Amyloid Protein Precursor in Development, Aging and Alzheimer’s Disease

[1]  S. Younkin,et al.  Processing of the amyloid β-protein precursor , 1995 .

[2]  J Carter,et al.  Molecular Pathology of Alzheimer's Disease , 2013 .

[3]  P. Greengard,et al.  Morphologic and biochemical analysis of the intracellular trafficking of the Alzheimer beta/A4 amyloid precursor protein , 1994, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[4]  L. Hunihan,et al.  Altered cleavage and secretion of a recombinant β–APP bearing the Swedish familial Alzheimer's disease mutation , 1994, Nature Genetics.

[5]  G. Schneider,et al.  The amyloid precursor protein is developmentally regulated and correlated with synaptogenesis. , 1994, Developmental biology.

[6]  D. Selkoe,et al.  Selective ectodomain phosphorylation and regulated cleavage of beta‐amyloid precursor protein. , 1994, The EMBO journal.

[7]  R. Tanzi,et al.  Expression of a ubiquitous, cross-reactive homologue of the mouse beta-amyloid precursor protein (APP). , 1994, The Journal of biological chemistry.

[8]  J. Roberts,et al.  Molecular cloning and primary structure of rat testes metalloendopeptidase EC 3.4.24.15. , 1990, Biochemistry.

[9]  A. Prochiantz,et al.  Transmembrane APP is Distributed into Two Pools and Associated with Polymerized Cytoskeleton , 1994 .

[10]  Taeko Nishiwaki,et al.  chondroitin sulfate proteoglycan , 1994 .

[11]  D. Borchelt,et al.  Amyloid in Alzheimer’s Disease and Animal Models , 1994 .

[12]  M. Brunori,et al.  A new point mutation of the prion protein gene in Creutzfeldt‐Jakob disease , 1993, Annals of neurology.

[13]  P. Greengard,et al.  Protein phosphorylation inhibits production of Alzheimer amyloid beta/A4 peptide. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[14]  J. Ott,et al.  Mutation and polymorphism of the prion protein gene in Libyan Jews with Creutzfeldt-Jakob disease (CJD). , 1993, American journal of human genetics.

[15]  A. Luini,et al.  Receptor-mediated regulation of constitutive secretion. , 1993, Trends in cell biology.

[16]  D. Price,et al.  Introduction and expression of the 400 kilobase precursor amyloid protein gene in transgenic mice , 1993, Nature Genetics.

[17]  C. Masters,et al.  A novel zinc(II) binding site modulates the function of the beta A4 amyloid protein precursor of Alzheimer's disease. , 1993, The Journal of biological chemistry.

[18]  R. Nelson,et al.  Identification of a Chymotrypsin‐Like Mast Cell Protease in Rat Brain Capable of Generating the N‐Terminus of the Alzheimer Amyloid β‐Protein , 1993, Journal of neurochemistry.

[19]  P E Fraser,et al.  A kinetic model for amyloid formation in the prion diseases: importance of seeding. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[20]  B. Winblad,et al.  Sequencing of exons 16 and 17 of the beta-amyloid precursor protein gene fails to identify new mutations in Swedish Alzheimer's disease patients. , 1993, Human molecular genetics.

[21]  T. Wisniewski,et al.  The cerebrospinal-fluid soluble form of Alzheimer's amyloid beta is complexed to SP-40,40 (apolipoprotein J), an inhibitor of the complement membrane-attack complex. , 1993, The Biochemical journal.

[22]  G. Perry,et al.  Identification and transport of full-length amyloid precursor proteins in rat peripheral nervous system , 1993, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[23]  P. Lansbury,et al.  Seeding “one-dimensional crystallization” of amyloid: A pathogenic mechanism in Alzheimer's disease and scrapie? , 1993, Cell.

[24]  A. Roses,et al.  Novel polymorphism in the A4 region of the amyloid precursor protein gene in a patient without Alzheimer's disease , 1993, Neurology.

[25]  D. Selkoe,et al.  Amyloid beta-protein as a substrate interacts with extracellular matrix to promote neurite outgrowth. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[26]  F. Grant,et al.  Molecular cloning of the cDNA for a human amyloid precursor protein homolog: evidence for a multigene family. , 1993, Biochemistry.

[27]  E. Masliah,et al.  SYNAPTIC ALTERATIONS IN THE CORTEX OF APP TRANSGENIC MICE , 1993 .

[28]  D. Price,et al.  Age‐Dependent Impairment of Mitochondrial Function in Primate Brain , 1993, Journal of neurochemistry.

[29]  P. Greengard,et al.  Altered processing of Alzheimer amyloid precursor protein in response to neuronal degeneration. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[30]  T. Kitamoto,et al.  An amber mutation of prion protein in Gerstmann-Sträussler syndrome with mutant PrP plaques. , 1993, Biochemical and biophysical research communications.

[31]  Miki Hasegawa,et al.  A metalloproteinase inhibitor domain in Alzheimer amyloid protein precursor , 1993, Nature.

[32]  J. Julien,et al.  Progressive neuronopathy in transgenic mice expressing the human neurofilament heavy gene: A mouse model of amyotrophic lateral sclerosis , 1993, Cell.

[33]  S. Brady.  Motor neurons and neurofilaments in sickness and in health , 1993, Cell.

[34]  L. Cork,et al.  Increased expression of neurofilament subunit NF-L produces morphological alterations that resemble the pathology of human motor neuron disease , 1993, Cell.

[35]  Carl W. Cotman,et al.  Neurodegeneration induced by beta-amyloid peptides in vitro: the role of peptide assembly state , 1993, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[36]  S. Rapoport,et al.  Localization of cytochrome oxidase (COX) activity and COX mRNA in the perirhinal and superior temporal sulci of the monkey brain , 1993, Brain Research.

[37]  J. Xu,et al.  An essential heparin-binding domain in the fibroblast growth factor receptor kinase. , 1993, Science.

[38]  K. Doh-ura,et al.  Novel missense variants of prion protein in Creutzfeldt-Jakob disease or Gerstmann-Sträussler syndrome. , 1993, Biochemical and biophysical research communications.

[39]  P. Matsudaira,et al.  Generation of beta-amyloid in the secretory pathway in neuronal and nonneuronal cells. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[40]  S. Hoyer.  Intermediary metabolism disturbance in AD/SDAT and its relation to molecular events , 1993, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[41]  H Serban,et al.  Immunologic and molecular biologic studies of prion proteins in bovine spongiform encephalopathy. , 1993, The Journal of infectious diseases.

[42]  Charles Duyckaerts,et al.  Beta A4 deposits are constant in the brain of the oldest old: an immunocytochemical study of 20 French centenarians. , 1993, Neurobiology of aging.

[43]  I. Nishimoto,et al.  Alzheimer amyloid protein precursor complexes with brain GTP-binding protein Go , 1993, Nature.

[44]  J. Haines,et al.  Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis , 1993, Nature.

[45]  M. Pericak-Vance,et al.  Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[46]  D. Selkoe,et al.  beta-Amyloid peptide and a 3-kDa fragment are derived by distinct cellular mechanisms. , 1993, The Journal of biological chemistry.

[47]  S. Younkin,et al.  Release of excess amyloid beta protein from a mutant amyloid beta protein precursor. , 1993, Science.

[48]  E. Rojas,et al.  Alzheimer disease amyloid beta protein forms calcium channels in bilayer membranes: blockade by tromethamine and aluminum. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[49]  L. Lim,et al.  A Drosophila gene encoding a protein with similarity to diacylglycerol kinase is expressed in specific neurons. , 1993, The Biochemical journal.

