Architectural (Type IA) Focal Cortical Dysplasia and Parvalbumin Immunostaining in Temporal Lobe Epilepsy

Summary:  Purpose: We analyzed 26 surgically treated patients operated on for intractable epilepsy associated with type IA (architectural) cortical dysplasia, to investigate neuropathologic and immunocytochemical features, particularly of the γ‐aminobutyric acid (GABA)ergic system, and to compare the findings with those observed in normal cortex.

[1]  E G Jones,et al.  Visualization of chandelier cell axons by parvalbumin immunoreactivity in monkey cerebral cortex. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[2]  R. Miller,et al.  Calcium buffering properties of calbindin D28k and parvalbumin in rat sensory neurones. , 1993, The Journal of physiology.

[3]  J. Engel.  Excitation and Inhibition in Epilepsy , 1996, Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques.

[4]  J. Cox,et al.  The Ca2+(-)binding proteins parvalbumin and oncomodulin and their genes: new structural and functional findings. , 1996, Biochimica et biophysica acta.

[5]  Rita Garbelli,et al.  Taylor's Cortical Dysplasia: A Confocal and Ultrastructural Immunohistochemical Study , 1999, Brain pathology.

[6]  S. Eisenschenk,et al.  Reduced density of parvalbumin- and calbindin D28k-immunoreactive neurons in experimental cortical dysplasia , 1999, Epilepsy Research.

[7]  Josemir W Sander,et al.  Microdysgenesis with abnormal cortical myelinated fibres in temporal lobe epilepsy: a histopathological study with calbindin D‐28‐K immunohistochemistry , 2000, Neuropathology and applied neurobiology.

[8]  R. Garbelli,et al.  Inhibitory Circuits in Human Dysplastic Tissue , 2000, Epilepsia.

[9]  A. J. Barkovich,et al.  Classification system for malformations of cortical development , 2001, Neurology.

[10]  O. Wiestler,et al.  Ammon's Horn Sclerosis: A Maldevelopmental Disorder Associated with Temporal Lobe Epilepsy , 2002, Brain pathology.

[11]  L Tassi,et al.  Focal cortical dysplasia: neuropathological subtypes, EEG, neuroimaging and surgical outcome. , 2002, Brain : a journal of neurology.

[12]  L. Martinian,et al.  Cajal-Retzius cells, inhibitory interneuronal populations and neuropeptide Y expression in focal cortical dysplasia and microdysgenesis , 2003, Acta Neuropathologica.

[13]  A. Palmini,et al.  Terminology and classification of the cortical dysplasias , 2004, Neurology.

[14]  M. Calcagnotto,et al.  Dysfunction of Synaptic Inhibition in Epilepsy Associated with Focal Cortical Dysplasia , 2005, The Journal of Neuroscience.

[15]  J. DeFelipe,et al.  Microanatomy of the dysplastic neocortex from epileptic patients. , 2004, Brain : a journal of neurology.