Mathematical models of drug resistance and chemotherapy effects.

Mathematical modelling allows one to study complex processes that may not be completely amenable to direct observation. The modelling approach requires the researcher to make explicit assumptions about the phenomenon he is studying and to place these within a rigorous mathematical framework. In this paper, we will describe some of the work that has been done in the specific area of drug resistance, beginning with earlier minimal models of the phenomenon, and then going on to discuss refinements that have been incorporated into the basic model structure.

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