei,et al.  Sandwich-type immunosensors and immunoassays exploiting nanostructure labels: A review. , 2013, Analytica chimica acta.

[34]  Mostafa A. El-Sayed,et al.  The optical, photothermal, and facile surface chemical properties of gold and silver nanoparticles in biodiagnostics, therapy, and drug delivery , 2014, Archives of Toxicology.

[35]  J. M. Madurro,et al.  Label-free electrochemical immunosensor for detection of oncomarker CA125 in serum , 2020, Microchemical Journal.

[36]  M. Suciu,et al.  Impedimetric aptasensor for the label-free and selective detection of Interleukin-6 for colorectal cancer screening. , 2019, Biosensors & bioelectronics.

[37]  Xing Xuan,et al.  A chemically modified laser-induced porous graphene based flexible and ultrasensitive electrochemical biosensor for sweat glucose detection , 2020, Sensors and Actuators B: Chemical.

[38]  Pranjal Chandra,et al.  Uricase grafted nanoconducting matrix based electrochemical biosensor for ultrafast uric acid detection in human serum samples. , 2019, International journal of biological macromolecules.

[39]  S. Campuzano,et al.  Surface plasmon resonance immunosensor for ErbB2 breast cancer biomarker determination in human serum and raw cancer cell lysates. , 2016, Analytica chimica acta.

[40]  Zhihua Wang,et al.  Microfluidic Device Directly Fabricated on Screen-Printed Electrodes for Ultrasensitive Electrochemical Sensing of PSA , 2019, Nanoscale Research Letters.

[41]  Yong Li,et al.  Investigation on electrochemical properties of carbon nanotubes , 2003 .

[42]  B. Bouchikhi,et al.  Development and characterization of an electrochemical biosensor for creatinine detection in human urine based on functional molecularly imprinted polymer , 2017 .

[43]  Minghua Wang,et al.  Gold nanoparticles conjugated to bimetallic manganese(II) and iron(II) Prussian Blue analogues for aptamer-based impedimetric determination of the human epidermal growth factor receptor-2 and living MCF-7 cells , 2019, Microchimica Acta.

[44]  H. Filik,et al.  Nanostructures for nonlabeled and labeled electrochemical immunosensors: Simultaneous electrochemical detection of cancer markers: A review. , 2019, Talanta.

[45]  Y. Xing,et al.  A sensitive and selective electrochemical biosensor for the determination of beta-amyloid oligomer by inhibiting the peptide-triggered in situ assembly of silver nanoparticles , 2017, International journal of nanomedicine.

[46]  Huaqing Xie,et al.  Electrochemical glucose biosensor based on silver nanoparticles/multiwalled carbon nanotubes modified electrode , 2012, Journal of Solid State Electrochemistry.

[47]  A. M. Peres,et al.  Voltammetric aptasensors for protein disease biomarkers detection: A review. , 2016, Biotechnology advances.

[48]  Juan C. Cruz,et al.  Enzyme-Based Electrochemical Biosensors for Microfluidic Platforms to Detect Pharmaceutical Residues in Wastewater , 2019, Biosensors.

[49]  Martin M Thuo,et al.  Corrigendum: A microfluidic paper-based electrochemical biosensor array for multiplexed detection of metabolic biomarkers (2013 Sci. Technol. Adv. Mater. 14 054402) , 2015, Science and technology of advanced materials.

[50]  Shivani Uniyal,et al.  Technological advancement in electrochemical biosensor based detection of Organophosphate pesticide chlorpyrifos in the environment: A review of status and prospects. , 2018, Biosensors & bioelectronics.

[51]  Nae-Eung Lee,et al.  Recent progress, challenges, and prospects of fully integrated mobile and wearable point-of-care testing systems for self-testing. , 2020, Chemical Society reviews.

[52]  Frank Hollmann,et al.  Electrochemical Regeneration of Oxidoreductases for Cell-free Biocatalytic Redox Reactions , 2004 .

[53]  Kecheng Zhang.  A Novel Sandwich-Type Electrochemical Immunosensor Based on the Signal Amplification Strategy of Core-shell Pd@Pt Nanoparticles for α-fetoprotein Detection , 2020 .

[54]  X. Qiao,et al.  A sandwich-type electrochemical immunosensor for detecting CEA based on CeO2-MoS2 absorbed Pb2. , 2020, Analytical biochemistry.

[55]  Min Jiang,et al.  An electrochemical immunosensor for CEA detection based on Au-Ag/rGO@PDA nanocomposites as integrated double signal amplification strategy , 2019 .

[56]  Jeong-Woo Choi,et al.  Electrochemical Dopamine Biosensor Composed of Silver Encapsulated MoS2 Hybrid Nanoparticle , 2019, Biotechnology and Bioprocess Engineering.

[57]  Prasad G. Jamkhande,et al.  Metal nanoparticles synthesis: An overview on methods of preparation, advantages and disadvantages, and applications , 2019, Journal of Drug Delivery Science and Technology.

[58]  Munezza Ata Khan,et al.  Recent Advances in Electrochemical and Optical Biosensors Designed for Detection of Interleukin 6 , 2020, Sensors.

[59]  Giovanna Marrazza,et al.  A label-free electrochemical affisensor for cancer marker detection: The case of HER2. , 2015, Bioelectrochemistry.

[60]  Jinqiong Xu,et al.  A novel electrochemical immunosensor for carcinoembryonic antigen based on Cu-MOFs-TB/polydopamine nanocarrier , 2020, Journal of Electroanalytical Chemistry.

[61]  S. M. Taghdisi,et al.  An ultrasensitive electrochemical sensor for 17β-estradiol using split aptamers. , 2019, Analytica chimica acta.

[62]  Edward Song,et al.  Lab-on-a-Chip Systems for Aptamer-Based Biosensing , 2020, Micromachines.

[63]  Igor L. Medintz,et al.  Enhanced electrochemical biosensor and supercapacitor with 3D porous architectured graphene via salt impregnated inkjet maskless lithography , 2019, Nanoscale Horizons.

[64]  Arghya Paul,et al.  Recent Advances in Application of Biosensors in Tissue Engineering , 2014, BioMed research international.

[65]  H. Pang,et al.  Controllable synthesis of copper ion guided MIL-96 octadecahedron: highly sensitive aptasensor toward alpha-fetoprotein , 2020 .

[66]  Shalini Menon,et al.  Recent advances and challenges in electrochemical biosensors for emerging and re-emerging infectious diseases , 2020, Journal of Electroanalytical Chemistry.

