Hif1a inactivation rescues photoreceptor degeneration induced by a chronic hypoxia-like stress

[1]  C. Grimm,et al.  Hif1a inactivation rescues photoreceptor degeneration induced by a chronic hypoxia-like stress , 2018, Cell Death & Differentiation.

[2]  M. Scott,et al.  Caspase‐1 as a multifunctional inflammatory mediator: noncytokine maturation roles , 2016, Journal of leukocyte biology.

[3]  J. Grossmann,et al.  Basement membrane protein ladinin-1 and the MIF-CD44-β1 integrin signaling axis are implicated in laryngeal cancer metastasis. , 2016, Biochimica et biophysica acta.

[4]  C. Wahl-Schott,et al.  AAV Vectors for FRET-Based Analysis of Protein-Protein Interactions in Photoreceptor Outer Segments , 2016, Front. Neurosci..

[5]  C. Grimm,et al.  Hypoxic preconditioning protects photoreceptors against light damage independently of hypoxia inducible transcription factors in rods. , 2016, Experimental eye research.

[6]  Marin L. Gantner,et al.  Hypoxia-induced metabolic stress in retinal pigment epithelial cells is sufficient to induce photoreceptor degeneration , 2016, eLife.

[7]  P. Campochiaro,et al.  Molecular pathogenesis of retinal and choroidal vascular diseases , 2015, Progress in Retinal and Eye Research.

[8]  C. Grimm,et al.  Blue light-induced retinal lesions, intraretinal vascular leakage and edema formation in the all-cone mouse retina , 2015, Cell Death and Disease.

[9]  D. Zacks,et al.  Hypoxia inducible factor 1α contributes to regulation of autophagy in retinal detachment. , 2015, Experimental eye research.

[10]  Tobias Duncker,et al.  Flecks in Recessive Stargardt Disease: Short-Wavelength Autofluorescence, Near-Infrared Autofluorescence, and Optical Coherence Tomography. , 2015, Investigative ophthalmology & visual science.

[11]  C. Grimm,et al.  Lack of paraoxonase 1 alters phospholipid composition, but not morphology and function of the mouse retina. , 2014, Investigative ophthalmology & visual science.

[12]  R. Simó,et al.  Ocular Anti-VEGF Therapy for Diabetic Retinopathy: The Role of VEGF in the Pathogenesis of Diabetic Retinopathy , 2014, Diabetes Care.

[13]  D. Kent Age-related macular degeneration: Beyond anti-angiogenesis , 2014, Molecular vision.

[14]  Pierre Baldi,et al.  Combining docking site and phosphosite predictions to find new substrates: identification of smoothelin-like-2 (SMTNL2) as a c-Jun N-terminal kinase (JNK) substrate. , 2013, Cellular signalling.

[15]  Cheng-Jun Hu,et al.  STAT3 or USF2 Contributes to HIF Target Gene Specificity , 2013, PloS one.

[16]  Aziz A. Khanifar,et al.  Age-related macular degeneration: choroidal ischaemia? , 2013, British Journal of Ophthalmology.

[17]  H. Takeshima,et al.  Hypoxia-induced decreases in SOCS3 increase STAT3 activation and upregulate VEGF gene expression , 2013, Brain Tumor Pathology.

[18]  Y. Le,et al.  Impacts of hypoxia-inducible factor-1 knockout in the retinal pigment epithelium on choroidal neovascularization. , 2012, Investigative ophthalmology & visual science.

[19]  G. Semenza Molecular mechanisms mediating metastasis of hypoxic breast cancer cells. , 2012, Trends in molecular medicine.

[20]  C. Grimm,et al.  From oxygen to erythropoietin: Relevance of hypoxia for retinal development, health and disease , 2012, Progress in Retinal and Eye Research.

[21]  G. Ying,et al.  THE ASSOCIATION BETWEEN DRUSEN EXTENT AND FOVEOLAR CHOROIDAL BLOOD FLOW IN AGE-RELATED MACULAR DEGENERATION , 2012, Retina.

[22]  C. Grimm,et al.  Retinal degeneration modulates intracellular localization of CDC42 in photoreceptors , 2011, Molecular vision.

[23]  A. Aderem,et al.  Caspase‐1‐induced pyroptotic cell death , 2011, Immunological reviews.

[24]  C. Grimm,et al.  Normoxic activation of hypoxia-inducible factors in photoreceptors provides transient protection against light-induced retinal degeneration. , 2011, Investigative ophthalmology & visual science.

[25]  C. Grimm,et al.  HIF1A is essential for the development of the intermediate plexus of the retinal vasculature. , 2011, Investigative ophthalmology & visual science.

[26]  E. Stefánsson,et al.  Metabolic physiology in age related macular degeneration , 2011, Progress in Retinal and Eye Research.

[27]  C. Grimm,et al.  Retina-specific activation of a sustained hypoxia-like response leads to severe retinal degeneration and loss of vision , 2011, Neurobiology of Disease.

