Pharmaceutical application of extremozymes

Abstract Extremophilic organisms are a significant source of extremozymes that live under extreme conditions. Extremozymes are of great importance and have numerous applications in several industries owing to their activity and stability under extreme conditions. But, a few extremozymes only are being used for their industrial applications, especially in the pharmaceutical industry. Even though extremozymes exhibit peculiar characteristics, their valuable potential remains unexplored. Therefore, researchers have recently focused the research on extremozymes since it is being considered as a new alternative to the current pharmaceutical applications. Henceforth, the current review presents a summary of recent advances about extremozymes, types of extremozymes, and their potential pharmaceutical applications. In the future, extremozymes will develop the research toward real-time industrial applications.

[1]  K. Timmis,et al.  Microbial enzymes mined from the Urania deep-sea hypersaline anoxic basin. , 2005, Chemistry & biology.

[2]  D. Janssen,et al.  Proteolysin, a Novel Highly Thermostable and Cosolvent-Compatible Protease from the Thermophilic Bacterium Coprothermobacter proteolyticus , 2013, Applied and Environmental Microbiology.

[3]  R. Cavicchioli,et al.  Life and applications of extremophiles. , 2011, Environmental Microbiology.

[4]  G. Zúñiga,et al.  Copper stress induces antioxidant responses and accumulation of sugars and phytochelatins in Antarctic Colobanthus quitensis (Kunth) Bartl. , 2018, Biological Research.

[5]  Dongming Lan,et al.  A Thermostable Monoacylglycerol Lipase from Marine Geobacillus sp. 12AMOR1: Biochemical Characterization and Mutagenesis Study , 2019, International journal of molecular sciences.

[6]  Bo Mattiasson,et al.  Starch hydrolysing Bacillus halodurans isolates from a Kenyan soda lake , 2004, Biotechnology Letters.

[7]  A. Silva,et al.  Functional expression and characterization of a chitinase from the marine archaeon Halobacterium salinarum CECT 395 in Escherichia coli , 2013, Applied Microbiology and Biotechnology.

[8]  D. Cowan,et al.  Some like it cold: understanding the survival strategies of psychrophiles , 2014, EMBO reports.

[9]  J. A. Jorge,et al.  Xylanases from fungi: properties and industrial applications , 2005, Applied Microbiology and Biotechnology.

[10]  M. Bonete,et al.  Extreme halophilic enzymes in organic solvents. , 2002, Current opinion in biotechnology.

[11]  Haïtham Sghaier,et al.  Contrasted resistance of stone-dwelling Geodermatophilaceae species to stresses known to give rise to reactive oxygen species. , 2012, FEMS microbiology ecology.

[12]  Manisha Sharma,et al.  Alkaliphilic bacteria: applications in industrial biotechnology , 2011, Journal of Industrial Microbiology & Biotechnology.

[13]  Li Xu,et al.  Biochemical Characterization of a Carboxylesterase from the Archaeon Pyrobaculum sp. 1860 and a Rational Explanation of Its Substrate Specificity and Thermostability , 2014, International journal of molecular sciences.

[14]  Purification and characterization of a thermostable aliphatic amidase from the hyperthermophilic archaeon Pyrococcus yayanosii CH1 , 2014, Extremophiles.

[15]  C. Vorgias,et al.  Cloning, overexpression, and characterization of a thermoactive nitrilase from the hyperthermophilic archaeon Pyrococcus abyssi. , 2006, Protein expression and purification.

[16]  C. Kennes,et al.  Isolation and Characterization of Thermophilic Bacteria from Jordanian Hot Springs: Bacillus licheniformis and Thermomonas hydrothermalis Isolates as Potential Producers of Thermostable Enzymes , 2017, International journal of microbiology.

[17]  P. Weigel,et al.  Characterization of the purified hyaluronan synthase from Streptococcus equisimilis. , 2004, Biochemistry.

[18]  S. Seshadri,et al.  Characterization of Thermostable Serine Alkaline Protease from an Alkaliphilic Strain Bacillus pumilus MCAS8 and Its Applications , 2012, Applied Biochemistry and Biotechnology.

[19]  F. Stelzer,et al.  Poly(hydroxy alkanoate)s in Medical Applications. , 2015, Chemical and biochemical engineering quarterly.

[20]  N. Radchenkova,et al.  Genomic analysis of Brevibacillus thermoruber 423 reveals its biotechnological and industrial potential , 2015, Applied Microbiology and Biotechnology.

[21]  M. Adams,et al.  The hyperthermophilic bacterium, Thermotoga maritima, contains an unusually complex iron-hydrogenase: amino acid sequence analyses versus biochemical characterization. , 1999, Biochimica et biophysica acta.