[50]  Magnus Malmqvist,et al.  Biospecific interaction analysis using biosensor technology , 1993, Nature.

[51]  R. Tanzi,et al.  The amyloid precursor-like protein (APLP) gene maps to the long arm of human chromosome 19. , 1993, Genomics.

[52]  S. Younkin,et al.  Molecular biology of Alzheimer's disease. , 1993, Molecular genetic medicine.

[53]  E. Stadtman.  Protein oxidation and aging , 2006, Science.

[54]  C. Masters,et al.  The abnormality of plasma amyloid protein precursor in Alzheimer's disease , 1992, Neurobiology of Aging.

[55]  F. Cuzin,et al.  A murine sequence-specific DNA binding protein shows extensive local similarities to the amyloid precursor protein. , 1992, Biochemical and biophysical research communications.

[56]  S. Dimauro,et al.  Accumulation of deletions in human mitochondrial DNA during normal aging: analysis by quantitative PCR. , 1992, Biochimica et biophysica acta.

[57]  Y. Agid,et al.  More missense in amyloid gene , 1992, Nature Genetics.

[58]  J. Hardy,et al.  A locus for familial early–onset Alzhelmer's disease on the long arm of chromosome 14, proximal to the α1–antichymotrypsin gene , 1992, Nature Genetics.

[59]  N. Arnheim,et al.  Mosaicism for a specific somatic mitochondrial DNA mutation in adult human brain , 1992, Nature Genetics.

[60]  C. Broeckhoven,et al.  Mapping of a gene predisposing to early–onset Alzheimer's disease to chromosome 14q24.3 , 1992, Nature Genetics.

[61]  D. Pollen,et al.  Genetic evidence for a novel familial Alzheimer's disease locus on chromosome 14 , 1992, Nature Genetics.

[62]  M. Beal,et al.  Mitochondrial DNA deletions in human brain: regional variability and increase with advanced age , 1992, Nature Genetics.

[63]  P. Lantos,et al.  Prion protein immunocytochemistry helps to establish the true incidence of prion diseases , 1992, Neuroscience Letters.

[64]  R. Tanzi,et al.  Identification of a mouse brain cDNA that encodes a protein related to the Alzheimer disease-associated amyloid beta protein precursor. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[65]  F. Cohen,et al.  Predicted alpha-helical regions of the prion protein when synthesized as peptides form amyloid. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[66]  E. Wijsman,et al.  Linkage and mutational analysis of familial Alzheimer disease kindreds for the APP gene region. , 1992, American journal of human genetics.

[67]  P. Greengard,et al.  Cholinergic agonists and interleukin 1 regulate processing and secretion of the Alzheimer beta/A4 amyloid protein precursor. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[68]  M. Rossor,et al.  Familial Alzheimer's disease. , 1992, Bailliere's clinical neurology.

[69]  Steven A. Johnson,et al.  Complement mRNA in the mammalian brain: Responses to Alzheimer's disease and experimental brain lesioning , 1992, Neurobiology of Aging.

[70]  B. Greenberg,et al.  Characterization of high affinity binding between laminin and Alzheimer's disease amyloid precursor proteins. , 1992, Laboratory investigation; a journal of technical methods and pathology.

[71]  G. Gyapay,et al.  A second-generation linkage map of the human genome , 1992, Nature.

[72]  J. Weber,et al.  Genetic linkage evidence for a familial Alzheimer's disease locus on chromosome 14. , 1992, Science.

[73]  E. Masliah,et al.  Amyloid precursor protein is localized in growing neurites of neonatal rat brain , 1992, Brain Research.

[74]  D. Selkoe,et al.  Increased expression of beta-amyloid precursor protein during neuronal differentiation is not accompanied by secretory cleavage. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[75]  S. Estus,et al.  Production of the Alzheimer amyloid beta protein by normal proteolytic processing. , 1992, Science.

[76]  J. Martín,et al.  Analysis of the prion protein gene in thalamic dementia , 1992, Neurology.

[77]  D. Price,et al.  Amyloidogenesis in Alzheimer's disease: basic biology and animal models , 1992, Current Biology.

[78]  J. Gilbert,et al.  Isolation of a cytochrome oxidase gene overexpressed in Alzheimer's disease brain , 1992, Molecular and Cellular Neuroscience.

[79]  S. Younkin,et al.  Secretory processing of the Alzheimer amyloid beta/A4 protein precursor is increased by protein phosphorylation. , 1992, Biochemical and biophysical research communications.

[80]  D. Selkoe,et al.  Isolation and quantification of soluble Alzheimer's β-peptide from biological fluids , 1992, Nature.

[81]  D. Selkoe,et al.  Amyloid β-peptide is produced by cultured cells during normal metabolism , 1992, Nature.

[82]  R. Crowther,et al.  The microtubule binding repeats of tau protein assemble into filaments like those found in Alzheimer's disease , 1992, FEBS letters.

[83]  M. Mattson,et al.  β-Amyloid precursor protein and alzheimer's disease: The peptide plot thickens , 1992, Neurobiology of Aging.

[84]  S. Prusiner,et al.  Regional mapping of prion proteins in brain. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[85]  I. Lieberburg,et al.  Evidence for a nonsecretory, acidic degradation pathway for amyloid precursor protein in 293 cells. Identification of a novel, 22-kDa, beta-peptide-containing intermediate. , 1992, The Journal of biological chemistry.

[86]  J. Nobrega,et al.  Brain Cytochrome Oxidase in Alzheimer's Disease , 1992, Journal of neurochemistry.

[87]  J. Haines,et al.  Assessment of amyloid beta-protein precursor gene mutations in a large set of familial and sporadic Alzheimer disease cases. , 1992, American journal of human genetics.

[88]  B. Winblad,et al.  A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N–terminus of β–amyloid , 1992, Nature Genetics.

[89]  E. Schon,et al.  Is a point mutation in the mitochondrial ND2 gene associated with Alzheimer's disease. , 1992, Biochemical and biophysical research communications.

[90]  S. Sisodia.  Beta-amyloid precursor protein cleavage by a membrane-bound protease. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[91]  D. Wallace,et al.  Leber's hereditary optic neuropathy: a model for mitochondrial neurodegenerative diseases , 1992, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[92]  S. Rapoport,et al.  Differential expression of cytochrome oxidase (COX) genes in different regions of monkey brain , 1992, Journal of neuroscience research.

[93]  C. Masters,et al.  The amyloid protein precursor of Alzheimer's disease is a mediator of the effects of nerve growth factor on neurite outgrowth , 1992, Neuron.

[94]  H. Vinters,et al.  Reversible in vitro growth of Alzheimer disease beta-amyloid plaques by deposition of labeled amyloid peptide. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[95]  D. Selkoe,et al.  Targeting of cell-surface β-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments , 1992, Nature.

[96]  P. Greengard,et al.  Phosphorylation of alzheimer amyloid precursor protein by protein kinase C , 1992, Neuroscience.

[97]  R. Shin,et al.  Abnormal isoform of prion proteins accumulates in the synaptic structures of the central nervous system in patients with Creutzfeldt-Jakob disease. , 1992, The American journal of pathology.

[98]  C. Frith,et al.  Inherited prion disease with 144 base pair gene insertion. 1. Genealogical and molecular studies. , 1992, Brain : a journal of neurology.

[99]  J. Hardy,et al.  Screening for mutations in the open reading frame and promoter of the beta-amyloid precursor protein gene in familial Alzheimer's disease: identification of a further family with APP717 Val-->Ile. , 1992, Human molecular genetics.