[67]  Junjie Liu,et al.  Disease-Related Detection with Electrochemical Biosensors: A Review , 2017, Sensors.

[68]  Dongwook Han,et al.  State of the Art Biocompatible Gold Nanoparticles for Cancer Theragnosis , 2020, Pharmaceutics.

[69]  R. Agarwal,et al.  Biopatterning of Keratinocytes in Aqueous Two-Phase Systems as a Potential Tool for Skin Tissue Engineering , 2017 .

[70]  K. Kalcher,et al.  An ultrasensitive immunosensor based on manganese dioxide-graphene nanoplatelets and core shell Fe3O4@Au nanoparticles for label-free detection of carcinoembryonic antigen. , 2020, Bioelectrochemistry.

[71]  E. Alocilja,et al.  A conductometric biosensor for biosecurity. , 2003, Biosensors & bioelectronics.

[72]  G. Slaughter,et al.  Towards a dual in-line electrochemical biosensor for the determination of glucose and hydrogen peroxide. , 2019, Bioelectrochemistry.

[73]  T. Sakata,et al.  Enhancement of signal-to-noise ratio for serotonin detection with well-designed nanofilter-coated potentiometric electrochemical biosensor. , 2020, ACS applied materials & interfaces.

[74]  O. Chailapakul,et al.  Electrochemical immunosensor based on gold-labeled monoclonal anti-LipL32 for leptospirosis diagnosis. , 2019, Biosensors & bioelectronics.

[75]  Wei Wang,et al.  Comorbidity and its impact on 1590 patients with COVID-19 in China: a nationwide analysis , 2020, European Respiratory Journal.

[76]  J. S. Bondili,et al.  Development of proof of concept for prostate cancer detection: an electrochemical immunosensor based on fullerene-C60 and copper nanoparticles composite film as diagnostic tool , 2020 .

[77]  Dong Min Kim,et al.  Activated jute carbon paste screen-printed FTO electrodes for nonenzymatic amperometric determination of nitrite , 2019, Journal of Electroanalytical Chemistry.

[78]  A. Sundramoorthy,et al.  Electrochemical biosensor for methyl parathion based on single-walled carbon nanotube/glutaraldehyde crosslinked acetylcholinesterase-wrapped bovine serum albumin nanocomposites. , 2019, Analytica chimica acta.

[79]  D. Cui,et al.  Electrochemical Biosensor Based on Dewdrop-Like Platinum Nanoparticles-Decorated Silver Nanoflowers Nanocomposites for H2O2 and Glucose Detection , 2019, Journal of The Electrochemical Society.

[80]  Marcus I. Gibson,et al.  Small Biomolecules for Big Applications , 2018, ACS central science.

[81]  Fredrik Y Frejd,et al.  Affibody molecules: Engineered proteins for therapeutic, diagnostic and biotechnological applications , 2010, FEBS letters.

[82]  Min Liu,et al.  An electrochemical biosensor for the detection of epithelial-mesenchymal transition , 2020, Nature Communications.

[83]  Avraham Rasooly,et al.  Polycytosine DNA Electric-Current-Generated Immunosensor for Electrochemical Detection of Human Epidermal Growth Factor Receptor 2 (HER2). , 2018, Analytical chemistry.

[84]  C. Delerue-Matos,et al.  Quantum dots as nanolabels for breast cancer biomarker HER2-ECD analysis in human serum. , 2020, Talanta.

[85]  L. Angnes,et al.  Electrochemical immunosensors - A powerful tool for analytical applications. , 2018, Biosensors & bioelectronics.

[86]  Dan Wu,et al.  Ultrasensitive immunoassay for CA125 detection using acid site compound as signal and enhancer. , 2015, Talanta.

[87]  E. Heydari-Bafrooei,et al.  Impedimetric aptasensing of the breast cancer biomarker HER2 using a glassy carbon electrode modified with gold nanoparticles in a composite consisting of electrochemically reduced graphene oxide and single-walled carbon nanotubes , 2019, Microchimica Acta.

[88]  J. Park,et al.  Trimetallic Pd@Au@Pt nanocomposites platform on -COOH terminated reduced graphene oxide for highly sensitive CEA and PSA biomarkers detection. , 2018, Biosensors & bioelectronics.

[89]  R. Chauhan,et al.  A novel copper-based 3D porous nanocomposite for electrochemical detection and inactivation of pathogenic bacteria , 2020 .

[90]  Drew A. Hall,et al.  Point-of-Care Smartphone-based Electrochemical Biosensing , 2018, Electroanalysis.

[91]  C. Mathers,et al.  Projections of Global Mortality and Burden of Disease from 2002 to 2030 , 2006, PLoS medicine.

[92]  Xuemin Zhou,et al.  A label-free electrochemical magnetic aptasensor based on exonuclease III–assisted signal amplification for determination of carcinoembryonic antigen , 2020, Microchimica Acta.

[93]  C. Hong,et al.  The Synergistic Effect of Ferrocene and Cu2O to Construct a Sandwich-Type Multi-Signal Amplification Ultra-Sensitive Immunosensor for Carcinoembryonic Antigen Detection , 2020 .

[94]  M. Bergamini,et al.  Label-free electrochemical immunosensor for quick detection of anti-hantavirus antibody , 2019, Journal of Electroanalytical Chemistry.

[95]  Yadong Yin,et al.  Encapsulated Metal Nanoparticles for Catalysis. , 2020, Chemical reviews.

[96]  A. Sundramoorthy,et al.  Humic acid/halloysite nanotube/flavin adenine dinucleotide nanocomposite based selective electrochemical biosensor for hydrogen peroxide , 2019, Applied Surface Science.

[97]  M. El-Sayed,et al.  Why gold nanoparticles are more precious than pretty gold: noble metal surface plasmon resonance and its enhancement of the radiative and nonradiative properties of nanocrystals of different shapes. , 2006, Chemical Society reviews.

[98]  Michael J. Schöning,et al.  Tobacco mosaic virus as enzyme nanocarrier for electrochemical biosensors , 2017 .

[99]  Xingxiang Zhang,et al.  Gamma irradiation and microemulsion assisted synthesis of monodisperse flower-like platinum-gold nanoparticles/reduced graphene oxide nanocomposites for ultrasensitive detection of carcinoembryonic antigen , 2019, Sensors and Actuators B: Chemical.

