Inhibitors of ROS production by the ubiquinone-binding site of mitochondrial complex I identified by chemical screening.

[1]  R. E. Hughes,et al.  Novel Inhibitors of Mitochondrial sn-Glycerol 3-phosphate Dehydrogenase , 2014, PloS one.

[2]  A. Orr,et al.  Sites of superoxide and hydrogen peroxide production during fatty acid oxidation in rat skeletal muscle mitochondria. , 2013, Free radical biology & medicine.

[3]  A. Orr,et al.  The role of mitochondrial function and cellular bioenergetics in ageing and disease , 2013, The British journal of dermatology.

[4]  Linda Partridge,et al.  Cardioprotection by S-nitrosation of a cysteine switch on mitochondrial complex I , 2013, Nature Medicine.

[5]  A. Orr,et al.  Sites of reactive oxygen species generation by mitochondria oxidizing different substrates☆ , 2013, Redox biology.

[6]  T. Sanderson,et al.  Molecular Mechanisms of Ischemia–Reperfusion Injury in Brain: Pivotal Role of the Mitochondrial Membrane Potential in Reactive Oxygen Species Generation , 2013, Molecular Neurobiology.

[7]  P. Grudnik,et al.  T cell activation is driven by an ADP-dependent glucokinase linking enhanced glycolysis with mitochondrial reactive oxygen species generation. , 2012, Cell reports.

[8]  A. Orr,et al.  A Refined Analysis of Superoxide Production by Mitochondrial sn-Glycerol 3-Phosphate Dehydrogenase* , 2012, The Journal of Biological Chemistry.

[9]  A. Orr,et al.  Native rates of superoxide production from multiple sites in isolated mitochondria measured using endogenous reporters. , 2012, Free radical biology & medicine.

[10]  J. Nunnari,et al.  Mitochondria: In Sickness and in Health , 2012, Cell.

[11]  A. Starkov,et al.  The Oxygen Free Radicals Originating from Mitochondrial Complex I Contribute to Oxidative Brain Injury Following Hypoxia–Ischemia in Neonatal Mice , 2012, The Journal of Neuroscience.

[12]  J. Eisenbart,et al.  Mitochondrial complex III ROS regulate adipocyte differentiation. , 2011, Cell metabolism.

[13]  M. Brand,et al.  High Throughput Microplate Respiratory Measurements Using Minimal Quantities Of Isolated Mitochondria , 2011, PloS one.

[14]  M. Brand,et al.  The Mechanism of Superoxide Production by the Antimycin-inhibited Mitochondrial Q-cycle* , 2011, The Journal of Biological Chemistry.

[15]  M. Brand,et al.  Evidence for Two Sites of Superoxide Production by Mitochondrial NADH-Ubiquinone Oxidoreductase (Complex I)* , 2011, The Journal of Biological Chemistry.

[16]  M. Brand,et al.  A Model of the Proton Translocation Mechanism of Complex I* , 2011, The Journal of Biological Chemistry.

[17]  J. Hirst,et al.  Superoxide Is Produced by the Reduced Flavin in Mitochondrial Complex I , 2011, The Journal of Biological Chemistry.

[18]  V. Fung,et al.  A double‐blind, placebo‐controlled study to assess the mitochondria‐targeted antioxidant MitoQ as a disease‐modifying therapy in Parkinson's disease , 2010, Movement disorders : official journal of the Movement Disorder Society.

[19]  Robin A. J. Smith,et al.  The mitochondria‐targeted anti‐oxidant mitoquinone decreases liver damage in a phase II study of hepatitis C patients , 2010, Liver international : official journal of the International Association for the Study of the Liver.

[20]  Martin D. Brand,et al.  The sites and topology of mitochondrial superoxide production , 2010, Experimental Gerontology.

[21]  W. Wheaton,et al.  Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity , 2010, Proceedings of the National Academy of Sciences.

[22]  D. Kerr Treatment of mitochondrial electron transport chain disorders: a review of clinical trials over the past decade. , 2010, Molecular genetics and metabolism.

[23]  A. J. Lambert,et al.  Low complex I content explains the low hydrogen peroxide production rate of heart mitochondria from the long‐lived pigeon, Columba livia , 2010, Aging cell.

[24]  A. J. Lambert,et al.  Diphenyleneiodonium acutely inhibits reactive oxygen species production by mitochondrial complex I during reverse, but not forward electron transport. , 2008, Biochimica et biophysica acta.

[25]  F. Muller,et al.  High rates of superoxide production in skeletal-muscle mitochondria respiring on both complex I- and complex II-linked substrates. , 2008, The Biochemical journal.

[26]  A. J. Lambert,et al.  Low rates of hydrogen peroxide production by isolated heart mitochondria associate with long maximum lifespan in vertebrate homeotherms , 2007, Aging cell.

[27]  F. Muller,et al.  Trends in oxidative aging theories. , 2007, Free radical biology & medicine.

[28]  J. Eisenbart,et al.  Jcb: Article , 2022 .

[29]  C. Block,et al.  Mechanisms linking obesity with cardiovascular disease , 2006, Nature.

[30]  M. Beal,et al.  Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases , 2006, Nature.

[31]  Robert Nadon,et al.  Statistical practice in high-throughput screening data analysis , 2006, Nature Biotechnology.

[32]  Bert Gunter,et al.  Improved Statistical Methods for Hit Selection in High-Throughput Screening , 2003, Journal of biomolecular screening.

[33]  M. Brand,et al.  Topology of Superoxide Production from Different Sites in the Mitochondrial Electron Transport Chain* , 2002, The Journal of Biological Chemistry.

[34]  Todd B. Sherer,et al.  Chronic systemic pesticide exposure reproduces features of Parkinson's disease , 2000, Nature Neuroscience.

[35]  N. Holbrook,et al.  Oxidants, oxidative stress and the biology of ageing , 2000, Nature.

[36]  Thomas D. Y. Chung,et al.  A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays , 1999, Journal of biomolecular screening.

[37]  J. Langston,et al.  Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis. , 1983, Science.

[38]  G. Benzi,et al.  Influence of some biological pyrimidines on the succinate cycle during and after cerebral ischemia. , 1979, Biochemical pharmacology.

[39]  B. Siesjö,et al.  Influence of complete ischemia on glycolytic metabolites, citric acid cycle intermediates, and associated amino acids in the rat cerebral cortex. , 1974, Brain research.

[40]  D. Harman,et al.  THE FREE RADICAL THEORY OF AGING: EFFECT OF AGE ON SERUM COPPER LEVELS. , 1965, Journal of gerontology.

[41]  M. Brand,et al.  Measurement of proton leak and electron leak in isolated mitochondria. , 2012, Methods in molecular biology.

[42]  P. Brookes,et al.  Response of mitochondrial reactive oxygen species generation to steady-state oxygen tension: implications for hypoxic cell signaling. , 2007, American journal of physiology. Heart and circulatory physiology.

[43]  R C Scaduto,et al.  Measurement of mitochondrial membrane potential using fluorescent rhodamine derivatives. , 1999, Biophysical journal.