Towards a comprehensive research and development plan to support the control, elimination and eradication of neglected tropical diseases

Abstract To maximise the likelihood of success, global health programmes need repeated, honest appraisal of their own weaknesses, with research undertaken to address any identified gaps. There is still much to be learned to optimise work against neglected tropical diseases. To facilitate that learning, a comprehensive research and development plan is required. Here, we discuss how such a plan might be developed.

[1]  Y. Amoako,et al.  Rifampicin and clarithromycin (extended release) versus rifampicin and streptomycin for limited Buruli ulcer lesions: a randomised, open-label, non-inferiority phase 3 trial , 2020, The Lancet.

[2]  George J. F. Swan,et al.  Ecology of domestic dogs Canis familiaris as an emerging reservoir of Guinea worm Dracunculus medinensis infection , 2020, bioRxiv.

[3]  Solomon E. Adelamo,et al.  The Interruption of Transmission of Human Onchocerciasis by an Annual Mass Drug Administration Program in Plateau and Nasarawa States, Nigeria , 2020, The American journal of tropical medicine and hygiene.

[4]  M. Burton,et al.  Ocular Chlamydia trachomatis infection, anti-Pgp3 antibodies and conjunctival scarring in Vanuatu and Tarawa, Kiribati before antibiotic treatment for trachoma , 2020, Journal of Infection.

[5]  E. Akl,et al.  New WHO guidelines for treatment of gambiense human African trypanosomiasis including fexinidazole: substantial changes for clinical practice. , 2019, The Lancet. Infectious diseases.

[6]  L. C. Fuller,et al.  The public health control of scabies: priorities for research and action , 2019, The Lancet.

[7]  M. Malecela,et al.  WHO's Snakebite Envenoming Strategy for prevention and control. , 2019, The Lancet. Global health.

[8]  P. Hotez,et al.  Resolving "worm wars": An extended comparison review of findings from key economics and epidemiological studies , 2019, PLoS neglected tropical diseases.

[9]  A. Solomon,et al.  Completing Baseline Mapping of Trachoma in Nepal: Results of 27 Population-Based Prevalence Surveys Conducted in 2013 and 2014 , 2018, Ophthalmic epidemiology.

[10]  P. van der Stuyft,et al.  Prioritizing surveillance activities for certification of yaws eradication based on a review and model of historical case reporting , 2018, PLoS neglected tropical diseases.

[11]  A. Fahal,et al.  A holistic approach to the mycetoma management , 2018, PLoS neglected tropical diseases.

[12]  P. Hotez,et al.  Could violent conflict derail the London Declaration on NTDs? , 2018, PLoS neglected tropical diseases.

[13]  Scott C Weaver,et al.  Epidemic arboviral diseases: priorities for research and public health. , 2017, The Lancet. Infectious diseases.

[14]  J. Koroma,et al.  Costs of Transmission Assessment Surveys to Provide Evidence for the Elimination of Lymphatic Filariasis , 2017, PLoS neglected tropical diseases.

[15]  P. Hotez.  Global urbanization and the neglected tropical diseases , 2017, PLoS neglected tropical diseases.

[16]  S. Funk,et al.  Mathematical Modeling of Programmatic Requirements for Yaws Eradication , 2017, Emerging infectious diseases.

[17]  O. Horstick,et al.  Dengue , 2015, The Lancet.

[18]  Q. Bassat,et al.  Challenges and key research questions for yaws eradication. , 2015, The Lancet. Infectious diseases.

[19]  E. Cupp,et al.  Elimination of Onchocerciasis from Mexico , 2015, PLoS neglected tropical diseases.

[20]  K. Hirayama,et al.  Host Determinants of Reinfection with Schistosomes in Humans: A Systematic Review and Meta-analysis , 2014, PLoS neglected tropical diseases.

[21]  Rosanna W. Peeling,et al.  Neglected Tropical Diseases : Rationale and Target Product Profiles , 2018 .

[22]  Q. Bassat,et al.  Single-dose azithromycin versus benzathine benzylpenicillin for treatment of yaws in children in Papua New Guinea: an open-label, non-inferiority, randomised trial , 2012, The Lancet.

[23]  Peter J Hotez,et al.  “Rapid-Impact Interventions”: How a Policy of Integrated Control for Africa's Neglected Tropical Diseases Could Benefit the Poor , 2005, PLoS medicine.

[24]  P. Hotez.  Poverty and the Impact of COVID-19: The Blue-Marble Health Approach , 2020 .

[25]  Dracunculiasis eradication: global surveillance summary, 2015. , 2016, Releve epidemiologique hebdomadaire.

[26]  Dracunculiasis eradication Global surveillance summary , 2015 .

[27]  A. Meheus,et al.  The endemic treponematoses. , 2002, Microbes and infection.