Subtype-specific β-adrenoceptor signaling pathways in the heart and their potential clinical implications
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Heping Cheng | E. Lakatta | Heping Cheng | M. Zheng | R. Bond | Edward G. Lakatta | Rui-Ping Xiao | R. Xiao | Richard A. Bond | Ming Zheng | Khalid Chakir | Weizhong Zhu | Weizhong Zhu | K. Chakir
[1] R. Lefkowitz,et al. Cardiac βARK1 inhibition prolongs survival and augments β blocker therapy in a mouse model of severe heart failure , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[2] S. Harding,et al. The effect of pertussis toxin on β‐adrenoceptor responses in isolated cardiac myocytes from noradrenaline‐treated guinea‐pigs and patients with cardiac failure , 1992, British journal of pharmacology.
[3] P. Barnes,et al. Gi-dependent suppression of β1-adrenoceptor effects in ventricular myocytes from NE-treated guinea pigs , 2000 .
[4] B. Kobilka,et al. Linkage of beta1-adrenergic stimulation to apoptotic heart cell death through protein kinase A-independent activation of Ca2+/calmodulin kinase II. , 2003, The Journal of clinical investigation.
[5] P. Poole‐Wilson,et al. Comparison of carvedilol and metoprolol on clinical outcomes in patients with chronic heart failure in the Carvedilol Or Metoprolol European Trial (COMET): randomised controlled trial , 2003, The Lancet.
[6] E. Lakatta,et al. The β2-Adrenergic receptor delivers an antiapoptotic signal to cardiac myocytes through Gi-Dependent coupling to phosphatidylinositol 3'-kinase , 2000 .
[7] G. Dorn,et al. Polymorphisms of the beta1-adrenergic receptor predict exercise capacity in heart failure. , 2002, American heart journal.
[8] E. Lakatta,et al. Functional coupling of the beta 2-adrenoceptor to a pertussis toxin-sensitive G protein in cardiac myocytes. , 1995, Molecular pharmacology.
[9] E. Lakatta,et al. Gi-Dependent Localization of β2-Adrenergic Receptor Signaling to L-Type Ca2+ Channels , 2000 .
[10] M. Bristow. Mechanistic and clinical rationales for using beta-blockers in heart failure. , 2000, Journal of cardiac failure.
[11] B. Brodie,et al. Relationship between delay in performing direct coronary angioplasty and early clinical outcome in patients with acute myocardial infarction. , 2000, Circulation.
[12] R. Xiao. β-Adrenergic Signaling in the Heart: Dual Coupling of the β2-Adrenergic Receptor to Gs and Gi Proteins , 2001, Science's STKE.
[13] P. Karczewski,et al. β2-Adrenoceptor activation by zinterol causes protein phosphorylation, contractile effects and relaxant effects through a cAMP pathway in human atrium , 1996, Molecular and Cellular Biochemistry.
[14] E. Lakatta,et al. Localized cAMP-dependent signaling mediates beta 2-adrenergic modulation of cardiac excitation-contraction coupling. , 1997, The American journal of physiology.
[15] E. Lakatta,et al. Beta 1-adrenoceptor stimulation and beta 2-adrenoceptor stimulation differ in their effects on contraction, cytosolic Ca2+, and Ca2+ current in single rat ventricular cells. , 1993, Circulation research.
[16] G. Dorn,et al. Low- and high-level transgenic expression of β2-adrenergic receptors differentially affect cardiac hypertrophy and function in Gαq-overexpressing mice , 1999 .
[17] H. Schulman,et al. The Nuclear δB Isoform of Ca2+/Calmodulin-dependent Protein Kinase II Regulates Atrial Natriuretic Factor Gene Expression in Ventricular Myocytes* , 1997, The Journal of Biological Chemistry.
[18] D. A. Mason,et al. A Gain-of-function Polymorphism in a G-protein Coupling Domain of the Human β1-Adrenergic Receptor* , 1999, The Journal of Biological Chemistry.