[100]  Y. Komiyama,et al.  Purification of factor XIa inhibitor from human platelets. , 1992, Thrombosis research.

[101]  K S Kosik,et al.  Alzheimer's disease: a cell biological perspective. , 1992, Science.

[102]  S. Rapoport,et al.  Localization of cytochrome oxidase (COX) activity and COX mRNA in the hippocampus and entorhinal cortex of the monkey brain: correlation with specific neuronal pathways , 1992, Brain Research.

[103]  D. Wallace.  Mitochondrial genetics: a paradigm for aging and degenerative diseases? , 1992, Science.

[104]  O. Pastoris,et al.  The mitochondrial electron transfer alteration as a factor involved in the brain aging , 1992, Neurobiology of Aging.

[105]  J. Hardy,et al.  Alzheimer's disease: the amyloid cascade hypothesis. , 1992, Science.

[106]  C. Cotman,et al.  Decreased levels of soluble amyloid beta-protein precursor in cerebrospinal fluid of live Alzheimer disease patients. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[107]  S. Prusiner,et al.  Further analysis of nucleic acids in purified scrapie prion preparations by improved return refocusing gel electrophoresis. , 1992, The Journal of general virology.

[108]  C. Vnencak-Jones,et al.  Identification of heterogeneous PrP gene deletions in controls by detection of allele-specific heteroduplexes (DASH) , 1992, American journal of human genetics.

[109]  S. Prusiner,et al.  Prion protein mutation at codon 102 in an Italian family with Gerstmann‐Sträussler‐Scheinker syndrome , 1992, Neurology.

[110]  S. Prusiner,et al.  Mutant prion proteins in Gerstmann-Sträussler-Scheinker disease with neurofibrillary tangles , 1992, Nature Genetics.

[111]  S. Prusiner,et al.  Linkage of the Indiana kindred of Gerstmann-Sträussler-Scheinker disease to the prion protein gene , 1992, Nature Genetics.

[112]  A. Marini,et al.  Zinc, a neurotoxin to cultured neurons, contaminates cycad flour prepared by traditional guamanian methods , 1992, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[113]  P. Greengard,et al.  Chloroquine inhibits intracellular degradation but not secretion of Alzheimer beta/A4 amyloid precursor protein. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[114]  J. Ryan,et al.  Bovine spongiform encephalopathy: aspects of the clinical picture and analyses of possible changes 1986-1990 , 1992, Veterinary Record.

[115]  E. Masliah,et al.  Localization of amyloid precursor protein in GAP43-immunoreactive aberrant sprouting neurites in Alzheimer's disease , 1992, Brain Research.

[116]  C. Miller,et al.  Characterization of Neutral Proteinases from Alzheimer‐Affected and Control Brain Specimens: Identification of Calcium‐Dependent Metalloproteinases from the Hippocampus , 1992, Journal of neurochemistry.

[117]  T. Crow,et al.  A dementing illness associated with a novel insertion in the prion protein gene. , 1992, Brain research. Molecular brain research.

[118]  H. Y. Chen,et al.  Fatal familial insomnia, a prion disease with a mutation at codon 178 of the prion protein gene. , 1992, The New England journal of medicine.

[119]  D. Selkoe,et al.  Processing of the amyloid protein precursor to potentially amyloidogenic derivatives. , 1992, Science.

[120]  S. Younkin,et al.  Potentially amyloidogenic, carboxyl-terminal derivatives of the amyloid protein precursor. , 1992, Science.

[121]  N. Robakis,et al.  Bacterial expression, purification, and functional mapping of the amyloid beta/A4 protein precursor. , 1992, The Journal of biological chemistry.

[122]  Thomas Wisniewski,et al.  Apolipoprotein E: A pathological chaperone protein in patients with cerebral and systemic amyloid , 1992, Neuroscience Letters.

[123]  E. Wijsman,et al.  Genetic association and linkage analysis of the apolipoprotein CII locus and familial Alzheimer's disease , 1992, Annals of neurology.

[124]  N. Cairns,et al.  Tau proteins of alzheimer paired helical filaments: Abnormal phosphorylation of all six brain isoforms , 1992, Neuron.

[125]  B. Ghetti,et al.  Spectrum of amyloid β-protein immunoreactivity in hereditary Alzheimer disease with a guanine to thymine missence change at position 1924 of the APP gene , 1992, Brain Research.

[126]  H. Wiśniewski,et al.  Detection of point mutations in codon 331 of mitochondrial NADH dehydrogenase subunit 2 in Alzheimer's brains. , 1992, Biochemical and biophysical research communications.

[127]  L. Lue,et al.  Full complement activation fails in diffuse plaques of the Alzheimer's disease cerebellum , 1992 .

[128]  D. Selkoe,et al.  The seminal role of beta-amyloid in the pathogenesis of Alzheimer disease. , 1992, Alzheimer disease and associated disorders.

[129]  D. Selkoe,et al.  Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production. , 1992, Nature.

[130]  T. Ozawa,et al.  Age-related decrease in respiratory muscle mitochondrial function in rats. , 1992, American journal of respiratory cell and molecular biology.

[131]  J. Hardy,et al.  Alzheimer's disease. In search of the soluble. , 1992, Nature.

[132]  P. Greengard,et al.  Amyloidogenesis in Alzheimer's disease: some possible therapeutic opportunities. , 1992, Trends in pharmacological sciences.

[133]  A. Prochiantz,et al.  In vitro control of neuronal polarity by glycosaminoglycans. , 1992, Development.

[134]  A. Hofman,et al.  Presenile dementia and cerebral haemorrhage linked to a mutation at codon 692 of the β–amyloid precursor protein gene , 1992, Nature Genetics.

[135]  R. Floyd.  Oxidative damage to behavior during aging. , 1991, Science.

[136]  G. Higgins,et al.  Amyloid plaques, neurofibrillary tangles and neuronal loss in brains of transgenic mice overexpressing a C-terminal fragment of human amyloid precursor protein , 1991, Nature.

[137]  C. Cotman,et al.  Beta-amyloid increases neuronal susceptibility to injury by glucose deprivation. , 1991, Neuroreport.

[138]  D. Selkoe,et al.  Processing of beta-amyloid precursor protein in microglia and astrocytes favors an internal localization over constitutive secretion , 1991, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[139]  W. Markesbery,et al.  Excess brain protein oxidation and enzyme dysfunction in normal aging and in Alzheimer disease. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[140]  J. Hardy,et al.  Sequencing of exons 16 and 17 of the β-amyloid precursor protein gene in 14 families with early onset Alzheimer's disease fails to reveal mutations in the β-amyloid sequence , 1991, Neuroscience Letters.

[141]  R. Tanzi,et al.  Molecular genetics of Alzheimer disease amyloid. , 1991, The Journal of biological chemistry.

[142]  Walter Schubert,et al.  Localization of Alzheimer βA4 amyloid precursor protein at central and peripheral synaptic sites , 1991, Brain Research.

[143]  T. Ozawa,et al.  Quantitative analysis of age-associated accumulation of mitochondrial DNA with deletion in human hearts. , 1991, Biochemical and biophysical research communications.

[144]  J. Hardy,et al.  Early-onset Alzheimer's disease caused by mutations at codon 717 of the β-amyloid precursor protein gene , 1991, Nature.

[145]  J. Riordan,et al.  Membrane proteins with soluble counterparts: role of proteolysis in the release of transmembrane proteins. , 1991, Biochemistry.

[146]  P. Greengard,et al.  Alzheimer beta/A4 amyloid precursor protein in human brain: aging-associated increases in holoprotein and in a proteolytic fragment. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[147]  B. Ghetti,et al.  A mutation in the amyloid precursor protein associated with hereditary Alzheimer's disease. , 1991, Science.

