OX40 Ligand Contributes to Human Lupus Pathogenesis by Promoting T Follicular Helper Response.

[1]  P. Gregersen,et al.  High-density genotyping of immune loci in Koreans and Europeans identifies eight new rheumatoid arthritis risk loci. , 2015, Annals of the rheumatic diseases.

[2]  H. Ueno,et al.  Pathophysiology of T follicular helper cells in humans and mice , 2015, Nature Immunology.

[3]  S. Crotty T follicular helper cell differentiation, function, and roles in disease. , 2014, Immunity.

[4]  H. Ueno,et al.  The cytokine TGF-β co-opts signaling via STAT3-STAT4 to promote the differentiation of human TFH cells , 2014, Nature Immunology.

[5]  F. Klauschen,et al.  T-cell-receptor-dependent signal intensity dominantly controls CD4(+) T cell polarization In Vivo. , 2014, Immunity.

[6]  M. Veldhoen,et al.  OX40 controls effector CD4+ T-cell expansion, not follicular T helper cell generation in acute Listeria infection , 2014, European journal of immunology.

[7]  M. Giger,et al.  Cell Distance Mapping Identifies Functional T Follicular Helper Cells in Inflamed Human Renal Tissue , 2014, Science Translational Medicine.

[8]  H. Clevers,et al.  Transcription factor Achaete-Scute homologue 2 initiates T follicular helper cell development , 2014, Nature.

[9]  M. Croft,et al.  Exogenous OX40 Stimulation during Lymphocytic Choriomeningitis Virus Infection Impairs Follicular Th Cell Differentiation and Diverts CD4 T Cells into the Effector Lineage by Upregulating Blimp-1 , 2013, The Journal of Immunology.

[10]  E. Steichen,et al.  Enhanced activity of Akt in Teff cells from children with lupus nephritis is associated with reduced induction of tumor necrosis factor receptor-associated factor 6 and increased OX40 expression. , 2013, Arthritis and rheumatism.

[11]  C. Mackay,et al.  Circulating precursor CCR7(lo)PD-1(hi) CXCR5⁺ CD4⁺ T cells indicate Tfh cell activity and promote antibody responses upon antigen reexposure. , 2013, Immunity.

[12]  D. Isenberg,et al.  Systemic lupus erythematosus and other autoimmune rheumatic diseases: challenges to treatment , 2013, The Lancet.

[13]  J. Casanova,et al.  Inherited human OX40 deficiency underlying classic Kaposi sarcoma of childhood , 2013, The Journal of experimental medicine.

[14]  Jiyuan Zhang,et al.  Upregulation of OX40 ligand on monocytes contributes to early virological control in patients with chronic hepatitis C , 2013, European journal of immunology.

[15]  S. Tangye,et al.  The good, the bad and the ugly — TFH cells in human health and disease , 2013, Nature Reviews Immunology.

[16]  Jonathan L. Linehan,et al.  Single Naive CD4+ T Cells from a Diverse Repertoire Produce Different Effector Cell Types during Infection , 2013, Cell.

[17]  H. Ueno,et al.  IL-12 receptor β1 deficiency alters in vivo T follicular helper cell response in humans. , 2013, Blood.

[18]  Diego G. Silva,et al.  Roquin-2 shares functions with its paralog Roquin-1 in the repression of mRNAs controlling T follicular helper cells and systemic inflammation. , 2013, Immunity.

[19]  H. Blum,et al.  Roquin paralogs 1 and 2 redundantly repress the Icos and Ox40 costimulator mRNAs and control follicular helper T cell differentiation. , 2013, Immunity.

[20]  Virginia Pascual,et al.  Induction of ICOS+CXCR3+CXCR5+ TH Cells Correlates with Antibody Responses to Influenza Vaccination , 2013, Science Translational Medicine.

[21]  Diego G. Silva,et al.  Interferon-γ excess leads to pathogenic accumulation of follicular helper T cells and germinal centers. , 2012, Immunity.

[22]  X. Li,et al.  OX40 signaling favors the induction of TH9 cells and airway inflammation , 2012, Nature Immunology.

[23]  K. Latinis,et al.  Belimumab reduces autoantibodies, normalizes low complement levels, and reduces select B cell populations in patients with systemic lupus erythematosus. , 2012, Arthritis and rheumatism.

[24]  V. Soumelis,et al.  Characterization of resident and migratory dendritic cells in human lymph nodes , 2012, The Journal of experimental medicine.

