Research at IMU: achievements, thrust areas and future challenges

There have been significant achievements in research at IMU as indicated by the increasing amount of external funds obtained, and number of publications and postgraduate students produced since it started its research activities in the year 2000. However, it is a great challenge indeed to ensure sustainability of our research, which is currently heavily dependent on internal funding. There is a need to realign our strategies to further enhance our competitiveness in securing external funding for research. In line with this, the Institute for Research, Development and Innovation (IRDI) was officially established on 18 September 2012. The Institute will serve as a platform to support all research activities at IMU. There are four Centres of Excellence based on the identified thrust areas under IRDI, namely 1) Centre for Bioactive Molecules and Drug Discovery; 2) Centre for Environmental and Population Health; 3) Centre for Cancer and Stem Cell Research, and 4) Centre for Health Professional Education Research. Major findings based on research in these four thrust areas are reviewed in this paper. With the strategic planning and establishment of IRDI, it is our aspiration to bring research at IMU to a higher level.

[1]  M. Whitcomb Medical education research. , 2004, Academic medicine : journal of the Association of American Medical Colleges.

[2]  R. Naidu,et al.  Inhibitory activities of microalgal extracts against Epstein-Barr virus DNA release from lymphoblastoid cells , 2011, Journal of Zhejiang University SCIENCE B.

[3]  W. Chu,et al.  Occurrence of airborne algae within the township of Bukit Jalil in Kuala Lumpur, Malaysia , 2011 .

[4]  Cho Naing,et al.  Buprenorphine for treating cancer pain , 2012 .

[5]  J. Mak,et al.  Molecular identification of Cryptosporidium parvum from avian hosts , 2011, Parasitology.

[6]  S. Wong,et al.  Molecular identification of house dust mites and storage mites , 2011, Experimental and Applied Acarology.

[7]  Kai Hung Tiong,et al.  Suppression of BCL-2 synergizes cisplatin sensitivity in nasopharyngeal carcinoma cells. , 2012, Cancer letters.

[8]  S. Cheong,et al.  Transfected human mesenchymal stem cells do not lose their surface markers and differentiation properties. , 2009, The Malaysian journal of pathology.

[9]  S. Chakravarthi,et al.  Effects of chronic lead acetate exposure on bone marrow lipid peroxidation and antioxidant enzyme activities in rats , 2011 .

[10]  K. Dua,et al.  Preparation, Characterization, and In Vitro Evaluation of Nitrendipine Solid Dispersions , 2012 .

[11]  N. Mitra,et al.  The effect of consequent exposure of stress and dermal application of low doses of chlorpyrifos on the expression of glial fibrillary acidic protein in the hippocampus of adult mice , 2011, Journal of occupational medicine and toxicology.

[12]  M. Rathbone,et al.  Recent developments in buccal and sublingual delivery systems , 2012, Expert opinion on drug delivery.

[13]  M. Kulkarni,et al.  Follicular Carcinoma Of The Thyroid Presenting As Distant Metastases: A Case Report And Review Of The Literature. , 2012 .

[14]  J. George,et al.  Unusual cause of neuropathy: extensive dural spread of primary cervical osteosarcoma , 2012, Acta radiologica short reports.

[15]  F. Othman,et al.  In vitro cytotoxicity of Strobilanthes crispus ethanol extract on hormone dependent human breast adenocarcinoma MCF-7 cell , 2012, BMC Complementary and Alternative Medicine.

[16]  Cho Naing,et al.  Understanding, perceptions and self-use of complementary and alternative medicine (CAM) among Malaysian pharmacy students , 2011, BMC complementary and alternative medicine.

[17]  S. Chakravart,et al.  A Comprehensive Review of the Occurrence and Management of Systemic Candidiasis as an Opportunistic Infection , 2011 .

[18]  S. DMani Literary appreciation for medical students at International Medical University, Kuala Lumpur: the learner’s experience , 2008, Medical Humanities.