[19] G. Nickenig,et al. Prospective crossover comparison of carvedilol and metoprolol in patients with chronic heart failure. , 2001, Journal of the American College of Cardiology.
[20] M. Raynolds,et al. Myocardial-directed overexpression of the human beta(1)-adrenergic receptor in transgenic mice. , 2000, Journal of molecular and cellular cardiology.
[21] T. McIntosh,et al. The Ile164 beta2-adrenergic receptor polymorphism adversely affects the outcome of congestive heart failure. , 1998, The Journal of clinical investigation.
[22] M. Crow,et al. Phosphatidylinositol 3-Kinase Functionally Compartmentalizes the Concurrent Gs Signaling During &bgr;2-Adrenergic Stimulation , 2002 .
[23] E. Lucchinetti,et al. β-Adrenergic Receptor Subtypes Differentially Affect Apoptosis in Adult Rat Ventricular Myocytes , 2000 .
[24] M. Brown,et al. Selective j31-Adrenoceptor Blockade Enhances Positive Inotropic Responses toEndogenous Catecholamines Mediated Through j2-Adrenoceptors inHumanAtrial Myocardium , 1990 .
[25] E. Lakatta,et al. Enhanced Gi Signaling Selectively Negates &bgr;2-Adrenergic Receptor (AR)– but Not &bgr;1-AR–Mediated Positive Inotropic Effect in Myocytes From Failing Rat Hearts , 2003, Circulation.
[26] M. Steinfath,et al. Radioimmunochemical quantification of Gi alpha in right and left ventricles from patients with ischaemic and dilated cardiomyopathy and predominant left ventricular failure. , 1994, Journal of molecular and cellular cardiology.
[27] Chronic elevation of calmodulin in the ventricles of transgenic mice increases the autonomous activity of calmodulin-dependent protein kinase II, which regulates atrial natriuretic factor gene expression. , 2000, Molecular endocrinology.
[28] D. Bernstein,et al. Cardiovascular and Metabolic Alterations in Mice Lacking Both β1- and β2-Adrenergic Receptors* , 1999, The Journal of Biological Chemistry.
[29] H. Dargie. β blockers in heart failure , 2003, The Lancet.
[30] R. Robinson,et al. β2-Adrenergic Receptor Actions in Neonatal and Adult Rat Ventricular Myocytes , 1995 .
[31] B. Kobilka,et al. Protecting the myocardium: A role for the &bgr;2 adrenergic receptor in the heart , 2004, Critical care medicine.
[32] E. Lakatta,et al. Culture and adenoviral infection of adult mouse cardiac myocytes: methods for cellular genetic physiology. , 2000, American journal of physiology. Heart and circulatory physiology.
[33] P. Ping,et al. Reduced beta-adrenergic receptor activation decreases G-protein expression and beta-adrenergic receptor kinase activity in porcine heart. , 1995, The Journal of clinical investigation.
[34] S. Vatner,et al. β-adrenergic cardiac hypertrophy is mediated primarily by the β1-subtype in the rat heart , 2001 .
[35] B. A. Evans,et al. Desensitization of cardiac beta-adrenoceptor signaling with heart failure produced by myocardial infarction in the rat. Evidence for the role of Gi but not Gs or phosphorylating proteins. , 1999, Journal of molecular and cellular cardiology.
[36] R. Virmani,et al. Apoptosis in myocytes in end-stage heart failure. , 1996, The New England journal of medicine.
[37] P. Karczewski,et al. Activation of (cid:98) 2 -Adrenergic Receptors Hastens Relaxation and Mediates Phosphorylation of Phospholamban, Troponin I, and C-Protein in Ventricular Myocardium From Patients With Terminal Heart Failure , 1998 .
[38] Catherine Communal,et al. Opposing Effects of β1- and β2-Adrenergic Receptors on Cardiac Myocyte Apoptosis Role of a Pertussis Toxin–Sensitive G Protein , 1999 .