[22]  R. Gross,et al.  A Cutinase with Polyester Synthesis Activity , 2007 .

[23]  Peter Marek,et al.  Commercial proteases: Present and future , 2013, FEBS letters.

[24]  C. Litchfield,et al.  Purification and characterization of a thermostable, haloalkaliphilic extracellular serine protease from the extreme halophilic archaeon Halogeometricum borinquense strain TSS101. , 2006, Archaea.

[25]  Bertus van den Burg,et al.  Extremophiles as a source for novel enzymes. , 2003 .

[26]  E. Antoine,et al.  Cloning and over-expression in Escherichia coli of the gene encoding NADPH group III alcohol dehydrogenase from Thermococcus hydrothermalis. Characterization and comparison of the native and the recombinant enzymes. , 1999, European journal of biochemistry.

[27]  R. Zeng,et al.  Properties and Applications of Extremozymes from Deep-Sea Extremophilic Microorganisms: A Mini Review , 2019, Marine drugs.

[28]  E. Pikuta,et al.  Microbial Extremophiles at the Limits of Life , 2007, Critical reviews in microbiology.

[29]  B. Dijkstra,et al.  Bacterial biocatalysts: molecular biology, three-dimensional structures, and biotechnological applications of lipases. , 1999, Annual review of microbiology.

[30]  Zhenghong Xu,et al.  Nitrilases in nitrile biocatalysis: recent progress and forthcoming research , 2012, Microbial Cell Factories.

[31]  D. Holmes,et al.  Metal resistance in acidophilic microorganisms and its significance for biotechnologies , 2014, Applied Microbiology and Biotechnology.

[32]  K. Ajisaka,et al.  Isolation and characterization of thermostable chitinases from Bacillus licheniformis X-7u. , 1991, Biochimica et biophysica acta.

[33]  M. Rossi,et al.  A New Pepstatin-Insensitive Thermopsin-Like Protease Overproduced in Peptide-Rich Cultures of Sulfolobus solfataricus , 2014, International journal of molecular sciences.

[34]  Haruyuki Atomi,et al.  Recent progress towards the application of hyperthermophiles and their enzymes. , 2005, Current opinion in chemical biology.

[35]  G. Feller,et al.  Biotechnological applications of psychrophiles , 2010, Environmental technology.

[36]  D. Bartlett,et al.  Current developments in marine microbiology: high-pressure biotechnology and the genetic engineering of piezophiles. , 2015, Current opinion in biotechnology.

[37]  John M Woodley,et al.  Protein engineering of enzymes for process applications. , 2013, Current opinion in chemical biology.

[38]  W. Steiner,et al.  The Biocatalytic Potential of Extremophiles and Extremozymes , 2004 .

[39]  A. Oren.  Industrial and environmental applications of halophilic microorganisms , 2010, Environmental technology.

[40]  M. E. Setati,et al.  Diversity and industrial potential of hydrolase- producing halophilic/halotolerant eubacteria , 2010 .

[41]  G. Antranikian,et al.  Degradation of crude oil by an arctic microbial consortium , 2005, Extremophiles.

[42]  Tau Chuan Ling,et al.  Pullulanase: Role in Starch Hydrolysis and Potential Industrial Applications , 2012, Enzyme research.

[43]  R. Fani,et al.  Antibiotics from Deep-Sea Microorganisms: Current Discoveries and Perspectives , 2018, Marine drugs.

[44]  J. Visser,et al.  The faeA genes from Aspergillus niger and Aspergillus tubingensis encode ferulic acid esterases involved in degradation of complex cell wall polysaccharides , 1997, Applied and environmental microbiology.

[45]  J. Blamey,et al.  Cloning, overexpression, and characterization of a thermostable nitrilase from an Antarctic Pyrococcus sp. , 2017, Extremophiles.

[46]  Doman Kim,et al.  Molecular cloning and biochemical characterization of a heat-stable type I pullulanase from Thermotoga neapolitana. , 2011, Enzyme and microbial technology.

[47]  D. Cowan,et al.  Metagenomics of extreme environments. , 2015, Current opinion in microbiology.

[48]  R. Kelly,et al.  Glycosyl hydrolases from hyperthermophilic microorganisms. , 1998, Current opinion in biotechnology.

[49]  D. Johnson,et al.  Biomining-biotechnologies for extracting and recovering metals from ores and waste materials. , 2014, Current opinion in biotechnology.

[50]  A novel thermostable esterase from the thermoacidophilic archaeon Sulfolobus tokodaii strain 7. , 2004 .