A STUB1 ubiquitin ligase/CHIC2 protein complex negatively regulates the IL-3, IL-5, and GM-CSF cytokine receptor common β chain (CSF2RB) protein stability

[1]  T. Golub,et al.  The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K , 2020, Nature.

[2]  L. Grinberg,et al.  Specificity for latent C termini links the E3 ubiquitin ligase CHIP to caspases , 2019, Nature Chemical Biology.

[3]  Benjamin L Ebert,et al.  Defining the human C2H2 zinc finger degrome targeted by thalidomide analogs through CRBN , 2018, Science.

[4]  C. Tepper,et al.  Proteostasis by STUB1/HSP70 complex controls sensitivity to androgen receptor targeted therapy in advanced prostate cancer , 2018, Nature Communications.

[5]  B. Ebert,et al.  Genome-wide screen identifies cullin-RING ligase machinery required for lenalidomide-dependent CRL4CRBN activity. , 2018, Blood.

[6]  Todd R. Golub,et al.  Improved estimation of cancer dependencies from large-scale RNAi screens using model-based normalization and data integration , 2018, bioRxiv.

[7]  Phillip G. Montgomery,et al.  Defining a Cancer Dependency Map , 2017, Cell.

[8]  Devin P. Sullivan,et al.  A subcellular map of the human proteome , 2017, Science.

[9]  J. Höhfeld,et al.  The Ubiquitin Ligase CHIP Integrates Proteostasis and Aging by Regulation of Insulin Receptor Turnover , 2017, Cell.

[10]  Eric S. Lander,et al.  Gene Essentiality Profiling Reveals Gene Networks and Synthetic Lethal Interactions with Oncogenic Ras , 2017, Cell.

[11]  Michael R. Green,et al.  MARCH1 regulates insulin sensitivity by controlling cell surface insulin receptor levels , 2016, Nature Communications.

[12]  Brian J. Druker,et al.  Discovery and functional characterization of a germline, CSF2RB-activating mutation in leukemia , 2016, Leukemia.

[13]  Angel F. Lopez,et al.  The βc receptor family - Structural insights and their functional implications. , 2015, Cytokine.

[14]  Matthew E. Ritchie,et al.  limma powers differential expression analyses for RNA-sequencing and microarray studies , 2015, Nucleic acids research.

[15]  L. You,et al.  CHIP is a novel tumor suppressor in pancreatic cancer and inhibits tumor growth through targeting EGFR , 2014, Oncotarget.

[16]  J. Larner,et al.  Androgen receptor degradation by the E3 ligase CHIP modulates mitotic arrest in prostate cancer cells , 2014, Oncogene.

[17]  N. Eissa,et al.  Regulation of IL-4 receptor signaling by STUB1 in lung inflammation. , 2013, American journal of respiratory and critical care medicine.

[18]  David A. Scott,et al.  Genome engineering using the CRISPR-Cas9 system , 2013, Nature Protocols.

[19]  Angel F. Lopez,et al.  The GM–CSF/IL‐3/IL‐5 cytokine receptor family: from ligand recognition to initiation of signaling , 2012, Immunological reviews.

[20]  E. De Braekeleer,et al.  ETV6 fusion genes in hematological malignancies: a review. , 2012, Leukemia research.

[21]  E. Chang,et al.  Intracellular Heat Shock Protein-70 Negatively Regulates TLR4 Signaling in the Newborn Intestinal Epithelium , 2012, The Journal of Immunology.

[22]  K. Song,et al.  The C-terminus of Hsp70-Interacting Protein Promotes Met Receptor Degradation , 2011, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.

[23]  C. Gomez-Sanchez,et al.  Mineralocorticoid receptor degradation is promoted by Hsp90 inhibition and the ubiquitin-protein ligase CHIP. , 2010, American journal of physiology. Renal physiology.

[24]  Anna L. Brown,et al.  Expression profiling of a hemopoietic cell survival transcriptome implicates osteopontin as a functional prognostic factor in AML. , 2009, Blood.

[25]  S. Ogawa,et al.  Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms , 2009, Nature.

[26]  K. Nephew,et al.  CHIP (carboxyl terminus of Hsc70-interacting protein) promotes basal and geldanamycin-induced degradation of estrogen receptor-alpha. , 2005, Molecular endocrinology.

[27]  C. Patterson,et al.  C-terminal Hsp-interacting protein slows androgen receptor synthesis and reduces its rate of degradation. , 2003, Archives of biochemistry and biophysics.

[28]  L. Neckers,et al.  Chaperone-dependent E3 ubiquitin ligase CHIP mediates a degradative pathway for c-ErbB2/Neu , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[29]  M. Martinez-Moczygemba,et al.  Proteasomal regulation of betac signaling reveals a novel mechanism for cytokine receptor heterotypic desensitization. , 2001, The Journal of clinical investigation.

[30]  D. Cyr,et al.  CHIP Is a U-box-dependent E3 Ubiquitin Ligase , 2001, The Journal of Biological Chemistry.

[31]  P. Connell,et al.  Identification of CHIP, a Novel Tetratricopeptide Repeat-Containing Protein That Interacts with Heat Shock Proteins and Negatively Regulates Chaperone Functions , 1999, Molecular and Cellular Biology.

[32]  F. Lanza,et al.  Flow cytometry measurement of GM-CSF receptors in acute leukemic blasts, and normal hemopoietic cells , 1997, Leukemia.

[33]  N. Copeland,et al.  A novel cytokine‐inducible gene CIS encodes an SH2‐containing protein that binds to tyrosine‐phosphorylated interleukin 3 and erythropoietin receptors. , 1995, The EMBO journal.

[34]  S. Clark,et al.  Interleukin-3 and granulocyte-monocyte colony-stimulating factor receptors on human acute myelocytic leukemia cells and relationship to the proliferative response. , 1989, Blood.

[35]  I. Bernstein,et al.  Interleukin-3, GM-CSF, and G-CSF receptor expression on cell lines and primary leukemia cells: receptor heterogeneity and relationship to growth factor responsiveness. , 1989, Blood.

[36]  P. Connell,et al.  The co-chaperone CHIP regulates protein triage decisions mediated by heat-shock proteins , 2000, Nature Cell Biology.

[37]  D. Cyr,et al.  The Hsc70 co-chaperone CHIP targets immature CFTR for proteasomal degradation , 2000, Nature Cell Biology.