[39] C A Beltrami,et al. Apoptosis in the failing human heart. , 1997, The New England journal of medicine.
[40] R. Lefkowitz,et al. Enhanced myocardial function in transgenic mice overexpressing the beta 2-adrenergic receptor. , 1994, Science.
[41] P. Buttrick,et al. Subtype specific roles of beta-adrenergic receptors in apoptosis of adult rat ventricular myocytes. , 2002, Journal of molecular and cellular cardiology.
[42] E. Lakatta,et al. Beta 2-adrenergic receptor-stimulated increase in cAMP in rat heart cells is not coupled to changes in Ca2+ dynamics, contractility, or phospholamban phosphorylation. , 1994, The Journal of biological chemistry.
[43] A. Brown,et al. Rapid beta-adrenergic modulation of cardiac calcium channel currents by a fast G protein pathway. , 1989, Science.
[44] Robert J. Lefkowitz,et al. Switching of the coupling of the β2-adrenergic receptor to different G proteins by protein kinase A , 1997, Nature.
[45] Dianqing Wu,et al. Inhibition of receptor-localized PI3K preserves cardiac beta-adrenergic receptor function and ameliorates pressure overload heart failure. , 2003, The Journal of clinical investigation.
[46] Tong Zhang,et al. The &dgr;C Isoform of CaMKII Is Activated in Cardiac Hypertrophy and Induces Dilated Cardiomyopathy and Heart Failure , 2003, Circulation research.
[47] E. Lakatta,et al. Gi Protein-mediated Functional Compartmentalization of Cardiac β2-Adrenergic Signaling* , 1999, The Journal of Biological Chemistry.
[48] J. Ross,et al. Expression of a beta-adrenergic receptor kinase 1 inhibitor prevents the development of myocardial failure in gene-targeted mice. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[49] B. Kobilka,et al. Dual modulation of cell survival and cell death by beta(2)-adrenergic signaling in adult mouse cardiac myocytes. , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[50] H. Drexler,et al. Gene expression of the cardiac Na(+)-Ca2+ exchanger in end-stage human heart failure. , 1994, Circulation research.
[51] G. Dorn,et al. Altering the receptor-effector ratio by transgenic overexpression of type V adenylyl cyclase: enhanced basal catalytic activity and function without increased cardiomyocyte beta-adrenergic signalling. , 1999, Biochemistry.
[52] S. Jamieson,et al. Beta 1- and beta 2-adrenergic-receptor subpopulations in nonfailing and failing human ventricular myocardium: coupling of both receptor subtypes to muscle contraction and selective beta 1-receptor down-regulation in heart failure. , 1986, Circulation research.
[53] P. Anversa,et al. Acute myocardial infarction in humans is associated with activation of programmed myocyte cell death in the surviving portion of the heart. , 1996, Journal of molecular and cellular cardiology.
[54] S. Kardia,et al. Synergistic Polymorphisms of β1- and α2C-Adrenergic Receptors and the Risk of Congestive Heart Failure , 2002 .
[55] R. Lefkowitz,et al. Cardiac function in mice overexpressing the beta-adrenergic receptor kinase or a beta ARK inhibitor. , 1995, Science.
[56] W. White,et al. &bgr;2-Adrenergic and Several Other G Protein–Coupled Receptors in Human Atrial Membranes Activate Both Gs and Gi , 2000 .
[57] H. Cantiello,et al. Cardiac Gsalpha overexpression enhances L-type calcium channels through an adenylyl cyclase independent pathway. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[58] E. Lakatta,et al. Erratum: Culture and adenoviral infection of adult mouse cardiac myocytes: Methods for cellular genetic physiology (American Journal of Physiology - Heart and Circulatory Physiology (July 2000) 279:48 (H429-H436)) , 2000 .
[59] R. Lefkowitz,et al. Reciprocal in vivo regulation of myocardial G protein-coupled receptor kinase expression by beta-adrenergic receptor stimulation and blockade. , 1998, Circulation.
