Regio- and stereo-selectively kinetic resolution of four stereoisomers of 1-phenylbutan-1,3-diol by Candida rugosa lipase

Regio- and stereo-selective Candida rugosa lipase (CRL)-catalyzed acetylations of (±)-syn-1-phenylbutan-1,3-diols ((±)-syn-1) generated two monoacetates, (+)-syn-2 and (–)-syn-3, whereas that of (±)-anti-1 produced a monoacetate, (+)-anti-3, and an unreacted (–)-anti-1.Key words: Candida rugosa lipase, kinetic resolution, 1,3-diols.