[148]  D. Wallace,et al.  Hypoxemia is associated with mitochondrial DNA damage and gene induction. Implications for cardiac disease. , 1991, JAMA.

[149]  D. Price,et al.  Neurofibrillary tangles and β-amyloid deposits in Alzheimer's disease , 1991, Current Opinion in Neurobiology.

[150]  D. Salmon,et al.  Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment , 1991, Annals of neurology.

[151]  R. Tanzi.  Genetic linkage studies of human neurodegenerative disorders , 1991, Current Opinion in Neurobiology.

[152]  T. Wisniewski,et al.  Peptides homologous to the amyloid protein of Alzheimer's disease containing a glutamine for glutamic acid substitution have accelerated amyloid fibril formation. , 1991, Biochemical and biophysical research communications.

[153]  D. Price,et al.  Developmental expression of α1-antichymotrypsin in brain may be related to astrogliosis , 1991, Neurobiology of Aging.

[154]  E. Kahana,et al.  Do Creutzfeldt‐Jakob disease patients of Jewish Libyan origin have unique clinical features? , 1991, Neurology.

[155]  G. Schellenberg,et al.  APP717, APP693, and PRIP gene mutations are rare in Alzheimer disease. , 1991, American journal of human genetics.

[156]  E. Kahana,et al.  The Libyan Creutzfeldt‐Jakob disease focus in Israel , 1991, Neurology.

[157]  T. Ogihara,et al.  The 717Val----Ile substitution in amyloid precursor protein is associated with familial Alzheimer's disease regardless of ethnic groups. , 1991, Biochemical and biophysical research communications.

[158]  L. Hood,et al.  Genomic structure of the human prion protein gene. , 1991, American journal of human genetics.

[159]  John Collinge,et al.  Homozygous prion protein genotype predisposes to sporadic Creutzfeldt–Jakob disease , 1991, Nature.

[160]  D. Wirak.  Deposits of amyloid β protein in the central nervous system of transgenic mice , 1991 .

[161]  K. Murakami,et al.  Formation of β-amyloid protein deposits in brains of transgenic mice , 1991, Nature.

[162]  B. Greenberg,et al.  High affinity interactions between the Alzheimer's beta-amyloid precursor proteins and the basement membrane form of heparan sulfate proteoglycan. , 1991, The Journal of biological chemistry.

[163]  S. Younkin,et al.  Processing of the Alzheimer's Disease ΒZA4 Amyloid Protein Precursor (APP) , 1991 .

[164]  M. Palmer,et al.  Genetic predisposition to iatrogenic Creutzfeldt-Jakob disease , 1991, The Lancet.

[165]  S. Prusiner,et al.  Molecular biology of prion diseases , 1991, Science.

[166]  T. Ozawa,et al.  Age-dependent increase in deleted mitochondrial DNA in the human heart: possible contributory factor to presbycardia. , 1991, American heart journal.

[167]  Molecular classification of Alzheimer's disease , 1991, The Lancet.

[168]  M. Pericak-Vance,et al.  Linkage studies in familial Alzheimer disease: evidence for chromosome 19 linkage. , 1991, American journal of human genetics.

[169]  T. Billiar,et al.  Effect of exogenous and endogenous nitric oxide on mitochondrial respiration of rat hepatocytes. , 1991, The American journal of physiology.

[170]  J. Hardy,et al.  Insertions in the prion protein gene in atypical dementias , 1991, Experimental Neurology.

[171]  S. Tsuji,et al.  Mis-sense mutation Val→Ile in exon 17 of amyloid precursor protein gene in Japanese familial Alzheimer's disease , 1991, The Lancet.

[172]  S. Prusiner,et al.  Mutation of the prion protein in Libyan Jews with Creutzfeldt-Jakob disease. , 1991, The New England journal of medicine.

[173]  B. Hyman,et al.  Alzheimer's mutation , 1991, Nature.

[174]  T. Ozawa,et al.  Massive conversion of guanosine to 8-hydroxy-guanosine in mouse liver mitochondrial DNA by administration of azidothymidine. , 1991, Biochemical and biophysical research communications.

[175]  D. Schubert.  The possible role of adhesion in synaptic modification , 1991, Trends in Neurosciences.

[176]  J. Massagué,et al.  Cleavage of the membrane precursor for transforming growth factor alpha is a regulated process. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[177]  E M Wijsman,et al.  Linkage analysis of familial Alzheimer disease, using chromosome 21 markers. , 1991, American journal of human genetics.

[178]  J. Miquel.  An integrated theory of aging as the result of mitochondrial-DNA mutation in differentiated cells. , 1991, Archives of gerontology and geriatrics.

[179]  S. Prusiner,et al.  Scrapie prion rod formation in vitro requires both detergent extraction and limited proteolysis , 1991, Journal of virology.

[180]  H. Schulman,et al.  Activation of chloride channels in normal and cystic fibrosis airway epithelial cells by multifunctional calcium/calmodulin-dependent protein kinase , 1991, Nature.

[181]  Jeffrey D. Esko,et al.  Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor , 1991, Cell.

[182]  M. Pericak-Vance,et al.  Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease , 1991, Nature.

[183]  D. Price,et al.  Amyloid precursor protein in aged nonhuman primates. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[184]  J. Trojanowski,et al.  A68: a major subunit of paired helical filaments and derivatized forms of normal Tau. , 1991, Science.

[185]  D. Selkoe,et al.  Antibodies to non-beta regions of the beta-amyloid precursor protein detect a subset of senile plaques. , 1991, The American journal of pathology.

[186]  G. H. Hall,et al.  65Zn Uptake from Blood into Brain in the Rat , 1991, Journal of neurochemistry.

[187]  A. Grollman,et al.  Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxodG , 1991, Nature.

[188]  C. van Broeckhoven,et al.  Early‐onset Alzheimer's disease in 2 large Belgian families , 1991, Neurology.

[189]  B. Anderton,et al.  Beta amyloid precursor protein mediates neuronal cell‐cell and cell‐surface adhesion , 1991, Journal of neuroscience research.

[190]  G. Glenner,et al.  A variant of Gerstmann-Sträussler-Scheinker disease with ß -protein epitopes and dystrophic neurites in the peripheral regions of PrP -immunoreactive amyloid plaques , 1991 .

[191]  M. Dizdaroglu.  Chemical determination of free radical-induced damage to DNA. , 1991, Free radical biology & medicine.

[192]  Y. Uchida.  [Growth-inhibitory factor]. , 1991, No to shinkei = Brain and nerve.

[193]  J. Hardy,et al.  Amyloid deposition as the central event in the aetiology of Alzheimer's disease. , 1991, Trends in pharmacological sciences.

[194]  C. Weissmann.  Spongiform encephalopathies. The prion's progress. , 1991, Nature.

[195]  N. Hunter,et al.  Different forms of the bovine PrP gene have five or six copies of a short, G-C-rich element within the protein-coding exon. , 1991, The Journal of general virology.

[196]  S. Prusiner,et al.  Search for a putative scrapie genome in purified prion fractions reveals a paucity of nucleic acids. , 1991, The Journal of general virology.

[197]  G. Neri,et al.  Growth delay in Down syndrome and zinc sulphate supplementation. , 2005, American journal of medical genetics. Supplement.

[198]  B. Bloem,et al.  Hereditary cerebral hemorrhage with amyloidosis-Dutch type , 2004, Neuroradiology.

[199]  S. Prusiner,et al.  Spontaneous neurodegeneration in transgenic mice with mutant prion protein , 1990, Science.

