The versatile, changing, and advancing roles of fish in sediment toxicity assessment—a review

[1]  H. Hollert,et al.  The SeKT Joint Research Project: Definition of reference conditions, control sediments and toxicity thresholds for limnic sediment contact tests (2 pp) , 2005, Environmental science and pollution research international.

[2]  M. Roberts,et al.  Effects of contaminated sediments and sediment-exposed effluent water on an estuarine fish: Acute toxicity , 1984 .

[3]  B. Nowak,et al.  Histological, growth and 7-ethoxyresorufin O-deethylase (EROD) activity responses of greenback flounder Rhombosolea tapirina to contaminated marine sediment and diet. , 2001, Aquatic toxicology.

[4]  H. Köhler,et al.  Developmental toxicity and stress protein responses in zebrafish embryos after exposure to diclofenac and its solvent, DMSO. , 2004, Chemosphere.

[5]  P. Balaguer,et al.  Bioanalytical characterisation of multiple endocrine- and dioxin-like activities in sediments from reference and impacted small rivers. , 2010, Environmental pollution.

[6]  T. Braunbeck,et al.  Cytotoxicity of settling particulate matter and sediments of the Neckar River (Germany) during a winter flood , 2000 .

[7]  W. Manz,et al.  A novel statistical approach for the evaluation of comet assay data. , 2008, Mutation research.

[8]  S. Stürzenbaum,et al.  Genes and environment - striking the fine balance between sophisticated biomonitoring and true functional environmental genomics. , 2008, The Science of the total environment.

[9]  T. Rushmore,et al.  Pathogenesis of skin and liver neoplasms in white suckers from industrially polluted areas in Lake Ontario. , 1990, The Science of the total environment.

[10]  J. Lazorchak,et al.  Evaluation of microsomal and cytosolic biomarkers in a seven-day larval trout sediment toxicity test , 1995 .

[11]  D. Klumpp,et al.  Toxic contaminants and their biological effects in coastal waters of Xiamen, China. I. Organic pollutants in mussel and fish tissues. , 2002, Marine pollution bulletin.

[12]  Markus Reischl,et al.  Zebrafish embryos as models for embryotoxic and teratological effects of chemicals. , 2009, Reproductive toxicology.

[13]  R. Triebskorn,et al.  Fish early life stage tests as a tool to assess embryotoxic potentials in small streams , 2001 .

[14]  G. A. Burton,et al.  Assessing the toxicity of freshwater sediments , 1991 .

[15]  K. Schirmer.  Proposal to improve vertebrate cell cultures to establish them as substitutes for the regulatory testing of chemicals and effluents using fish. , 2006, Toxicology.

[16]  U. Förstner,et al.  Data Quality Assurance of Sediment Monitoring , 2008 .

[17]  A. Brouwer,et al.  Alterations in plasma and hepatic retinoid levels in flounder (Platichthys flesus) after chronic exposure to contaminated harbour sludge in a mesocosm study , 1998 .

[18]  J. F. Skidmore.  Resistance to zinc sulphate of the zebrafish (Brachydanio rerio Hamilton-Buchanan) at different phases of its life history. , 1965, The Annals of applied biology.

[19]  H. Segner.  Cytotoxicity Assays with Fish Cells as an Alternative to the Acute Lethality Test with Fish , 2004, Alternatives to laboratory animals : ATLA.

[20]  T. A. DelValls,et al.  Determining sediment quality for regulatory proposes using fish chronic bioassays. , 2007, Environment International.

[21]  J. Stein,et al.  Accumulation and dose-response of hepatic DNA adducts in English sole (Pleuronectes vetulus) exposed to a gradient of contaminated sediments , 1996 .

[22]  K. Adeli,et al.  Development of a Rapid and Simple Genotoxicity Assay Using a Brown Bullhead Fish Cell-Line: Application to Toxicological Surveys of Sediments in the Huron-Erie Corridor , 1993 .

[23]  K. Solomon,et al.  New concepts in ecological risk assessment: where do we go from here? , 2002, Marine pollution bulletin.

[24]  F. Kelly,et al.  THE WATER FRAMEWORK DIRECTIVE: USING FISH AS A MANAGEMENT TOOL , 2022, Biology and Environment: Proceedings of the Royal Irish Academy.

[25]  R. Triebskorn,et al.  Assessment of the developmental success of brown trout (Salmo trutta f. fario L.) embryos in two differently polluted streams in Germany , 2004, Hydrobiologia.

