CD4+ T cell-derived IL21 regulates stem cell fate in acute myeloid leukemia by activation of p38-MAPK signaling
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C. Riether | A. Ochsenbein | L. Tortola | S. Höpner | Rémy Bruggman | Viviana Rubino | M. Kronig | Michelle Hüppi | Lea Taylor | Irene Keller | Ulrike Bacher | Manfred Kopf | Ulrike Bacher | M. Kopf
[1] C. Riether,et al. Regulation of hematopoietic and leukemia stem cells by regulatory T cells , 2022, Frontiers in immunology.
[2] Sandra Pinho,et al. Leukemic Stem Cells: From Leukemic Niche Biology to Treatment Opportunities , 2021, Frontiers in Immunology.
[3] L. Smit,et al. Escape From Treatment; the Different Faces of Leukemic Stem Cells and Therapy Resistance in Acute Myeloid Leukemia , 2021, Frontiers in Oncology.
[4] M. Konopleva,et al. IDH1/IDH2 Inhibition in Acute Myeloid Leukemia , 2021, Frontiers in Oncology.
[5] D. Bezerra,et al. Cell signaling pathways as molecular targets to eliminate AML stem cells. , 2021, Critical reviews in oncology/hematology.
[6] A. Nebreda,et al. Diversity and versatility of p38 kinase signalling in health and disease , 2021, Nature Reviews Molecular Cell Biology.
[7] Danfeng Xue,et al. Emerging role of NRF2 in ROS-mediated tumor chemoresistance. , 2020, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
[8] A. Letai,et al. Azacitidine and Venetoclax in Previously Untreated Acute Myeloid Leukemia. , 2020, The New England journal of medicine.
[9] R. Bruggmann,et al. Targeting CD70 with cusatuzumab eliminates acute myeloid leukemia stem cells in patients treated with hypomethylating agents , 2020, Nature Medicine.
[10] Song-Tao Liu,et al. Cell division symmetry control and cancer stem cells , 2020, AIMS molecular science.
[11] Zhichen Sun,et al. Targeting tumors with IL-21 reshapes the tumor microenvironment by proliferating PD-1intTim-3-CD8+ T cells. , 2020, JCI insight.
[12] Patrick M. Helbling,et al. Combined single-cell and spatial transcriptomics reveal the molecular, cellular and spatial bone marrow niche organization , 2019, Nature Cell Biology.
[13] Andreas Keller,et al. Undulating changes in human plasma proteome profiles across the lifespan , 2019, Nature Medicine.
[14] C. Récher,et al. Targeting Myeloperoxidase Disrupts Mitochondrial Redox Balance and Overcomes Cytarabine Resistance in Human Acute Myeloid Leukemia. , 2019, Cancer research.
[15] Xiaomei Ma,et al. Epidemiology of acute myeloid leukemia: Recent progress and enduring challenges. , 2019, Blood reviews.
[16] A. D’Alessandro,et al. Inhibition of Amino Acid Metabolism Selectively Targets Human Leukemia Stem Cells. , 2019, Cancer cell.
[17] S. Nimer. Faculty Opinions recommendation of Midostaurin plus Chemotherapy for Acute Myeloid Leukemia with a FLT3 Mutation. , 2018, Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature.
[18] Ø. Bruserud,et al. Therapeutic targeting of leukemic stem cells in acute myeloid leukemia – the biological background for possible strategies , 2017, Expert opinion on drug discovery.
[19] C. Bloomfield,et al. Midostaurin plus Chemotherapy for Acute Myeloid Leukemia with a FLT3 Mutation , 2017, The New England journal of medicine.
[20] R. Majeti,et al. Biology and relevance of human acute myeloid leukemia stem cells. , 2017, Blood.
[21] D. Pollyea,et al. Therapeutic targeting of acute myeloid leukemia stem cells. , 2017, Blood.
[22] F. Vallières,et al. Mechanism involved in interleukin‐21‐induced phagocytosis in human monocytes and macrophages , 2017, Clinical and experimental immunology.
[23] T. Pabst,et al. CD70/CD27 signaling promotes blast stemness and is a viable therapeutic target in acute myeloid leukemia , 2017, The Journal of experimental medicine.
[24] F. Ramos,et al. Acute myeloid leukemia in the older adults , 2016, Leukemia research reports.
[25] W. Leonard,et al. IL-21 Signaling in Immunity , 2016, F1000Research.
