Sensitivity analysis of geometric errors in additive manufacturing medical models.

Additive manufacturing (AM) models are used in medical applications for surgical planning, prosthesis design and teaching. For these applications, the accuracy of the AM models is essential. Unfortunately, this accuracy is compromised due to errors introduced by each of the building steps: image acquisition, segmentation, triangulation, printing and infiltration. However, the contribution of each step to the final error remains unclear. We performed a sensitivity analysis comparing errors obtained from a reference with those obtained modifying parameters of each building step. Our analysis considered global indexes to evaluate the overall error, and local indexes to show how this error is distributed along the surface of the AM models. Our results show that the standard building process tends to overestimate the AM models, i.e. models are larger than the original structures. They also show that the triangulation resolution and the segmentation threshold are critical factors, and that the errors are concentrated at regions with high curvatures. Errors could be reduced choosing better triangulation and printing resolutions, but there is an important need for modifying some of the standard building processes, particularly the segmentation algorithms.

[1]  Francesca De Crescenzio,et al.  CAD/CAM and rapid prototyped scaffold construction for bone regenerative medicine and surgical transfer of virtual planning: A pilot study , 2009, Comput. Medical Imaging Graph..

[2]  Franz Kainberger,et al.  Accuracy of treatment planning based on stereolithography in computer assisted surgery. , 2006, Medical physics.

[3]  Lu Bingheng,et al.  Design and fabrication of custom mandible titanium tray based on rapid prototyping. , 2004, Medical engineering & physics.

[4]  Peter Liacouras,et al.  Designing and manufacturing an auricular prosthesis using computed tomography, 3-dimensional photographic imaging, and additive manufacturing: a clinical report. , 2011, The Journal of prosthetic dentistry.

[5]  Pablo Irarrazaval,et al.  Quantitative assessments of geometric errors for rapid prototyping in medical applications , 2012 .

[6]  Predrag Sukovic,et al.  Accuracy of implant placement with a stereolithographic surgical guide. , 2003, The International journal of oral & maxillofacial implants.

[7]  Tony F. Chan,et al.  Active contours without edges , 2001, IEEE Trans. Image Process..

[8]  J. Y. Choi,et al.  Analysis of errors in medical rapid prototyping models. , 2002, International journal of oral and maxillofacial surgery.

[9]  Jason Watson,et al.  Development of in-house rapid manufacturing of three-dimensional models in maxillofacial surgery. , 2010, The British journal of oral & maxillofacial surgery.

[10]  Xun Wang,et al.  A comparative study of deformable contour methods on medical image segmentation , 2008, Image Vis. Comput..

[11]  Michele Germani,et al.  A method for performance evaluation of RE/RP systems in dentistry , 2010 .

[12]  Seiichi Serikawa,et al.  Active Contours Model for Image Segmentation: A Review , 2013 .

[13]  C. Kerber,et al.  Stereolithographic vascular replicas from CT scans: choosing treatment strategies, teaching, and research from live patient scan data. , 2005, AJNR. American journal of neuroradiology.

[14]  Milan Kljajin,et al.  Geometric Accuracy by 2-D Printing Model , 2008 .

[15]  Chung-Shing Wang,et al.  STL rapid prototyping bio-CAD model for CT medical image segmentation , 2010, Comput. Ind..

[16]  Mika Salmi,et al.  Accuracy of medical models made by additive manufacturing (rapid manufacturing). , 2013, Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery.

[17]  G. Pei,et al.  Use of patient-specific templates in hip resurfacing arthroplasty: experience from sixteen cases , 2013, International Orthopaedics.

[18]  Peter Liacouras,et al.  Digital image capture and rapid prototyping of the maxillofacial defect. , 2011, Journal of prosthodontics : official journal of the American College of Prosthodontists.

[19]  Denis J Marcellin-Little,et al.  Evaluation of the effect of computed tomography scan protocols and freeform fabrication methods on bone biomodel accuracy. , 2011, American journal of veterinary research.

[20]  John Winder,et al.  A review of the issues surrounding three-dimensional computed tomography for medical modelling using rapid prototyping techniques , 2010 .

[21]  Liang Xiao,et al.  A robust patch-statistical active contour model for image segmentation , 2012, Pattern Recognit. Lett..

[22]  Jorge Vicente Lopes da Silva,et al.  Dimensional error in selective laser sintering and 3D-printing of models for craniomaxillary anatomy reconstruction. , 2008, Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery.

[23]  Thomas L Toth,et al.  Dose reduction and compliance with pediatric CT protocols adapted to patient size, clinical indication, and number of prior studies. , 2009, Radiology.

[24]  Richard J. Bibb Medical Modelling: The application of advanced design and development techniques in Medicine , 2006 .

[25]  Richard J. Bibb,et al.  Medical Modelling: The Application of Advanced Design and Rapid Prototyping Techniques in Medicine (Woodhead Publishing Series in Biomaterials) , 2014 .

[26]  D. Silva,et al.  Dimensional error of selective laser sintering, three-dimensional printing and PolyJet models in the reproduction of mandibular anatomy. , 2009, Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery.

[27]  Greta Toncheva,et al.  Radiation dose from contemporary cardiothoracic multidetector CT protocols with an anthropomorphic female phantom: implications for cancer induction. , 2007, Radiology.

[28]  Y. Yamashita,et al.  Reduction in radiation and contrast medium dose via optimization of low-kilovoltage CT protocols using a hybrid iterative reconstruction algorithm at 256-slice body CT: phantom study and clinical correlation. , 2013, Clinical radiology.

[29]  Judith R. Meakin,et al.  Fused deposition models from CT scans , 2004 .

[30]  J. Winder,et al.  Medical rapid prototyping technologies: state of the art and current limitations for application in oral and maxillofacial surgery. , 2005, Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons.

[31]  Mika Salmi,et al.  Imaging requirements for medical applications of additive manufacturing , 2014, Acta radiologica.

[32]  Bernhard Mueller,et al.  Additive Manufacturing Technologies – Rapid Prototyping to Direct Digital Manufacturing , 2012 .

[33]  Roger Toogood,et al.  An Experimental Method for Stereolithic Mandible Fabrication and Image Preparation , 2007, The open biomedical engineering journal.

[34]  Rafiq Noorani,et al.  Rapid prototyping : principles and applications , 2006 .

[35]  Lin Naing,et al.  Dimensional Accuracy of the Skull Models Produced by Rapid Prototyping Technology Using Stereolithography Apparatus , 2006 .

[36]  David Palousek,et al.  Use of digital technologies for nasal prosthesis manufacturing , 2014, Prosthetics and orthotics international.

[37]  Yosry Morsi,et al.  Error analysis of FDM fabricated medical replicas , 2010 .