[26]  D. Dixon,et al.  The use of fish cell cultures as an indication of contaminant toxicity to fish , 1985 .

[27]  P. Hodson,et al.  Evaluation of an Exposure Assay to Measure Uptake of Sediment Pah by Fish , 2006, Environmental monitoring and assessment.

[28]  P. Chapman.  Survey of biological effects of toxicants upon Puget Sound biota. I. Broad-scale toxicity survey , 1982 .

[29]  L. Viganò,et al.  Biomarkers of exposure and effect in flounder (Platichthys flesus) exposed to sediments of the Adriatic sea. , 2001, Marine pollution bulletin.

[30]  J. B. Sprague.  Measurement of pollutant toxicity to fish I. Bioassay methods for acute toxicity , 1969 .

[31]  C. Mothersill,et al.  Identification of a multixenobiotic resistance mechanism in primary cultured epidermal cells from Oncorhynchus mykiss and the effects of environmental complex mixtures on its activity. , 2005, Aquatic toxicology.

[32]  S. Caeiro,et al.  Toxicity ranking of estuarine sediments on the basis of Sparus aurata biomarkers , 2007, Environmental toxicology and chemistry.

[33]  M. Stanton,et al.  HEPATIC NEOPLASMS IN NATIVE BOTTOM-FEEDING FISH OF DEEP CREEK LAKE, MARYLAND. , 1964, Cancer research.

[34]  Monika Nendza,et al.  Inventory of marine biotest methods for the evaluation of dredged material and sediments. , 2002, Chemosphere.

[35]  William G. Brumbaugh,et al.  Toxicity of metal-contaminated sediments from the upper Clark Fork River, Montana, to aquatic invertebrates and fish in laboratory exposures , 1994 .

[36]  H. Köhler,et al.  Assessing water quality in a tropical lake using biomarkers in zebrafish embryos: developmental toxicity and stress protein responses , 2005, Environmental monitoring and assessment.

[37]  S. Scholz,et al.  Gene expression analysis in zebrafish embryos: A potential approach to predict effect concentrations in the fish early life stage test , 2009, Environmental toxicology and chemistry.

[38]  P. Balaguer,et al.  Assessment of Estrogen (ER) and Aryl Hydrocarbon Receptor (AhR) Mediated Activities in Organic Sediment Extracts of the Detroit River, Using In Vitro Bioassays Based on Human MELN and Teleost PLHC-1 Cell Lines , 2004 .

[39]  K. Munkittrick,et al.  An Ecological Impact Assessment Framework for Decision-Making Related to Sediment Quality , 1991 .

[40]  D. Cyr,et al.  Exposure of male american plaice (Hippoglossoides platessoides) to contaminated marine sediments decreases the hatching success of their progeny , 1997 .

[41]  R. Peddicord,et al.  Ecological Evaluation of Proposed Discharge of Dredged Material into Ocean Waters. , 1977 .

[42]  G. Ankley,et al.  Integrated assessment of contaminated sediments in the lower Fox River and Green Bay, Wisconsin. , 1992, Ecotoxicology and environmental safety.

[43]  R. Nagel.  DarT: The embryo test with the Zebrafish Danio rerio--a general model in ecotoxicology and toxicology. , 2002, ALTEX.

[44]  Gerald T. Ankley,et al.  Methods for measuring the toxicity and bioaccumulation of sediment-associated contaminants with freshwater invertebrates , 1994 .

[45]  U. Kammann.  PAH Metabolites in Bile Fluids of Dab (Limanda limanda) and Flounder (Platichthys flesus): Spatial Distribution and Seasonal Changes (7 pp) , 2007, Environmental science and pollution research international.

[46]  T. Braunbeck,et al.  Changes in toxicity and Ah receptor agonist activity of suspended particulate matter during flood events at the rivers Neckar and Rhine — a mass balance approach using in vitro methods and chemical analysis , 2008, Environmental science and pollution research international.

[47]  D. Spira,et al.  Variability of sediment-contact tests in freshwater sediments with low-level anthropogenic contamination--determination of toxicity thresholds. , 2010, Environmental pollution.

[48]  H. Hühnerfuss,et al.  Genotoxic and teratogenic potential of marine sediment extracts investigated with comet assay and zebrafish test. , 2004, Environmental pollution.

[49]  P. Chapman,et al.  Assessing sediment contamination in estuaries , 2001, Environmental toxicology and chemistry.

