The E3 ubiquitin ligase Nrdp1 'preferentially' promotes TLR-mediated production of type I interferon

[1]  Shao-Cong Sun,et al.  Regulation of IκB Kinase-related Kinases and Antiviral Responses by Tumor Suppressor CYLD* , 2008, Journal of Biological Chemistry.

[2]  Shao-Cong Sun.  Deubiquitylation and regulation of the immune response , 2008, Nature Reviews Immunology.

[3]  Xuetao Cao,et al.  Phosphatase SHP-1 promotes TLR- and RIG-I-activated production of type I interferon by inhibiting the kinase IRAK1 , 2008, Nature Immunology.

[4]  C. Elly,et al.  The E3 ubiquitin ligase Itch regulates expression of transcription factor Foxp3 and airway inflammation by enhancing the function of transcription factor TIEG1 , 2008, Nature Immunology.

[5]  N. Copeland,et al.  The E3 ligase Itch negatively regulates inflammatory signaling pathways by controlling the function of the ubiquitin-editing enzyme A20 , 2008, Nature Immunology.

[6]  Bettina L. Lee,et al.  Homeostatic MyD88-dependent signals cause lethal inflamMation in the absence of A20 , 2008, The Journal of experimental medicine.

[7]  E. Pietras,et al.  A Deubiquitinase That Regulates Type I Interferon Production , 2007, Science.

[8]  J. Gatot,et al.  Lipopolysaccharide-mediated Interferon Regulatory Factor Activation Involves TBK1-IKKϵ-dependent Lys63-linked Polyubiquitination and Phosphorylation of TANK/I-TRAF* , 2007, Journal of Biological Chemistry.

[9]  J. Christman,et al.  E3 ubiquitin ligase Cblb regulates the acute inflammatory response underlying lung injury , 2007, Nature Medicine.

[10]  Taoyong Chen,et al.  Lysosome-associated small Rab GTPase Rab7b negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4. , 2007, Blood.

[11]  Qiang Sun,et al.  The NEMO adaptor bridges the nuclear factor-κB and interferon regulatory factor signaling pathways , 2007, Nature Immunology.

[12]  B. Beutler,et al.  TLR-dependent and TLR-independent pathways of type I interferon induction in systemic autoimmunity , 2007, Nature Medicine.

[13]  T. Kaisho,et al.  PDLIM2-mediated termination of transcription factor NF-κB activation by intranuclear sequestration and degradation of the p65 subunit , 2007, Nature Immunology.

[14]  Kermit L. Carraway,et al.  Neuregulin-Induced ErbB3 Downregulation Is Mediated by a Protein Stability Cascade Involving the E3 Ubiquitin Ligase Nrdp1 , 2007, Molecular and Cellular Biology.

[15]  Xiuli Wu,et al.  Loss of Nrdp1 enhances ErbB2/ErbB3-dependent breast tumor cell growth. , 2006, Cancer research.

[16]  Gabriel Pineda,et al.  Activation of IKK by TNFalpha requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO. , 2006, Molecular cell.

[17]  M. Mann,et al.  Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6 , 2006, Nature.

[18]  A. Shahangian,et al.  Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response , 2006, Nature.

[19]  Jian-Dong Li,et al.  The Tumor Suppressor Cylindromatosis (CYLD) Acts as a Negative Regulator for Toll-like Receptor 2 Signaling via Negative Cross-talk with TRAF6 and TRAF7* , 2005, Journal of Biological Chemistry.

[20]  M. Karin,et al.  Immunity by ubiquitylation: a reversible process of modification , 2005, Nature Reviews Immunology.

[21]  N. Van Rooijen,et al.  Impact of macrophage and dendritic cell subset elimination on antiviral immunity, viral clearance and production of type 1 interferon. , 2005, Virology.

[22]  Z. Zhai,et al.  VISA Is an Adapter Protein Required for Virus-Triggered IFN-β Signaling , 2005 .

[23]  Zhijian J. Chen.  Ubiquitin signalling in the NF-κB pathway , 2005, Nature Cell Biology.

[24]  F. Liew,et al.  Negative regulation of Toll-like receptor-mediated immune responses , 2005, Nature Reviews Immunology.

[25]  Matthew T Wheeler,et al.  The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses , 2004, Nature Immunology.

[26]  A. Iwasaki,et al.  Toll-like receptor control of the adaptive immune responses , 2004, Nature Immunology.

[27]  Somasekar Seshagiri,et al.  De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-κB signalling , 2004, Nature.

[28]  Shizuo Akira,et al.  Toll-like receptor signalling , 2004, Nature Reviews Immunology.

[29]  Shizuo Akira,et al.  The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses , 2004, Nature Immunology.

[30]  A. Goldberg,et al.  Nrdp1‐mediated degradation of the gigantic IAP, BRUCE, is a novel pathway for triggering apoptosis , 2004, The EMBO journal.

[31]  T. Maniatis,et al.  IFN-regulatory factor 3-dependent gene expression is defective in Tbk1-deficient mouse embryonic fibroblasts , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[32]  G. Courtois,et al.  The tumour suppressor CYLD negatively regulates NF-κB signalling by deubiquitination , 2003, Nature.

[33]  T. Maniatis,et al.  IKKε and TBK1 are essential components of the IRF3 signaling pathway , 2003, Nature Immunology.

[34]  K. Burns,et al.  Inhibition of Interleukin 1 Receptor/Toll-like Receptor Signaling through the Alternatively Spliced, Short Form of MyD88 Is Due to Its Failure to Recruit IRAK-4 , 2003, The Journal of experimental medicine.

[35]  A. Goldberg,et al.  Nrdp1/FLRF is a ubiquitin ligase promoting ubiquitination and degradation of the epidermal growth factor receptor family member, ErbB3 , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[36]  K. Carraway,et al.  An RBCC protein implicated in maintenance of steady-state neuregulin receptor levels , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[37]  Zhijian J. Chen,et al.  TAK1 is a ubiquitin-dependent kinase of MKK and IKK , 2001, Nature.

[38]  Zhijian J. Chen,et al.  Activation of the IκB Kinase Complex by TRAF6 Requires a Dimeric Ubiquitin-Conjugating Enzyme Complex and a Unique Polyubiquitin Chain , 2000, Cell.

[39]  T. Taniguchi,et al.  Distinct and Essential Roles of Transcription Factors IRF-3 and IRF-7 in Response to Viruses for IFN-α/β Gene Induction , 2000 .

[40]  K. Irie,et al.  TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway. , 2000, Molecular cell.

[41]  M. Karin,et al.  JNK2 and IKKbeta are required for activating the innate response to viral infection. , 1999, Immunity.

[42]  D. Baltimore,et al.  NF‐κB activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK‐related kinase , 1999, The EMBO journal.

[43]  S. Akira,et al.  Unresponsiveness of MyD88-deficient mice to endotoxin. , 1999, Immunity.

[44]  S. Akira,et al.  Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function. , 1998, Immunity.

[45]  E. Kopp.  IFN-regulatory factor 3-dependent gene expression is defective in Tbk1-deficient mouse embryonic fibroblasts , 2004 .

[46]  R. Jurecic,et al.  FLRF, a novel evolutionarily conserved RING finger gene, is differentially expressed in mouse fetal and adult hematopoietic stem cells and progenitors. , 2001, Blood cells, molecules & diseases.