Mathematical Model of Airflow in the Lungs of Children I: Effects of Tumor Sizes and Locations

To contribute to the development of more effective aerosol therapy protocols in pediatric medicine, we examined airflow patterns in the lung of a four-year-old child. In particular, we addressed how the presence of tumors in airways affected the character of airflow patterns. To study the effects of tumors we employed a computational fluid dynamics package, FIDAP, to define flow conditions within a model lung. The results indicated that tumors have a pronounced affect on both (i) localized velocity profiles in airways and (ii) bulk flow distribution within the lung. By identifying the effects of physical factors on flow conditions the findings will lead to improved drug delivery regimens.

[1]  F. Simons,et al.  A comparison of beclomethasone, salmeterol, and placebo in children with asthma. Canadian Beclomethasone Dipropionate-Salmeterol Xinafoate Study Group. , 1997, The New England journal of medicine.

[2]  D E Olson,et al.  Pressure drop and fluid flow regime of air inspired into the human lung. , 1970, Journal of applied physiology.

[3]  T. Martonen,et al.  Cystic fibrosis: treatment with a supercomputer drug delivery model , 1997 .

[4]  R. C. Graham,et al.  Human subject age and activity level: factors addressed in a biomathematical deposition program for extrapolation modeling. , 1989, Health physics.

[5]  R. Cleveland.  Symmetry of bronchial angles in children. , 1979, Radiology.

[6]  K. Roberts.  Bronchial Adenoma in Childhood , 1954, Archives of disease in childhood.

[7]  J. Meyer,et al.  Tumors of the pediatric chest. , 1998, Seminars in roentgenology.

[8]  B. Kotecha,et al.  Ribavirin treatment for juvenile respiratory papillomatosis , 1993, The Journal of Laryngology & Otology.

[9]  P. Wurnig,et al.  Endotracheal and endobronchial tumours in childhood. , 1987, Progress in pediatric surgery.

[10]  R. C. Graham,et al.  Predicted Deposition of Nonhygroscopic Aerosols in the Human Lung as a Function of Subject Age , 1989 .

[11]  S. Kagamimori,et al.  Further study of nebulisation chemotherapy, a new chemotherapeutic method in the treatment of lung carcinomas: fundamental and clinical. , 1993, British Journal of Cancer.

[12]  G. Vawter,et al.  Primary bronchial tumors in childhood: A clinicopathologic study of six cases , 1983, Cancer.

[13]  Ted B. Martonen,et al.  Effects of Carinal Ridge Shapes on Lung Airstreams , 1994 .

[14]  R. Darling,et al.  A CONTINUING CLINICAL SURVEY OF ADENOMAS OF THE TRACHEA AND BRONCHUS IN A GENERAL HOSPITAL. , 1963, The Journal of thoracic and cardiovascular surgery.

[15]  S. Yazbeck,et al.  Childhood primary pulmonary neoplasms. , 1993, Journal of pediatric surgery.

[16]  S. Kramer,et al.  Pulmonary manifestations of juvenile laryngotracheal papillomatosis. , 1985, AJR. American journal of roentgenology.

[17]  Ted B. Martonen,et al.  Influences of Cartilaginous Rings on Tracheobronchial Fluid Dynamics , 1994 .

[18]  Thomas Heistracher,et al.  Physiologically realistic models of bronchial airway bifurcations , 1995 .

[19]  Seymour R. Cohen,et al.  Papilloma of the Larynx and Tracheobronchial Tree in Children , 1980, The Annals of otology, rhinology, and laryngology.

[20]  R C Schroter,et al.  Flow patterns in models of the human bronchial airways. , 1969, Respiration physiology.

[21]  H. Spjut,et al.  Bronchial adenomas in children. , 1965, Texas medicine.

[22]  C. Carrington,et al.  Morphometry of the Human Lung , 1965, The Yale Journal of Biology and Medicine.

[23]  W. Pierce,et al.  Bronchogenic tumors in children. , 1970, Archives of surgery.

[24]  Bahman Asgharian,et al.  Inertial and gravitational deposition of particles in a square cross section bifurcating airway , 1994 .

[25]  T. Duff.  Laryngeal papillomatosis , 1971, The Journal of Laryngology & Otology.

[26]  S. Malozowski,et al.  Comparison of beclomethasone, salmeterol, and placebo in children with asthma. , 1998, The New England journal of medicine.

[27]  Ted B. Martonen,et al.  Fluid Dynamics of the Human Larynx and Upper Tracheobronchial Airways , 1993 .

[28]  E. Weibel.  Morphometry of the Human Lung , 1965, Springer Berlin Heidelberg.

[29]  J. Kirchner.  Papilloma of the larynx with extensive lung involvement , 1951, The Laryngoscope.

[30]  R. Andrassy,et al.  Bronchial carcinoid tumors in children and adolescents. , 1977, Journal of pediatric surgery.