[50]  Peter M Chapman,et al.  Pore water testing and analysis: the good, the bad, and the ugly. , 2002, Marine pollution bulletin.

[51]  J. Snodgrass,et al.  Altered Swimming Performance of a Benthic Fish (Erimyzon sucetta) Exposed to Contaminated Sediments , 2003, Archives of environmental contamination and toxicology.

[52]  P. C. Francis,et al.  Effects of cadmium-enriched sediment on fish and amphibian embryo-larval stages. , 1984, Ecotoxicology and environmental safety.

[53]  S. Anderson,et al.  Effects of contaminants on genetic patterns in aquatic organisms: a review. , 2001, Mutation research.

[54]  M. E. Hahn,et al.  Cytochrome P4501A Induction and Porphyrin Accumulation in PLHC-1 Fish Cells Exposed to Sediment and Oil Shale Extracts , 2000, Archives of environmental contamination and toxicology.

[55]  E. Gallagher,et al.  Effects of Black Rock Harbor sediments on indices of biotransformation, oxidative stress, and DNA integrity in channel catfish , 1993 .

[56]  P. Seel,et al.  Der Embryotest mit dem Zebrabärbling - eine neue Möglichkeit zur Prüfung und Bewertung der Toxizität von Abwasserproben , 1995 .

[57]  W. E. Bishop,et al.  Aquatic Toxicology and Hazard Assessment: Sixth Symposium , 1983 .

[58]  T. A. DelValls,et al.  Evaluation of heavy metal sediment toxicity in littoral ecosystems using juveniles of the fish Sparus aurata. , 1998, Ecotoxicology and environmental safety.

[59]  H. Steinhart,et al.  A permanent fish cell line (EPC) for genotoxicity testing of marine sediments with the comet assay. , 2001, Mutation research.

[60]  J. Giesy,et al.  Freshwater Sediment Toxicity Bioassessment: Rationale for Species Selection and Test Design , 1989 .

[61]  R. Ishaq,et al.  A bio-effect directed fractionation study for toxicological and chemical characterization of organic compounds in bottom sediment. , 2005, Toxicological sciences : an official journal of the Society of Toxicology.

[62]  Amer M. Diab,et al.  Hepatic gene expression in flounder chronically exposed to multiply polluted estuarine sediment: Absence of classical exposure 'biomarker' signals and induction of inflammatory, innate immune and apoptotic pathways. , 2010, Aquatic toxicology.

[63]  C. Mothersill,et al.  Effects of contaminated sediment from Cork Harbour, Ireland on the cytochrome P450 system of turbot. , 2009, Ecotoxicology and environmental safety.

[64]  T. Braunbeck,et al.  Isolated hepatocytes of rainbow trout (Oncorhynchus mykiss) as a tool to discriminate between differently contaminated small river systems. , 2000, Toxicology in vitro : an international journal published in association with BIBRA.

[65]  G. A. Burton,et al.  Toxicity and bioaccumulation of sediment-associated contaminants using freshwater invertebrates: A review of methods and applications , 1995 .

[66]  T. Schulze,et al.  The risk of altering soil and sediment samples upon extract preparation for analytical and bio-analytical investigations—a review , 2008, Analytical and bioanalytical chemistry.

[67]  N. Garcia-Reyero,et al.  Fish 'n' chips: the use of microarrays for aquatic toxicology. , 2007, Molecular bioSystems.

[68]  T. Braunbeck,et al.  DNA damage induced by genotoxicants in zebrafish (Danio rerio) embryos after contact exposure to freeze-dried sediment and sediment extracts from Laguna Lake (The Philippines) as measured by the comet assay. , 2008, Mutation research.

[69]  T. Braunbeck,et al.  Assessment of water and sediment contamination in small streams by means of cytological and biochemical alterations in isolated rainbow trout (Oncorhynchus mykiss) hepatocytes , 2001 .

[70]  O. Parra,et al.  Bioavailability of PAHs in the Biobio river (Chile): MFO activity and biliary fluorescence in juvenile Oncorhynchus mykiss. , 2001, Chemosphere.

[71]  A. Castaño,et al.  Correlations between the RTG-2 cytotoxicity test EC50 and in vivo LC50 rainbow trout bioassay , 1996 .

[72]  H. Steinhart,et al.  Bioassay-directed Fractionation of Organic Extracts of Marine Surface Sediments from the North and Baltic Sea - Part II: Results of the biotest battery and development of a biotest index (8 pp) , 2005 .