[25]  G. Tsokos,et al.  Systemic lupus erythematosus. , 2011, The New England journal of medicine.

[26]  J. Cyster,et al.  How T cells earn the follicular rite of passage. , 2011, Immunity.

[27]  H. Ueno,et al.  Human tonsil B-cell lymphoma 6 (BCL6)-expressing CD4+ T-cell subset specialized for B-cell help outside germinal centers , 2011, Proceedings of the National Academy of Sciences.

[28]  S. Crotty,et al.  ICOS receptor instructs T follicular helper cell versus effector cell differentiation via induction of the transcriptional repressor Bcl6. , 2011, Immunity.

[29]  T. So,et al.  OX40 Complexes with Phosphoinositide 3-Kinase and Protein Kinase B (PKB) To Augment TCR-Dependent PKB Signaling , 2011, The Journal of Immunology.

[30]  Tomoki Ito,et al.  Neutrophils Activate Plasmacytoid Dendritic Cells by Releasing Self-DNA–Peptide Complexes in Systemic Lupus Erythematosus , 2011, Science Translational Medicine.

[31]  J. Connolly,et al.  Netting Neutrophils Are Major Inducers of Type I IFN Production in Pediatric Systemic Lupus Erythematosus , 2011, Science Translational Medicine.

[32]  R. Jonsson,et al.  Association of EBF1, FAM167A(C8orf13)-BLK and TNFSF4 gene variants with primary Sjögren's syndrome , 2011, Genes and Immunity.

[33]  E. Meffre,et al.  In Situ B Cell-Mediated Immune Responses and Tubulointerstitial Inflammation in Human Lupus Nephritis , 2011, The Journal of Immunology.

[34]  H. Ueno,et al.  Human blood CXCR5(+)CD4(+) T cells are counterparts of T follicular cells and contain specific subsets that differentially support antibody secretion. , 2011, Immunity.

[35]  Jeffrey A. Gold,et al.  OX40 Ligand Regulates Inflammation and Mortality in the Innate Immune Response to Sepsis , 2010, The Journal of Immunology.

[36]  J. Casanova,et al.  Human CD14dim Monocytes Patrol and Sense Nucleic Acids and Viruses via TLR7 and TLR8 Receptors , 2010, Immunity.

[37]  S. Tangye,et al.  Follicular helper T cell differentiation requires continuous antigen presentation that is independent of unique B cell signaling. , 2010, Immunity.

[38]  R. Cantor,et al.  Sex-specific association of X-linked Toll-like receptor 7 (TLR7) with male systemic lupus erythematosus , 2010, Proceedings of the National Academy of Sciences.

[39]  M. Croft Control of immunity by the TNFR-related molecule OX40 (CD134). , 2010, Annual review of immunology.

[40]  S. Tangye,et al.  Expansion of circulating T cells resembling follicular helper T cells is a fixed phenotype that identifies a subset of severe systemic lupus erythematosus. , 2010, Arthritis and rheumatism.

[41]  T. Mak,et al.  Inducible costimulator promotes helper T-cell differentiation through phosphoinositide 3-kinase , 2009, Proceedings of the National Academy of Sciences.

[42]  Hideki Ueno,et al.  Human dendritic cells induce the differentiation of interleukin-21-producing T follicular helper-like cells through interleukin-12. , 2009, Immunity.

[43]  A. Delgado-Vega,et al.  Replication of the TNFSF4 (OX40L) promoter region association with systemic lupus erythematosus , 2009, Genes and Immunity.

[44]  M. Cook,et al.  Follicular helper T cells are required for systemic autoimmunity , 2009, The Journal of experimental medicine.

[45]  N. Fazilleau,et al.  The function of follicular helper T cells is regulated by the strength of T cell antigen receptor binding , 2009, Nature Immunology.

[46]  W. Leonard,et al.  A critical role for IL-21 receptor signaling in the pathogenesis of systemic lupus erythematosus in BXSB-Yaa mice , 2009, Proceedings of the National Academy of Sciences.

[47]  R. Flavell,et al.  ICOS-dependent extrafollicular helper T cells elicit IgG production via IL-21 in systemic autoimmunity , 2008, The Journal of experimental medicine.

[48]  H. Ueno,et al.  Functional specializations of human epidermal Langerhans cells and CD14+ dermal dendritic cells. , 2008, Immunity.

[49]  R. Coffman,et al.  Development of TLR inhibitors for the treatment of autoimmune diseases , 2008, Immunological reviews.

