Ras oncoprotein inhibitors: the discovery of potent, ras nucleotide exchange inhibitors and the structural determination of a drug-protein complex.

[1]  P. Kirschmeier,et al.  Synthesis and evaluation of pyrazolo[3,4-b]quinoline ribofuranosides and their derivatives as inhibitors of oncogenic Ras , 1996 .

[2]  L. Feig,et al.  Guanine-nucleotide exchange factors: a family of positive regulators of Ras and related GTPases. , 1994, Current opinion in cell biology.

[3]  P. Kraulis,et al.  Solution structure and dynamics of ras p21.GDP determined by heteronuclear three- and four-dimensional NMR spectroscopy. , 1994, Biochemistry.

[4]  A. Cherniack,et al.  Phosphorylation of the Ras nucleotide exchange factor son of sevenless by mitogen-activated protein kinase. , 1994, The Journal of biological chemistry.

[5]  S. Liberles,et al.  Studies of the Ras-GDP and Ras-GTP noncovalent complexes by electrospray mass spectrometry , 1993 .

[6]  Chuan Yi Tang,et al.  A 2.|E|-Bit Distributed Algorithm for the Directed Euler Trail Problem , 1993, Inf. Process. Lett..

[7]  E. Laue,et al.  Sequential assignment of the backbone nuclei (1H,15N and13C) of c-H-ras p21 (1–166).GDP using a novel 4D NMR strategy , 1992, Journal of biomolecular NMR.

[8]  T. Covey,et al.  Mass spectrometric detection of the noncovalent GDP-bound conformational state of the human H-ras protein , 1992 .

[9]  H. Kung,et al.  Nerve growth factor stimulation of the Ras-guanine nucleotide exchange factor and GAP activities. , 1992, Science.

[10]  N. Brown,et al.  Interaction of GTP derivatives with cellular and oncogenic ras-p21 proteins. , 1991, Journal of medicinal chemistry.

[11]  S H Kim,et al.  Crystal structures at 2.2 A resolution of the catalytic domains of normal ras protein and an oncogenic mutant complexed with GDP. , 1991, Journal of molecular biology.

[12]  W. Kabsch,et al.  Refined crystal structure of the triphosphate conformation of H‐ras p21 at 1.35 A resolution: implications for the mechanism of GTP hydrolysis. , 1990, The EMBO journal.

[13]  M. Barbacid,et al.  ras oncogenes: their role in neoplasia , 1990, European journal of clinical investigation.

[14]  Y. Kaziro,et al.  Induction of neurite formation in PC12 cells by microinjection of proto-oncogenic Ha-ras protein preincubated with guanosine-5'-O-(3-thiotriphosphate) , 1987, Molecular and cellular biology.

[15]  S. Hattori,et al.  Neutralizing monoclonal antibody against ras oncogene product p21 which impairs guanine nucleotide exchange , 1987, Molecular and cellular biology.

[16]  K. Wüthrich NMR of proteins and nucleic acids , 1988 .

[17]  A. Hall,et al.  The effect of Mg2+ on the guanine nucleotide exchange rate of p21N-ras. , 1986, The Journal of biological chemistry.

[18]  C. Rondestvedt,et al.  Rapid Preparation of Chloroarylhydroxylamines by Hydrazine-Palladium Reduction of Chloronitroarenes , 1977 .

[19]  W. A. Sexton,et al.  The relationship between the constitution and the effect of chemical compounds on plant growth. 1. 2-Phenoxyethylamine derivatives. , 1949, The Biochemical journal.