Apolipoprotein E-epsilon 2 and Alzheimer's disease

Article abstract-To determine whether apolipoprotein E epsilon 2 (APOE-epsilon 2) affects neuropathology in aging and Alzheimer's disease (AD), we compared beta-amyloid plaque (A beta P) and neurofibrillary tangle densities, neuropil thread formation, and amyloid angiopathy in five APOE-epsilon 2/3 AD patients, five APOE-epsilon 3/3 AD patients, five APOE-epsilon 2/3 control patients, and five APOE-epsilon 3/3 control patients. We examined the (frontal and parietal) neocortex, hippocampus, entorhinal cortex, and cerebellum and found A beta P densities to be lower (t = 3.121, p = 0.011) in the cortex of APOE-epsilon 2/3 AD patients than in APOE-epsilon 3/3 AD patients. Amyloid angiopathy was also less in APOE-epsilon 2/3 patients than in APOE-3/3 patients (U = 4.500, p = 0.027). Control APOE-epsilon 2/3 brains had little AD-related pathology; even our 102-year-old control case showed few A beta Ps compared with the elderly APOE-epsilon 3/3 cases. The APOE-epsilon 2/3 genotype may influence pathologic phenotype in some aged normal and AD populations. NEUROLOGY 1997;48: 515-519

[1]  R. Daroff.  A new look and feel , 1996, Neurology.

[2]  M. Levitt,et al.  A Comparison of Symptoms after the Consumption of Milk or Lactose-Hydrolyzed Milk by People with Self-Reported Severe Lactose Intolerance , 1995 .

[3]  Michael V. Cohen,et al.  Ischaemic preconditioning: can the protection be bottled? , 1993, The Lancet.

[4]  P. Almqvist,et al.  Morphology and Growth of Embryonic, Human Dorsal Root Ganglion Explants in Long-Term Culture: Expression of Cell Type-Specific Markers during Early Differentiation , 1994, Experimental Neurology.

[5]  D. Deregt,et al.  ELISA reliable for detection of antibodies to BHV1. , 1993, The Canadian veterinary journal = La revue veterinaire canadienne.

[6]  L Junck,et al.  Machado-Joseph disease and SCA3 , 1996, Neurology.

[7]  B. Kirkwood,et al.  Vitamin A supplementation in northern Ghana: effects on clinic attendances, hospital admissions, and child mortality , 1993, The Lancet.

[8]  M. Misawa,et al.  The role of dopamine D1-receptors in morphine-induced hyperlocomotion in mice , 1994, Neuroscience Letters.

[9]  M. Hallett,et al.  Clinical research criteria for the diagnosis of progressive supranuclear palsy (Steele-Richardson-Olszewski syndrome) , 1996, Neurology.

[10]  R. Fletterick,et al.  Perturbation of the secondary structure of the scrapie prion protein under conditions that alter infectivity. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[11]  N. Bogdanov,et al.  The role of 5-HT1A serotonin and D2 dopamine receptors in buspirone effects on cortical electrical activity in rats , 1994, Neuroscience Letters.

[12]  R. Penn,et al.  Neurosurgical horizons in Parkinson's disease , 1993, Neurology.

[13]  R. Myers,et al.  The axon in guillain‐Barré syndrome: Immune target or innocent bystander?; , 1996, Annals of neurology.