Increased prokineticin 2 expression in gut inflammation: role in visceral pain and intestinal ion transport

Background  Prokineticin 2 (PROK2) is an inflammatory cytokine‐like molecule expressed predominantly by macrophages and neutrophils infiltrating sites of tissue damage. Given the established role of prokineticin signaling on gastrointestinal function, we have explored Prok2 gene expression in inflammatory conditions of the gastrointestinal tract and assessed the possible consequences on gut physiology.

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