Dl‐3‐N‐butylphthalide promotes angiogenesis and upregulates sonic hedgehog expression after cerebral ischemia in rats

Dl‐3‐N‐butylphthalide (NBP), a small molecule drug used clinically in the acute phase of ischemic stroke, has been shown to improve functional recovery and promote angiogenesis and collateral vessel circulation after experimental cerebral ischemia. However, the underlying molecular mechanism is unknown.

[1]  Zhijun Zhang,et al.  Simultaneous Imaging of Cerebrovascular Structure and Function in Hypertensive Rats Using Synchrotron Radiation Angiography , 2017, Front. Aging Neurosci..

[2]  Z. Nie,et al.  Effects of Dl-3-n-butylphthalide on Cerebral Ischemia Infarction in Rat Model by Mass Spectrometry Imaging , 2017, International journal of molecular sciences.

[3]  Jun Chen,et al.  Promoting Neurovascular Recovery in Aged Mice after Ischemic Stroke - Prophylactic Effect of Omega-3 Polyunsaturated Fatty Acids , 2017, Aging and disease.

[4]  B. Zhao,et al.  MicroRNA‐137 and microRNA‐195* inhibit vasculogenesis in brain arteriovenous malformations , 2017, Annals of neurology.

[5]  Zhijun Zhang,et al.  Monomeric CXCL12 outperforms its dimeric and wild type variants in the promotion of human endothelial progenitor cells' function. , 2017, Biochemical and biophysical research communications.

[6]  Weiliang He,et al.  Dl-3-n-butylphthalide protects the heart against ischemic injury and H9c2 cardiomyoblasts against oxidative stress: involvement of mitochondrial function and biogenesis , 2017, Journal of Biomedical Science.

[7]  Guo-Yuan Yang,et al.  Hypoxia Response Element-Regulated MMP-9 Promotes Neurological Recovery via Glial Scar Degradation and Angiogenesis in Delayed Stroke. , 2017, Molecular therapy : the journal of the American Society of Gene Therapy.

[8]  I. Abdoulaye,et al.  A Review of Recent Advances in Neuroprotective Potential of 3-N-Butylphthalide and Its Derivatives , 2016, BioMed research international.

[9]  Ji-xian Wang,et al.  Ischemia-induced Angiogenesis is Attenuated in Aged Rats. , 2016, Aging and disease.

[10]  Zhi-jun Zhang,et al.  Vessel Dilation Attenuates Endothelial Dysfunction Following Middle Cerebral Artery Occlusion in Hyperglycemic Rats , 2016, CNS neuroscience & therapeutics.

[11]  H. Duan,et al.  DL-3-n-butylphthalide delays the onset and progression of diabetic cataract by inhibiting oxidative stress in rat diabetic model , 2016, Scientific Reports.

[12]  M. Conconi,et al.  Ligand engagement of Toll-like receptors regulates their expression in cortical microglia and astrocytes , 2015, Journal of Neuroinflammation.

[13]  K. Jin,et al.  Herbal Formula Danggui-Shaoyao-San Promotes Neurogenesis and Angiogenesis in Rat Following Middle Cerebral Artery Occlusion. , 2015, Aging and disease.

[14]  Ji-xian Wang,et al.  Effect of HMGB1 on the Paracrine Action of EPC Promotes Post‐Ischemic Neovascularization in Mice , 2014, Stem cells.

[15]  Yong Cao,et al.  High-resolution three-dimensional visualization of the rat spinal cord microvasculature by synchrotron radiation micro-CT. , 2014, Medical physics.

[16]  Xiao-tong Wang,et al.  Protective Effect of Dl-3n-butylphthalide on Learning and Memory Impairment Induced by Chronic Intermittent Hypoxia-Hypercapnia Exposure , 2014, Scientific Reports.

