Rational construction of a practical enzyme-activatable fluorogenic substrate for hNotum and its applications in functional imaging and inhibitor screening
暂无分享,去创建一个
Guangbo Ge | Zhenhao Tian | Yunqing Song | Meng-Ru Sun | Jinhui Shi | Li-Lin Song | Hui Wei | Tian Tian | Bei Zhao | Guang-Hui Zhu
[1] Tong Zhu,et al. Monitoring acetylcholinesterase level changes under oxidative stress through ESIPT-ICT-based near-infrared fluorescent probe , 2023, Sensors and Actuators B: Chemical.
[2] Hui Liu,et al. Rational Construction of a Novel Bioluminescent Substrate for Sensing the Tumor-Associated Hydrolase Notum. , 2023, Analytical chemistry.
[3] Guanghao Zhu,et al. Functional Imaging and Inhibitor Screening of Human Pancreatic Lipase by a Resorufin-Based Fluorescent Probe , 2023, Biosensors.
[4] J. Zhang,et al. High-throughput optical assays for sensing serine hydrolases in living systems and their applications , 2022, TrAC Trends in Analytical Chemistry.
[5] M. Finel,et al. Optical substrates for drug-metabolizing enzymes: Recent advances and future perspectives , 2022, Acta pharmaceutica Sinica. B.
[6] Marie J Parsons,et al. WNT as a Driver and Dependency in Cancer. , 2021, Cancer discovery.
[7] Zhenhao Tian,et al. Rational design and development of a novel and highly specific near-infrared fluorogenic substrate for sensing and imaging of human pancreatic lipase in living systems , 2021 .
[8] Maria C. Lecca,et al. Apc-mutant cells act as supercompetitors in intestinal tumour initiation , 2021, Nature.
[9] H. Clevers,et al. NOTUM from Apc-mutant cells biases clonal competition to initiate cancer , 2021, Nature.
[10] M. Finel,et al. A fluorescence-based microplate assay for high-throughput screening and evaluation of human UGT inhibitors. , 2021, Analytica chimica acta.
[11] F. Svensson,et al. Carboxylesterase Notum Is a Druggable Target to Modulate Wnt Signaling , 2021, Journal of medicinal chemistry.
[12] E. Jones,et al. Notum deacylates octanoylated ghrelin , 2021, Molecular metabolism.
[13] A. Joyner,et al. Single-Cell Profiling and SCOPE-Seq Reveal Lineage Dynamics of Adult Ventricular-Subventricular Zone Neurogenesis and NOTUM as a Key Regulator , 2020, Cell reports.
[14] Guangbo Ge,et al. Sensing cytochrome P450 1A1 activity by a resorufin-based isoform-specific fluorescent probe , 2020 .
[15] S. Kabekkodu,et al. Aberrant canonical Wnt signaling: Phytochemical based modulation. , 2020, Phytomedicine : international journal of phytotherapy and phytopharmacology.
[16] Weixian Lu,et al. Structural characterization of melatonin as an inhibitor of the Wnt deacylase Notum , 2019, Journal of pineal research.
[17] P. Auvinen,et al. Notum produced by Paneth cells attenuates regeneration of aged intestinal epithelium , 2019, Nature.
[18] P. Fish,et al. An improved, scalable synthesis of Notum inhibitor LP-922056 using 1-chloro-1,2-benziodoxol-3-one as a superior electrophilic chlorinating agent , 2019, Beilstein Journal of Organic Chemistry.
[19] F. Rivadeneira,et al. Osteoblast-derived NOTUM reduces cortical bone mass in mice and the NOTUM locus is associated with bone mineral density in humans , 2019, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[20] F. Mseeh,et al. NOTUM inhibition increases endocortical bone formation and bone strength , 2019, Bone Research.
[21] S. Angers,et al. Wnt signaling in development and tissue homeostasis , 2018, Development.
[22] B. Cravatt,et al. Selective Irreversible Inhibitors of the Wnt-Deacylating Enzyme NOTUM Developed by Activity-Based Protein Profiling , 2018, ACS medicinal chemistry letters.
[23] W. Matthijs Blankesteijn,et al. WNT Signaling in Cardiac and Vascular Disease , 2018, Pharmacological Reviews.
[24] Y. Huang,et al. Rescued expression of WIF-1 in gallbladder cancer inhibits tumor growth and induces tumor cell apoptosis with altered expression of proteins , 2016, Molecular medicine reports.
[25] R. Martins,et al. sFRP-mediated Wnt sequestration as a potential therapeutic target for Alzheimer's disease. , 2016, The international journal of biochemistry & cell biology.
[26] Alan G. E. Wilson,et al. Stimulation of cortical bone formation with thienopyrimidine based inhibitors of Notum Pectinacetylesterase. , 2016, Bioorganic & medicinal chemistry letters.
[27] Y. Feodorova,et al. Novel insights into Notum and glypicans regulation in colorectal cancer , 2015, Oncotarget.
[28] R. Brommage. Genetic Approaches To Identifying Novel Osteoporosis Drug Targets , 2015, Journal of cellular biochemistry.
[29] M. Grossel,et al. An enhanced chimeric firefly luciferase-inspired enzyme for ATP detection and bioluminescence reporter and imaging applications. , 2015, Analytical biochemistry.
[30] E. Jones,et al. Notum is required for neural and head induction via Wnt deacylation, oxidation, and inactivation. , 2015, Developmental cell.
[31] Jean-Paul Vincent,et al. Notum deacylates Wnts to suppress signalling activity , 2015, Nature.
[32] F. Zhou,et al. Dickkopf-1 is a key regulator of myeloma bone disease: opportunities and challenges for therapeutic intervention. , 2013, Blood reviews.
[33] Christof Niehrs,et al. Secreted and transmembrane wnt inhibitors and activators. , 2013, Cold Spring Harbor perspectives in biology.
[34] K. Garcia,et al. Structural Basis of Wnt Recognition by Frizzled , 2012, Science.
[35] H. Varmus,et al. Three decades of Wnts: a personal perspective on how a scientific field developed , 2012, The EMBO journal.
[36] Hans Clevers,et al. Wnt/β-Catenin Signaling and Disease , 2012, Cell.
[37] Paula van Tijn,et al. Wnt signaling in Alzheimer's disease: Up or down, that is the question , 2009, Ageing Research Reviews.
[38] Robin S. Dothager,et al. Advances in bioluminescence imaging of live animal models. , 2009, Current opinion in biotechnology.
[39] H. Aburatani,et al. Human homolog of NOTUM, overexpressed in hepatocellular carcinoma, is regulated transcriptionally by β‐catenin/TCF , 2008, Cancer science.
[40] R. Nusse,et al. Wnt signaling and stem cell control , 2008, Cell Research.
[41] N. Ueno,et al. Monounsaturated fatty acid modification of Wnt protein: its role in Wnt secretion. , 2006, Developmental cell.
[42] Hans Clevers,et al. Wnt/β-Catenin Signaling in Development and Disease , 2006, Cell.
[43] F. Le Grand,et al. Wnt Signaling in Skeletal Muscle Development and Regeneration. , 2018, Progress in molecular biology and translational science.
[44] R. Nusse,et al. Wnt proteins. , 2012, Cold Spring Harbor perspectives in biology.