[26] Steven L Salzberg,et al. HISAT: a fast spliced aligner with low memory requirements , 2015, Nature Methods.
[27] W. Huber,et al. Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2 , 2014, Genome Biology.
[28] C. Schürch,et al. Regulation of hematopoietic and leukemic stem cells by the immune system , 2014, Cell Death and Differentiation.
[29] W. Leonard,et al. Interleukin-21: a double-edged sword with therapeutic potential , 2014, Nature Reviews Drug Discovery.
[30] Y. Iwakura,et al. Positive feedback between NF-κB and TNF-α promotes leukemia-initiating cell capacity. , 2014, The Journal of clinical investigation.
[31] G. Hardiman,et al. Lis1 regulates asymmetric division in hematopoietic stem cells and in leukemia , 2014, Nature Genetics.
[32] E. Remmerswaal,et al. IL-21 and CD40L signals from autologous T cells can induce antigen-independent proliferation of CLL cells. , 2013, Blood.
[33] John M. Ashton,et al. Targeting Aberrant Glutathione Metabolism to Eradicate Human Acute Myelogenous Leukemia Cells* , 2013, The Journal of Biological Chemistry.
[34] M. Dyer,et al. Enhancement of CD154/IL4 proliferation by the T follicular helper (Tfh) cytokine, IL21 and increased numbers of circulating cells resembling Tfh cells in chronic lymphocytic leukaemia , 2013, British journal of haematology.
[35] M. Caligiuri,et al. A stem cell-like gene expression signature associates with inferior outcomes and a distinct microRNA expression profile in adults with primary cytogenetically normal acute myeloid leukemia , 2013, Leukemia.
[36] D. LeBrun,et al. Abundant expression of interleukin-21 receptor in follicular lymphoma cells is associated with more aggressive disease , 2013, Leukemia & lymphoma.
[37] Wei Shi,et al. featureCounts: an efficient general purpose program for assigning sequence reads to genomic features , 2013, Bioinform..
[38] W. Leonard,et al. IL-21 Restricts Virus-driven Treg Cell Expansion in Chronic LCMV Infection , 2013, PLoS pathogens.
[39] John M. Ashton,et al. BCL-2 inhibition targets oxidative phosphorylation and selectively eradicates quiescent human leukemia stem cells. , 2013, Cell stem cell.
[40] Wei Li,et al. RSeQC: quality control of RNA-seq experiments , 2012, Bioinform..
[41] Guangchuang Yu,et al. clusterProfiler: an R package for comparing biological themes among gene clusters. , 2012, Omics : a journal of integrative biology.
[42] Angelo J. Canty,et al. Stem cell gene expression programs influence clinical outcome in human leukemia , 2011, Nature Medicine.
[43] W. Telford,et al. Key role for IL-21 in experimental autoimmune uveitis , 2011, Proceedings of the National Academy of Sciences of the United States of America.
[44] R. Hills,et al. Refinement of cytogenetic classification in acute myeloid leukemia: determination of prognostic significance of rare recurring chromosomal abnormalities among 5876 younger adult patients treated in the United Kingdom Medical Research Council trials. , 2010, Blood.
[45] Wolfram Goessling,et al. The Wnt/β-Catenin Pathway Is Required for the Development of Leukemia Stem Cells in AML , 2010, Science.
[46] I. Lossos,et al. Novel IL-21 signaling pathway up-regulates c-Myc and induces apoptosis of diffuse large B-cell lymphomas. , 2010, Blood.
[47] G. Smyth,et al. ELDA: extreme limiting dilution analysis for comparing depleted and enriched populations in stem cell and other assays. , 2009, Journal of immunological methods.
[48] M. Minden,et al. Outcomes and quality of care in acute myeloid leukemia over 40 years , 2009, Cancer.
[49] Jeffrey M. Rosen,et al. The Increasing Complexity of the Cancer Stem Cell Paradigm , 2009, Science.
[50] K. Sauer,et al. IL-21 Is Required to Control Chronic Viral Infection , 2009, Science.
[51] J. Weber,et al. IL-21R on T Cells Is Critical for Sustained Functionality and Control of Chronic Viral Infection , 2009, Science.
[52] Daniel Nowak,et al. Differentiation therapy of leukemia: 3 decades of development. , 2009, Blood.
[53] Ulrich Mansmann,et al. An 86-probe-set gene-expression signature predicts survival in cytogenetically normal acute myeloid leukemia. , 2008, Blood.