[17]  Guo-Yuan Yang,et al.  Postacute Stromal Cell–Derived Factor-1&agr; Expression Promotes Neurovascular Recovery in Ischemic Mice , 2014, Stroke.

[18]  Guo-Yuan Yang,et al.  Neural Stem Cell Protects Aged Rat Brain from Ischemia–Reperfusion Injury through Neurogenesis and Angiogenesis , 2014, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[19]  Mengqi Zhang,et al.  Synchrotron radiation imaging is a powerful tool to image brain microvasculature. , 2014, Medical physics.

[20]  M. Renault,et al.  Hedgehog-Dependent Regulation of Angiogenesis and Myogenesis Is Impaired in Aged Mice , 2013, Arteriosclerosis, thrombosis, and vascular biology.

[21]  Guo-Yuan Yang,et al.  Netrin-1 Overexpression Promotes White Matter Repairing and Remodeling after Focal Cerebral Ischemia in Mice , 2013, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[22]  Ting Zhang,et al.  3-N-Butylphthalide (NBP) Attenuates the Amyloid-ß-Induced Inflammatory Responses in Cultured Astrocytes via the Nuclear Factor-κB Signaling Pathway , 2013, Cellular Physiology and Biochemistry.

[23]  Guo-Yuan Yang,et al.  CXCR4 Antagonist AMD3100 Protects Blood–Brain Barrier Integrity and Reduces Inflammatory Response After Focal Ischemia in Mice , 2013, Stroke.

[24]  Beryl Plimmer,et al.  RATA.Gesture: A gesture recognizer developed using data mining , 2012, Artificial Intelligence for Engineering Design, Analysis and Manufacturing.

[25]  Weihong Yang,et al.  Hypoxia inducible factor-1alpha mediates protection of DL-3-n-butylphthalide in brain microvascular endothelial cells against oxygen glucose deprivation-induced injury , 2012, Neural regeneration research.

[26]  S. Lee,et al.  dl-3n-Butylphthalide Promotes Angiogenesis Via the Extracellular Signal-regulated Kinase 1/2 and Phosphatidylinositol 3-Kinase/Akt-endothelial Nitric Oxide Synthase Signaling Pathways , 2012, Journal of cardiovascular pharmacology.

[27]  Lanhai Lü,et al.  Effects of DL-3-n-Butylphthalide on Vascular Dementia and Angiogenesis , 2012, Neurochemical Research.

[28]  F. Charron,et al.  The Hedgehog Pathway Promotes Blood-Brain Barrier Integrity and CNS Immune Quiescence , 2011, Science.

[29]  C. Kirkpatrick,et al.  Comparative study assessing effects of sonic hedgehog and VEGF in a human co-culture model for bone vascularisation strategies. , 2011, European cells & materials.

[30]  Ling Wei,et al.  dl-3-n-Butylphthalide prevents neuronal cell death after focal cerebral ischemia in mice via the JNK pathway , 2010, Brain Research.

[31]  M. Kazanietz,et al.  Hedgehog proteins activate pro-angiogenic responses in endothelial cells through non-canonical signaling pathways , 2010, Cell cycle.

[32]  C. Kirkpatrick,et al.  Sonic hedgehog promotes angiogenesis and osteogenesis in a coculture system consisting of primary osteoblasts and outgrowth endothelial cells. , 2010, Tissue engineering. Part A.

[33]  M Przybylski,et al.  A review of the current research on the role of bFGF and VEGF in angiogenesis. , 2009, Journal of wound care.

[34]  Z. Pei,et al.  Enhanced angiogenesis with dl-3n-butylphthalide treatment after focal cerebral ischemia in RHRSP , 2009, Brain Research.

[35]  Chunli Liu,et al.  dl-3n-butylphthalide prevents stroke via improvement of cerebral microvessels in RHRSP , 2007, Journal of the Neurological Sciences.

[36]  Guo-Yuan Yang,et al.  Therapeutic Angiogenesis for Brain Ischemia: A Brief Review , 2007, Journal of Neuroimmune Pharmacology.