[100]  A. Salimi,et al.  Ultrasensitive Bioaffinity Electrochemical Sensors: Advances and New Perspectives , 2018, Electroanalysis.

[101]  M. Nair,et al.  Gold nanocubes embedded biocompatible hybrid hydrogels for electrochemical detection of H2O2. , 2020, Bioelectrochemistry.

[102]  Y. Hashimoto,et al.  A Review of Silver Nanoparticles: Synthesis Methods, Properties and Applications , 2015 .

[103]  Parnaz Assari,et al.  An electrochemical immunosensor for the prostate specific antigen based on the use of reduced graphene oxide decorated with gold nanoparticles , 2019, Microchimica Acta.

[104]  A. Pich,et al.  Preparation of Hybrid Microgels Functionalized by Silver Nanoparticles , 2006 .

[105]  Jingkun Xu,et al.  Label-free electrochemical immunosensor for the detection of prostate specific antigen based three-dimensional Au nanoparticles/MoS2-graphene aerogels composite , 2020 .

[106]  Ashutosh Tiwari,et al.  Functionalized Gold Nanoparticles: Synthesis, Properties and Applications--A Review. , 2015, Journal of nanoscience and nanotechnology.

[107]  Linli Hou,et al.  Modification-free amperometric biosensor for the detection of wild-type p53 protein based on the in situ formation of silver nanoparticle networks for signal amplification. , 2020, International journal of biological macromolecules.

[108]  A. Pugazhendhi,et al.  Gold nanoparticles using red seaweed Gracilaria verrucosa: Green synthesis, characterization and biocompatibility studies , 2019, Process Biochemistry.

[109]  Yayuan Liu,et al.  Silver Nanoparticle-Enzyme Composite Films for Hydrogen Peroxide Detection , 2019, ACS Applied Nano Materials.

[110]  S. Alwarappan,et al.  Magnetic bead-amplified voltammetric detection for carbohydrate antigen 125 with enzyme labels using aptamer-antigen-antibody sandwiched assay , 2020, Sensors and Actuators B: Chemical.

[111]  Yuguo Tang,et al.  Peptide cleavage-based electrochemical biosensor coupling graphene oxide and silver nanoparticles. , 2019, Analytica chimica acta.

[112]  L. Trnková,et al.  Nanoparticle-Based Immunochemical Biosensors and Assays: Recent Advances and Challenges. , 2017, Chemical reviews.

[113]  N. Shetti,et al.  Nanostructured titanium oxide hybrids-based electrochemical biosensors for healthcare applications. , 2019, Colloids and surfaces. B, Biointerfaces.

[114]  N. Zhang,et al.  Nanochannels Photoelectrochemical Biosensor. , 2018, Analytical chemistry.

[115]  N. Jaffrezic‐Renault,et al.  Direct detection of phenol using a new bacterial strain-based conductometric biosensor , 2018 .

[116]  Zhanfang Ma,et al.  pH responsive amperometric immunoassay for carcinoma antigen 125 based on hollow polydopamine encapsulating methylene blue , 2019, Sensors and Actuators B: Chemical.

[117]  M I Katsnelson,et al.  Strong suppression of weak localization in graphene. , 2006, Physical review letters.

[118]  Jeong‐Yeol Yoon.  Basic principles of electrochemical biosensing using a smartphone , 2020 .

[119]  Lei Yu,et al.  A ratiometric electrochemical sensor for multiplex detection of cancer biomarkers using bismuth as an internal reference and metal sulfide nanoparticles as signal tags. , 2019, The Analyst.

[120]  D. Di Carlo,et al.  A review of biosensor technologies for blood biomarkers toward monitoring cardiovascular diseases at the point-of-care. , 2020, Biosensors & bioelectronics.

[121]  S. Jaganathan,et al.  An electrodeposited Au nanoparticle/porous graphene nanoribbon composite for electrochemical detection of alpha-fetoprotein , 2020 .

[122]  Yanjing Su,et al.  Size-Dependent Electrochemical Properties of Pure Metallic Nanoparticles , 2020 .

[123]  Huan Xu,et al.  A label-free electrochemical biosensor for microRNAs detection based on DNA nanomaterial by coupling with Y-shaped DNA structure and non-linear hybridization chain reaction. , 2019, Biosensors & bioelectronics.

[124]  D. Vashaee,et al.  A novel electrochemical biosensor based on Fe3O4 nanoparticles-polyvinyl alcohol composite for sensitive detection of glucose. , 2017, Analytical biochemistry.

[125]  S. Baek,et al.  Cu-nanoflower decorated gold nanoparticles-graphene oxide nanofiber as electrochemical biosensor for glucose detection. , 2020, Materials science & engineering. C, Materials for biological applications.

[126]  Md. Kawsar Alam,et al.  Poly (brilliant cresyl blue)-reduced graphene oxide modified activated GCE for nitrite detection: Analyzing the synergistic interactions through experimental and computational study , 2020 .

[127]  S. Srivastava,et al.  Core–shell gold–silver nanoparticles based impedimetric immunosensor for cancer antigen CA125 , 2015 .

[128]  P. Bottoni,et al.  The Role of CA 125 as Tumor Marker: Biochemical and Clinical Aspects. , 2015, Advances in experimental medicine and biology.

[129]  A. El'skaya,et al.  Conductometric enzyme biosensor for patulin determination , 2017 .

[130]  Juan Li,et al.  Platinum nanoparticle-assembled nanoflake-like tin disulfide for enzyme-based amperometric sensing of glucose , 2017, Microchimica Acta.

[131]  Olga S. Ivanova,et al.  Size-dependent electrochemical oxidation of silver nanoparticles. , 2010, Journal of the American Chemical Society.

[132]  M.Z.H. Khan,et al.  Ultrasensitive detection of pathogenic viruses with electrochemical biosensor: State of the art , 2020, Biosensors and Bioelectronics.

[133]  V. Shanmugam,et al.  Anti-inflammatory mechanism of various metal and metal oxide nanoparticles synthesized using plant extracts: A review. , 2019, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[134]  M. Ghahremani,et al.  Gold and silver bio/nano-hybrids-based electrochemical immunosensor for ultrasensitive detection of carcinoembryonic antigen. , 2019, Biosensors & bioelectronics.

[135]  Sang Joon Kim,et al.  Facile fabrication of flexible glutamate biosensor using direct writing of platinum nanoparticle-based nanocomposite ink. , 2019, Biosensors & bioelectronics.

