Biological Stimuli-responsive Polymer Systems: Design, Construction and Controlled Self-assembly

Biological stimuli-responsive polymers have increasingly attracted attention in recent years because it can satisfy many requirements of applications related with human body while traditional systems do not meet. Due to the importance of this burgeoning field, great efforts have been devoted and, up to now, polymer chemists have made a remarkable success in this prospective research topic. In this review, we systematically generalize the present state of biological stimuli-responsive polymer systems. We highlight several representative examples to specify the current problems and look ahead a clear sense of direction in this area.

[1]  Andrew J. Boydston,et al.  Controlled Depolymerization: Stimuli-Responsive Self-Immolative Polymers , 2012 .

[2]  Yue Zhao,et al.  A new design for light-breakable polymer micelles. , 2005, Journal of the American Chemical Society.

[3]  S. Snyder,et al.  Signaling by Gasotransmitters , 2009, Science Signaling.

[4]  Jin-Zhi Du,et al.  Tailor-made dual pH-sensitive polymer-doxorubicin nanoparticles for efficient anticancer drug delivery. , 2011, Journal of the American Chemical Society.

[5]  Mark T. Gladwin,et al.  Vascular biology: Nitric oxide caught in traffic , 2012, Nature.

[6]  B. Sumerlin,et al.  Future perspectives and recent advances in stimuli-responsive materials , 2010 .

[7]  Jean-François Lutz,et al.  Point by point comparison of two thermosensitive polymers exhibiting a similar LCST: is the age of poly(NIPAM) over? , 2006, Journal of the American Chemical Society.

[8]  Uma Sampathkumaran,et al.  Fluorescent-dye-doped sol-gel sensor for highly sensitive carbon dioxide gas detection below atmospheric concentrations. , 2010, Analytical chemistry.

[9]  Ke Zhang,et al.  Light-triggered, self-immolative nucleic Acid-drug nanostructures. , 2015, Journal of the American Chemical Society.

[10]  Hossein Derakhshankhah,et al.  Classification of stimuli–responsive polymers as anticancer drug delivery systems , 2015, Drug delivery.

[11]  Zhiyuan Zhong,et al.  Glutathione-responsive nano-vehicles as a promising platform for targeted intracellular drug and gene delivery. , 2011, Journal of controlled release : official journal of the Controlled Release Society.

[12]  Linqi Shi,et al.  Formation of complex micelles with double-responsive channels from self-assembly of two diblock copolymers. , 2006, Angewandte Chemie.

[13]  Rafael Radi,et al.  Chemical biology of peroxynitrite: kinetics, diffusion, and radicals. , 2009, ACS chemical biology.

[14]  Simone Mocellin,et al.  Nitric oxide, a double edged sword in cancer biology: Searching for therapeutic opportunities , 2007, Medicinal research reviews.

[15]  Jinying Yuan,et al.  CO2-responsive polymeric vesicles that breathe. , 2011, Angewandte Chemie.

[16]  Faisal A. Aldaye,et al.  Assembling Materials with DNA as the Guide , 2008, Science.

[17]  M. C. Stuart,et al.  Emerging applications of stimuli-responsive polymer materials. , 2010, Nature materials.

[18]  K. Arndt,et al.  Stimuli-Responsive Polymer Systems , 2012 .

[19]  Victor V. Krasnikov,et al.  Supramolecular self-assembly and opto-electronic properties of semiconducting block copolymers , 2001 .

[20]  Yue Zhao,et al.  CO2-stimulated diversiform deformations of polymer assemblies. , 2013, Journal of the American Chemical Society.

[21]  Ziyu Lv,et al.  Smart drug release systems based on stimuli-responsive polymers. , 2013, Mini reviews in medicinal chemistry.

[22]  C. Boyer,et al.  Biomimetic polymers responsive to a biological signaling molecule: nitric oxide triggered reversible self-assembly of single macromolecular chains into nanoparticles. , 2014, Angewandte Chemie.

[23]  B. Jeong,et al.  CO2 - and O2 -sensitive fluorophenyl end-capped poly(ethylene glycol). , 2014, Macromolecular rapid communications.

[24]  P. Meers,et al.  Enzyme-activated targeting of liposomes. , 2001, Advanced drug delivery reviews.

[25]  Hongti Zhang,et al.  A glucose-responsive controlled release of insulin system based on enzyme multilayers-coated mesoporous silica particles. , 2011, Chemical communications.

[26]  Dan Yang,et al.  A highly selective fluorescent probe for the detection and imaging of peroxynitrite in living cells. , 2006, Journal of the American Chemical Society.

[27]  R. Banerjee,et al.  H2S and its role in redox signaling. , 2014, Biochimica et biophysica acta.

[28]  H. Sleiman,et al.  Supramolecular DNA assembly. , 2011, Chemical Society reviews.

[29]  Patrick Couvreur,et al.  Stimuli-responsive nanocarriers for drug delivery. , 2013, Nature materials.

[30]  Jun Hu,et al.  Peroxynitrite (ONOO-) Redox Signaling Molecule-Responsive Polymersomes. , 2016, ACS macro letters.