[200]  R. Lacey,et al.  Transmissible spongiform encephalopathies: The threat of BSE to man , 1990 .

[201]  S. Prusiner,et al.  Inherited human prion diseases , 1990, Neurology.

[202]  D. Price,et al.  Development of senile plaques. Relationships of neuronal abnormalities and amyloid deposits. , 1990, The American journal of pathology.

[203]  J. Laplanche,et al.  Deletion in prion protein gene in a Moroccan family. , 1990, Nucleic acids research.

[204]  C. Cotman,et al.  β-Amyloid protein increases the vulnerability of cultured cortical neurons to excitotoxic damage , 1990, Brain Research.

[205]  Stephen J. DeArmond,et al.  Transgenetic studies implicate interactions between homologous PrP isoforms in scrapie prion replication , 1990, Cell.

[206]  W. Markesbery,et al.  Trace element imbalances in isolated subcellular fractions of Alzheimer's disease brains , 1990, Brain Research.

[207]  B. Yankner,et al.  Nerve growth factor potentiates the neurotoxicity of beta amyloid. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[208]  B. Ghetti,et al.  Neurofibrillary tangles of the Indiana kindred of Gerstmann-Stra¨ussler-Scheinker disease share antigenic determinants with those of Alzheimer disease , 1990, Brain Research.

[209]  D. Kirschner,et al.  Neurotrophic and neurotoxic effects of amyloid beta protein: reversal by tachykinin neuropeptides. , 1990, Science.

[210]  K. Davies,et al.  The oxidative inactivation of mitochondrial electron transport chain components and ATPase. , 1990, The Journal of biological chemistry.

[211]  R. Martins,et al.  The amyloid precursor protein of Alzheimer's disease is released by human platelets. , 1990, The Journal of biological chemistry.

[212]  R. Roos,et al.  Dementia in hereditary cerebral hemorrhage with amyloidosis-Dutch type. , 1990, Archives of neurology.

[213]  R. Neve,et al.  The Alzheimer amyloid precursor-related transcript lacking the β/A4 sequence is specifically increased in Alzheimer's disease brain , 1990, Neuron.

[214]  J. Aiken,et al.  The search for scrapie agent nucleic acid. , 1990, Microbiological reviews.

[215]  G. Benzi,et al.  Age-related modifications of cytochrome c oxidase activity in discrete brain regions , 1990, Mechanisms of Ageing and Development.

[216]  P. Greengard,et al.  Processing of Alzheimer beta/A4 amyloid precursor protein: modulation by agents that regulate protein phosphorylation. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[217]  P. Davies,et al.  A preparation of Alzheimer paired helical filaments that displays distinct tau proteins by polyacrylamide gel electrophoresis. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[218]  C. Filley,et al.  Cytochrome oxidase deficiency in Alzheimer's disease , 1990, Neurology.

[219]  D. Galasko,et al.  STIMULATED PLATELETS RELEASE AMYLOID β–PROTEIN PRECURSOR , 1990 .

[220]  L. Ang,et al.  Autopsy Samples of Alzheimer's Cortex Show Increased Peroxidation In Vitro , 1990, Journal of neurochemistry.

[221]  D. Wolf,et al.  Identification and characterization of C‐terminal fragments of the beta‐amyloid precursor produced in cell culture. , 1990, The EMBO journal.

[222]  I. Lieberburg,et al.  Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage, Dutch type. , 1990, Science.

[223]  G. Broze,et al.  Platelet coagulation factor XIa-inhibitor, a form of Alzheimer amyloid precursor protein. , 1990, Science.

[224]  T. Crow,et al.  Codon 129 changes in the prion protein gene in Caucasians. , 1990, American journal of human genetics.

[225]  T. Oltersdorf,et al.  Cleavage of amyloid beta peptide during constitutive processing of its precursor. , 1990, Science.

[226]  M. Fisman,et al.  Metals and the Liver in Alzheimer's Disease An Investigation of Hepatic Zinc, Copper, Cadmium, and Metallothionein , 1990, Journal of the American Geriatrics Society.

[227]  J. Cassiman,et al.  The core protein of the matrix-associated heparan sulfate proteoglycan binds to fibronectin. , 1990, The Journal of biological chemistry.

[228]  C. Finch,et al.  Relation of neuronal APP-751/APP-695 mRNA ratio and neuritic plaque density in Alzheimer's disease. , 1990, Science.

[229]  S. A. Ross,et al.  Phosphorylation of the polymeric immunoglobulin receptor required for its efficient transcytosis. , 1990, Science.

[230]  G. Cole,et al.  Amyloid β-protein precursor is associated with extracellular matrix , 1990, Brain Research.

[231]  M. Brammer,et al.  Brain membrane fluidity and lipid peroxidation in Alzheimer's disease , 1990, Neuroscience Letters.

[232]  S. DeKosky,et al.  Synapse loss in frontal cortex biopsies in Alzheimer's disease: Correlation with cognitive severity , 1990, Annals of neurology.

[233]  F. Gage,et al.  Altered levels of amyloid protein precursor transcripts in the basal forebrain of behaviorally impaired aged rats. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[234]  P. Cohen,et al.  Okadaic acid: a new probe for the study of cellular regulation. , 1990, Trends in biochemical sciences.

[235]  M. Brown,et al.  NPXY, a sequence often found in cytoplasmic tails, is required for coated pit-mediated internalization of the low density lipoprotein receptor. , 1990, The Journal of biological chemistry.

[236]  Y. Takahashi,et al.  Determination of amyloid beta protein precursors harboring active form of proteinase inhibitor domains in cerebrospinal fluid of Alzheimer's disease patients by trypsin-antibody sandwich ELISA. , 1990, Biochemical and biophysical research communications.

[237]  B. Freeman,et al.  Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[238]  D. Price,et al.  Precursor of amyloid protein in Alzheimer disease undergoes fast anterograde axonal transport. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[239]  D. Price,et al.  Differential expression of amyloid precursor protein mRNAs in cases of Alzheimer's disease and in aged nonhuman primates , 1990, Neuron.

[240]  S. Prusiner,et al.  Prion liposomes. , 1990, The Biochemical journal.

[241]  G. Cole,et al.  Amyloid beta-protein precursor is associated with extracellular matrix. , 1990, Brain research.

[242]  N. Arnheim,et al.  Detection of a specific mitochondrial DNA deletion in tissues of older humans. , 1990, Nucleic acids research.

[243]  Y. Wei,et al.  Liver mitochondrial respiratory functions decline with age. , 1989, Biochemical and biophysical research communications.

[244]  P. Mcgeer,et al.  Activation of the classical complement pathway in brain tissue of Alzheimer patients , 1989, Neuroscience Letters.

[245]  G. Cole,et al.  The regulation of amyloid β protein precursor secretion and its modulatory role in cell adhesion , 1989, Neuron.

[246]  D. Mann,et al.  EARLY SENILE PLAQUES IN DOWN'S SYNDROME BRAINS SHOW A CLOSE RELATIONSHIP WITH CELL BODIES OF NEURONS , 1989, Neuropathology and applied neurobiology.

[247]  G. Glenner,et al.  Amyloidosis of the nervous system , 1989, Journal of the Neurological Sciences.

[248]  R. Neve,et al.  The amyloid precursor protein is concentrated in neuronal lysosomes in normal and Alzheimer disease subjects , 1989, Experimental Neurology.

[249]  M. Albert,et al.  Prevalence of Alzheimer's disease in a community population of older persons. Higher than previously reported. , 1989, JAMA.