[136]  C. Hong,et al.  First use of inorganic copper silicate-transduced enzyme-free electrochemical immunosensor for carcinoembryonic antigen detection , 2020 .

[137]  Min Zhang,et al.  Electrochemical Aptasensor of Carcinoembryonic Antigen Based on Concanavalin A-Functionalized Magnetic Copper Silicate Carbon Microtubes and Gold-Nanocluster-Assisted Signal Amplification , 2020 .

[138]  Jun Chen,et al.  A novel sandwich aptasensor for detecting T-2 toxin based on rGO-TEPA-Au@Pt nanorods with a dual signal amplification strategy. , 2019, Biosensors & bioelectronics.

[139]  M. L. Yola,et al.  A novel and ultrasensitive sandwich-type electrochemical immunosensor based on delaminated MXene@AuNPs as signal amplification for prostate specific antigen (PSA) detection and immunosensor validation. , 2020, Talanta.

[140]  Vinay Sharma,et al.  Electrochemical Aptasensors for Food and Environmental Safeguarding: A Review , 2018, Biosensors.

[141]  M. Ganjali,et al.  A Sensitive Aptamer-Based Biosensor for Electrochemical Quantification of PSA as a Specific Diagnostic Marker of Prostate Cancer. , 2020, Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques.

[142]  Jianfeng Ping,et al.  Flexible freestanding graphene paper-based potentiometric enzymatic aptasensor for ultrasensitive wireless detection of kanamycin. , 2019, Biosensors & bioelectronics.

[143]  Jiaobing Tu,et al.  The Era of Digital Health: A Review of Portable and Wearable Affinity Biosensors , 2019, Advanced Functional Materials.

[144]  Sheng Xu,et al.  Gold-nanoparticle-decorated boron-doped graphene/BDD electrode for tumor marker sensor , 2020 .

[145]  Degang Li,et al.  Sensitive Detection of Prostate Specific Antigen Based on Copper Ions Doped Ag-Au Nanospheres Labeled Immunosensor , 2019, Journal of The Electrochemical Society.

[146]  M I Katsnelson,et al.  Intrinsic ripples in graphene. , 2007, Nature materials.

[147]  H. Sugimura,et al.  CLCA2 as a Novel Immunohistochemical Marker for Differential Diagnosis of Squamous Cell Carcinoma from Adenocarcinoma of the Lung , 2014, Disease markers.

[148]  C. Delerue-Matos,et al.  Immunomagnetic bead-based bioassay for the voltammetric analysis of the breast cancer biomarker HER2-ECD and tumour cells using quantum dots as detection labels , 2020, Microchimica Acta.

[149]  F. Wudl,et al.  The unusual electrochemical properties of the higher fullerene, chiral C76 , 1992 .

[150]  Hua-Zhong Yu,et al.  A USB-based electrochemical biosensor prototype for point-of-care diagnosis , 2012 .

[151]  G. Stan,et al.  Direct Immobilization of Biomolecules through Magnetic Forces on Ni Electrodes via Ni Nanoparticles: Applications in Electrochemical Biosensors. , 2019, ACS applied materials & interfaces.

[152]  F. He,et al.  Electrochemical biosensor for rapid detection of bacteria based on facile synthesis of silver wire across electrodes. , 2020, Biosensors & bioelectronics.

[153]  David S. Goodsell,et al.  RCSB Protein Data Bank: A Resource for Chemical, Biochemical, and Structural Explorations of Large and Small Biomolecules , 2016 .

[154]  R. Jain,et al.  Next-generation polymer nanocomposite-based electrochemical sensors and biosensors: A review , 2016 .

[155]  M. Shamsipur,et al.  Employing AgNPs doped amidoxime-modified polyacrylonitrile (PAN-oxime) nanofibers for target induced strand displacement-based electrochemical aptasensing of CA125 in ovarian cancer patients. , 2019, Materials science & engineering. C, Materials for biological applications.

[156]  Fritz Scholz,et al.  Voltammetric techniques of analysis: the essentials , 2015, ChemTexts.

[157]  J. Chaput,et al.  Generating Biologically Stable TNA Aptamers that Function with High Affinity and Thermal Stability. , 2020, Journal of the American Chemical Society.

[158]  F. Shimizu,et al.  Improving direct immunoassay response by layer-by-layer films of gold nanoparticles - Antibody conjugate towards label-free detection. , 2019, Materials science & engineering. C, Materials for biological applications.

[159]  A. Ugur,et al.  Antimicrobial characteristics and biocompatibility of the surgical sutures coated with biosynthesized silver nanoparticles. , 2019, Bioorganic chemistry.

[160]  Y. Ying,et al.  Spontaneous growth and regulation of noble metal nanoparticles on flexible biomimetic MXene paper for bioelectronics. , 2020, Biosensors & bioelectronics.

[161]  M. Ehsan,et al.  Fabrication of Nanostructured Pd Thin Films Using Aerosol-Assisted Chemical Vapor Deposition for the Nonenzymatic Electrochemical Detection of H2O2 , 2019, ACS Applied Electronic Materials.

[162]  Dong-Hyung Kim,et al.  Current Technologies of Electrochemical Immunosensors: Perspective on Signal Amplification , 2018, Sensors.

[163]  Jianfang Wang,et al.  Shape- and size-dependent refractive index sensitivity of gold nanoparticles. , 2008, Langmuir : the ACS journal of surfaces and colloids.

[164]  Yu-Dong Shen,et al.  Portable amperometric immunosensor for histamine detection using Prussian blue-chitosan-gold nanoparticle nanocomposite films. , 2017, Biosensors & bioelectronics.

[165]  Y. Omidi,et al.  Electrochemical immunosensor based on chitosan-gold nanoparticle/carbon nanotube as a platform and lactate oxidase as a label for detection of CA125 oncomarker. , 2018, Biosensors & bioelectronics.

[166]  Kang Mao,et al.  Graphene nanocomposites modified electrochemical aptamer sensor for rapid and highly sensitive detection of prostate specific antigen. , 2018, Biosensors & bioelectronics.

[167]  Linshen Xie,et al.  Facile incorporation of DNA-templated quantum dots for sensitive electrochemical detection of the oral cancer biomarker interleukin-8 , 2020, Analytical and Bioanalytical Chemistry.

[168]  Blake N. Johnson,et al.  Electrochemical biosensors for pathogen detection , 2020, Biosensors and Bioelectronics.