[73]  M. Westerfield.  The zebrafish book : a guide for the laboratory use of zebrafish (Danio rerio) , 1995 .

[74]  K. Fent.  Fish cell lines as versatile tools in ecotoxicology: assessment of cytotoxicity, cytochrome P4501A induction potential and estrogenic activity of chemicals and environmental samples. , 2001, Toxicology in vitro : an international journal published in association with BIBRA.

[75]  J. J. Black.  Field and Laboratory Studies of Environmental Carcinogenesis in Niagara River Fish , 1983 .

[76]  Markus Hecker,et al.  Effect-directed analysis (EDA) in aquatic ecotoxicology: state of the art and future challenges , 2009, Environmental science and pollution research international.

[77]  Christoph Schulte,et al.  Testing Acute Toxicity in the Embryo of Zebrafish, Brachydanio rerio, as an Alternative to the Acute Fish Test: Preliminary Results , 1994 .

[78]  W. Liss,et al.  Evidence from whole-sediment, porewater, and elutriate testing in toxicity assessment of contaminated sediments. , 1997, Ecotoxicology and environmental safety.

[79]  L. Bat.  A Review of Sediment Toxicity Bioassays Using the Amphipods and Polychaetes , 2005 .

[80]  G. Klobučar,et al.  Genotoxicity monitoring of freshwater environments using caged carp (Cyprinus carpio) , 2010, Ecotoxicology.

[81]  L. Folmar,et al.  Array technology as a tool to monitor exposure of fish to xenoestrogens. , 2002, Marine environmental research.

[82]  O. Zapata-Pérez,et al.  Toxicity of sediments from Bahía de Chetumal, México, as assessed by hepatic EROD induction and histology in nile tilapia Oreochromis niloticus. , 2000, Marine environmental research.

[83]  Histochemical and biochemical markers in trout larvae exposed to river sediments , 1998 .

[84]  P. Olsvik,et al.  Gene expression profiling in atlantic cod (Gadus Morhua L.) from two contaminated sites using a custom‐made cDNA microarray , 2009, Environmental toxicology and chemistry.

[85]  C. Mothersill,et al.  Genotoxicity of field‐collected inter‐tidal sediments from Cork Harbor, Ireland, to juvenile turbot (Scophthalmus maximus L.) as measured by the Comet assay , 2004, Environmental and molecular mutagenesis.

[86]  Relationship of per cent mortality of four species of aquatic biota from 96-hour sediment bioassays of five lake Michigan harbors and elutriate chemistry of the sediments , 1980, Bulletin of environmental contamination and toxicology.

[87]  T. Braunbeck,et al.  Sediment genotoxicity in the Tietê River (São Paulo, Brazil): in vitro comet assay versus in situ micronucleus assay studies. , 2009, Ecotoxicology and environmental safety.

[88]  W. Brack,et al.  Effect-directed identification of oxygen and sulfur heterocycles as major polycyclic aromatic cytochrome P4501A-inducers in a contaminated sediment. , 2003, Environmental science & technology.

[89]  M. Mac,et al.  A bioaccumulation bioassay for freshwater sediments , 1990 .

[90]  F. Gagné,et al.  Evaluation of the Genotoxicity of Environmental Contaminants in Sediments to Rainbow Trout Hepatocytes , 1995 .

[91]  R. Geisler,et al.  Differential gene expression as a toxicant-sensitive endpoint in zebrafish embryos and larvae. , 2007, Aquatic toxicology.

[92]  H. Budzinski,et al.  Characterization of toxic effects of sediment-associated organic pollutants using the lambda transgenic medaka. , 2007, Environmental science & technology.

[93]  G. Dave,et al.  Toxicity of mercury, copper, nickel, lead, and cobalt to embryos and larvae of zebrafish,Brachydanio rerio , 1991, Archives of environmental contamination and toxicology.

[94]  Peter M. Chapman,et al.  Should the Sediment Quality Triad Become a Tetrad, a Pentad, or Possibly even a Hexad? , 2006 .

[95]  Arnold V. Hallare,et al.  Combined effects of temperature and cadmium on developmental parameters and biomarker responses in zebrafish (Danio rerio) embryos , 2005 .

[96]  K. Scott,et al.  Sediment toxicity evaluations , 1992 .

[97]  Björn Ekwall,et al.  SCREENING OF TOXIC COMPOUNDS IN MAMMALIAN CELL CULTURES , 1983, Annals of the New York Academy of Sciences.

