Attenuation of the lysosomal death pathway by lysosomal cholesterol accumulation

[1]  E. Ikonen,et al.  Role for LAMP-2 in endosomal cholesterol transport , 2009, Journal of cellular and molecular medicine.

[2]  R. Grafström,et al.  Intrinsic differences in cisplatin sensitivity of head and neck cancer cell lines: Correlation to lysosomal pH , 2010, Head & neck.

[3]  F. Platt,et al.  Lipids on Trial: The Search for the Offending Metabolite in Niemann‐Pick type C Disease , 2010, Traffic.

[4]  M. Vanier.  Niemann-Pick disease type C , 2010, Orphanet journal of rare diseases.

[5]  X. Bi,et al.  Cholesterol in Niemann-Pick Type C disease. , 2010, Sub-cellular biochemistry.

[6]  K. Öllinger,et al.  Regulation of apoptosis-associated lysosomal membrane permeabilization , 2010, Apoptosis.

[7]  Barbara Karten,et al.  Mechanisms and consequences of impaired lipid trafficking in Niemann-Pick type C1-deficient mammalian cells. , 2009, Biochimica et biophysica acta.

[8]  F. Maxfield,et al.  Intracellular sterol dynamics. , 2009, Biochimica et biophysica acta.

[9]  R. Cenedella.  Cholesterol Synthesis Inhibitor U18666A and the Role of Sterol Metabolism and Trafficking in Numerous Pathophysiological Processes , 2009, Lipids.

[10]  M. Jäättelä,et al.  Lysosomal involvement in cell death and cancer. , 2009, Biochimica et biophysica acta.

[11]  Mitsuru Nenoi,et al.  Regulation of , 2004 .

[12]  Andrew J. Brown,et al.  Sterol regulators of cholesterol homeostasis and beyond: the oxysterol hypothesis revisited and revised. , 2008, Progress in lipid research.

[13]  G. Kroemer,et al.  Lysosomal membrane permeabilization in cell death , 2008, Oncogene.

[14]  A. Galione,et al.  Niemann-Pick disease type C1 is a sphingosine storage disease that causes deregulation of lysosomal calcium , 2008, Nature Medicine.

[15]  G. Prestwich,et al.  Lysobisphosphatidic Acid Controls Endosomal Cholesterol Levels* , 2008, Journal of Biological Chemistry.

[16]  W. Balch,et al.  NPC1/NPC2 function as a tag team duo to mobilize cholesterol , 2008, Proceedings of the National Academy of Sciences.

[17]  S. Shirasawa,et al.  Sensitization to the lysosomal cell death pathway by oncogene-induced down-regulation of lysosome-associated membrane proteins 1 and 2. , 2008, Cancer research.

[18]  R. Nixon,et al.  Neurodegenerative lysosomal disorders: A continuum from development to late age , 2008, Autophagy.

[19]  J. Martinou,et al.  Bax activation and stress-induced apoptosis delayed by the accumulation of cholesterol in mitochondrial membranes , 2008, Cell Death and Differentiation.

[20]  X. Bi,et al.  Autophagic-Lysosomal Dysfunction and Neurodegeneration in Niemann-Pick Type C Mice: Lipid Starvation or Indigestion? , 2007, Autophagy.

[21]  M. Fivaz,et al.  Late Endosomal Cholesterol Accumulation Leads to Impaired Intra-Endosomal Trafficking , 2007, PloS one.

[22]  X. Bi,et al.  Cholesterol accumulation is associated with lysosomal dysfunction and autophagic stress in Npc1 -/- mouse brain. , 2007, The American journal of pathology.

[23]  G. Gimpl,et al.  Cholesterol Reporter Molecules , 2007, Bioscience reports.

[24]  N. Mizushima,et al.  How to Interpret LC3 Immunoblotting , 2007, Autophagy.

[25]  A. Lieberman,et al.  Autophagy in Niemann-Pick C disease is dependent upon Beclin-1 and responsive to lipid trafficking defects. , 2007, Human molecular genetics.

[26]  Y. Ohsaki,et al.  Cholesterol depletion induces autophagy. , 2006, Biochemical and biophysical research communications.

[27]  B. Bay,et al.  U18666A-mediated apoptosis in cultured murine cortical neurons: role of caspases, calpains and kinases. , 2006, Cellular signalling.

[28]  J. Richardson,et al.  Cholesterol accumulation and liver cell death in mice with Niemann‐Pick type C disease , 2005, Hepatology.

[29]  P. Riederer,et al.  Dolichol is the major lipid component of human substantia nigra neuromelanin , 2005, Journal of neurochemistry.

[30]  R. Proia,et al.  Apoptosis accompanied by up-regulation of TNF-alpha death pathway genes in the brain of Niemann-Pick type C disease. , 2005, Molecular genetics and metabolism.

