A branched chain amino acid metabolite drives vascular transport of fat and causes insulin resistance

[1]  Y. Kamei,et al.  Metabolomic Analysis of the Skeletal Muscle of Mice Overexpressing PGC-1α , 2015, PloS one.

[2]  M. Birnbaum,et al.  Hepatic Insulin Signaling is Dispensable for Suppression of Glucose Output by Insulin in Vivo , 2015, Nature Communications.

[3]  H. Daniel,et al.  Metabolite profiling in plasma and tissues of ob/ob and db/db mice identifies novel markers of obesity and type 2 diabetes , 2015, Diabetologia.

[4]  G. Shulman Ectopic fat in insulin resistance, dyslipidemia, and cardiometabolic disease. , 2014, The New England journal of medicine.

[5]  R. Arena,et al.  Analysis of skeletal muscle gene expression patterns and the impact of functional capacity in patients with systolic heart failure. , 2014, Journal of cardiac failure.

[6]  Mun Chun Chan,et al.  The many roles of PGC-1α in muscle--recent developments. , 2014, Metabolism: clinical and experimental.

[7]  F. Jaffer,et al.  Endothelial PGC-1α mediates vascular dysfunction in diabetes. , 2014, Cell metabolism.

[8]  Chad A. Cowan,et al.  β-Aminoisobutyric acid induces browning of white fat and hepatic β-oxidation and is inversely correlated with cardiometabolic risk factors. , 2014, Cell metabolism.

[9]  P. Rustin,et al.  Disconnecting mitochondrial content from respiratory chain capacity in PGC-1-deficient skeletal muscle. , 2013, Cell reports.

[10]  C. Bertozzi,et al.  Real-time noninvasive imaging of fatty acid uptake in vivo. , 2012, ACS chemical biology.

[11]  Shoko Iwaki,et al.  Vascular endothelial hyperpermeability induces the clinical symptoms of Clarkson disease (the systemic capillary leak syndrome). , 2012, Blood.

[12]  C. Newgard Interplay between lipids and branched-chain amino acids in development of insulin resistance. , 2012, Cell metabolism.

[13]  V. Mootha,et al.  Metabolite profiles and the risk of developing diabetes , 2011, Nature Medicine.

[14]  S. Stone-Elander,et al.  Vascular endothelial growth factor B controls endothelial fatty acid uptake , 2010, Nature.

[15]  K. Ohlendieck,et al.  Proteomic profiling of non-obese type 2 diabetic skeletal muscle. , 2010, International journal of molecular medicine.

[16]  Svati H Shah,et al.  A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance. , 2009, Cell metabolism.

[17]  Jiandie D. Lin,et al.  Paradoxical effects of increased expression of PGC-1α on muscle mitochondrial function and insulin-stimulated muscle glucose metabolism , 2008, Proceedings of the National Academy of Sciences.

[18]  D. Kwiatkowski,et al.  Regulation of Endothelial Nitric Oxide Synthase and Postnatal Angiogenesis by Rac1 , 2008, Circulation research.

[19]  B. Spiegelman,et al.  HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1α , 2008, Nature.

[20]  B. Spiegelman,et al.  The transcriptional coactivator PGC-1beta drives the formation of oxidative type IIX fibers in skeletal muscle. , 2007, Cell metabolism.

[21]  B. Spiegelman,et al.  Peroxisome proliferator-activated receptor gamma coactivator 1 coactivators, energy homeostasis, and metabolism. , 2006, Endocrine reviews.

[22]  D. Darland,et al.  TGFβ is required for the formation of capillary-like structures in three-dimensional cocultures of 10T1/2 and endothelial cells , 2004, Angiogenesis.

[23]  Jiandie D. Lin,et al.  Transcriptional co-activator PGC-1α drives the formation of slow-twitch muscle fibres , 2002, Nature.

[24]  Jiandie D. Lin,et al.  Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibres. , 2002, Nature.

[25]  M. Sasaki,et al.  A severely brain-damaged case of 3-hydroxyisobutyric aciduria , 2001, Brain and Development.

[26]  D. Darland,et al.  TGF beta is required for the formation of capillary-like structures in three-dimensional cocultures of 10T1/2 and endothelial cells. , 2001, Angiogenesis.

[27]  J. Greenwood,et al.  Development and characterisation of a rat brain capillary endothelial culture: towards an in vitro blood-brain barrier. , 1992, Journal of cell science.

[28]  A. Avogaro,et al.  Contribution of 3-hydroxyisobutyrate to the measurement of 3-hydroxybutyrate in human plasma: comparison of enzymatic and gas-liquid chromatography-mass spectrometry assays in normal and in diabetic subjects. , 1989, Journal of lipid research.