[37]  Yiqian Zhu,et al.  Adeno-Associated Viral Vector-Mediated Hypoxia-Inducible Vascular Endothelial Growth Factor Gene Expression Attenuates Ischemic Brain Injury After Focal Cerebral Ischemia in Mice , 2006, Stroke.

[38]  T. Nagase,et al.  Defects in Aortic Fusion and Craniofacial Vasculature in the Holoprosencephalic Mouse Embryo under Inhibition of Sonic Hedgehog Signaling , 2006, The Journal of craniofacial surgery.

[39]  Jun Asai,et al.  Topical Sonic Hedgehog Gene Therapy Accelerates Wound Healing in Diabetes by Enhancing Endothelial Progenitor Cell–Mediated Microvascular Remodeling , 2006, Circulation.

[40]  C. Mussolino,et al.  Inhibition of ocular neovascularization by hedgehog blockade. , 2006, Molecular therapy : the journal of the American Society of Gene Therapy.

[41]  T. Fujita,et al.  Angiogenesis within the developing mouse neural tube is dependent on sonic hedgehog signaling: possible roles of motor neurons , 2005, Genes to cells : devoted to molecular & cellular mechanisms.

[42]  Stefanie Dimmeler,et al.  Therapeutic angiogenesis and vasculogenesis for ischemic disease. Part I: angiogenic cytokines. , 2004, Circulation.

[43]  J. Ware,et al.  Therapeutic angiogenesis in cardiovascular disease , 2003, Nature Reviews Drug Discovery.

[44]  Y. Ng,et al.  Therapeutic angiogenesis for cardiovascular disease , 2001, Current controlled trials in cardiovascular medicine.

[45]  Takayuki Asahara,et al.  The morphogen Sonic hedgehog is an indirect angiogenic agent upregulating two families of angiogenic growth factors , 2001, Nature Medicine.

[46]  M. Chopp,et al.  Intrastriatal Transplantation of Bone Marrow Nonhematopoietic Cells Improves Functional Recovery After Stroke in Adult Mice , 2000, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[47]  A. Słowik,et al.  Serial measurement of vascular endothelial growth factor and transforming growth factor-beta1 in serum of patients with acute ischemic stroke. , 2000, Stroke.

[48]  A. McMahon,et al.  Sonic hedgehog regulates branching morphogenesis in the mammalian lung , 1998, Current Biology.

[49]  Pamela F. Jones,et al.  Requisite Role of Angiopoietin-1, a Ligand for the TIE2 Receptor, during Embryonic Angiogenesis , 1996, Cell.

[50]  A. Sbarbati,et al.  The microvascular system in ischemic cortical lesions , 1996, Acta Neuropathologica.

[51]  R. Moon,et al.  Patterning activities of vertebrate hedgehog proteins in the developing eye and brain , 1995, Current Biology.

[52]  C. Borlongan,et al.  Elevated body swing test: a new behavioral parameter for rats with 6- hydroxydopamine-induced hemiparkinsonism , 1995, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[53]  Guo-Yuan Yang,et al.  Stimulation of cerebral angiogenesis by gene delivery. , 2014, Methods in molecular biology.

[54]  JunHuang,et al.  Postacute Stromal Cell–Derived Factor-1α Expression Promotes Neurovascular Recovery in Ischemic Mice , 2014 .

[55]  C. Kirkpatrick,et al.  Sonic Hedgehog-mediated synergistic effects guiding angiogenesis and osteogenesis. , 2012, Vitamins and hormones.

[56]  P. Edwards,et al.  Sonic hedgehog gene-enhanced tissue engineering for bone regeneration , 2005, Gene Therapy.

[57]  B. Pike,et al.  The rotarod test: an evaluation of its effectiveness in assessing motor deficits following traumatic brain injury. , 1994, Journal of neurotrauma.