[50]  Virginia Pascual,et al.  Dendritic cells and cytokines in human inflammatory and autoimmune diseases. , 2008, Cytokine & growth factor reviews.

[51]  David Altshuler,et al.  Polymorphism at the TNF superfamily gene TNFSF4 confers susceptibility to systemic lupus erythematosus , 2008, Nature Genetics.

[52]  Y. Li,et al.  Cytokine-Mediated Regulation of Human B Cell Differentiation into Ig-Secreting Cells: Predominant Role of IL-21 Produced by CXCR5+ T Follicular Helper Cells1 , 2007, The Journal of Immunology.

[53]  J. Cyster,et al.  Role of CXCR5 and CCR7 in Follicular Th Cell Positioning and Appearance of a Programmed Cell Death Gene-1High Germinal Center-Associated Subpopulation1 , 2007, The Journal of Immunology.

[54]  M. Collins,et al.  IL-21 Has a Pathogenic Role in a Lupus-Prone Mouse Model and Its Blockade with IL-21R.Fc Reduces Disease Progression , 2007, The Journal of Immunology.

[55]  M. Nussenzweig,et al.  Autoreactivity in human IgG+ memory B cells. , 2007, Immunity.

[56]  A. Plebani,et al.  ICOS Deficiency Is Associated with a Severe Reduction of CXCR5+CD4 Germinal Center Th Cells1 , 2006, The Journal of Immunology.

[57]  L. Rönnblom,et al.  Induction of interferon-alpha by immune complexes or liposomes containing systemic lupus erythematosus autoantigen- and Sjögren's syndrome autoantigen-associated RNA. , 2006, Arthritis and rheumatism.

[58]  S. Akira,et al.  Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus , 2005, The Journal of experimental medicine.

[59]  Juan Ma,et al.  The Role of ICOS in the CXCR5+ Follicular B Helper T Cell Maintenance In Vivo1 , 2005, The Journal of Immunology.

[60]  G. Illei,et al.  A short course of BG9588 (anti-CD40 ligand antibody) improves serologic activity and decreases hematuria in patients with proliferative lupus glomerulonephritis. , 2003, Arthritis and rheumatism.

[61]  D. Gray,et al.  T Cell Accumulation in B Cell Follicles Is Regulated by Dendritic Cells and Is Independent of B Cell Activation , 2003, The Journal of experimental medicine.

[62]  K. Sugamura,et al.  Constitutive OX40/OX40 Ligand Interaction Induces Autoimmune-Like Diseases1 , 2002, The Journal of Immunology.

[63]  H. Mages,et al.  ICOS and CD28 reversely regulate IL‐10 on re‐activation of human effector T cells with mature dendritic cells , 2002, European journal of immunology.

[64]  Virginia Pascual,et al.  Induction of Dendritic Cell Differentiation by IFN-α in Systemic Lupus Erythematosus , 2001, Science.

[65]  V. Pascual,et al.  Induction of dendritic cell differentiation by IFN-alpha in systemic lupus erythematosus. , 2001, Science.

[66]  E. Clark,et al.  Characterization of Human Inducible Costimulator Ligand Expression and Function1 , 2000, The Journal of Immunology.

[67]  T. Noda,et al.  Impairment of Antigen-Presenting Cell Function in Mice Lacking Expression of Ox40 Ligand , 2000, The Journal of experimental medicine.

[68]  M. Bachmann,et al.  OX40-deficient mice are defective in Th cell proliferation but are competent in generating B cell and CTL Responses after virus infection. , 1999, Immunity.

[69]  M. Riedinger,et al.  CD4 T cell traffic control: in vivo evidence that ligation of OX40 on CD4 T cells by OX40‐ligand expressed on dendritic cells leads to the accumulation of CD4 T cells in B follicles , 1999, European journal of immunology.

[70]  K. Toellner,et al.  CD4 T Cell Cytokine Differentiation: The B Cell Activation Molecule, OX40 Ligand, Instructs CD4 T Cells to Express Interleukin 4 and Upregulates Expression of the Chemokine Receptor, Blr-1 , 1998, The Journal of experimental medicine.

[71]  S. Kalled,et al.  Anti-CD40 ligand antibody treatment of SNF1 mice with established nephritis: preservation of kidney function. , 1998, Journal of immunology.

[72]  Yuetsu Tanaka,et al.  Expression and function of OX40 ligand on human dendritic cells. , 1997, Journal of immunology.