[60] W. Koch,et al. Overexpression of wild‐type Gαi‐2 suppresses β‐adrenergic signaling in cardiac myocytes , 2003 .
[61] M. Lohse,et al. Progressive hypertrophy and heart failure in beta1-adrenergic receptor transgenic mice. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[62] R. Kitsis,et al. A mechanistic role for cardiac myocyte apoptosis in heart failure. , 2003, The Journal of clinical investigation.
[63] E. Lakatta,et al. beta2-adrenergic cAMP signaling is uncoupled from phosphorylation of cytoplasmic proteins in canine heart. , 1999, Circulation.
[64] T. Kenakin,et al. Agonist-receptor efficacy. II. Agonist trafficking of receptor signals. , 1995, Trends in pharmacological sciences.
[65] E. Lakatta,et al. Coupling of beta2-adrenoceptor to Gi proteins and its physiological relevance in murine cardiac myocytes. , 1999, Circulation research.
[66] T. Anzai,et al. Adenylylcyclase increases responsiveness to catecholamine stimulation in transgenic mice. , 1999, Circulation.
[67] E. Lakatta,et al. Age-associated reductions in cardiac beta1- and beta2-adrenergic responses without changes in inhibitory G proteins or receptor kinases. , 1998, The Journal of clinical investigation.
[68] E. Braunwald,et al. Congestive Heart Failure: Fifty Years of Progress , 2000, Circulation.
[69] E. Lakatta,et al. Response of Failing Canine and Human Heart Cells to β2-Adrenergic Stimulation , 1995 .
[70] G. Condorelli,et al. The Akt-Glycogen Synthase Kinase 3β Pathway Regulates Transcription of Atrial Natriuretic Factor Induced by β-Adrenergic Receptor Stimulation in Cardiac Myocytes* , 2000, The Journal of Biological Chemistry.
[71] G. Dorn,et al. Early and delayed consequences of beta(2)-adrenergic receptor overexpression in mouse hearts: critical role for expression level. , 2000, Circulation.
[72] K. Schlüter,et al. Hypertrophic effect of selective beta(1)-adrenoceptor stimulation on ventricular cardiomyocytes from adult rat. , 2000, American journal of physiology. Cell physiology.
[73] W. Koch,et al. Specific β2AR Blocker ICI 118,551 Actively Decreases Contraction Through a Gi-Coupled Form of the β2AR in Myocytes From Failing Human Heart , 2002 .
[74] W. Colucci,et al. p38 Mitogen-activated Protein Kinase Pathway Protects Adult Rat Ventricular Myocytes against β-Adrenergic Receptor-stimulated Apoptosis , 2000, The Journal of Biological Chemistry.
[75] W. Schmitz,et al. Increased messenger RNA level of the inhibitory G protein alpha subunit Gi alpha-2 in human end-stage heart failure. , 1992, Circulation research.
[76] S. Vatner,et al. Adverse Effects of Chronic Endogenous Sympathetic Drive Induced by Cardiac Gsα Overexpression , 1996 .
[77] E. Lakatta,et al. Increased cardiomyocyte apoptosis during the transition to heart failure in the spontaneously hypertensive rat. , 1997, The American journal of physiology.
[78] Cesare M. Terracciano,et al. Loss of β-adrenoceptor response in myocytes overexpressing the Na+/Ca2+-exchanger , 2004 .
[79] C. Iwai,et al. Arg389Gly polymorphism of the human beta1-adrenergic receptor in patients with nonfatal acute myocardial infarction. , 2003, American heart journal.
[80] S. Vatner,et al. Myocardial beta-adrenergic receptor function during the development of pacing-induced heart failure. , 1993, The Journal of clinical investigation.
[81] M. Petch,et al. In vivo demonstration of cardiac beta 2-adrenoreceptor sensitization by beta 1-antagonist treatment. , 1991, Circulation research.
[82] M. Metra,et al. Differential Effects of β-Blockers in Patients With Heart Failure , 2000 .