Regeneration of human bone using different bone substitute biomaterials.

PURPOSE The present study aimed to assess clinical and biological performances of several bone substitute biomaterials (BSBs). MATERIALS AND METHODS The evaluation was conducted at 6 months and after several years on 295 patients undergoing sinus augmentation with 13 different BSBs; the data belonging to previously published studies have been analyzed using innovative mathematical models to evaluate the bone regenerative index (Br) and the structural density index (Ds). RESULTS After 6 months, compared to the Ds index of native bone, the regenerated bone showed a D3 bone type; while, after several years, the regenerated bone type was D2, with an evident increase in the density of the regenerated bone over time. Moreover, the values of Br were higher for combined biomaterials indicating a fewer amount of residual particles and marrow spaces, while the values of Ds were higher for anorganic bovine bone indicating a greater new bone formation and a lesser amount of marrow spaces. After 20 years, the bone regenerated using hydroxyapatite still had a D4 bone quality. CONCLUSIONS After 6 months of healing, the regenerated bone had a composite structure resembling poor D3 bone type, and covered approximately one-third of the space filled by BSBs. None of the evaluated biomaterials seemed to be ideal.

[1]  Klaas de Groot,et al.  Bioceramics of Calcium Phosphate , 2017 .

[2]  P. Galindo-Moreno,et al.  Are short dental implants (<10 mm) effective? a meta-analysis on prospective clinical trials. , 2013, Journal of periodontology.

[3]  Cameo Borntrager,et al.  A Case Series , 2013 .

[4]  A. Piattelli,et al.  Comparative histological results of different biomaterials used in sinus augmentation procedures: a human study at 6 months. , 2012, Clinical Oral Implants Research.

[5]  A. Piattelli,et al.  Histologic and histomorphometric evaluation of an implant retrieved 8 years after insertion in a sinus augmented with anorganic bovine bone and anorganic bovine matrix associated with a cell-binding peptide: a case report. , 2012, The International journal of periodontics & restorative dentistry.

[6]  W. Świȩszkowski,et al.  Micro CT-based multiscale elasticity of double-porous (pre-cracked) hydroxyapatite granules for regenerative medicine. , 2012, Journal of biomechanics.

[7]  A. Piattelli,et al.  Sinus augmentation with phycogene hydroxyapatite: histological and histomorphometrical results after 6 months in humans. A case series , 2012, Oral and Maxillofacial Surgery.

[8]  G. Gómez-Moreno,et al.  Meta-analytic study of implant survival following sinus augmentation , 2011, Medicina oral, patologia oral y cirugia bucal.

[9]  A. Piattelli,et al.  Maxillary sinus augmentation in humans using cortical porcine bone: a histological and histomorphometrical evaluation after 4 and 6 months. , 2011, Clinical implant dentistry and related research.

[10]  S. Taschieri,et al.  Implant survival rates after maxillary sinus augmentation. , 2008, European journal of oral sciences.

[11]  A. Piattelli,et al.  Histologic and Elemental Microanalytical Study of Anorganic Bovine Bone Substitution Following Sinus Floor Augmentation in Humans , 2008 .

[12]  M. Quirynen,et al.  Impact of local and systemic factors on the incidence of late oral implant loss. , 2008, Clinical oral implants research.

[13]  A. Piattelli,et al.  Dense Hydroxyapatite Inserted Into Postextraction Sockets: A Histologic and Histomorphometric 20‐Year Case Report , 2008 .

[14]  Hom-lay Wang,et al.  Long-term evaluation of implant survival in augmented sinuses: a case series. , 2008, The International journal of periodontics & restorative dentistry.

[15]  A. Piattelli,et al.  Maxillary sinus augmentation with a porous synthetic hydroxyapatite and bovine-derived hydroxyapatite: a comparative clinical and histologic study. , 2007, The International journal of oral & maxillofacial implants.