[169]  Bo Chen,et al.  Detection of COVID-19: A review of the current literature and future perspectives , 2020, Biosensors and Bioelectronics.

[170]  Danila Moscone,et al.  A wearable origami-like paper-based electrochemical biosensor for sulfur mustard detection. , 2019, Biosensors & bioelectronics.

[171]  Donny Nugraha Mazaafrianto,et al.  An Electrochemical Sensor Based on Structure Switching of Dithiol-modified Aptamer for Simple Detection of Ochratoxin A , 2019, Analytical Sciences.

[172]  D. Meisel,et al.  Adsorption and surface-enhanced Raman of dyes on silver and gold sols , 1982 .

[173]  Xiangke Wang,et al.  A brief review of graphene-based material synthesis and its application in environmental pollution management , 2012 .

[174]  Horia N. Roman,et al.  An AgNP-deposited commercial electrochemistry test strip as a platform for urea detection , 2020, Scientific Reports.

[175]  Yaohua Guo,et al.  A paper-based electrochemical immunosensor with reduced graphene oxide/thionine/gold nanoparticles nanocomposites modification for the detection of cancer antigen 125. , 2019, Biosensors & bioelectronics.

[176]  Simone Morais,et al.  Alzheimer's disease: Development of a sensitive label-free electrochemical immunosensor for detection of amyloid beta peptide , 2017 .

[177]  A. Ahammad,et al.  Graphene-Based Electrochemical Sensors for Biomedical Applications , 2019, Biomedical Applications of Graphene and 2D Nanomaterials.

[178]  Hui-Fang Cui,et al.  A label-free and lectin-based sandwich aptasensor for detection of carcinoembryonic antigen , 2018 .

[179]  Lobat Tayebi,et al.  Nanomaterials-based electrochemical immunosensors for cardiac troponin recognition: An illustrated review , 2016 .

[180]  C. Sloby,et al.  Discovering the fullerenes , 1997 .

[181]  S. Tabassum,et al.  Sensitive competitive label-free electrochemical immunosensor for primal detection of ovarian cancer , 2020, Chemical Papers.

[182]  C. Friesen,et al.  Electrochemical stability of elemental metal nanoparticles. , 2010, Journal of the American Chemical Society.

[183]  E. Morallón,et al.  Carbon Nanotubes Modified With Au for Electrochemical Detection of Prostate Specific Antigen: Effect of Au Nanoparticle Size Distribution , 2019, Front. Chem..

[184]  S. Gaffar,et al.  Cerium oxide-monoclonal antibody bioconjugate for electrochemical immunosensing of HER2 as a breast cancer biomarker , 2020 .

[185]  M. Shahlaei,et al.  An Impedimetric Immunosensor modified with electrospun core-shell nanofibers for determination of the carcinoma embryonic antigen , 2020 .

[186]  M. Rahman,et al.  A systematic review on silver nanoparticles-induced cytotoxicity: Physicochemical properties and perspectives , 2017, Journal of Advanced Research.

[187]  Hafiz M.N. Iqbal,et al.  Multifunctional metal–organic frameworks-based biocatalytic platforms: recent developments and future prospects , 2019, Journal of Materials Research and Technology.

[188]  Fredrik Y Frejd,et al.  Affibody molecules as engineered protein drugs , 2017, Experimental &Molecular Medicine.

[189]  P. Suchomel,et al.  Simple size-controlled synthesis of Au nanoparticles and their size-dependent catalytic activity , 2018, Scientific Reports.

[190]  G. Neri,et al.  MgNi2O3 nanoparticles as novel and versatile sensing material for non-enzymatic electrochemical sensing of glucose and conductometric determination of acetone , 2020 .

[191]  X. Qiao,et al.  An immunosensor detects carcinoembryonic antigen by a double reduction strategy based on polyphenylamine as a sacrifice reducing agent , 2020 .

[192]  H. S. Zhou,et al.  Review—Measurement and Analysis of Cancer Biomarkers Based on Electrochemical Biosensors , 2020, Journal of The Electrochemical Society.

[193]  M. Suciu,et al.  Label-free electrochemical aptasensor based on gold and polypyrrole nanoparticles for interleukin 6 detection , 2017 .

[194]  O. Chailapakul,et al.  “Signal-On” electrochemical biosensor based on a competitive immunoassay format for the sensitive determination of oxytetracycline , 2020 .

[195]  Li Fu,et al.  Highly stable and regenerative graphene-diamond hybrid electrochemical biosensor for fouling target dopamine detection. , 2018, Biosensors & bioelectronics.

[196]  Shivesh Sharma,et al.  Dual gold nanostructure-based electrochemical immunosensor for CA125 detection , 2018, Applied Nanoscience.

[197]  Zhanfang Ma,et al.  New immunoprobes based on bovine serum albumin-stabilized copper nanoclusters with triple signal amplification for ultrasensitive electrochemical immunosensing for tumor marker , 2017 .

[198]  T. Saleh,et al.  Electrodes modified with 3D graphene composites: a review on methods for preparation, properties and sensing applications , 2018, Microchimica Acta.

[199]  F. Tadayon,et al.  A novel label-free impedimetric immunosensor for sensitive detection of prostate specific antigen using Au nanoparticles/MWCNTs- graphene quantum dots nanocomposite , 2020 .

[200]  J. S. Bondili,et al.  Fabrication of Immunosensor Based on Polyaniline, Fullerene‐C 60 and Palladium Nanoparticles Nanocomposite: An Electrochemical Detection Tool for Prostate Cancer , 2020 .

[201]  Meysam Safari,et al.  Enzyme-free sandwich-type electrochemical immunosensor for highly sensitive prostate specific antigen based on conjugation of quantum dots and antibody on surface of modified glassy carbon electrode with core-shell magnetic metal-organic frameworks. , 2020, Talanta.

[202]  Feng Li,et al.  Nucleic Acid-Functionalized Metal-Organic Framework-Based Homogeneous Electrochemical Biosensor for Simultaneous Detection of Multiple Tumor Biomarkers. , 2019, Analytical chemistry.

[203]  Jeong-Woo Choi,et al.  Electrochemical H2O2 biosensor composed of myoglobin on MoS2 nanoparticle-graphene oxide hybrid structure. , 2017, Biosensors & bioelectronics.

[204]  Longjiao Zhu,et al.  A universal electrochemical biosensor using nick-HCR nanostructure as molecular gate of nanochannel for detecting Chromium (III) ions and microRNA. , 2019, Analytical chemistry.