[250]  R. Katzman.,et al.  Reduced protein kinase C immunoreactivity and altered protein phosphorylation in Alzheimer's disease fibroblasts. , 1989, Archives of neurology.

[251]  G. Heinrich.  Amyloid A4 protein and its precursor in Down's syndrome and Alzheimer's disease. , 1989, The New England journal of medicine.

[252]  Carl W. Cotman,et al.  Protease nexin-II, a potent anti-chymotrypsin, shows identity to amyloid β-protein precursor , 1989, Nature.

[253]  R N Kalaria,et al.  Reduced Glucose Transporter at the Blood‐Brain Barrier and in Cerebral Cortex in Alzheimer Disease , 1989, Journal of neurochemistry.

[254]  K. Johnson-wood,et al.  The secreted form of the Alzheimer's amyloid precursor protein with the Kunitz domain is protease nexin-II , 1989, Nature.

[255]  A. Delacourte,et al.  Immunocytochemical profile of neurofibrillary tangles in Down's syndrome patients of different ages , 1989, Journal of the Neurological Sciences.

[256]  D. Schubert.  The biological roles of heparan sulfate proteoglycans in the nervous system , 1989, Neurobiology of Aging.

[257]  J. Haines,et al.  Familial Alzheimer's disease: Progress and problems , 1989, Neurobiology of Aging.

[258]  F. Tagliavini,et al.  Alzheimer's disease amyloid precursor protein is present in senile plaques and cerebrospinal fluid: immunohistochemical and biochemical characterization. , 1989, Biochemical and biophysical research communications.

[259]  T. Oltersdorf,et al.  Secreted form of amyloid β protein precursor is involved in the growth regulation of fibroblasts , 1989, Cell.

[260]  F. D. de Sauvage,et al.  A novel mRNA of the A4 amyloid precursor gene coding for a possibly secreted protein. , 1989, Science.

[261]  L. Villa-komaroff,et al.  Neurotoxicity of a fragment of the amyloid precursor associated with Alzheimer's disease. , 1989, Science.

[262]  J. Downing,et al.  Ligand and protein kinase C downmodulate the colony-stimulating factor 1 receptor by independent mechanisms , 1989, Molecular and cellular biology.

[263]  S. M. Sumi,et al.  Familial dementia with PrP‐positive amyloid plaques , 1989, Neurology.

[264]  R. Martins,et al.  Amyloid A4 protein and its precursor in Down's syndrome and Alzheimer's disease. , 1989, The New England journal of medicine.

[265]  Andreas Weidemann,et al.  Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein , 1989, Cell.

[266]  Edward Byrne,et al.  DECLINE IN SKELETAL MUSCLE MITOCHONDRIAL RESPIRATORY CHAIN FUNCTION: POSSIBLE FACTOR IN AGEING , 1989, The Lancet.

[267]  Jurg Ott,et al.  Linkage of a prion protein missense variant to Gerstmann–Sträussler syndrome , 1989, Nature.

[268]  G. Cole,et al.  Characterization of an amyloid beta precursor protein that binds heparin and contains tyrosine sulfate. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[269]  R. Katzman.,et al.  Decreased adhesiveness of alzheimer's disease fibroblasts: Is amyloid β‐protein precursor involved? , 1989, Annals of neurology.

[270]  D. Price,et al.  Age-related changes in multiple neurotransmitter systems in the monkey brain , 1989, Neurobiology of Aging.

[271]  Martin Farrall,et al.  PREDISPOSING LOCUS FOR ALZHEIMER'S DISEASE ON CHROMOSOME 21 , 1989, The Lancet.

[272]  R. Akeson,et al.  Identification of a heparin binding domain of the neural cell adhesion molecule N-CAM using synthetic peptides , 1989, Neuron.

[273]  J. Wagner,et al.  Heparin potentiates the action of acidic fibroblast growth factor by prolonging its biological half‐life , 1989, Journal of cellular physiology.

[274]  D. Mann,et al.  The pattern of acquisition of plaques and tangles in the brains of patients under 50 years of age with Down's syndrome , 1989, Journal of the Neurological Sciences.

[275]  T. Crow,et al.  INSERTION IN PRION PROTEIN GENE IN FAMILIAL CREUTZFELDT-IAKOB DISEASE , 1989, The Lancet.

[276]  A. Bairoch,et al.  A unique signature identifies a family of zinc‐dependent metallopeptidases , 1989, FEBS letters.

[277]  K. Beyreuther,et al.  The promoter of Alzheimer's disease amyloid A4 precursor gene. , 1988, Progress in clinical and biological research.

[278]  C. Cotman,et al.  Protease nexin-II, a potent antichymotrypsin, shows identity to amyloid beta-protein precursor. , 1989, Nature.

[279]  D. Selkoe,et al.  Biochemistry of altered brain proteins in Alzheimer's disease. , 1989, Annual review of neuroscience.

[280]  S. Prusiner.  Scrapie prions. , 1989, Annual review of microbiology.

[281]  C. Frederickson.  Neurobiology of zinc and zinc-containing neurons. , 1989, International review of neurobiology.

[282]  C. Franceschi,et al.  Oral zinc supplementation in Down's syndrome: restoration of thymic endocrine activity and of some immune defects. , 2008, Journal of mental deficiency research.

[283]  K. Ueda,et al.  Three types of amyloid protein precursor mRNA in human brain: their differential expression in Alzheimer's disease. , 1988, Biochemical and biophysical research communications.

[284]  J. Hibbs,et al.  Nitric oxide: a cytotoxic activated macrophage effector molecule. , 1988, Biochemical and biophysical research communications.

[285]  R. Neve,et al.  Expression of the Alzheimer amyloid precursor gene transcripts in the human brain , 1988, Neuron.

[286]  T. Crow,et al.  CNS amyloid proteins in neurodegenerative diseases , 1988, Neurology.

[287]  S. M. Sumi,et al.  Absence of linkage of chromosome 21q21 markers to familial Alzheimer's disease. , 1988, Science.

[288]  Y. Okada,et al.  The precursor of a metalloendopeptidase from human rheumatoid synovial fibroblasts. Purification and mechanisms of activation by endopeptidases and 4-aminophenylmercuric acetate. , 1988, The Biochemical journal.

[289]  S. Prusiner,et al.  Immunoaffinity purification and neutralization of scrapie prion infectivity. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[290]  B. Ames,et al.  Normal oxidative damage to mitochondrial and nuclear DNA is extensive. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[291]  J. Blass,et al.  Reduced activities of thiamine-dependent enzymes in the brains and peripheral tissues of patients with Alzheimer's disease. , 1988, Archives of neurology.

[292]  G. Pezeshkpour,et al.  Clinical significance of types of cerebellar amyloid plaques in human spongiform encephalopathies , 1988, Neurology.

[293]  P. Greengard,et al.  Phosphorylation of Alzheimer disease amyloid precursor peptide by protein kinase C and Ca2+/calmodulin-dependent protein kinase II. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[294]  B. Seed,et al.  Isolation of cDNAs of scrapie-modulated RNAs by subtractive hybridization of a cDNA library. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[295]  F. Zoccarato,et al.  Pathways of hydrogen peroxide generation in guinea pig cerebral cortex mitochondria. , 1988, Biochemical and biophysical research communications.

[296]  K. Dobkins,et al.  Decreased levels of protein kinase C in Alzheimer brain , 1988, Brain Research.

[297]  G. Multhaup,et al.  Alzheimer's disease amyloidogenic glycoprotein: expression pattern in rat brain suggests a role in cell contact. , 1988, The EMBO journal.

[298]  R. Mahley,et al.  Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. , 1988, Science.