[16]  Richard Weinkamer,et al.  Nature’s hierarchical materials , 2007 .

[17]  A. Piattelli,et al.  A histologic and histomorphometric evaluation of anorganic bovine bone retrieved 9 years after a sinus augmentation procedure. , 2007, Journal of periodontology.

[18]  David Taylor,et al.  Living with cracks: damage and repair in human bone. , 2007, Nature materials.

[19]  Alexander G Robling,et al.  Biomechanical and molecular regulation of bone remodeling. , 2006, Annual review of biomedical engineering.

[20]  S. Caputi,et al.  Maxillary Sinus Augmentation With Different Biomaterials: A Comparative Histologic and Histomorphometric Study in Man , 2006, Implant dentistry.

[21]  A. Piattelli,et al.  Maxillary sinus augmentation with a synthetic cell-binding peptide: histological and histomorphometrical results in humans. , 2004, The Journal of oral implantology.

[22]  T. Testori,et al.  Systematic review of survival rates for implants placed in the grafted maxillary sinus. , 2004, The International journal of periodontics & restorative dentistry.

[23]  Chad Johnson,et al.  The effect of scaffold degradation rate on three-dimensional cell growth and angiogenesis. , 2004, Biomaterials.

[24]  B. Rahn,et al.  Mechanical characterisation of a bone defect model filled with ceramic cements , 2004, Journal of materials science. Materials in medicine.

[25]  A. Piattelli,et al.  Osseointegration in a sinus augmented with bovine porous bone mineral: histological results in an implant retrieved 4 years after insertion. A case report. , 2004, Journal of periodontology.

[26]  Himadri S. Gupta,et al.  Structure and mechanical quality of the collagen–mineral nano-composite in bone , 2004 .

[27]  S. Froum,et al.  Effect of maxillary sinus augmentation on the survival of endosseous dental implants. A systematic review. , 2003, Annals of periodontology.

[28]  D. Taylor.,et al.  The cellular transducer in damage-stimulated bone remodelling: a theoretical investigation using fracture mechanics. , 2003, Journal of theoretical biology.

[29]  C. Kirkpatrick,et al.  Tissue response and biomaterial integration: the efficacy of in vitro methods. , 2002, Biomolecular engineering.

[30]  E. Burger,et al.  Histological observations on biopsies harvested following sinus floor elevation using a bioactive glass material of narrow size range. , 2000, Clinical oral implants research.

[31]  C. Hämmerle,et al.  Complication rate with prosthodontic reconstructions on ITI and IMZ dental implants , 1998 .

[32]  J. Zerwekh,et al.  Porous ceramics as bone graft substitutes in long bone defects: A biomechanical, histological, and radiographic analysis , 1996, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[33]  H. Frost.  Bone “mass” and the “mechanostat”: A proposal , 1987, The Anatomical record.

[34]  George A. Zarb,et al.  Tissue-Integrated Prostheses: Osseointegration in Clinical Dentistry , 1985 .

[35]  Howard J. Sanders,et al.  High-tech ceramics , 1984 .

[36]  A. Piattelli,et al.  Histologic results from a human implant retrieved due to fracture 5 years after insertion in a sinus augmented with anorganic bovine bone. , 2008, Journal of periodontology.

[37]  D. Tarnow,et al.  Human histologic evidence of integration of functionally loaded hydroxyapatite-coated implants placed simultaneously with sinus augmentation: a case report 2 1/2 years postplacement. , 1999, The Journal of oral implantology.

[38]  C. Hämmerle,et al.  Histological evaluation of Bio-Oss in a 2-stage sinus floor elevation and implantation procedure. A human case report. , 1998, Clinical oral implants research.

[39]  G. Rodan,et al.  Bone mass homeostasis and bisphosphonate action. , 1997, Bone.

[40]  I Binderman,et al.  Regional accelerated phenomenon in the mandible following mucoperiosteal flap surgery. , 1994, Journal of periodontology.