[205]  E. Aydın,et al.  A disposable and ultrasensitive ITO based biosensor modified by 6-phosphonohexanoic acid for electrochemical sensing of IL-1β in human serum and saliva. , 2018, Analytica chimica acta.

[206]  Ellen Jo Baron,et al.  Multiplex pathogen identification for polymicrobial urinary tract infections using biosensor technology: a prospective clinical study. , 2009, The Journal of urology.

[207]  A. Turner,et al.  Home blood glucose biosensors: a commercial perspective. , 2005, Biosensors & bioelectronics.

[208]  M. Nagata,et al.  ITGA3 and ITGB4 expression biomarkers estimate the risks of locoregional and hematogenous dissemination of oral squamous cell carcinoma , 2013, BMC Cancer.

[209]  Ming Zheng,et al.  Label-Free and Ultrasensitive Electrochemical DNA Biosensor Based on Urchin-like Carbon Nanotube-Gold Nanoparticle Nanoclusters. , 2020, Analytical chemistry.

[210]  Huan Yang,et al.  Detection of serum human epididymis secretory protein 4 in patients with ovarian cancer using a label-free biosensor based on localized surface plasmon resonance , 2012, International journal of nanomedicine.

[211]  M. Guardingo,et al.  Carbon nanotube-based nanocomposite sensor tuned with a catechol as novel electrochemical recognition platform of uranyl ion in aqueous samples , 2018, Sensors and Actuators B: Chemical.

[212]  Jenny R. Roberts,et al.  Metal nanomaterials: Immune effects and implications of physicochemical properties on sensitization, elicitation, and exacerbation of allergic disease , 2019, Journal of immunotoxicology.

[213]  N. Jaffrezic‐Renault,et al.  Signal multi-amplified electrochemical biosensor for voltammetric determination of tau-441 protein in biological samples using carbon nanomaterials and gold nanoparticles to hint dementia , 2020, Microchimica Acta.

[214]  Ying Liu,et al.  Human papilloma virus DNA-biomarker analysis for cervical cancer: Signal enhancement by gold nanoparticle-coupled tetravalent streptavidin-biotin strategy. , 2019, International journal of biological macromolecules.

[215]  Mehdi Kamali,et al.  Recent biomedical applications of gold nanoparticles: A review. , 2018, Talanta.

[216]  Wei Qin,et al.  Recent advances in potentiometric biosensors , 2020 .

[217]  Y. Omidi,et al.  A novel electrochemical immunosensor for ultrasensitive detection of CA125 in ovarian cancer. , 2020, Biosensors & bioelectronics.

[218]  X. Qiao,et al.  A novel electrochemical immunosensor based on CoS2 for early screening of tumor marker carcinoembryonic antigen , 2020 .

[219]  L. García-Cruz,et al.  Shape-controlled metal nanoparticles for electrocatalytic applications , 2018, Physical Sciences Reviews.

[220]  Hongying Liu,et al.  A review on nanomaterial-based electrochemical sensors for H2O2, H2S and NO inside cells or released by cells , 2017, Microchimica Acta.

[221]  Ya Wang,et al.  DNA concatemer-silver nanoparticles as a signal probe for electrochemical prostate-specific antigen detection. , 2019, The Analyst.

[222]  Pranjal Chandra,et al.  Miniaturized label-free smartphone assisted electrochemical sensing approach for personalized COVID-19 diagnosis , 2020, Sensors International.

[223]  C. Harris,et al.  Biomarker development in the precision medicine era: lung cancer as a case study , 2016, Nature Reviews Cancer.

[224]  Vamsi K Yadavalli,et al.  Flexible Biosensors for the Impedimetric Detection of Protein Targets Using Silk-Conductive Polymer Biocomposites. , 2019, ACS sensors.

[225]  Chun-San Tai,et al.  Improving the reproducibility, accuracy, and stability of an electrochemical biosensor platform for point-of-care use. , 2020, Biosensors & bioelectronics.

[226]  Syed Shaheen Shah,et al.  Porous tal palm carbon nanosheets: preparation, characterization and application for the simultaneous determination of dopamine and uric acid , 2018, Nanoscale advances.

[227]  Suyatman,et al.  Sonochemical synthesis of magnetic Fe3O4/graphene nanocomposites for label-free electrochemical biosensors , 2020, Journal of Materials Science: Materials in Electronics.

[228]  S. Çevik.  Xanthine biosensor based on XO/AuNP/PtNP/MWCNT hybrid nanocomposite modified GCPE , 2016, Biotechnology and Bioprocess Engineering.

[229]  Mostafa Ghanei,et al.  Electrochemical biosensors for the detection of lung cancer biomarkers: A review. , 2020, Talanta.

[230]  Y. Dilgin,et al.  A novel enzyme-free FI-amperometric glucose biosensor at Cu nanoparticles modified graphite pencil electrode , 2020 .

[231]  Nina Dimcheva.  Nanostructures of noble metals as functional materials in biosensors , 2020 .

[232]  M. Hulman,et al.  Raman spectroscopy of fullerenes and fullerene–nanotube composites , 2004, Philosophical Transactions of the Royal Society of London. Series A: Mathematical, Physical and Engineering Sciences.

[233]  S. Gopinath,et al.  Immunosensing prostate-specific antigen: Faradaic vs non-Faradaic electrochemical impedance spectroscopy analysis on interdigitated microelectrode device. , 2020, International journal of biological macromolecules.

[234]  A. Mokhtarzadeh,et al.  Ultrasensitive bioassay of epitope of Mucin-16 protein (CA 125) in human plasma samples using a novel immunoassay based on silver conductive nano-ink: A new platform in early stage diagnosis of ovarian cancer and efficient management. , 2019, International journal of biological macromolecules.

[235]  M. Karim,et al.  Fabrication of Ni–Co-Based Heterometallo-Supramolecular Polymer Films and the Study of Electron Transfer Kinetics for the Nonenzymatic Electrochemical Detection of Nitrite , 2020 .

[236]  P. Solanki,et al.  Silver molybdate nanoparticles based immunosensor for the non-invasive detection of Interleukin-8 biomarker. , 2020, Materials science & engineering. C, Materials for biological applications.

[237]  Wei Wang,et al.  Comorbidity and its impact on 1590 patients with COVID-19 in China: a nationwide analysis , 2020, European Respiratory Journal.