[98]  A. Castaño,et al.  Comparison of basal cytotoxicity data between mammalian and fish cell lines: a literature survey. , 2005, Toxicology in vitro : an international journal published in association with BIBRA.

[99]  J. B. Sprague.  Measurement of pollutant toxicity to fish—III: Sublethal effects and “safe” concentrations , 1971 .

[100]  S. Minchin,et al.  A DNA expression array to detect toxic stress response in European flounder (Platichthys flesus). , 2003, Aquatic toxicology.

[101]  Malcolm H. Taylor,et al.  Effects of sediment‐bound zinc contamination on early life stages of the mummichog (Fundulus heteroclitus L.) in the Christina Watershed, Delaware, USA , 2006, Environmental toxicology and chemistry.

[102]  Thomas Braunbeck,et al.  Towards an alternative for the acute fish LC(50) test in chemical assessment: the fish embryo toxicity test goes multi-species -- an update. , 2005, ALTEX.

[103]  R. Gingold,et al.  The weaker points of fish acute toxicity tests and how tests on embryos can solve some issues. , 2007, Environmental pollution.

[104]  Edward P. Kolodziej,et al.  In vivo bioassay‐guided fractionation of marine sediment extracts from the Southern California Bight, USA, for estrogenic activity , 2005, Environmental toxicology and chemistry.

[105]  A. Oikari,et al.  Hepatic responses of gene expression in juvenile brown trout (Salmo trutta lacustris) exposed to three model contaminants applied singly and in combination , 2007, Environmental toxicology and chemistry.

[106]  H. Laale.  The biology and use of zebrafish, Brachydanio rerio in fisheries research. , 1977 .

[107]  R. Nagel,et al.  Toxicity of Binary Chemical Mixtures: Effects on Reproduction of Zebrafish (Brachydanio rerio) , 1997, Archives of environmental contamination and toxicology.

[108]  Biological effect monitoring in dab (Limanda limanda) using gene transcript of CYP1A1 or EROD—a comparison , 2008, Environmental science and pollution research international.

[109]  T. Braunbeck,et al.  Is the fish embryo toxicity test (FET) with the zebrafish (Danio rerio) a potential alternative for the fish acute toxicity test? , 2009, Comparative biochemistry and physiology. Toxicology & pharmacology : CBP.

[110]  S. George,et al.  In vitro alternatives to whole animal testing. Comparative cytotoxicity studies of divalent metals in established cell lines derived from tropical and temperate water fish species in a neutral red assay , 1996 .

[111]  A. E. Wiklund,et al.  Toxicity evaluation by using intact sediments and sediment extracts. , 2005 .

[112]  T. Braunbeck.  Cytological alterations in fish hepatocytes following in vivo and in vitro sublethal exposure to xenobiotics — structural biomarkers of environmental contamination , 1998 .

[113]  C. Mothersill,et al.  Assessing the potential of fish cell lines as tools for the cytotoxicity testing of estuarine sediment aqueous elutriates. , 2005, Toxicology in vitro : an international journal published in association with BIBRA.

[114]  G. A. Burton,et al.  Sediment Toxicity Assessment , 1992 .

[115]  J. Delfino.  Toxic substances in the Great Lakes , 1979 .

[116]  A. Dipple,et al.  METABOLIC PROPERTIES OF IN VITRO SYSTEMS * , 1983, Annals of the New York Academy of Sciences.

[117]  B. McCain,et al.  Bioavailability of Crude Oil from Experimentally Oiled Sediments to English Sole (Parophrys vetulus), and Pathological Consequences , 1978 .

[118]  W. Manz,et al.  Differentiation between bioavailable and total hazard potential of sediment-induced DNA fragmentation as measured by the comet assay with Zebrafish embryos , 2007 .

[119]  F. Gagné,et al.  Lethal and sublethal effects of marine sediment extracts on rainbow trout hepatocytes. , 1996, Toxicology letters.

[120]  Werner Brack,et al.  Endocrine Disruption of Water and Sediment Extracts in a Non-Radioactive Dot Blot/RNAse Protection-Assay Using Isolated Hepatocytes of Rainbow Trout (14 pp).Deficiencies between bioanalytical effectiveness and chemically determined concentrations and how to explain them , 2005, Environmental science and pollution research international.

[121]  J. Besser,et al.  Contaminated sediments from tributaries of the Great Lakes: Chemical characterization and carcinogenic effects in medaka (Oryzias latipes) , 1991, Archives of environmental contamination and toxicology.