[28]  H. Okano,et al.  von Hippel-Lindau protein regulates transition from the fetal to the adult circulatory system in retina , 2010, Development.

[29]  A. Józkowicz,et al.  HIF-1 and HIF-2 transcription factors — Similar but not identical , 2010, Molecules and cells.

[30]  A. Salminen,et al.  Regulatory role of HIF-1α in the pathogenesis of age-related macular degeneration (AMD) , 2009, Ageing Research Reviews.

[31]  M. Coleman,et al.  Hypoxia, hypoxia-inducible factors (HIF), HIF hydroxylases and oxygen sensing , 2009, Cellular and Molecular Life Sciences.

[32]  C. Grimm,et al.  Endogenous leukemia inhibitory factor protects photoreceptor cells against light-induced degeneration , 2009, Molecular vision.

[33]  C. Grimm,et al.  Retinal neuroprotection by hypoxic preconditioning is independent of hypoxia‐inducible factor‐1α expression in photoreceptors , 2009, The European journal of neuroscience.

[34]  B. Feigl Age-related maculopathy – Linking aetiology and pathophysiological changes to the ischaemia hypothesis , 2008, Progress in Retinal and Eye Research.

[35]  Gordon L. Fain,et al.  ATP Consumption by Mammalian Rod Photoreceptors in Darkness and in Light , 2008, Current Biology.

[36]  C. Grimm,et al.  Leukemia Inhibitory Factor Extends the Lifespan of Injured Photoreceptors In Vivo , 2008, The Journal of Neuroscience.

[37]  Tae-You Kim,et al.  STAT3 inhibits the degradation of HIF-1α by pVHL-mediated ubiquitination , 2008, Experimental & Molecular Medicine.

[38]  M. Chung,et al.  STAT3 inhibits the degradation of HIF-1alpha by pVHL-mediated ubiquitination. , 2008, Experimental & molecular medicine.

[39]  C. Grimm,et al.  Analysis of the retinal gene expression profile after hypoxic preconditioning identifies candidate genes for neuroprotection , 2008, BMC Genomics.

[40]  R. Johnson,et al.  Acute postnatal ablation of Hif-2α results in anemia , 2007, Proceedings of the National Academy of Sciences.

[41]  R. Johnson,et al.  Acute postnatal ablation of Hif-2alpha results in anemia. , 2007, Proceedings of the National Academy of Sciences of the United States of America.

[42]  C. Grimm,et al.  Caspase-1 ablation protects photoreceptors in a model of autosomal dominant retinitis pigmentosa. , 2006, Investigative ophthalmology & visual science.

[43]  C. Grimm,et al.  The FASEB Journal • FJ Express Full-Length Article Differential role of Jak-STAT signaling in retinal degenerations , 2022 .

[44]  Y. Le,et al.  Mouse opsin promoter-directed Cre recombinase expression in transgenic mice. , 2006, Molecular vision.

[45]  G. Ying,et al.  Reduced foveolar choroidal blood flow in eyes with increasing AMD severity. , 2005, Investigative ophthalmology & visual science.

[46]  Suk-tak Chan,et al.  The Effect of Age on Ocular Blood Supply Determined by Pulsatile Ocular Blood Flow and Color Doppler Ultrasonography , 2003, Optometry and vision science : official publication of the American Academy of Optometry.

[47]  C. Grimm,et al.  HIF-1-induced erythropoietin in the hypoxic retina protects against light-induced retinal degeneration , 2002, Nature Medicine.

[48]  Michael I. Wilson,et al.  Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O2-Regulated Prolyl Hydroxylation , 2001, Science.

[49]  M. Jaye,et al.  Hypoxia induces the expression of the pro-apoptotic gene BNIP3 , 2001, Cell Death and Differentiation.

[50]  R. Jaenisch,et al.  Vascular tumors in livers with targeted inactivation of the von Hippel-Lindau tumor suppressor. , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[51]  J. M. Arbeit,et al.  Hypoxia-inducible Factor-1α Is a Positive Factor in Solid Tumor Growth , 2000 .

[52]  D. Farber,et al.  A QTL on distal Chromosome 3 that influences the severity of light-induced damage to mouse photoreceptors , 2000, Mammalian Genome.

[53]  J. M. Arbeit,et al.  Hypoxia-inducible factor-1alpha is a positive factor in solid tumor growth. , 2000, Cancer research.

[54]  R P Danis,et al.  Color Doppler imaging discloses reduced ocular blood flow velocities in nonexudative age-related macular degeneration. , 1999, American journal of ophthalmology.

[55]  C. Wykoff,et al.  The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis , 1999, Nature.

[56]  W. Hauswirth,et al.  Ribozyme rescue of photoreceptor cells in a transgenic rat model of autosomal dominant retinitis pigmentosa , 1998, Nature Medicine.

[57]  M. Wolzt,et al.  Age Dependence of Choroidal Blood Flow , 1998, Journal of the American Geriatrics Society.

[58]  C. Curcio,et al.  Photoreceptor loss in age-related macular degeneration. , 1996, Investigative ophthalmology & visual science.