A Phase-Locking Analysis of Neuronal Firing Rhythms with Transcranial Magneto-Acoustical Stimulation Based on the Hodgkin-Huxley Neuron Model

Transcranial magneto-acoustical stimulation (TMAS) uses ultrasonic waves and a static magnetic field to generate electric current in nerve tissues for the purpose of modulating neuronal activities. It has the advantage of high spatial resolution and penetration depth. Neuronal firing rhythms carry and transmit nerve information in neural systems. In this study, we investigated the phase-locking characteristics of neuronal firing rhythms with TMAS based on the Hodgkin-Huxley neuron model. The simulation results indicate that the modulation frequency of ultrasound can affect the phase-locking behaviors. The results of this study may help us to explain the potential firing mechanism of TMAS.

[1]  Yusuf Tufail,et al.  Ultrasonic neuromodulation by brain stimulation with transcranial ultrasound , 2011, Nature Protocols.

[2]  Jean-Yves Chapelon,et al.  Lorentz force electrical impedance tomography , 2013, 1402.2573.

[3]  Xiaoli Li,et al.  Theoretical Analysis of Transcranial Magneto-Acoustical Stimulation with Hodgkin-Huxley Neuron Model , 2016, Front. Comput. Neurosci..

[4]  Alvaro Pascual-Leone,et al.  Safety and tolerability of repetitive transcranial magnetic stimulation in patients with pathologic positive sensory phenomena: A review of literature , 2012, Brain Stimulation.

[5]  M. Carandini,et al.  Membrane Potential and Firing Rate in Cat Primary Visual Cortex , 2000, The Journal of Neuroscience.

[6]  Stephen J Norton,et al.  Can ultrasound be used to stimulate nerve tissue? , 2003, Biomedical engineering online.

[7]  Xiaoli Li,et al.  Noninvasive transcranial focused ultrasonic-magnetic stimulation for modulating brain oscillatory activity , 2016 .

[8]  Piotr J Durka,et al.  From wavelets to adaptive approximations: time-frequency parametrization of EEG , 2003, Biomedical engineering online.

[9]  Terrence J. Sejnowski,et al.  Biophysical Basis for Three Distinct Dynamical Mechanisms of Action Potential Initiation , 2008, PLoS Comput. Biol..

[10]  Laurent Seppecher,et al.  A mathematical and numerical framework for ultrasonically-induced Lorentz force electrical impedance tomography☆ , 2014 .

[11]  S. Tillery,et al.  Transcranial Pulsed Ultrasound Stimulates Intact Brain Circuits , 2010, Neuron.

[12]  Yanqiu Che,et al.  Phase-locking and chaos in a silent Hodgkin–Huxley neuron exposed to sinusoidal electric field , 2009 .

[13]  J. Jossinet,et al.  Electric current generated by ultrasonically induced Lorentz force in biological media , 2006, Medical and Biological Engineering and Computing.

[14]  Amit P. Mulgaonkar,et al.  A review of low-intensity focused ultrasound pulsation , 2011, Brain Stimulation.

[15]  Jong-Hwan Lee,et al.  Focused ultrasound modulates region-specific brain activity , 2011, NeuroImage.

[16]  A. Hodgkin,et al.  A quantitative description of membrane current and its application to conduction and excitation in nerve , 1952, The Journal of physiology.

[17]  Y. Koninck,et al.  Four cell types with distinctive membrane properties and morphologies in lamina I of the spinal dorsal horn of the adult rat , 2002, The Journal of physiology.