Development of nanostructured magnetic capsules by means of the layer by layer technique

Nanomagnetic particles have been already taken into account as drug carriers thank to the possibility to control their movement to a specific location where the treatment is required by means of high gradient magnetic fields (HGMF). In this work the layer-by-layer technique (LbL) and nanomagnetic particles were used to developed innovative nanostructured magnetic capsules (NSMC). Their potential application as magnetic drug carriers was investigated under the influence of both static and oscillating magnetic fields used respectively to control capsule displacement and shell permeability. The assembly process of the nanostructured magnetic capsules, its characterization by Quartz Crystal Microbalance (QCM), and the results obtained under the influence of the magnetic fields are presented.

[1]  Y. Lvov,et al.  Layer-by-layer assembly , 2008 .

[2]  Gleb B. Sukhorukov,et al.  LAYER-BY-LAYER SELF ASSEMBLY OF POLYELECTROLYTES ON COLLOIDAL PARTICLES , 1998 .

[3]  J. Dobson,et al.  Development of Superparamagnetic Iron Oxide Nanoparticles (SPIONS) for Translation to Clinical Applications , 2008, IEEE Transactions on NanoBioscience.

[4]  J. Dobson,et al.  Magnetic nanoparticles for gene and drug delivery , 2008, International journal of nanomedicine.

[5]  B. Shapiro.  Towards dynamic control of magnetic fields to focus magnetic carriers to targets deep inside the body. , 2009, Journal of magnetism and magnetic materials.

[6]  Sungho Jin,et al.  Magnetic nanoparticles for theragnostics. , 2009, Advanced drug delivery reviews.

[7]  Catherine C. Berry,et al.  Functionalisation of magnetic nanoparticles for applications in biomedicine , 2003 .

[8]  Multicomposites Gero Decher.  Fuzzy Nanoassemblies: Toward Layered Polymeric , 1997 .

[9]  Wolfgang J Parak,et al.  Multifunctionalized polymer microcapsules: novel tools for biological and pharmacological applications. , 2007, Small.

[10]  Armin D. Ebner,et al.  Theoretical analysis of a transdermal ferromagnetic implant for retention of magnetic drug carrier particles , 2005 .

[11]  Junbo Ge,et al.  In vitro study of deep capture of paramagnetic particle for targeting therapeutics , 2009 .

[12]  Gleb B. Sukhorukov,et al.  Intelligent micro- and nanocapsules , 2005 .

[13]  Antony K. Chen,et al.  Superparamagnetic Iron Oxide Nanoparticle Probes for Molecular Imaging , 2006, Annals of Biomedical Engineering.

[14]  Gero Decher,et al.  Fuzzy Nanoassemblies: Toward Layered Polymeric Multicomposites , 1997 .

[15]  Carmelina Ruggiero,et al.  Paclitaxel-containing nano-engineered polymeric capsules towards cancer therapy. , 2009, Journal of nanoscience and nanotechnology.

[16]  C. Bárcena,et al.  APPLICATIONS OF MAGNETIC NANOPARTICLES IN BIOMEDICINE , 2003 .

[17]  H. Hofmann,et al.  Superparamagnetic nanoparticles for biomedical applications: Possibilities and limitations of a new drug delivery system , 2005 .

[18]  D. Rüfenacht,et al.  Local moderate magnetically induced hyperthermia using an implant formed in situ in a mouse tumor model , 2009, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

[19]  H. Möhwald,et al.  The pros and cons of polyelectrolyte capsules in drug delivery , 2009, Expert opinion on drug delivery.

[20]  H. Möhwald,et al.  Hollow polyelectrolyte shells: Exclusion of polymers and Donnan equilibrium. , 1999 .