[31]  B. Bay,et al.  Chronic exposure to U18666A induces apoptosis in cultured murine cortical neurons. , 2004, Biochemical and biophysical research communications.

[32]  W. Hickey,et al.  A novel cholesterol stain reveals early neuronal cholesterol accumulation in the Niemann-Pick type C1 mouse brain Published, JLR Papers in Press, January 1, 2004. DOI 10.1194/jlr.D300032-JLR200 , 2004, Journal of Lipid Research.

[33]  K. Öllinger,et al.  Cathepsin D mediates cytochrome c release and caspase activation in human fibroblast apoptosis induced by staurosporine , 2003, Cell Death and Differentiation.

[34]  George Kuriakose,et al.  The endoplasmic reticulum is the site of cholesterol-induced cytotoxicity in macrophages , 2003, Nature Cell Biology.

[35]  J. Crowley,et al.  NPC1 and NPC2 Regulate Cellular Cholesterol Homeostasis through Generation of Low Density Lipoprotein Cholesterol-derived Oxysterols* , 2003, Journal of Biological Chemistry.

[36]  L. Liscum,et al.  The Transport of Low Density Lipoprotein-derived Cholesterol to the Plasma Membrane Is Defective in NPC1 Cells* , 2003, The Journal of Biological Chemistry.

[37]  R. Campenot,et al.  Cholesterol accumulates in cell bodies, but is decreased in distal axons, of Niemann–Pick C1‐deficient neurons , 2002, Journal of neurochemistry.

[38]  K. Kågedal,et al.  Microinjection of cathepsin d induces caspase-dependent apoptosis in fibroblasts. , 2002, The American journal of pathology.

[39]  Mingde Zhao,et al.  Sphingosine-induced apoptosis is dependent on lysosomal proteases. , 2001, The Biochemical journal.

[40]  F Dubois,et al.  Effects of methylcyclodextrin on lysosomes. , 2001, European journal of biochemistry.

[41]  T. Steck,et al.  Cholesterol Movement in Niemann-Pick Type C Cells and in Cells Treated with Amphiphiles* , 2000, The Journal of Biological Chemistry.

[42]  Wei Li,et al.  Induction of cell death by the lysosomotropic detergent MSDH , 2000, FEBS letters.

[43]  Masashi Yamada,et al.  Maternal Pumilio acts together with Nanos in germline development in Drosophila embryos , 1999, Nature Cell Biology.

[44]  R. Palmiter,et al.  Late endosomal membranes rich in lysobisphosphatidic acid regulate cholesterol transport , 1999, Nature Cell Biology.

[45]  T. Steck,et al.  Circulation of Cholesterol between Lysosomes and the Plasma Membrane* , 1998, The Journal of Biological Chemistry.

[46]  L. Liscum,et al.  Evidence for a Cholesterol Transport Pathway from Lysosomes to Endoplasmic Reticulum That Is Independent of the Plasma Membrane* , 1998, The Journal of Biological Chemistry.

[47]  H. Ninomiya,et al.  [Niemann-Pick disease type C]. , 2001, Nihon rinsho. Japanese journal of clinical medicine.

[48]  L. Liscum,et al.  A second complementation class of cholesterol transport mutants with a variant Niemann-Pick type C phenotype. , 1994, Journal of lipid research.

[49]  T. Koeda,et al.  Type C Niemann-Pick disease Detection and quantification of cholesterol-accumulating cells in bone marrow , 1993, Brain and Development.

[50]  L. Liscum,et al.  Isolation and characterization of Chinese hamster ovary cells defective in the intracellular metabolism of low density lipoprotein-derived cholesterol. , 1992, The Journal of biological chemistry.

[51]  L. Liscum,et al.  The intracellular transport of low density lipoprotein-derived cholesterol is inhibited in Chinese hamster ovary cells cultured with 3-beta-[2-(diethylamino)ethoxy]androst-5-en-17-one. , 1989, The Journal of biological chemistry.

[52]  Haruomi Nakamura,et al.  Cerebellar Involvement in Murine Sphingomyelinosis: A New Model of Niemann-Pick Disease , 1988, Journal of neuropathology and experimental neurology.

[53]  R. Brady,et al.  Type C Niemann-Pick disease. Lysosomal accumulation and defective intracellular mobilization of low density lipoprotein cholesterol. , 1988, The Journal of biological chemistry.

[54]  J. L. Mego,et al.  Thyroid lysosomes: the stability of the lysosomal membrane. , 1983, European journal of cell biology.

[55]  R. Firestone,et al.  Lysosomotropic agents. 1. Synthesis and cytotoxic action of lysosomotropic detergents. , 1979, Journal of medicinal chemistry.

[56]  P. Zuurendonk,et al.  Rapid separation of particulate components and soluble cytoplasm of isolated rat-liver cells. , 1974, Biochimica et biophysica acta.