[31]  H. Taguchi,et al.  Biomolecular robotics for chemomechanically driven guest delivery fuelled by intracellular ATP. , 2013, Nature chemistry.

[32]  Hui-wang Ai,et al.  Genetically encoded fluorescent probe for the selective detection of peroxynitrite. , 2013, Journal of the American Chemical Society.

[33]  Jie Tian,et al.  Reversibly Switching Bilayer Permeability and Release Modules of Photochromic Polymersomes Stabilized by Cooperative Noncovalent Interactions. , 2015, Journal of the American Chemical Society.

[34]  Chen-Ho Tung,et al.  Design strategies of fluorescent probes for selective detection among biothiols. , 2015, Chemical Society reviews.

[35]  Shiping Zhu,et al.  Oxygen and Carbon Dioxide Dual Responsive Nanoaggregates of Fluoro- and Amino-Containing Copolymer. , 2014, ACS macro letters.

[36]  S Thayumanavan,et al.  Noncovalent encapsulation stabilities in supramolecular nanoassemblies. , 2010, Journal of the American Chemical Society.

[37]  N. Seeman.  DNA in a material world , 2003, Nature.

[38]  P. Moore,et al.  Hydrogen sulfide and cell signaling. , 2011, Annual review of pharmacology and toxicology.

[39]  S. Remington,et al.  The N-B Interaction through a Water Bridge: Understanding the Chemoselectivity of a Fluorescent Protein Based Probe for Peroxynitrite. , 2016, Journal of the American Chemical Society.

[40]  S. Armes,et al.  Stimuli-Responsive Polymer Ultrathin Films with a Binary Architecture: Combined Layer-by-Layer Polyelectrolyte and Surface-Initiated Polymerization Approach , 2008 .

[41]  C. Piantadosi.  Carbon monoxide, reactive oxygen signaling, and oxidative stress. , 2008, Free radical biology & medicine.

[42]  J. Feijen,et al.  Redox and pH-responsive degradable micelles for dually activated intracellular anticancer drug release. , 2013, Journal of controlled release : official journal of the Controlled Release Society.

[43]  Adah Almutairi,et al.  UV and near-IR triggered release from polymeric nanoparticles. , 2010, Journal of the American Chemical Society.

[44]  Wei Cao,et al.  Red light responsive diselenide-containing block copolymer micelles. , 2013, Journal of materials chemistry. B.

[45]  James B. Mitchell,et al.  Noninvasive imaging of tumor redox status and its modification by tissue glutathione levels. , 2002, Cancer research.

[46]  Kyle E Broaders,et al.  A biocompatible oxidation-triggered carrier polymer with potential in therapeutics. , 2011, Journal of the American Chemical Society.

[47]  Ying Li,et al.  Dual redox responsive assemblies formed from diselenide block copolymers. , 2010, Journal of the American Chemical Society.

[48]  J. Tour,et al.  Green carbon as a bridge to renewable energy. , 2010, Nature materials.

[49]  Zhen Gu,et al.  ATP-triggered anticancer drug delivery , 2014, Nature Communications.

[50]  Rein V Ulijn,et al.  Enzyme-assisted self-assembly under thermodynamic control. , 2009, Nature nanotechnology.

[51]  Wei Sang,et al.  Hydrogen Polysulfide Biosignal-Responsive Polymersomes as a Nanoplatform for Distinguishing Intracellular Reactive Sulfur Species (RSS). , 2017, Small.

[52]  S. Armes,et al.  A Schizophrenic Water-Soluble Diblock Copolymer. , 2001, Angewandte Chemie.

[53]  Jun Hu,et al.  CO-Signaling Molecule-Responsive Nanoparticles Formed from Palladium-Containing Block Copolymers. , 2017, ACS macro letters.

[54]  J. Sethi,et al.  Carbon monoxide and human disease. , 2002, Antioxidants & redox signaling.

[55]  M. Jayakannan,et al.  Enzyme and pH dual responsive l-amino acid based biodegradable polymer nanocarrier for multidrug delivery to cancer cells , 2016 .

[56]  Yuting Li,et al.  Thermally responsive vesicles and their structural "locking" through polyelectrolyte complex formation. , 2006, Angewandte Chemie.

[57]  Cornelia G Palivan,et al.  Stimuli-Responsive Polymers and Their Applications in Nanomedicine , 2012, Biointerphases.

[58]  Zhiqian Guo,et al.  A benzobisimidazolium-based fluorescent and colorimetric chemosensor for CO2. , 2012, Journal of the American Chemical Society.

[59]  J. Hurd.  Synthesis and self-assembly of copolymers , 2004 .

[60]  Reuben T Chacko,et al.  Self-cross-linked polymer nanogels: a versatile nanoscopic drug delivery platform. , 2010, Journal of the American Chemical Society.

[61]  Roey J. Amir,et al.  Enzymatically triggered self-assembly of block copolymers. , 2009, Journal of the American Chemical Society.