[299]  G. Multhaup,et al.  Identification, transmembrane orientation and biogenesis of the amyloid A4 precursor of Alzheimer's disease. , 1988, The EMBO journal.

[300]  D. Price,et al.  Multiple Transmitter Systems Contribute Neurites to Individual Senile Plaques , 1988, Journal of neuropathology and experimental neurology.

[301]  D. Selkoe,et al.  Immunochemical identification of the serine protease inhibitor α 1-antichymotrypsin in the brain amyloid deposits of Alzheimer's disease , 1988, Cell.

[302]  S. Shiojiri,et al.  Novel precursor of Alzheimer's disease amyloid protein shows protease inhibitory activity , 1988, Nature.

[303]  L. Villa-komaroff,et al.  Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's disease , 1988, Nature.

[304]  B. Greenberg,et al.  A new A4 amyloid mRNA contains a domain homologous to serine proteinase inhibitors , 1988, Nature.

[305]  D. Choi,et al.  Zinc neurotoxicity in cortical cell culture , 1988, Neuroscience.

[306]  R. Tanzi,et al.  Amyloid β protein gene: cDNA, mRNA distribution and genetic linkage near the Alzheimer locus , 1988 .

[307]  B. Greenberg,et al.  A new A4 amyloid mRNA contains a domain homologous to serine protease inhibitors , 1988 .

[308]  S. Prusiner,et al.  Search for a scrapie-specific nucleic acid: a progress report. , 1988, Ciba Foundation symposium.

[309]  Y. Sakaki,et al.  Complementary DNA for the mouse homolog of the human amyloid beta protein precursor. , 1987, Biochemical and biophysical research communications.

[310]  A. Sandrock,et al.  Identification of a peripheral nerve neurite growth-promoting activity by development and use of an in vitro bioassay. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[311]  J. Haines,et al.  The genetic defect in familial Alzheimer's disease is not tightly linked to the amyloid β-protein gene , 1987, Nature.

[312]  C. Broeckhoven,et al.  Failure of familial Alzheimer's disease to segregate with the A4-amyloid gene in several European families , 1987, Nature.

[313]  M. Mishkin,et al.  Age differences in recognition memory of the rhesus monkey (Macaca mulatta) , 1987, Neurobiology of Aging.

[314]  S. V. van Duinen,et al.  Hereditary cerebral hemorrhage with amyloidosis in patients of Dutch origin is related to Alzheimer disease. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[315]  W. V. Van Nostrand,et al.  Purification of protease nexin II from human fibroblasts. , 1987, The Journal of biological chemistry.

[316]  H. Wiśniewski,et al.  Molecular cloning and characterization of a cDNA encoding the cerebrovascular and the neuritic plaque amyloid peptides. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[317]  S. Prusiner,et al.  Purified prion proteins and scrapie infectivity copartition into liposomes. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[318]  H. Kasai,et al.  Misreading of DNA templates containing 8-hydroxydeoxyguanosine at the modified base and at adjacent residues , 1987, Nature.

[319]  G. Danscher,et al.  Zinc-containing 7S-NGF complex. Evidence from zinc histochemistry for localization in salivary secretory granules. , 1987, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[320]  R. Floyd,et al.  Age-dependent changes in rat brain mitochondria of synaptic and non-synaptic origins , 1987, Mechanisms of Ageing and Development.

[321]  J. Penney,et al.  Homozygotes for Huntington's disease , 1987, Nature.

[322]  M. Lerman,et al.  Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer's disease. , 1987, Science.

[323]  D. Pollen,et al.  The genetic defect causing familial Alzheimer's disease maps on chromosome 21. , 1987, Science.

[324]  D. Price,et al.  Conservation of brain amyloid proteins in aged mammals and humans with Alzheimer's disease. , 1987, Science.

[325]  P. S. St George-Hyslop,et al.  Amyloid beta protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus. , 1987, Science.

[326]  K. Grzeschik,et al.  The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor , 1987, Nature.

[327]  H. Wiśniewski,et al.  Antisera to scrapie-associated fibril protein and prion protein decorate scrapie-associated fibrils , 1987, Journal of virology.

[328]  B. Chesebro,et al.  Cloning of a gene whose expression is increased in scrapie and in senile plaques in human brain , 1987 .

[329]  Nicholas J Hicks,et al.  PLATELET MEMBRANE PROPERTIES IN ALZHEIMER AND MULTI-INFARCT DEMENTIAS , 1987, Alzheimer disease and associated disorders.

[330]  G. Schellenberg,et al.  Association of an apolipoprotein CII allele with familial dementia of the Alzheimer type. , 1987, Journal of neurogenetics.

[331]  T. Crow,et al.  Prion-protein immunoreactivity in human transmissible dementias. , 1986, The New England journal of medicine.

[332]  D. Wallace.  Mitochondrial genes and disease. , 1986, Hospital practice.

[333]  H. Pelham.  Speculations on the functions of the major heat shock and glucose-regulated proteins , 1986, Cell.

[334]  S. Prusiner,et al.  Linkage of prion protein and scrapie incubation time genes , 1986, Cell.

[335]  S. Prusiner,et al.  Amyloid plaques in Creutzfeldt‐Jakob disease stain with prion protein antibodies , 1986, Annals of neurology.

[336]  S. Prusiner,et al.  Molecular cloning of a human prion protein cDNA. , 1986, DNA.

[337]  I. Trowbridge,et al.  Identification of lymphocyte integral membrane proteins as substrates for protein kinase C. Phosphorylation of the interleukin-2 receptor, class I HLA antigens, and T200 glycoprotein. , 1986, The Journal of biological chemistry.

[338]  Cori Bargmann,et al.  Multiple independent activations of the neu oncogene by a point mutation altering the transmembrane domain of p185 , 1986, Cell.

[339]  D. Selkoe,et al.  Isolation of Low‐Molecular‐Weight Proteins from Amyloid Plaque Fibers in Alzheimer's Disease , 1986, Journal of neurochemistry.

[340]  D. Dickson,et al.  A neuronal antigen in the brains of Alzheimer patients. , 1986, Science.

[341]  A. Loewy,et al.  Neuronal cell–cell adhesion depends on interactions of N-CAM with heparin-like molecules , 1986, Nature.

[342]  L. Glaser,et al.  A heparin-binding domain from N-CAM is involved in neural cell- substratum adhesion , 1986, The Journal of cell biology.

[343]  D. Price,et al.  Senile plaques in cortex of aged normal monkeys , 1985, Brain Research.

[344]  R. Martins,et al.  Neuronal origin of a cerebral amyloid: neurofibrillary tangles of Alzheimer's disease contain the same protein as the amyloid of plaque cores and blood vessels. , 1985, The EMBO journal.

[345]  D. Price,et al.  Catecholaminergic neurites in senile plaques in prefrontal cortex of aged nonhuman primates , 1985, Neuroscience.

[346]  A. Eldor,et al.  Zinc-induced platelet aggregation is mediated by the fibrinogen receptor and is not accompanied by release or by thromboxane synthesis. , 1985, Blood.

[347]  G. Danscher,et al.  Intravesicular localization of zinc in rat telencephalic boutons. A histochemical study , 1985, Brain Research.

[348]  C. Masters,et al.  Amyloid plaque core protein in Alzheimer disease and Down syndrome. , 1985, Proceedings of the National Academy of Sciences of the United States of America.

[349]  Ruedi Aebersold,et al.  A cellular gene encodes scrapie PrP 27-30 protein , 1985, Cell.

[350]  H. Wiśniewski,et al.  Occurrence of neuropathological changes and dementia of Alzheimer's disease in Down's syndrome , 1985, Annals of neurology.

