The Impact of Time to Rate Control of Junctional Ectopic Tachycardia After Congenital Heart Surgery

Background: Junctional ectopic tachycardia (JET) after congenital heart disease (CHD) surgery is often self-limiting but is associated with increased risk of morbidity and mortality. Contributing factors and impact of time to achieve rate control of JET are poorly described. Methods: From January 2010 to June 2015, a retrospective, single-center cohort study was performed of children who developed JET after CHD surgery . We classified the cohort into two groups: patients who achieved rate control of JET in ≤24 hours and in >24 hours. We examined factors associated with time to rate control and compared clinical outcomes (mortality, duration of mechanical ventilation, length of intensive care unit [ICU], and hospital stay) between the two groups. Results: Our cohort included 27 children, with a median age of 3 (interquartile range: 0.7-38] months. The most common CHD lesions were ventricular septal defect (n = 10, 37%), tetralogy of Fallot (n = 7, 25.9%), and transposition of the great arteries (n = 4, 14.8%). In all, 15 (55.6%) and 12 (44.4%) patients achieved rate control of JET in ≤24 hours and >24 hours, respectively. There was a difference in median mechanical ventilation time (97 [21-145) vs 311 [100-676] hours; P = .013) and ICU stay (5.0 [2.0-8.0] vs 15.5 [5.5-32.8] days, P = .023) between the patients who achieved faster rate control than those who didn’t. There was no difference in length of hospital stay and mortality between the groups. Conclusion: Our study demonstrated that time to achieve rate control of JET was associated with increased duration of mechanical ventilation and ICU stay.

[1]  B. Meibohm,et al.  Pharmacokinetics of intravenous amiodarone in children , 2013, Archives of Disease in Childhood.

[2]  A. Batra,et al.  Junctional ectopic tachycardia: Current strategies for diagnosis and management , 2013 .

[3]  M. Oster,et al.  Junctional Ectopic Tachycardia After Congenital Heart Surgery in the Current Surgical Era , 2013, Pediatric Cardiology.

[4]  D. Hanauer,et al.  Junctional Ectopic Tachycardia After Infant Heart Surgery: Incidence and Outcomes , 2012, Pediatric Cardiology.

[5]  V. Pettilä,et al.  Junctional ectopic tachycardia after surgery for congenital heart disease: incidence, risk factors and outcome. , 2011, European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery.

[6]  Nina Hakacova,et al.  Amiodarone as a first-line therapy for postoperative junctional ectopic tachycardia. , 2009, The Annals of thoracic surgery.

[7]  H. Ravn,et al.  Junctional ectopic tachycardia after surgery for congenital heart disease in children , 2008, Intensive Care Medicine.

[8]  M. Rodefeld,et al.  A Prospective Analysis of the Incidence and Risk Factors Associated with Junctional Ectopic Tachycardia Following Surgery for Congenital Heart Disease , 2006, Pediatric Cardiology.

[9]  R. Justo,et al.  Amiodarone for post-operative junctional ectopic tachycardia , 2005, Cardiology in the Young.

[10]  R. Friedman,et al.  Use of Intravenous Amiodarone for Postoperative Junctional Ectopic Tachycardia in Children , 2003, Pediatric Cardiology.

[11]  T. Spray,et al.  Postoperative junctional ectopic tachycardia in children: incidence, risk factors, and treatment. , 2002, The Annals of thoracic surgery.

[12]  M. D. de Leval,et al.  Impact of junctional ectopic tachycardia on postoperative morbidity following repair of congenital heart defects. , 2002, European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery.

[13]  Kimberlee Gauvreau,et al.  Consensus-based method for risk adjustment for surgery for congenital heart disease. , 2002, The Journal of thoracic and cardiovascular surgery.

[14]  R. Mee Surgical substrates of postoperative junctional ectopic tachycardia in congenital heart defects. , 2002, The Journal of thoracic and cardiovascular surgery.

[15]  J. Mayer,et al.  Evaluation of a staged treatment protocol for rapid automatic junctional tachycardia after operation for congenital heart disease. , 1997, Journal of the American College of Cardiology.

[16]  T. Paul,et al.  Successful management of junctional tachycardia by hypothermia after cardiac operations in infants. , 1995, The Annals of thoracic surgery.

[17]  G. Sholler,et al.  Amiodarone management of junctional ectopic tachycardia after cardiac surgery in children. , 1994, British heart journal.

[18]  S. Ho,et al.  Histopathological findings in three children with His bundle tachycardia occurring subsequent to cardiac surgery. , 1992, European heart journal.

[19]  J. Deanfield,et al.  Moderate hypothermia in the management of resistant automatic tachycardias in children. , 1991, British heart journal.

[20]  E. Rowland,et al.  Atrial pacing as an adjunct to the management of post-surgical His bundle tachycardia. , 1991, British heart journal.