Fine-Tuning ResNet for Breast Cancer Classification from Mammography

Breast cancer classification from mammography is significant for treatment decisions and assessments of prognosis. However, the traditional classification method is not efficient due to the need for professional domain knowledge, time-consuming, and difficult in extracting high-quality features. Therefore, this paper proposed an automatic classification method based on convolutional neural network (CNN). In this paper, the fine-tuning residual network (ResNet) has been introduced to have good performance, reduce training time, and automatically extract features. Then, a data augmentation policy was adopted to expand training data which can reduce the probability of overfitting caused by small training set. The main contribution of this paper is to introduce transfer learning and data augmentation to construct an automatic mammography classification, which has high prediction performance. Experiments were conducted on a public data set CBIS-DDSM which contains 2620 scanned film mammography studies. The proposed method obtains desirable performances on accuracy, specificity, sensitivity, AUC, and loss, corresponding to 93.15, 92.17, 93.83%, 0.95, and 0.15. The proposed method is of good robustness and generalization.

[1]  Jonathan H Sunshine,et al.  How widely is computer-aided detection used in screening and diagnostic mammography? , 2010, Journal of the American College of Radiology : JACR.

[2]  Sergey Ioffe,et al.  Batch Normalization: Accelerating Deep Network Training by Reducing Internal Covariate Shift , 2015, ICML.

[3]  Leonid Karlinsky,et al.  A Region Based Convolutional Network for Tumor Detection and Classification in Breast Mammography , 2016, LABELS/DLMIA@MICCAI.

[4]  Jian Sun,et al.  Identity Mappings in Deep Residual Networks , 2016, ECCV.

[5]  Qiang Yang,et al.  A Survey on Transfer Learning , 2010, IEEE Transactions on Knowledge and Data Engineering.

[6]  Kyunghyun Cho,et al.  High-Resolution Breast Cancer Screening with Multi-View Deep Convolutional Neural Networks , 2017, ArXiv.

[7]  Jian Sun,et al.  Convolutional neural networks at constrained time cost , 2014, 2015 IEEE Conference on Computer Vision and Pattern Recognition (CVPR).

[8]  F. Collins,et al.  A new initiative on precision medicine. , 2015, The New England journal of medicine.

[9]  Daniel Lévy,et al.  Breast Mass Classification from Mammograms using Deep Convolutional Neural Networks , 2016, ArXiv.

[10]  Daniel L. Rubin,et al.  Optimizing and Visualizing Deep Learning for Benign/Malignant Classification in Breast Tumors , 2017, ArXiv.

[11]  Stefan Carlsson,et al.  CNN Features Off-the-Shelf: An Astounding Baseline for Recognition , 2014, 2014 IEEE Conference on Computer Vision and Pattern Recognition Workshops.

[12]  Yoshua Bengio,et al.  How transferable are features in deep neural networks? , 2014, NIPS.

[13]  Sara Reardon,et al.  US precision-medicine proposal sparks questions , 2015, Nature.

[14]  Geoffrey E. Hinton,et al.  Rectified Linear Units Improve Restricted Boltzmann Machines , 2010, ICML.

[15]  B. Stewart,et al.  World cancer report 2014. , 2014 .

[16]  Yoshua Bengio,et al.  Convolutional networks for images, speech, and time series , 1998 .

[17]  Heung-Il Suk,et al.  Deep Learning in Medical Image Analysis. , 2017, Annual review of biomedical engineering.

[18]  Daniel L Rubin,et al.  A curated mammography data set for use in computer-aided detection and diagnosis research , 2017, Scientific Data.

[19]  L. Tabár,et al.  The impact of organized mammography service screening on breast carcinoma mortality in seven Swedish counties , 2002, Cancer.

[20]  Trevor Darrell,et al.  DeCAF: A Deep Convolutional Activation Feature for Generic Visual Recognition , 2013, ICML.

[21]  Nico Karssemeijer,et al.  Large scale deep learning for computer aided detection of mammographic lesions , 2017, Medical Image Anal..

[22]  Andrew Zisserman,et al.  Very Deep Convolutional Networks for Large-Scale Image Recognition , 2014, ICLR.