[351]  D. Price,et al.  Evidence for cholinergic neurites in senile plaques. , 1984, Science.

[352]  G. Glenner,et al.  Alzheimer's disease and Down's syndrome: sharing of a unique cerebrovascular amyloid fibril protein. , 1984, Biochemical and biophysical research communications.

[353]  L. Hood,et al.  Purification and structural studies of a major scrapie prion protein , 1984, Cell.

[354]  E. Kasarskis.  Zinc metabolism in normal and zinc-deficient rat brain , 1984, Experimental Neurology.

[355]  G. A. Howell,et al.  Stimulation-induced uptake and release of zinc in hippocampal slices , 1984, Nature.

[356]  Shin-Ho Chung,et al.  Release of endogenous Zn2+ from brain tissue during activity , 1984, Nature.

[357]  J. Price,et al.  Fiber systems in the olfactory bulb and cortex: A study in adult and developing rats, Using the Timm method with the light and electron microscope , 1984, The Journal of comparative neurology.

[358]  G. Glenner,et al.  Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. , 1984, Biochemical and biophysical research communications.

[359]  S. Prusiner,et al.  Scrapie prions aggregate to form amyloid-like birefringent rods , 1983, Cell.

[360]  L. Hershey,et al.  Cerebrospinal fluid trace element content in dementia , 1983, Neurology.

[361]  Christopher J. Frederickson,et al.  Cytoarchitectonic distribution of zinc in the hippocampus of man and the rat , 1983, Brain Research.

[362]  S. Prusiner,et al.  RESISTANCE OF THE SCRAPIE AGENT TO INACTIVATION BY PSORALENS , 1983, Photochemistry and photobiology.

[363]  G. Salvesen,et al.  Human plasma proteinase inhibitors. , 1983, Annual review of biochemistry.

[364]  S. Prusiner,et al.  Further purification and characterization of scrapie prions. , 1982, Biochemistry.

[365]  S. Prusiner,et al.  Viroids and prions. , 1982, Proceedings of the National Academy of Sciences of the United States of America.

[366]  D. Price,et al.  Cholinergic innervation in neuritic plaques. , 1982, Science.

[367]  S. Prusiner.  Novel proteinaceous infectious particles cause scrapie. , 1982, Science.

[368]  S. Prusiner,et al.  Scrapie agent contains a hydrophobic protein. , 1981, Proceedings of the National Academy of Sciences of the United States of America.

[369]  J. Griffin,et al.  Incorporation of axonally transported glycoproteins into axolemma during nerve regeneration , 1981, The Journal of cell biology.

[370]  M. Baggiolini,et al.  The latent collagenase and gelatinase of human polymorphonuclear neutrophil leucocytes. , 1980, The Biochemical journal.

[371]  M. Ball,et al.  Neurofibrillary tangles, granulovacuolar degeneration, and neuron loss in down syndrome: Quantitative comparison with alzheimer dementia , 1980, Annals of neurology.

[372]  D. E. Green,et al.  Cardiolipin requirement by cytochrome oxidase and the catalytic role of phospholipid. , 1980, Biochemical and biophysical research communications.

[373]  M. Mattei,et al.  Erythrocyte copper levels in children with trisomy 21. , 2008, Journal of mental deficiency research.

[374]  W. Rutter,et al.  Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. , 1979, Biochemistry.

[375]  W. Brown,et al.  Rapid evolution of animal mitochondrial DNA. , 1979, Proceedings of the National Academy of Sciences of the United States of America.

[376]  R. E. Burch,et al.  A zinc tolerance test. , 1979, The Journal of laboratory and clinical medicine.

[377]  Jonathan O. Harris,et al.  Creutzfeldt‐Jakob disease: Patterns of worldwide occurrence and the significance of familial and sporadic clustering , 1979, Annals of neurology.

[378]  T. Alper,et al.  The scrapie agent: evidence against its dependence for replication on intrinsic nucleic acid. , 1978, The Journal of general virology.

[379]  H. Lander,et al.  Platelet Metal Levels in Normal Subjects Determined by Atomic Absorption Spectrophotometry , 1978, Thrombosis and Haemostasis.

[380]  D. Hegner,et al.  Do mitochondria produce oxygen radicals in vivo? , 1978, European journal of biochemistry.

[381]  E. Cadenas,et al.  Production of superoxide radicals and hydrogen peroxide by NADH-ubiquinone reductase and ubiquinol-cytochrome c reductase from beef-heart mitochondria. , 1977, Archives of biochemistry and biophysics.

[382]  D. A. Clayton,et al.  The absence of a pyrimidine dimer repair mechanism in mammalian mitochondria. , 1974, Proceedings of the National Academy of Sciences of the United States of America.

[383]  M. Alter,et al.  Creutzfeldt-Jakob Disease: Focus among Libyan Jews in Israel , 1974, Science.

[384]  H. Wiśniewski,et al.  NEURITIC (SENILE) PLAQUES AND FILAMENTOUS CHANGES IN AGED RHESUS MONKEYS , 1973, Journal of neuropathology and experimental neurology.

[385]  D. Gajdusek,et al.  The clinical characteristics of transmissible Creutzfeldt-Jakob disease. , 1973, Brain : a journal of neurology.

[386]  H. Wiśniewski,et al.  Morphology of the aging brain, human and animal. , 1973, Progress in brain research.

[387]  A. Tappel.  Lipid peroxidation damage to cell components. , 1973, Federation proceedings.

[388]  G. D. Hunter.  Scrapie: a prototype slow infection. , 1972, The Journal of infectious diseases.

[389]  R. O'Neal,et al.  Effect of zinc deficiency and restricted feeding on protein and ribonucleic acid metabolism of rat brain. , 1970, The Journal of nutrition.

[390]  Y. Ibata,et al.  ELECTRON MICROSCOPIC DEMONSTRATION OF ZINC IN THE HIPPOCAMPAL FORMATION USING TIMM'S SULFIDE-SILVER TECHNIQUE , 1969, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[391]  P. Daniel,et al.  Creutzfeldt-Jakob Disease (Spongiform Encephalopathy): Transmission to the Chimpanzee , 1968, Science.

[392]  I. J. Davies,et al.  Measurements of plasma zinc , 1968, Journal of clinical pathology.

[393]  I. Pattison,et al.  The possible nature of the transmissible agent of scrapie , 1967, Veterinary Record.

[394]  L. Heston,et al.  Alzheimer's disease. A family study. , 1966, Archives of neurology.

[395]  I. Pattison.  The relative susceptibility of sheep, goats and mice to two types of the goat scrapie agent. , 1966, Research in veterinary science.

[396]  M. Alpers,et al.  Experimental Transmission of a Kuru-like Syndrome to Chimpanzees , 1966, Nature.

[397]  N. E. Mckinnon,et al.  Estimating the impact of the COVID-19 pandemic on rising trends in drug overdose mortality in the United States, 2018-2021 , 2022, Annals of Epidemiology.

[398]  J. Gerstmann,et al.  Über eine eigenartige hereditär- familiäre Erkrankung des Zentralnervensystems , 1935 .

[399]  B. Sigurdsson.  RIDA, A Chronic Encephalitis of Sheep: With General Remarks on Infections Which Develop Slowly and Some of Their Special Characteristics , 1954 .

[400]  D. Moffie.  Presenile dementia. , 1953, Folia psychiatrica, neurologica et neurochirurgica Neerlandica.

[401]  P. Mcgeer,et al.  Complement activation by f8-amyloid in Alzheimer disease , 2022 .