[122]  J. Porcher,et al.  Monitoring of dioxin-like, estrogenic and anti-androgenic activities in sediments of the Bizerta lagoon (Tunisia) by means of in vitro cell-based bioassays : Contribution of low concentrations of polynuclear aromatic hydrocarbons (PAHs) , 2008 .

[123]  J. Giesy,et al.  Characterization of dioxin‐like activity of sediments from a Czech River Basin , 2001, Environmental toxicology and chemistry.

[124]  A. Goksøyr,et al.  Cellular localization of cytochrome P450 (CYP1A) induction and histology in Atlantic cod (Gadus morhua L.) and European flounder (Platichthys flesus) after environmental exposure to contaminants by caging in Sørfjorden, Norway , 1996 .

[125]  W. Manz,et al.  Comparative genotoxicity testing of rhine river sediment extracts using the comet assay with permanent fish cell lines (rtg-2 and rtl-w1) and the ames test* , 2004 .

[126]  S. Caeiro,et al.  Genotoxic damage in Solea senegalensis exposed to sediments from the Sado Estuary (Portugal): effects of metallic and organic contaminants. , 2008, Mutation research.

[127]  S. Scholz,et al.  The zebrafish embryo model in environmental risk assessment—applications beyond acute toxicity testing , 2008, Environmental science and pollution research international.

[128]  Bingsheng Zhou,et al.  Primary cultured cells as sensitive in vitro model for assessment of toxicants--comparison to hepatocytes and gill epithelia. , 2006, Aquatic toxicology.

[129]  Jonny Beyer,et al.  Fish bioaccumulation and biomarkers in environmental risk assessment: a review. , 2003, Environmental toxicology and pharmacology.

[130]  Jens C. Otte,et al.  DanTox—a novel joint research project using zebrafish (Danio rerio) to identify specific toxicity and molecular modes of action of sediment-bound pollutants , 2010 .

[131]  W. Manz,et al.  Activities and identification of aryl hydrocarbon receptor agonists in sediments from the Danube river , 2008, Analytical and bioanalytical chemistry.

[132]  M. Pacheco,et al.  Responses of European eel (Anguilla anguilla L.) in two polluted environments: in situ experiments. , 2004, Ecotoxicology and environmental safety.

[133]  A. Goksøyr,et al.  Contaminant accumulation and biomarker responses in flounder (Platichthys flesus L.) and Atlantic cod (Gadus morhua L.) exposed by caging to polluted sediments in Sørfjorden, Norway , 1996 .

[134]  D. Barceló,et al.  Environmental monitoring by gene expression biomarkers in Barbus graellsii: laboratory and field studies. , 2007, Chemosphere.

[135]  M. Tysklind,et al.  Biological and Chemical Determination of Dioxin-like Compounds in Sediments by Means of a Sediment Triad Approach in the Catchment Area of the River Neckar , 2002, Ecotoxicology.

[136]  M. Schubauer-Berigan,et al.  Predicting the toxicity of bulk sediments to aquatic organisms with aqueous test fractions: Pore water vs. elutriate , 1991 .

[137]  A. DeCaprio,et al.  Lethal and sublethal effects of polychlorinated biphenyls on Rana sylvatica tadpoles , 2002, Environmental toxicology and chemistry.

[138]  Teresa Lettieri,et al.  Recent Applications of DNA Microarray Technology to Toxicology and Ecotoxicology , 2005, Environmental health perspectives.

[139]  Werner Brack,et al.  Effect‐directed analysis of mutagens and ethoxyresorufin‐O‐deethylase inducers in aquatic sediments , 2005, Environmental toxicology and chemistry.

[140]  D. Powers.  Fish as model systems. , 1989, Science.

[141]  E. Foekema,et al.  Prolonged ELS test with the marine flatfish sole (Solea solea) shows delayed toxic effects of previous exposure to PCB 126. , 2008, Aquatic toxicology.

[142]  M. E. Hahn,et al.  Comparison of two bioassays, a fish liver cell line (PLHC-1) and a midge (Chironomus riparius), in monitoring freshwater sediments , 1998 .

[143]  P. Beelen.  A review on the application of microbial toxicity tests for deriving sediment quality guidelines , 2003 .

[144]  M. Landolt,et al.  Lethal and sublethal effects of marine sediment extracts on fish cells and chromosomes , 1984, Helgoländer Meeresuntersuchungen.