[238]  Y. Fang,et al.  Optical absorption of nanoscale colloidal silver: Aggregate band and adsorbate-silver surface band , 1998 .

[239]  Ye Zhu,et al.  Bi-directionally amplified ratiometric electrochemical aptasensor for the ultrasensitive detection of alpha-fetoprotein , 2020 .

[240]  Tania Akter,et al.  Enzyme-free impedimetric glucose sensor based on gold nanoparticles/polyaniline composite film , 2016, Journal of Solid State Electrochemistry.

[241]  D. Freire,et al.  Nanomaterials for biocatalyst immobilization – state of the art and future trends , 2016 .

[242]  K. Tschulik,et al.  The electrochemical dissolution of single silver nanoparticles enlightened by hyperspectral dark-field microscopy , 2019, Electrochimica Acta.

[243]  Xiurong Yang,et al.  Au and Au-Based nanomaterials: Synthesis and recent progress in electrochemical sensor applications. , 2020, Talanta.

[244]  Minghua Wang,et al.  Bifunctional bioplatform based on NiCo Prussian blue analogue: Label-free impedimetric aptasensor for the early detection of carcino-embryonic antigen and living cancer cells , 2019, Sensors and Actuators B: Chemical.

[245]  Vallee,et al.  Size-dependent electron-electron interactions in metal nanoparticles , 2000, Physical review letters.

[246]  Gao-Qiang Liu,et al.  An electrochemical strategy for tetracycline detection coupled triple helix aptamer probe with catalyzed hairpin assembly signal amplification. , 2019, Biosensors & bioelectronics.

[247]  T. Kaya,et al.  Electrochemical amperometric biosensor applications of nanostructured metal oxides: a review , 2019, Materials Research Express.

[248]  Mustafa Kemal Sezgintürk,et al.  A review on impedimetric biosensors , 2016, Artificial cells, nanomedicine, and biotechnology.

[249]  Nádia F D Silva,et al.  Development of a disposable paper-based potentiometric immunosensor for real-time detection of a foodborne pathogen. , 2019, Biosensors & bioelectronics.

[250]  M. Mirzaei,et al.  Electrochemical aptasensor for activated protein C using a gold nanoparticle - Chitosan/graphene paste modified carbon paste electrode. , 2019, Bioelectrochemistry.

[251]  X. Qiao,et al.  Microwave-assisted preparation of ZnFe2O4-Ag/rGO nanocomposites for amplification signal detection of alpha-fetoprotein. , 2019, Bioelectrochemistry.

[252]  M. T. Rahman,et al.  Green Synthesis and Layer-by-Layer Assembly of Amino-Functionalized Graphene Oxide/Carboxylic Surface Modified Trimetallic Nanoparticles Nanocomposite for Label-Free Electrochemical Biosensing , 2019, Journal of The Electrochemical Society.

[253]  Kasarla Ramakrushna Reddy,et al.  Development of an electrochemical immunosensor based on gold nanoparticles incorporated chitosan biopolymer nanocomposite film for the detection of prostate cancer using PSA as biomarker. , 2017, Enzyme and microbial technology.

[254]  Fanggui Ye,et al.  A competitive immunoassay for electrochemical impedimetric determination of chlorpyrifos using a nanogold-modified glassy carbon electrode based on enzymatic biocatalytic precipitation , 2020, Microchimica Acta.

[255]  S. Shahrokhian,et al.  Electrochemical sensing based on carbon nanoparticles: A review , 2019, Sensors and Actuators B: Chemical.

[256]  S. Ahmad,et al.  An Electrochemical Sandwich Immunosensor for the Detection of HER2 using Antibody-Conjugated PbS Quantum Dot as a label. , 2019, Journal of pharmaceutical and biomedical analysis.

[257]  Bo Zhao,et al.  Design of nanogold electrochemical immunosensor for detection of four phenolic estrogens , 2019, Chemical Physics Letters.

[258]  Yuting Zhao,et al.  A novel fluorescent and electrochemical dual-responsive immunosensor for sensitive and reliable detection of biomarkers based on cation-exchange reaction. , 2020, Analytica chimica acta.

[259]  Jintao Liang,et al.  A novel aptasensor based on light-addressable potentiometric sensor for the determination of Alpha-fetoprotein , 2020 .

[260]  Xiliang Luo,et al.  A label-free electrochemical immunosensor based on rhombic dodecahedral Cu3Pt nanoframes with advanced oxygen reduction performance for highly sensitive alpha-fetoprotein detection , 2019, Sensors and Actuators B: Chemical.

[261]  Zuanguang Chen,et al.  Label-free and competitive aptamer cytosensor based on layer-by-layer assembly of DNA-platinum nanoparticles for ultrasensitive determination of tumor cells , 2018, Sensors and Actuators B: Chemical.

[262]  Fenglin Liu,et al.  Ultrasensitive supersandwich-type electrochemical sensor for SARS-CoV-2 from the infected COVID-19 patients using a smartphone , 2020, Sensors and Actuators B: Chemical.

[263]  Yixian Wang,et al.  Laser-induced noble metal nanoparticle-graphene composites enabled flexible biosensor for pathogen detection. , 2019, Biosensors & bioelectronics.

[264]  Mirella Di Lorenzo,et al.  Impedimetric paper-based biosensor for the detection of bacterial contamination in water , 2018, Sensors and Actuators B: Chemical.

[265]  A. Meng,et al.  The construction of electrochemical aptasensor based on coral-like poly-aniline and Au nano-particles for the sensitive detection of prostate specific antigen , 2019, Sensors and Actuators B: Chemical.

[266]  S. M. Taghdisi,et al.  A novel colorimetric sandwich aptasensor based on an indirect competitive enzyme-free method for ultrasensitive detection of chloramphenicol. , 2016, Biosensors & bioelectronics.

[267]  J. Claussen,et al.  Electrochemical cotinine sensing with a molecularly imprinted polymer on a graphene-platinum nanoparticle modified carbon electrode towards cigarette smoke exposure monitoring , 2019, Sensors and Actuators B: Chemical.

[268]  S. Dzyadevych,et al.  Advances in nanomaterial application in enzyme-based electrochemical biosensors: a review , 2019, Nanoscale advances.

[269]  C. Hong,et al.  Bimetallic PtCu nanoparticles supported on molybdenum disulfide–functionalized graphitic carbon nitride for the detection of carcinoembryonic antigen , 2020, Microchimica Acta.