[19]  Jamalludin Ab Rahman,et al.  High prevalence of vitamin D insufficiency and its association with BMI-for-age among primary school children in Kuala Lumpur, Malaysia , 2011, BMC public health.

[20]  N. Mitra,et al.  A comparison of neurotoxicity in cerebellum produced by dermal application of chlorpyrifos in young and adult mice , 2012, Journal of Neural Transmission.

[21]  G. Khor,et al.  Determination of folate content in commonly consumed Malaysian foods , 2012 .

[22]  S. Chen,et al.  Apoptosis induced by para‐phenylenediamine involves formation of ROS and activation of p38 and JNK in chang liver cells , 2014, Environmental toxicology.

[23]  E. Boyer Scholarship Reconsidered: Priorities of the Professoriate , 1990 .

[24]  G. Khor,et al.  Micronutrient interventions on cognitive performance of children aged 5-15 years in developing countries. , 2012, Asia Pacific journal of clinical nutrition.

[25]  K. Sim,et al.  Acute coronary syndrome in women of reproductive age , 2011 .

[26]  Z. Bhutta,et al.  Maternal, neonatal, and child health in southeast Asia: towards greater regional collaboration , 2011, The Lancet.

[27]  Y. W. Poh,et al.  Effects of IL-6, IL-10 and TGF-β on the expression of survivin and apoptosis in nasopharyngeal carcinoma TW01 cells. , 2012, Experimental oncology.

[28]  A. Radhakrishnan,et al.  Palm tocotrienols decrease levels of pro-angiogenic markers in human umbilical vein endothelial cells (HUVEC) and murine mammary cancer cells , 2011, Genes & Nutrition.

[29]  S. Wong,et al.  Differential expression of the angiogenesis growth factors in psoriasis vulgaris , 2012, BMC Research Notes.

[30]  K. Chinna,et al.  Ethnic differences in the prognostic utility of rheumatoid factor isotypes and anticyclic citrullinated peptides in rheumatoid arthritis patients: a cross-sectional study , 2013, Modern rheumatology.

[31]  Cho Naing,et al.  Relationship between hepatitis C virus infection and type 2 diabetes mellitus: meta-analysis. , 2012, World journal of gastroenterology.

[32]  P. Lim,et al.  Protective effect of aqueous extract from Spirulina platensis against cell death induced by free radicals , 2010, BMC complementary and alternative medicine.

[33]  R. Koh,et al.  Screening of anti-dengue activity in methanolic extracts of medicinal plants , 2012, BMC Complementary and Alternative Medicine.

[34]  E. Chowdhury,et al.  Reversing multidrug resistance in breast cancer cells by silencing ABC transporter genes with nanoparticle-facilitated delivery of target siRNAs , 2012, International journal of nanomedicine.

[35]  V. R. Kolapalli,et al.  Characterization and In Vitro Drug Release Studies of a Natural Polysaccharide Terminalia catappa Gum (Badam Gum) , 2012, AAPS PharmSciTech.

[36]  A. F. Yusoff,et al.  Optimal BMI cut-off values for predicting diabetes, hypertension and hypercholesterolaemia in a multi-ethnic population , 2012, Public Health Nutrition.

[37]  S. Cheong,et al.  Cryopreserved mesenchymal stromal cell treatment is safe and feasible for severe dilated ischemic cardiomyopathy. , 2010, Cytotherapy.

[38]  J. Mak,et al.  Isolation and characterization of Acanthamoeba spp. from air-conditioners in Kuala Lumpur, Malaysia , 2010, Acta Tropica.

[39]  F. Othman,et al.  In vitro evaluation of Pandanus amaryllifolius ethanol extract for induction of cell death on non-hormone dependent human breast adenocarcinoma MDA-MB-231 cell via apoptosis , 2012, BMC Complementary and Alternative Medicine.

[40]  S. Ambu,et al.  Toxoplasma gondii: determination of the onset of chronic infection in mice and the in vitro reactivation of brain cysts. , 2012, Experimental parasitology.