[145]  M. Landolt,et al.  Cytotoxicity/genotoxicity: The application of cell culture techniques to the measurement of marine sediment pollution , 1985 .

[146]  Helmut Segner,et al.  Isolation and primary culture of teleost hepatocytes , 1998 .

[147]  H. Steinhart,et al.  Genotoxic potential of marine sediments from the North Sea. , 2000, Mutation research.

[148]  E. Perkins,et al.  Playing in the Mud-Using Gene Expression to Assess Contaminant Effects on Sediment Dwelling Invertebrates , 2003, Ecotoxicology.

[149]  C. Kimmel,et al.  Stages of embryonic development of the zebrafish , 1995, Developmental dynamics : an official publication of the American Association of Anatomists.

[150]  T. McDonald,et al.  In situ biomonitoring of PAH-contaminated sediments using juvenile coho salmon (Oncorhynchus kisutch). , 2008, Ecotoxicology and environmental safety.

[151]  D. Klumpp,et al.  Toxic contaminants and their biological effects in coastal waters of Xiamen, China. II. Biomarkers and embryo malformation rates as indicators of pollution stress in fish. , 2002, Marine pollution bulletin.

[152]  S. Stürzenbaum,et al.  Gene expression profiling to characterize sediment toxicity – a pilot study using Caenorhabditis elegans whole genome microarrays , 2009, BMC Genomics.

[153]  Alex Netzband.  Sediment Management: An essential element of River Basin Management Plans , 2007 .

[154]  W. Clements,et al.  Gene expression in caged fish as a first‐tier indicator of contaminant exposure in streams , 2005, Environmental toxicology and chemistry.

[155]  J. Frazier,et al.  Isolated fish hepatocytes — model systems for toxicology research☆ , 1990 .

[156]  N. Maclean,et al.  Teleost microarrays: development in a broad phylogenetic range reflecting diverse applications , 2008 .

[157]  A. Scott,et al.  A comparison of pollutant biomarker responses with transcriptional responses in European flounders (Platicthys flesus) subjected to estuarine pollution. , 2004, Marine environmental research.

[158]  H. Hollert,et al.  Ecotoxicological characterization of sediment cores from the western Baltic Sea (Mecklenburg Bight) using GC–MS and in vitro biotests , 2009 .

[159]  R. Sonstegard.  ENVIRONMENTAL CARCINOGENESIS STUDIES IN FISHES OF THE GREAT LAKES OF NORTH AMERICA * , 1977, Annals of the New York Academy of Sciences.

[160]  C. Travis,et al.  The Genomic Revolution: What Does it Mean for Human and Ecological Risk Assessment? , 2003, Ecotoxicology.

[161]  M. Roberts,et al.  Acute toxicity of PAH contaminated sediments to the estuarine fish,Leiostomus xanthurus , 1989, Bulletin of environmental contamination and toxicology.

[162]  R. Altenburger,et al.  Oxygen decline in biotesting of environmental samples—Is there a need for consideration in the acute zebrafish embryo assay? , 2008, Environmental Toxicology.

[163]  Gary M Williams,et al.  Cellular systems for toxicity testing. , 1983, Annals of the New York Academy of Sciences.

[164]  R. Barra,et al.  Analysis of CYP4501A1, PAHs metabolites in bile, and genotoxic damage in Oncorhynchus mykiss exposed to Biobío River sediments, Central Chile. , 2006, Ecotoxicology and environmental safety.

[165]  R. Baudo,et al.  In situ tests to assess the potential toxicity of aquatic sediments , 1999 .

[166]  T. Braunbeck,et al.  Effects of sediment eluates and extracts from differently polluted small rivers on zebrafish embryos and larvae , 2002 .

[167]  F. Gagné,et al.  Genotoxicity of sediment extracts obtained in the vicinity of a creosote-treated wharf to rainbow trout hepatocytes. , 1995, Toxicology letters.

[168]  M. Schubauer-Berigan,et al.  The contribution of ammonia, metals and nonpolar organic compounds to the toxicity of sediment interstitial water from an illinois river tributary , 1991 .

[169]  G. Leblanc,et al.  A Method of Assessing the Toxicity of Contaminated Freshwater Sediments , 1985 .

[170]  T. Snell,et al.  Gene Expression Profiling in Ecotoxicology , 2003, Ecotoxicology.

