Successful use of terlipressin in post-cardiac arrest resuscitation after an epinephrine-resistant anaphylactic shock to suxamethonium.

EPINEPHRINE is considered in most guidelines as the first-line treatment of anaphylactic shock occurring during anesthesia. In some cases, epinephrine is not effective, and alternative therapies have been proposed, such as norepinephrine or metaraminol 1 or, more recently, arginine vasopressin. 2 ' 4 To our knowledge, we are the first to report the successful treatment of anaphylactic shock with terlipressin, a structural analog of arginine vasopressin.

[1]  D. Longrois,et al.  Comparison of Arginine Vasopressin, Terlipressin, or Epinephrine to Correct Hypotension in a Model of Anaphylactic Shock in Anesthetized Brown Norway Rats , 2006, Anesthesiology.

[2]  A. Rainbird,et al.  Use of alpha‐agonists for management of anaphylaxis occurring under anaesthesia: case studies and review , 2004, Anaesthesia.

[3]  W. Schummer,et al.  Anaphylactic shock: is vasopressin the drug of choice? , 2004, Anesthesiology.

[4]  C. Kill,et al.  Successful Treatment of Severe Anaphylactic Shock with Vasopressin , 2004, International Archives of Allergy and Immunology.

[5]  A. Denault,et al.  Vasopressin for treatment of shock following aprotinin administration , 2004, Canadian journal of anaesthesia = Journal canadien d'anesthesie.

[6]  F. Alla,et al.  Anaphylactic and Anaphylactoid Reactions Occurring during Anesthesia in France in 1999–2000 , 2003, Anesthesiology.

[7]  M. Pinaud,et al.  [What are the physiopathological mechanisms? How can severe anaphylactoid reactions be explained]. , 2002, Annales francaises d'anesthesie et de reanimation.

[8]  M. Pinaud,et al.  Quels sont les mécanismes en général ?Comment expliquer les expressions cliniques gravissimes ? , 2002 .

[9]  M. Singer,et al.  Terlipressin for norepinephrine-resistant septic shock , 2002, The Lancet.

[10]  D. Østergaard,et al.  Management of anaphylactic shock evaluated using a full‐scale anaesthesia simulator , 2001, Acta anaesthesiologica Scandinavica.

[11]  M. Laxenaire Épidémiologie des réactions anaphylactoïdes peranesthésiques. Quatrième enquête multicentrique (juillet 1994-décembre 1996) , 1999 .

[12]  P. Coriat,et al.  Treatment of intraoperative refractory hypotension with terlipressin in patients chronically treated with an antagonist of the renin-angiotensin system. , 1999, Anesthesia and analgesia.

[13]  M. Laxenaire [Epidemiology of anesthetic anaphylactoid reactions. Fourth multicenter survey (July 1994-December 1996)]. , 1999, Annales francaises d'anesthesie et de reanimation.