[270]  C. Hong,et al.  A sandwich-type electrochemical immunosensor using Ag@CeO2-Au as a lable for sensitive detection of carcinoembryonic antigen , 2020, Microchemical Journal.

[271]  Yiyu Feng,et al.  Carbon-based functional nanomaterials: Preparation, properties and applications , 2019, Composites Science and Technology.

[272]  Martin Pumera,et al.  3D-printed graphene direct electron transfer enzyme biosensors. , 2020, Biosensors & bioelectronics.

[273]  Chaoqun Huang,et al.  A magneto-controlled microfluidic device for voltammetric immunoassay of carbohydrate antigen-125 with silver–polypyrrole nanotags , 2020 .

[274]  Shujie Wu,et al.  Electrochemical aptamer-based determination of protein tyrosine kinase-7 using toehold-mediated strand displacement amplification on gold nanoparticles and graphene oxide , 2019, Microchimica Acta.

[275]  E. Arkan,et al.  Fabrication of a novel electrochemical aptasensor assisted by a novel computerized monitoring system for real-time determination of the prostate specific antigen: A computerized experimental method brought elegancy , 2020 .

[276]  S. Balakumar,et al.  Facile synthesis of paper based graphene electrodes for point of care devices: A double stranded DNA (dsDNA) biosensor. , 2020, Journal of colloid and interface science.

[277]  Jie Chao,et al.  Dual-Target Electrochemical Biosensing Based on DNA Structural Switching on Gold Nanoparticle-Decorated MoS2 Nanosheets. , 2016, ACS applied materials & interfaces.

[278]  Umme Thahira Khatoon,et al.  Strategies to synthesize various nanostructures of silver and their applications – a review , 2018, RSC advances.

[279]  Minghua Wang,et al.  Bimetallic ZrHf-based metal-organic framework embedded with carbon dots: Ultra-sensitive platform for early diagnosis of HER2 and HER2-overexpressed living cancer cells. , 2019, Biosensors & bioelectronics.

[280]  X. Yang,et al.  Ultra-sensitive electrochemical DNA biosensor based on a label-free assembling strategy using a triblock polyA DNA probe. , 2019, Analytical chemistry.

[281]  M. Nurunnabi,et al.  Preparation of ultra-thin hexagonal boron nitride nanoplates for cancer cell imaging and neurotransmitter sensing. , 2016, Chemical communications.

[282]  A. Umar,et al.  Solid-state synthesis of Ag-doped PANI nanocomposites for their end-use as an electrochemical sensor for hydrogen peroxide and dopamine , 2020 .

[283]  Chunhai Fan,et al.  Effective immobilization of Au nanoparticles on TiO2 loaded graphene for a novel sandwich-type immunosensor. , 2018, Biosensors & bioelectronics.

[284]  Wlodzimierz Kutner,et al.  Electrocatalytic Properties and Sensor Applications of Fullerenes and Carbon Nanotubes , 2003 .

[285]  Qionglin Liang,et al.  Self-polymerized Dopamine Decorated Au NPs and Coordinated with Fe-MOF as a Dual Binding Sites and Dual Signal-amplifying Electrochemical Aptasensor for the Detection of CEA. , 2020, ACS applied materials & interfaces.

[286]  Lei Liu,et al.  Smartphone-based cyclic voltammetry system with graphene modified screen printed electrodes for glucose detection. , 2017, Biosensors & bioelectronics.

[287]  Jianbin Zheng,et al.  A voltammetric immunoassay for the carcinoembryonic antigen using silver(I)-terephthalate metal-organic frameworks containing gold nanoparticles as a signal probe , 2019, Microchimica Acta.

[288]  Zhangxing He,et al.  A novel electrochemical sensor for glucose detection based on Ag@ZIF-67 nanocomposite , 2018 .

[289]  Giuseppe Biondi-Zoccai,et al.  Cardiovascular Considerations for Patients, Health Care Workers, and Health Systems During the COVID-19 Pandemic , 2020, Journal of the American College of Cardiology.

[290]  E. Park,et al.  Electrical pulse-induced electrochemical biosensor for hepatitis E virus detection , 2019, Nature Communications.

[291]  Shilpi Verma,et al.  An electrochemical biosensor based on novel butylamine capped CZTS nanoparticles immobilized by uricase for uric acid detection. , 2019, Biosensors & bioelectronics.

[292]  A. Soldatkin,et al.  Electrochemical biosensors based on multienzyme systems: Main groups, advantages and limitations - A review. , 2020, Analytica chimica acta.

[293]  S. Kamel,et al.  Recent Advances in Cellulose-Based Biosensors for Medical Diagnosis , 2020, Biosensors.

[294]  Yuanqing Zhang,et al.  A DNA nanostructured biosensor for electrochemical analysis of HER2 using bioconjugate of GNR@Pd SSs—Apt—HRP , 2019, Sensors and Actuators B: Chemical.

[295]  Mingji Li,et al.  Electrochemical immunosensors with AuPt-vertical graphene/glassy carbon electrode for alpha-fetoprotein detection based on label-free and sandwich-type strategies. , 2019, Biosensors & bioelectronics.

[296]  C. A. Amarnath,et al.  Polyaniline Based Electrochemical Biosensor for α‐Fetoprotein Detection Using Bio‐functionalized Nanoparticles as Detection Probe , 2020 .

[297]  Shilpi Verma,et al.  Anti-IL8/AuNPs-rGO/ITO as an Immunosensing Platform for Noninvasive Electrochemical Detection of Oral Cancer. , 2017, ACS applied materials & interfaces.

[298]  Kaitai Zhang,et al.  An Approach to Studying Lung Cancer-related Proteins in Human Blood*S , 2005, Molecular & Cellular Proteomics.

[299]  Vincent Gau,et al.  Antimicrobial susceptibility testing using high surface-to-volume ratio microchannels. , 2010, Analytical chemistry.

[300]  Niina J. Ronkainen,et al.  Electrochemical biosensors. , 2010, Chemical Society reviews.

[301]  B. D. Malhotra,et al.  Amine-Functionalized MoO3@RGO Nanohybrid-Based Biosensor for Breast Cancer Detection , 2019, ACS Applied Bio Materials.

[302]  M. Ehsan,et al.  Selective Detection of Dopamine at the AACVD Synthesized Palladium Nanoparticles and Understanding the Sensing Mechanism through Electrochemical and Computational Study , 2019, Journal of The Electrochemical Society.