Effect of salicylates and related compounds on ablastic response in rats infected with Trypanosoma lewisi. I. Isomers of salicylic acid.

Trypanosoma lewisi reproduces asexually for a few days after introduction into the blood of susceptible rats, after which it ceases to multiply, its population becomes reduced by trypanolytic antibody, and the survivors assume the "resting" or "adult" form. The dynamics for the transition of the population from the reproducing to the "resting" phase are believed to consist of host responses to the parasitemia which culminate in the forniation of the circu-