[54] R. Bataille,et al. IL-21 Stimulates Human Myeloma Cell Growth through an Autocrine IGF-1 Loop , 2008, The Journal of Immunology.
[55] R. Meier,et al. IL‐21 and IL‐21R are not required for development of Th17 cells and autoimmunity in vivo , 2008, European journal of immunology.
[56] Thomas D. Schmittgen,et al. Analyzing real-time PCR data by the comparative CT method , 2008, Nature Protocols.
[57] K. Karube,et al. IL-21 is expressed in Hodgkin lymphoma and activates STAT5: evidence that activated STAT5 is required for Hodgkin lymphomagenesis. , 2008, Blood.
[58] W. Leonard,et al. Interleukin-21: basic biology and implications for cancer and autoimmunity. , 2008, Annual review of immunology.
[59] Keisuke Ito,et al. Function of oxidative stress in the regulation of hematopoietic stem cell-niche interaction. , 2007, Biochemical and biophysical research communications.
[60] I. Weissman,et al. Identification of a hierarchy of multipotent hematopoietic progenitors in human cord blood. , 2007, Cell stem cell.
[61] S. Sharkis,et al. A low level of reactive oxygen species selects for primitive hematopoietic stem cells that may reside in the low-oxygenic niche. , 2007, Blood.
[62] D. Levy,et al. The molecular basis of IL-21-mediated proliferation. , 2007, Blood.
[63] M. Kurrer,et al. IL-21 receptor signaling is integral to the development of Th2 effector responses in vivo. , 2007, Blood.
[64] P. Kristjansen,et al. Interleukin 21 therapy increases the density of tumor infiltrating CD8+ T cells and inhibits the growth of syngeneic tumors , 2007, Cancer Immunology, Immunotherapy.
[65] Arne Traulsen,et al. (A)Symmetric Stem Cell Replication and Cancer , 2007, PLoS Comput. Biol..
[66] T. Wynn,et al. The IL-21 receptor augments Th2 effector function and alternative macrophage activation. , 2006, The Journal of clinical investigation.
[67] Younghun Jung,et al. Regulation of SDF-1 (CXCL12) production by osteoblasts; a possible mechanism for stem cell homing. , 2006, Bone.
[68] J. Dick,et al. Cancer stem cells: lessons from leukemia. , 2005, Trends in cell biology.
[69] L. Lanier,et al. IL-21 Enhances Tumor Rejection through a NKG2D-Dependent Mechanism1 , 2005, The Journal of Immunology.
[70] J. Dick. Acute Myeloid Leukemia Stem Cells , 2005, Annals of the New York Academy of Sciences.
[71] Tak W. Mak,et al. Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells , 2004, Nature.
[72] Qingsheng Li,et al. IL-21 Enhances and Sustains CD8+ T Cell Responses to Achieve Durable Tumor Immunity: Comparative Evaluation of IL-2, IL-15, and IL-211 , 2004, The Journal of Immunology.
[73] J. Dick,et al. Acute myeloid leukemia originates from a hierarchy of leukemic stem cell classes that differ in self-renewal capacity , 2004, Nature Immunology.
[74] R. Verhaak,et al. Prognostically useful gene-expression profiles in acute myeloid leukemia. , 2004, The New England journal of medicine.
[75] W. Leonard,et al. In vivo antitumor activity of interleukin 21 mediated by natural killer cells. , 2003, Cancer research.
[76] M. Tagawa,et al. Expression of the interleukin-21 gene in murine colon carcinoma cells generates systemic immunity in the inoculated hosts , 2003, Cancer Gene Therapy.
[77] Daniel G. Tenen,et al. Disruption of differentiation in human cancer: AML shows the way , 2003, Nature Reviews Cancer.
[78] A. Sher,et al. A Critical Role for IL-21 in Regulating Immunoglobulin Production , 2002, Science.
[79] J. Dick,et al. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell , 1997, Nature Medicine.
[80] M. Caligiuri,et al. A cell initiating human acute myeloid leukaemia after transplantation into SCID mice , 1994, Nature.
[81] 雁金 大樹. p38α activates purine metabolism to initiate hematopoietic stem/progenitor cell cycling in response to stress(要約) , 2016 .
[82] 中田 潤,et al. In vivo eradication of MLL/ENL leukemia cells by NK cells in the absence of adaptive immunity , 2014 .
[83] W. Leonard,et al. The Dectin-2 family of C-type lectin-like receptors: an update , 2013, International immunology.