SYNTHESIS AND ANTI-INFLAMATORY ACTIVITY OF 2-((1H-BENZIMIDAZOLE-2YL METHYL) SULFONYL) -N- (PHENYL METHYLIDINE) ACETOHYDRAZIDE DERIVATIVES

Benzimidazole derivates play vital role in biological field such as antimicrobial, antiviral, antidiabetic, and anticancer activity. Therapeutic significance of these clinically useful drugs in treatment of microbial infections encouraged the development of some potent and significant compounds. A series of 2-substituted benzimidazoles derivatives (Va-g) were synthesized and evaluated for their possible anti-inflammatory activity. The structures of the synthesized compounds were confirmed on the basis of their spectral data and elemental analysis. Majority of the compounds were active in Carrageenan induced hind paw edema method test and compounds Vd and Vf had shown high potency in terms of % inhibition and are moderately potent to that of standard drug diclofenac (20 mg/kg body weight).

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