[171]  G. Ankley,et al.  Identification of ammonia as an important sediment‐associated toxicant in the lower fox River and green bay, Wisconsin , 1990 .

[172]  J. Lech,et al.  Caged and wild fish: Induction of hepatic cytochrome P‐450 (CYP1A1) as an environmental biomonitor , 1993 .

[173]  M. Hecker,et al.  In search for the ecological and toxicological relevance of sediment re-mobilisation and transport during flood events , 2009 .

[174]  J. Bantle,et al.  Evaluation of the developmental toxicity of metal-contaminated sediments using short-term fathead minnow and frog embryo-larval assays , 1988 .

[175]  H. Köhler,et al.  Assessing contamination levels of Laguna Lake sediments (Philippines) using a contact assay with zebrafish (Danio rerio) embryos. , 2005, The Science of the total environment.

[176]  A. Goksøyr,et al.  Influence of Temperature and Polyaromatic Contaminants on Cyp1a Levels in North-Sea Dab (Limanda-Limanda) , 1995 .

[177]  V. Mićović,et al.  CYP1A induction potential and the concentration of priority pollutants in marine sediment samples--in vitro evaluation using the PLHC-1 fish hepatoma cell line. , 2008, Toxicology in vitro : an international journal published in association with BIBRA.

[178]  U. Förstner,et al.  Historical Contaminated Sediments and Soils at the River Basin Scale , 2004 .

[179]  Paul D. Jones,et al.  Advanced fluorescence in situ hybridization to localize and quantify gene expression in Japanese medaka (Oryzias latipes) exposed to endocrine‐disrupting compounds , 2009, Environmental toxicology and chemistry.

[180]  L. DiPinto.  Trophic transfer of a sediment-associated organophosphate pesticide from meiobenthos to bottom feeding fish , 1996, Archives of environmental contamination and toxicology.

[181]  Wolfgang Gebauer,et al.  Comparison of testing acute toxicity on embryo of zebrafish, Brachydanio rerio and RTG-2 cytotoxicity as possible alternatives to the acute fish test , 1995 .

[182]  J. Fleeger,et al.  Effects of sediment-bound polycyclic aromatic hydrocarbons on feeding behavior in juvenile spot (Leiostomus xanthurus Lacépède: Pisces) , 1998 .

[183]  H. Steinhart,et al.  Expression of heat shock protein 70 in a permanent cell line (EPC) exposed to sediment extracts from the North Sea and the Baltic Sea. , 2007, Marine environmental research.

[184]  S. De Flora,et al.  Multiple genotoxicity biomarkers in fish exposed in situ to polluted river water. , 1993, Mutation research.

[185]  K. Tollefsen,et al.  Use of fish in vitro hepatocyte assays to detect multi-endpoint toxicity in Slovenian river sediments. , 2006, Marine environmental research.

[186]  C. Martinez,et al.  Acute effects of sediments taken from an urban stream on physiological and biochemical parameters of the neotropical fish Prochilodus lineatus. , 2005, Comparative biochemistry and physiology. Toxicology & pharmacology : CBP.

[187]  Y H Cheung,et al.  Assessment of Sediment Toxicity Using Different Trophic Organisms , 1997, Archives of environmental contamination and toxicology.

[188]  Thomas Braunbeck,et al.  A new sediment contact assay to assess particle-bound pollutants using zebrafish (danio rerio) embryos , 2004 .

[189]  J. Karlsson,et al.  Hazard identification of contaminated sites—ranking potential toxicity of organic sediment extracts in crustacean and fish , 2008 .

[190]  R. Law,et al.  The measurement of disease susceptibility in dab, Limanda limanda L., following long-term exposure to contaminated sediments: Preliminary studies , 1989 .

[191]  T. Braunbeck,et al.  Ecotoxicological Assessment of Sediment, Suspended Matter and Water Samples in the Upper Danube River. A pilot study in search for the causes for the decline of fish catches (12 pp) , 2006, Environmental science and pollution research international.

[192]  R. Lloyd,et al.  Sublethal and chronic effects of pollutants on freshwater fish , 1994 .

[193]  C. Metcalfe,et al.  Carcinogenic and genotoxic activity of extracts from contaminated sediments in western Lake Ontario. , 1990, The Science of the total environment.

[194]  P. Ozoh.  Malformations and inhibitory tendencies induced toBrachydanio rerio (Hamilton-Buchanan) eggs and larvae due to exposures in low concentrations of lead and copper ions , 1979, Bulletin of environmental contamination and toxicology.