[62]  Yue Zhao,et al.  ATP-triggered biomimetic deformations of bioinspired receptor-containing polymer assemblies , 2015, Chemical science.

[63]  H. Kimura.  Physiological role of hydrogen sulfide and polysulfide in the central nervous system , 2013, Neurochemistry International.

[64]  Yongming Zhang,et al.  A novel smart polymer responsive to CO2. , 2011, Chemical communications.

[65]  Xinge Zhang,et al.  Block versus Random Amphiphilic Glycopolymer Nanopaticles as Glucose-Responsive Vehicles. , 2015, Biomacromolecules.

[66]  Anzar Khan,et al.  Enzyme sensitive synthetic polymer micelles based on the azobenzene motif. , 2013, Journal of the American Chemical Society.

[67]  Young Jik Kwon,et al.  Stimuli-responsive polymers and nanomaterials for gene delivery and imaging applications. , 2012, Advanced drug delivery reviews.

[68]  I. Manners,et al.  Redox-mediated synthesis and encapsulation of inorganic nanoparticles in shell-cross-linked cylindrical polyferrocenylsilane block copolymer micelles. , 2008, Journal of the American Chemical Society.

[69]  John-Christopher Boyer,et al.  Near-infrared light-triggered dissociation of block copolymer micelles using upconverting nanoparticles. , 2011, Journal of the American Chemical Society.

[70]  Wei Sang,et al.  H2S gasotransmitter-responsive polymer vesicles , 2015, Chemical science.

[71]  J Gutknecht,et al.  Diffusion of carbon dioxide through lipid bilayer membranes. Effects of carbonic anhydrase, bicarbonate, and unstirred layers , 1977, The Journal of general physiology.

[72]  Xiaorui Wang,et al.  Enzyme-Responsive Polymeric Vesicles for Bacterial-Strain-Selective Delivery of Antimicrobial Agents. , 2016, Angewandte Chemie.

[73]  H. Yoon,et al.  Expression of a glutathione reductase from Brassica rapa subsp. pekinensis enhanced cellular redox homeostasis by modulating antioxidant proteins in Escherichia coli , 2009, Molecules and cells.

[74]  Xi Zhang,et al.  An enzyme-responsive polymeric superamphiphile. , 2010, Angewandte Chemie.

[75]  Reuben T Chacko,et al.  Surface-functionalizable polymer nanogels with facile hydrophobic guest encapsulation capabilities. , 2010, Journal of the American Chemical Society.

[76]  R. Zhuo,et al.  Biological glucose metabolism regulated peptide self-assembly as a simple visual biosensor for glucose detection. , 2012, Macromolecular rapid communications.

[77]  Xiao Feng,et al.  A fluorescent probe with an aggregation-enhanced emission feature for real-time monitoring of low carbon dioxide levels , 2015 .

[78]  T. Peng,et al.  HKGreen-3: a rhodol-based fluorescent probe for peroxynitrite. , 2010, Organic letters.

[79]  A. Nagy,et al.  Chemical aspects of hydrogen sulfide measurements in physiological samples. , 2014, Biochimica et biophysica acta.

[80]  H. Sleiman,et al.  Site-specific positioning of dendritic alkyl chains on DNA cages enables their geometry-dependent self-assembly. , 2013, Nature chemistry.

[81]  V. Torchilin.  Multifunctional, stimuli-sensitive nanoparticulate systems for drug delivery , 2014, Nature Reviews Drug Discovery.

[82]  Roey J. Amir,et al.  Modular Synthetic Approach for Adjusting the Disassembly Rates of Enzyme-Responsive Polymeric Micelles. , 2017, Biomacromolecules.

[83]  Csaba Szabó,et al.  Peroxynitrite: biochemistry, pathophysiology and development of therapeutics , 2007, Nature Reviews Drug Discovery.

[84]  Kyoung Taek Kim,et al.  Monosaccharide-responsive release of insulin from polymersomes of polyboroxole block copolymers at neutral pH. , 2012, Journal of the American Chemical Society.

[85]  Paul W. Wiseman,et al.  Sequence-responsive unzipping DNA cubes with tunable cellular uptake profiles , 2014 .

[86]  L. Otterbein,et al.  The therapeutic potential of carbon monoxide , 2010, Nature Reviews Drug Discovery.

[87]  H. El‐Nezami,et al.  Molecular imaging of peroxynitrite with HKGreen-4 in live cells and tissues. , 2014, Journal of the American Chemical Society.

[88]  Sébastien Lecommandoux,et al.  Reversible inside-out micellization of pH-responsive and water-soluble vesicles based on polypeptide diblock copolymers. , 2005, Journal of the American Chemical Society.

[89]  Roey J. Amir,et al.  Enzyme-responsive amphiphilic PEG-dendron hybrids and their assembly into smart micellar nanocarriers. , 2014, Journal of the American Chemical Society.

[90]  T. Aida,et al.  Boronic Acid-Appended Molecular Glues for ATP-Responsive Activity Modulation of Enzymes. , 2016, Journal of the American Chemical Society.